P63RhoGEF-mediated formation of a single polarized lamellipodium is required for chemotactic migration in breast carcinoma cells

FEBS Letters

Volumn 587, Issue 6, 2013, Pages 698-705

  Hayashi, Aya ^a   Hiatari, Ryuichi ^a   Tsuji, Takuji ^a   Ohashi, Kazumasa ^a   Mizuno, Kensaku ^a  

^a TOHOKU UNIVERSITY   (Japan)

Author keywords

Cell migration; Lamellipodium; MDA MB 231 cell; p63RhoGEF; Rho GEF; RhoA

Indexed keywords

COMPLEMENTARY DNA; DUET PROTEIN; FGD4 PROTEIN; FRABIN PROTEIN; NET1 PROTEIN; PROTEIN P63; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; RNA; SHORT HAIRPIN RNA; TRIO PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER; CANCER CELL; CELL MIGRATION; CHEMOTAXIS; HUMAN; HUMAN CELL; LAMELLIPODIUM; POLARIZATION; PRIORITY JOURNAL; PROTEIN TARGETING; RNA SEQUENCE;

BREAST NEOPLASMS; CARCINOMA; CELL LINE, TUMOR; CHEMOTAXIS; FEMALE; GENE EXPRESSION; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; PLASMIDS; PSEUDOPODIA; RNA, SMALL INTERFERING; SERUM; TRANSFECTION;

EID: 84875215211     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2013.01.043     Document Type: Article

References (25)

1. A.B. Jaffe, and A. Hall Rho GTPases: biochemistry and biology Ann. Rev. Cell Dev. Biol. 21 2005 247 269
2. A. Schmidt, and A. Hall Guanine nucleotide exchange factors for Rho GTPases: turning on the switch Genes Dev. 16 2002 1587 1609
3. K.L. Rossman, C.J. Der, and J. Sondek GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors Nat. Rev. Mol. Cell Biol. 6 2005 167 180
4. M. Souchet Human p63RhoGEF, a novel RhoA-specific guanine nucleotide exchange factor, is localized in cardiac sarcomere J. Cell Sci. 115 2002 629 640
5. X. Guo A Rac/Cdc42-specific exchange factor, GEFT, induces cell proliferation, transformation, and migration J. Biol. Chem. 278 2003 13207 13215
6. S. Lutz, A. Freichel-Blomquist, U. Rumenapp, M. Schmidt, K.H. Jakobs, and T. Wieland P63RhoGEF and GEFT are Rho-specific guanine nucleotide exchange factors encoded by the same gene Naunyn Schmiedebergs Arch. Pharmacol. 369 2004 540 546
7. q/11-coupled receptor signaling and RhoA J. Biol. Chem. 280 2005 11134 11139
8. q directly activates p63RhoGEF and Trio via a conserved extension of the Dbl homology-associated pleckstrin homology domain J. Biol. Chem. 282 2007 29201 29210
9. q-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs Science 318 2007 1923 1927
10. C.M. Wuertz P63RhoGEF-a key mediator of angiotensin II-dependent signaling and processes in vascular smooth muscle cells FASEB J. 24 2010 4865 4876
11. 2+ sensitization of vascular smooth muscle contractility Circ. Res. 109 2011 993 1002
12. K. Ui-Tei Guidelines of the selection of highly effective siRNA sequences for mammalian and chick RNA interference Nucleic Acids Res. 32 2004 936 948
13. T. Tsuji, Y. Ohta, Y. Kanno, K. Hirose, K. Ohashi, and K. Mizuno Involvement of p114-RhoGEF and Lfc in Wnt-3a- and dishevelled-induced RhoA activation and neurite retraction in N1E-115 mouse neuroblastoma cells Mol. Biol. Cell 21 2010 3590 3600
14. M. Nishita, H. Aizawa, and K. Mizuno Stromal cell-derived factor 1α activates LIM kinase 1 and induces cofilin phosphorylation for T-cell chemotaxis Mol. Cell. Biol. 22 2002 774 783
15. R. Garcia-Mata, K. Wennerberg, W.T. Arthur, N.K. Noren, S.M. Ellerbroek, and K. Burridge Analysis of activated GAPs and GEFs in cell lysates Methods Enzymol. 406 2006 425 437
16. M. Aittaleb, A. Nishimura, M.E. Linder, and J.J.G. Tesmer Plasma membrane association of p63 Rho guanine nucleotide exchange factor (p63RhoGEF) is mediated by palmitoylation and is required for basal activity in cells J. Biol. Chem. 286 2011 34448 34456
17. J. Bateman, and D. Van Vactor The Trio family of guanine-nucleotide- exchange factors: regulators of axon guidance J. Cell Sci. 114 2001 1973 1980
18. H. Nakanishi, and Y. Takai Frabin and other related Cdc42-specific guanine nucleotide exchange factors couple the actin cytoskeleton with the plasma membrane J. Cell. Mol. Med. 12 2008 1169 1176
19. D. Murray, G. Horgan, P. Macmathuna, and P. Doran NET1-mediated RhoA activation facilitates lysophosphatidic acid-induced cell migration and invasion in gastric cancer Br. J. Cancer 99 2008 1322 1329
20. q signaling to Rho by binding to p63RhoGEF Mol. Cell 32 2008 43 56
21. R.A. Worthylake, and K. Burridge RhoA and ROCK promote migration by limiting membrane protrusions J. Biol. Chem. 278 2003 13578 13584
22. M. El-Sibai RhoA/ROCK-mediated switching between Cdc42- and Rac1-dependent protrusion in MTLn3 carcinoma cells Exp. Cell Res. 314 2008 1540 1552
23. V. Sanz-Moreno Rac activation and inactivation control plasticity of tumor cell movement Cell 135 2008 510 523
24. E. Sahai, and C.J. Marshall RHO-GTPases and cancer Nat. Rev. Cancer 2 2002 133 142
25. C.-H. Chan Deciphering the transcriptional complex critical for RhoA gene expression and cancer metastasis Nat. Cell Biol. 12 2010 457 467