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Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 14, 2012, Pages 4640-4644

Novel BACE1 inhibitors possessing a 5-nitroisophthalic scaffold at the P2 position

(8) Hamada, Yoshio a,b Nakanishi, Tomoya b Suzuki, Kenji b Yamaguchi, Ryoji b Hamada, Takashi b,d Hidaka, Koushi a,b Ishiura, Shoichi c Kiso, Yoshiaki a,b,d

a KOBE GAKUIN UNIVERSITY (Japan)

b KYOTO PHARMACEUTICAL UNIVERSITY (Japan)

c UNIVERSITY OF TOKYO (Japan)

d NAGAHAMA INSTITUTE OF BIO SCIENCE AND TECHNOLOGY (Japan)

Author keywords

Secretase; Alzheimer's disease; BACE1; BACE1 inhibitor

Indexed keywords

5 NITROISOPHTHALIC; BETA SECRETASE 1; BETA SECRETASE 1 INHIBITOR; BETA SECRETASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BIOAVAILABILITY; ENZYME INHIBITION; MEMBRANE PERMEABILITY; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ACID ENDOPEPTIDASES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NITRO COMPOUNDS; PEPTIDE HYDROLASES; PHTHALIC ACIDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84863486038 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2012.05.089 Document Type: Article

Times cited : (16)

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