Structures of two coronavirus main proteases: Implications for substrate binding and antiviral drug design

Journal of Virology

Volumn 82, Issue 5, 2008, Pages 2515-2527

  Xue, Xiaoyu ^a,b   Yu, Hongwei ^c   Yang, Haitao ^a,b   Xue, Fei ^a,b   Wu, Zhixin ^c   Shen, Wei ^a,b   Li, Jun ^a,b   Zhou, Zhe ^a   Ding, Yi ^a   Zhao, Qi ^a,b   Zhang, Xuejun C ^b   Liao, Ming ^c   Bartlam, Mark ^a,b,d   Rao, Zihe ^a,b,d  

^a TSINGHUA UNIVERSITY   (China)

^b INSTITUTE OF BIOPHYSICS   (China)

^c SOUTH CHINA AGRICULTURAL UNIVERSITY   (China)

^d NANKAI UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEINASE; PROTEINASE INHIBITOR; VIRUS ENZYME;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; ANTIVIRAL ACTIVITY; ARTICLE; AVIAN INFECTIOUS BRONCHITIS VIRUS; CHICKEN; CONTROLLED STUDY; CORONAVIRUS; CRYSTAL STRUCTURE; CRYSTALLIZATION; DRUG DESIGN; EMBRYO; ENZYME DEGRADATION; ENZYME INACTIVATION; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; FEASIBILITY STUDY; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN TARGETING; SARS CORONAVIRUS; VIRUS MUTANT;

AMINO ACID SEQUENCE; ANTIVIRAL AGENTS; BASE SEQUENCE; CORONAVIRUS; CRYSTALLIZATION; DNA PRIMERS; DRUG DESIGN; MOLECULAR SEQUENCE DATA; PEPTIDE HYDROLASES; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY;

ANIMALIA; AVIAN INFECTIOUS BRONCHITIS VIRUS; CORONAVIRUS; SARS CORONAVIRUS;

EID: 39749091131     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.02114-07     Document Type: Article

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