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Volumn 57, Issue 1-3, 2013, Pages 354-360

Age effects on mouse and human B cells

Author keywords

Aging; Antibody production; B cells; Transcription factors; Vaccines

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INFLUENZA VACCINE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR E47; TRANSCRIPTION FACTOR PAX5; TRISTETRAPROLIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 84891490118     PISSN: 0257277X     EISSN: 15590755     Source Type: Journal    
DOI: 10.1007/s12026-013-8440-9     Document Type: Article
Times cited : (33)

References (72)
  • 1
    • 0031450341 scopus 로고    scopus 로고
    • Aging and the immune system
    • 9476660 10.1111/j.1600-065X.1997.tb01022.x 1:STN:280:DyaK1c7jslWnsw%3D%3D
    • Hodes RJ. Aging and the immune system. Immunol Rev. 1997;160:5-8.
    • (1997) Immunol Rev , vol.160 , pp. 5-8
    • Hodes, R.J.1
  • 2
    • 0031436582 scopus 로고    scopus 로고
    • Effect of age on humoral immunity, selection of the B-cell repertoire and B-cell development
    • 9476670 10.1111/j.1600-065X.1997.tb01032.x 1:CAS:528:DyaK1cXlvVSmuw%3D%3D
    • LeMaoult J, Szabo P, Weksler ME. Effect of age on humoral immunity, selection of the B-cell repertoire and B-cell development. Immunol Rev. 1997;160:115-26.
    • (1997) Immunol Rev , vol.160 , pp. 115-126
    • Lemaoult, J.1    Szabo, P.2    Weksler, M.E.3
  • 3
    • 1142275269 scopus 로고    scopus 로고
    • Age-related changes in lymphocyte development and function
    • 10.1038/ni1033 14749784 10.1038/ni1033 1:CAS:528:DC%2BD2cXntFWmsQ%3D%3D
    • Linton PJ, Dorshkind K. Age-related changes in lymphocyte development and function. Nat Immunol. 2004;5(2):133-9. doi: 10.1038/ni1033.
    • (2004) Nat Immunol , vol.5 , Issue.2 , pp. 133-139
    • Linton, P.J.1    Dorshkind, K.2
  • 5
    • 23944501611 scopus 로고    scopus 로고
    • Signal transduction in the aging immune system
    • doi: 10.1016/j.coi.2005.07.004
    • Sadighi Akha AA, Miller RA. Signal transduction in the aging immune system. Curr Opin Immunol. 2005;17(5): 486-91. doi: 10.1016/j.coi.2005.07.004.
    • (2005) Curr Opin Immunol , vol.17 , Issue.5 , pp. 486-491
    • Sadighi Akha, A.A.1    Miller, R.A.2
  • 6
    • 0344304396 scopus 로고    scopus 로고
    • CD4 T cell memory derived from young naive cells functions well into old age, but memory generated from aged naive cells functions poorly
    • 10.1073/pnas.2433717100 14657384 10.1073/pnas.2433717100 1:CAS:528:DC%2BD3sXpvFaqtbw%3D
    • Haynes L, Eaton SM, Burns EM, Randall TD, Swain SL. CD4 T cell memory derived from young naive cells functions well into old age, but memory generated from aged naive cells functions poorly. Proc Natl Acad Sci USA. 2003;100(25):15053-8. doi: 10.1073/pnas.2433717100.
    • (2003) Proc Natl Acad Sci USA , vol.100 , Issue.25 , pp. 15053-15058
    • Haynes, L.1    Eaton, S.M.2    Burns, E.M.3    Randall, T.D.4    Swain, S.L.5
  • 7
    • 79955011716 scopus 로고    scopus 로고
    • Role of CMV in immune senescence
    • 10.1016/j.virusres.2010.09.010 20869407 10.1016/j.virusres.2010.09.010 1:CAS:528:DC%2BC3MXltFaisrw%3D
    • Pawelec G, Derhovanessian E. Role of CMV in immune senescence. Virus Res. 2011;157(2):175-9. doi: 10.1016/j.virusres.2010.09.010.
    • (2011) Virus Res , vol.157 , Issue.2 , pp. 175-179
    • Pawelec, G.1    Derhovanessian, E.2
  • 8
    • 0024347136 scopus 로고
    • Antibody-forming cell induction during an early phase of germinal centre development and its delay with ageing
    • 2592007 1:STN:280:DyaK3c%2FnslGjtw%3D%3D
    • Kosco MH, Burton GF, Kapasi ZF, Szakal AK, Tew JG. Antibody-forming cell induction during an early phase of germinal centre development and its delay with ageing. Immunology. 1989;68(3):312-8.
    • (1989) Immunology , vol.68 , Issue.3 , pp. 312-318
    • Kosco, M.H.1    Burton, G.F.2    Kapasi, Z.F.3    Szakal, A.K.4    Tew, J.G.5
  • 9
    • 0037849072 scopus 로고    scopus 로고
    • Age-related impaired affinity maturation and differential D-JH gene usage in human VH6-expressing B lymphocytes from healthy individuals
    • 10.1002/eji.1830270613 9209488 10.1002/eji.1830270613
    • van Dijk-Hard I, Soderstrom I, Feld S, Holmberg D, Lundkvist I. Age-related impaired affinity maturation and differential D-JH gene usage in human VH6-expressing B lymphocytes from healthy individuals. Eur J Immunol. 1997;27(6):1381-6. doi: 10.1002/eji.1830270613.
    • (1997) Eur J Immunol , vol.27 , Issue.6 , pp. 1381-1386
    • Van Dijk-Hard, I.1    Soderstrom, I.2    Feld, S.3    Holmberg, D.4    Lundkvist, I.5
  • 10
    • 0031464890 scopus 로고    scopus 로고
    • Immunosenescence and germinal center reaction
    • 9476666 10.1111/j.1600-065X.1997.tb01028.x 1:CAS:528:DyaK1cXlvVSmtw%3D%3D
    • Zheng B, Han S, Takahashi Y, Kelsoe G. Immunosenescence and germinal center reaction. Immunol Rev. 1997;160:63-77.
    • (1997) Immunol Rev , vol.160 , pp. 63-77
    • Zheng, B.1    Han, S.2    Takahashi, Y.3    Kelsoe, G.4
  • 11
    • 0032694334 scopus 로고    scopus 로고
    • Immunoglobulin VH gene expression in human aging
    • 10.1006/clim 10527689 10.1006/clim.1999.4781 1:CAS:528:DyaK1MXnvVehsL0%3D 1999.4781
    • Wang X, Stollar BD. Immunoglobulin VH gene expression in human aging. Clin Immunol. 1999;93(2):132-42. doi: 10.1006/clim 1999.4781.
    • (1999) Clin Immunol , vol.93 , Issue.2 , pp. 132-142
    • Wang, X.1    Stollar, B.D.2
  • 12
    • 0028355045 scopus 로고
    • Repertoire diversity of antibody response to bacterial antigens in aged mice. IV. Study of VH and VL gene utilization in splenic antibody foci by in situ hybridization
    • 8133035 1:CAS:528:DyaK2cXisVajurc%3D
    • Yang X, Stedra J, Cerny J. Repertoire diversity of antibody response to bacterial antigens in aged mice. IV. Study of VH and VL gene utilization in splenic antibody foci by in situ hybridization. J Immunol. 1994;152(5):2214-21.
    • (1994) J Immunol , vol.152 , Issue.5 , pp. 2214-2221
    • Yang, X.1    Stedra, J.2    Cerny, J.3
  • 13
    • 34548754592 scopus 로고    scopus 로고
    • Tristetraprolin, a negative regulator of mRNA stability, is increased in old B cells and is involved in the degradation of E47 mRNA
    • 17617583 1:CAS:528:DC%2BD2sXnt1WmtLw%3D
    • Frasca D, Landin AM, Alvarez JP, Blackshear PJ, Riley RL, Blomberg BB. Tristetraprolin, a negative regulator of mRNA stability, is increased in old B cells and is involved in the degradation of E47 mRNA. J Immunol. 2007;179(2):918-27.
    • (2007) J Immunol , vol.179 , Issue.2 , pp. 918-927
    • Frasca, D.1    Landin, A.M.2    Alvarez, J.P.3    Blackshear, P.J.4    Riley, R.L.5    Blomberg, B.B.6
  • 14
    • 33846249269 scopus 로고    scopus 로고
    • Aging murine B cells have decreased class switch induced by anti-CD40 or BAFF
    • 17067770 10.1016/j.exger.2006.09.003 1:CAS:528:DC%2BD2sXnslyjtA%3D%3D
    • Frasca D, Riley RL, Blomberg BB. Aging murine B cells have decreased class switch induced by anti-CD40 or BAFF. Exp Gerontol. 2007;42(3):192-203.
    • (2007) Exp Gerontol , vol.42 , Issue.3 , pp. 192-203
    • Frasca, D.1    Riley, R.L.2    Blomberg, B.B.3
  • 15
    • 77953050555 scopus 로고    scopus 로고
    • Protein phosphatase 2A (PP2A) is increased in old murine B cells and mediates p38 MAPK/tristetraprolin dephosphorylation and E47 mRNA instability
    • 10.1016/j.mad.2010.02.002 20219523 10.1016/j.mad.2010.02.002 1:CAS:528:DC%2BC3cXmsVegtrc%3D
    • Frasca D, Romero M, Landin AM, Diaz A, Riley RL, Blomberg BB. Protein phosphatase 2A (PP2A) is increased in old murine B cells and mediates p38 MAPK/tristetraprolin dephosphorylation and E47 mRNA instability. Mech Ageing Dev. 2010;131(5):306-14. doi: 10.1016/j.mad.2010.02.002.
    • (2010) Mech Ageing Dev , vol.131 , Issue.5 , pp. 306-314
    • Frasca, D.1    Romero, M.2    Landin, A.M.3    Diaz, A.4    Riley, R.L.5    Blomberg, B.B.6
  • 16
    • 27744483838 scopus 로고    scopus 로고
    • RNA stability of the E2A-encoded transcription factor E47 is lower in splenic activated B cells from aged mice
    • 16272318 1:CAS:528:DC%2BD2MXhtF2jurfP
    • Frasca D, Van der Put E, Landin AM, Gong D, Riley RL, Blomberg BB. RNA stability of the E2A-encoded transcription factor E47 is lower in splenic activated B cells from aged mice. J Immunol. 2005;175(10):6633-44.
    • (2005) J Immunol , vol.175 , Issue.10 , pp. 6633-6644
    • Frasca, D.1    Van Der Put, E.2    Landin, A.M.3    Gong, D.4    Riley, R.L.5    Blomberg, B.B.6
  • 17
    • 0842321787 scopus 로고    scopus 로고
    • Reduced Ig class switch in aged mice correlates with decreased E47 and activation-induced cytidine deaminase
    • 14764681 1:CAS:528:DC%2BD2cXpslWntA%3D%3D
    • Frasca D, Van der Put E, Riley RL, Blomberg BB. Reduced Ig class switch in aged mice correlates with decreased E47 and activation-induced cytidine deaminase. J Immunol. 2004;172(4):2155-62.
    • (2004) J Immunol , vol.172 , Issue.4 , pp. 2155-2162
    • Frasca, D.1    Van Der Put, E.2    Riley, R.L.3    Blomberg, B.B.4
  • 18
    • 78649641896 scopus 로고    scopus 로고
    • Intrinsic defects in B cell response to seasonal influenza vaccination in elderly humans
    • 10.1016/j.vaccine.2010.10.023 20974306 10.1016/j.vaccine.2010.10.023 1:CAS:528:DC%2BC3cXhsFWqtrjM
    • Frasca D, Diaz A, Romero M, Landin AM, Phillips M, Lechner SC, et al. Intrinsic defects in B cell response to seasonal influenza vaccination in elderly humans. Vaccine. 2010;28(51):8077-84. doi: 10.1016/j.vaccine.2010.10. 023.
    • (2010) Vaccine , vol.28 , Issue.51 , pp. 8077-8084
    • Frasca, D.1    Diaz, A.2    Romero, M.3    Landin, A.M.4    Phillips, M.5    Lechner, S.C.6
  • 19
    • 84880709954 scopus 로고    scopus 로고
    • Young and elderly patients with type 2 diabetes have optimal B cell responses to the seasonal influenza vaccine
    • 10.1016/j.vaccine.2013.05.003 23711934
    • Frasca D, Diaz A, Romero M, Mendez NV, Landin AM, Ryan JG, et al. Young and elderly patients with type 2 diabetes have optimal B cell responses to the seasonal influenza vaccine. Vaccine. 2013. doi: 10.1016/j.vaccine.2013.05.003.
    • (2013) Vaccine
    • Frasca, D.1    Diaz, A.2    Romero, M.3    Mendez, N.V.4    Landin, A.M.5    Ryan, J.G.6
  • 20
    • 84857609917 scopus 로고    scopus 로고
    • Unique biomarkers for B-cell function predict the serum response to pandemic H1N1 influenza vaccine
    • 10.1093/intimm/dxr123 22281510 10.1093/intimm/dxr123 1:CAS:528: DC%2BC38XivVelt7w%3D
    • Frasca D, Diaz A, Romero M, Phillips M, Mendez NV, Landin AM, et al. Unique biomarkers for B-cell function predict the serum response to pandemic H1N1 influenza vaccine. Int Immunol. 2012;24(3):175-82. doi: 10.1093/intimm/dxr123.
    • (2012) Int Immunol , vol.24 , Issue.3 , pp. 175-182
    • Frasca, D.1    Diaz, A.2    Romero, M.3    Phillips, M.4    Mendez, N.V.5    Landin, A.M.6
  • 21
    • 45949103917 scopus 로고    scopus 로고
    • Aging down-regulates the transcription factor E2A, activation-induced cytidine deaminase, and Ig class switch in human B cells
    • 18390709 1:CAS:528:DC%2BD1cXkt1arsLg%3D
    • Frasca D, Landin AM, Lechner SC, Ryan JG, Schwartz R, Riley RL, et al. Aging down-regulates the transcription factor E2A, activation-induced cytidine deaminase, and Ig class switch in human B cells. J Immunol. 2008;180(8):5283-90.
    • (2008) J Immunol , vol.180 , Issue.8 , pp. 5283-5290
    • Frasca, D.1    Landin, A.M.2    Lechner, S.C.3    Ryan, J.G.4    Schwartz, R.5    Riley, R.L.6
  • 22
    • 11144349086 scopus 로고    scopus 로고
    • Antibody diversity: One enzyme to rule them all
    • 10.1038/nm1204-1304 15580255 10.1038/nm1204-1304 1:CAS:528: DC%2BD2cXhtVCitrzF
    • Nussenzweig MC, Alt FW. Antibody diversity: one enzyme to rule them all. Nat Med. 2004;10(12):1304-5. doi: 10.1038/nm1204-1304.
    • (2004) Nat Med , vol.10 , Issue.12 , pp. 1304-1305
    • Nussenzweig, M.C.1    Alt, F.W.2
  • 23
    • 0037149473 scopus 로고    scopus 로고
    • The AID enzyme induces class switch recombination in fibroblasts
    • 10.1038/nature727 11875397 10.1038/nature727 1:CAS:528: DC%2BD38XisFSksrY%3D
    • Okazaki IM, Kinoshita K, Muramatsu M, Yoshikawa K, Honjo T the AID enzyme induces class switch recombination in fibroblasts. Nature. 2002;416(6878):340- 5. doi: 10.1038/nature727.
    • (2002) Nature , vol.416 , Issue.6878 , pp. 340-345
    • Okazaki, I.M.1    Kinoshita, K.2    Muramatsu, M.3    Yoshikawa, K.4    Honjo, T.5
  • 24
    • 0037108463 scopus 로고    scopus 로고
    • Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice
    • 12401169 10.1016/S0960-9822(02)01215-0 1:CAS:528:DC%2BD38Xot1ags7s%3D
    • Rada C, Williams GT, Nilsen H, Barnes DE, Lindahl T, Neuberger MS. Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice. Curr Biol: CB. 2002;12(20):1748-55.
    • (2002) Curr Biol: CB , vol.12 , Issue.20 , pp. 1748-1755
    • Rada, C.1    Williams, G.T.2    Nilsen, H.3    Barnes, D.E.4    Lindahl, T.5    Neuberger, M.S.6
  • 25
    • 0036670717 scopus 로고    scopus 로고
    • Hyper-IgM syndromes: A model for studying the regulation of class switch recombination and somatic hypermutation generation
    • 10.1042/ 12196205 10.1042/BST0300815 1:CAS:528:DC%2BD38XntVels7c%3D
    • Durandy A. Hyper-IgM syndromes: a model for studying the regulation of class switch recombination and somatic hypermutation generation. Biochem Soc Trans. 2002;30(4):815-8. doi: 10.1042/.
    • (2002) Biochem Soc Trans , vol.30 , Issue.4 , pp. 815-818
    • Durandy, A.1
  • 26
    • 33646942168 scopus 로고    scopus 로고
    • Defects of class-switch recombination
    • 10.1016/j.jaci.2006.01.043 16630945 10.1016/j.jaci.2006.01.043 1:CAS:528:DC%2BD28XjslelsLk%3D
    • Notarangelo LD, Lanzi G, Peron S, Durandy A. Defects of class-switch recombination. J Allergy Clin Immunol. 2006;117(4):855-64. doi: 10.1016/j.jaci.2006.01.043.
    • (2006) J Allergy Clin Immunol , vol.117 , Issue.4 , pp. 855-864
    • Notarangelo, L.D.1    Lanzi, G.2    Peron, S.3    Durandy, A.4
  • 27
    • 13144259651 scopus 로고    scopus 로고
    • BCL-6 mutations in normal germinal center B cells: Evidence of somatic hypermutation acting outside Ig loci
    • 9751748 10.1073/pnas.95.20.11816 1:CAS:528:DyaK1cXmsV2hsL8%3D
    • Pasqualucci L, Migliazza A, Fracchiolla N, William C, Neri A, Baldini L, et al. BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig loci. Proc Natl Acad Sci USA. 1998;95(20):11816-21.
    • (1998) Proc Natl Acad Sci USA , vol.95 , Issue.20 , pp. 11816-11821
    • Pasqualucci, L.1    Migliazza, A.2    Fracchiolla, N.3    William, C.4    Neri, A.5    Baldini, L.6
  • 28
    • 34548420553 scopus 로고    scopus 로고
    • A role for AID in chromosome translocations between c-myc and the IgH variable region
    • 10.1084/jem.20070884 17724134 10.1084/jem.20070884 1:CAS:528: DC%2BD2sXhtVWnurnL
    • Dorsett Y, Robbiani DF, Jankovic M, Reina-San-Martin B, Eisenreich TR, Nussenzweig MC. A role for AID in chromosome translocations between c-myc and the IgH variable region. J Exp Med. 2007;204(9):2225-32. doi: 10.1084/jem.20070884.
    • (2007) J Exp Med , vol.204 , Issue.9 , pp. 2225-2232
    • Dorsett, Y.1    Robbiani, D.F.2    Jankovic, M.3    Reina-San-Martin, B.4    Eisenreich, T.R.5    Nussenzweig, M.C.6
  • 29
    • 0038515309 scopus 로고    scopus 로고
    • E-proteins directly regulate expression of activation-induced deaminase in mature B cells
    • 10.1038/ni923 12717431 10.1038/ni923 1:CAS:528:DC%2BD3sXktVygu70%3D
    • Sayegh CE, Quong MW, Agata Y, Murre C. E-proteins directly regulate expression of activation-induced deaminase in mature B cells. Nat Immunol. 2003;4(6):586-93. doi: 10.1038/ni923.
    • (2003) Nat Immunol , vol.4 , Issue.6 , pp. 586-593
    • Sayegh, C.E.1    Quong, M.W.2    Agata, Y.3    Murre, C.4
  • 30
    • 75649096381 scopus 로고    scopus 로고
    • B cell-specific and stimulation-responsive enhancers derepress Aicda by overcoming the effects of silencers
    • 10.1038/ni.1829 19966806 10.1038/ni.1829 1:CAS:528:DC%2BD1MXhsFWksb3K
    • Tran TH, Nakata M, Suzuki K, Begum NA, Shinkura R, Fagarasan S, et al. B cell-specific and stimulation-responsive enhancers derepress Aicda by overcoming the effects of silencers. Nat Immunol. 2010;11(2):148-54. doi: 10.1038/ni.1829.
    • (2010) Nat Immunol , vol.11 , Issue.2 , pp. 148-154
    • Tran, T.H.1    Nakata, M.2    Suzuki, K.3    Begum, N.A.4    Shinkura, R.5    Fagarasan, S.6
  • 31
    • 0021928806 scopus 로고
    • B lineage-specific interactions of an immunoglobulin enhancer with cellular factors in vivo
    • 3917574 10.1126/science.3917574 1:CAS:528:DyaL2MXht1Kntbc%3D
    • Ephrussi A, Church GM, Tonegawa S, Gilbert W. B lineage-specific interactions of an immunoglobulin enhancer with cellular factors in vivo. Science. 1985;227(4683):134-40.
    • (1985) Science , vol.227 , Issue.4683 , pp. 134-140
    • Ephrussi, A.1    Church, G.M.2    Tonegawa, S.3    Gilbert, W.4
  • 32
    • 0025034673 scopus 로고
    • Two distinct transcription factors that bind the immunoglobulin enhancer microE5/kappa 2 motif
    • 2105528 10.1126/science.2105528 1:CAS:528:DyaK3cXhtlOiurk%3D
    • Henthorn P, Kiledjian M, Kadesch T. Two distinct transcription factors that bind the immunoglobulin enhancer microE5/kappa 2 motif. Science. 1990;247(4941):467-70.
    • (1990) Science , vol.247 , Issue.4941 , pp. 467-470
    • Henthorn, P.1    Kiledjian, M.2    Kadesch, T.3
  • 33
    • 0036217915 scopus 로고    scopus 로고
    • E protein function in lymphocyte development
    • 10.1146/annurev.immunol.20.092501.162048 11861605 10.1146/annurev. immunol.20.092501.162048 1:CAS:528:DC%2BD38XjtlWgtL8%3D
    • Quong MW, Romanow WJ, Murre C. E protein function in lymphocyte development. Annu Rev Immunol. 2002;20:301-22. doi: 10.1146/annurev.immunol.20. 092501.162048.
    • (2002) Annu Rev Immunol , vol.20 , pp. 301-322
    • Quong, M.W.1    Romanow, W.J.2    Murre, C.3
  • 34
    • 0033980393 scopus 로고    scopus 로고
    • Helix-loop-helix proteins: Regulators of transcription in eucaryotic organisms
    • 10611221 10.1128/MCB.20.2.429-440.2000 1:CAS:528:DC%2BD3cXjtVKnsg%3D%3D
    • Massari ME, Murre C. Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms. Mol Cell Biol. 2000;20(2):429-40.
    • (2000) Mol Cell Biol , vol.20 , Issue.2 , pp. 429-440
    • Massari, M.E.1    Murre, C.2
  • 35
    • 0024554495 scopus 로고
    • A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins
    • 2493990 10.1016/0092-8674(89)90682-X 1:CAS:528:DyaL1MXitVyjsb0%3D
    • Murre C, McCaw PS, Baltimore D. A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins. Cell. 1989;56(5):777-83.
    • (1989) Cell , vol.56 , Issue.5 , pp. 777-783
    • Murre, C.1    McCaw, P.S.2    Baltimore, D.3
  • 36
    • 0026045243 scopus 로고
    • Helix-loop-helix transcription factor E47 activates germ-line immunoglobulin heavy-chain gene transcription and rearrangement in a pre-T-cell line
    • 1714414 10.1101/gad.5.8.1367 1:CAS:528:DyaK3MXmsFeksbc%3D
    • Schlissel M, Voronova A, Baltimore D. Helix-loop-helix transcription factor E47 activates germ-line immunoglobulin heavy-chain gene transcription and rearrangement in a pre-T-cell line. Genes Dev. 1991;5(8):1367-76.
    • (1991) Genes Dev , vol.5 , Issue.8 , pp. 1367-1376
    • Schlissel, M.1    Voronova, A.2    Baltimore, D.3
  • 37
    • 0030790713 scopus 로고    scopus 로고
    • EBF and E47 collaborate to induce expression of the endogenous immunoglobulin surrogate light chain genes
    • 9252117 10.1016/S1074-7613(00)80507-5 1:CAS:528:DyaK2sXltFWhtrY%3D
    • Sigvardsson M, O'Riordan M, Grosschedl R. EBF and E47 collaborate to induce expression of the endogenous immunoglobulin surrogate light chain genes. Immunity. 1997;7(1):25-36.
    • (1997) Immunity , vol.7 , Issue.1 , pp. 25-36
    • Sigvardsson, M.1    O'Riordan, M.2    Grosschedl, R.3
  • 38
    • 0035865059 scopus 로고    scopus 로고
    • Reduction in DNA binding activity of the transcription factor Pax-5a in B lymphocytes of aged mice
    • 11160324 1:CAS:528:DC%2BD3MXht1Ghsr4%3D
    • Anspach J, Poulsen G, Kaattari I, Pollock R, Zwollo P. Reduction in DNA binding activity of the transcription factor Pax-5a in B lymphocytes of aged mice. J Immunol. 2001;166(4):2617-26.
    • (2001) J Immunol , vol.166 , Issue.4 , pp. 2617-2626
    • Anspach, J.1    Poulsen, G.2    Kaattari, I.3    Pollock, R.4    Zwollo, P.5
  • 39
    • 84855408862 scopus 로고    scopus 로고
    • A molecular mechanism for TNF-alpha-mediated downregulation of B cell responses
    • 10.4049/jimmunol.1003964 22116831 10.4049/jimmunol.1003964 1:CAS:528:DC%2BC3MXhs1Gltr3O
    • Frasca D, Romero M, Diaz A, Alter-Wolf S, Ratliff M, Landin AM, et al. A molecular mechanism for TNF-alpha-mediated downregulation of B cell responses. J Immunol. 2012;188(1):279-86. doi: 10.4049/jimmunol.1003964.
    • (2012) J Immunol , vol.188 , Issue.1 , pp. 279-286
    • Frasca, D.1    Romero, M.2    Diaz, A.3    Alter-Wolf, S.4    Ratliff, M.5    Landin, A.M.6
  • 40
    • 0037396302 scopus 로고    scopus 로고
    • Effects of aging on proliferation and E47 transcription factor activity induced by different stimuli in murine splenic B cells
    • 12714241 10.1016/S0047-6374(03)00009-5 1:CAS:528:DC%2BD3sXjtVCqsbg%3D
    • Frasca D, Nguyen D, Riley RL, Blomberg BB. Effects of aging on proliferation and E47 transcription factor activity induced by different stimuli in murine splenic B cells. Mech Ageing Dev. 2003;124(4):361-9.
    • (2003) Mech Ageing Dev , vol.124 , Issue.4 , pp. 361-369
    • Frasca, D.1    Nguyen, D.2    Riley, R.L.3    Blomberg, B.B.4
  • 41
    • 0037438596 scopus 로고    scopus 로고
    • Decreased E12 and/or E47 transcription factor activity in the bone marrow as well as in the spleen of aged mice
    • 12517933 1:CAS:528:DC%2BD3sXktlGgtg%3D%3D
    • Frasca D, Nguyen D, Riley RL, Blomberg BB. Decreased E12 and/or E47 transcription factor activity in the bone marrow as well as in the spleen of aged mice. J Immunol. 2003;170(2):719-26.
    • (2003) J Immunol , vol.170 , Issue.2 , pp. 719-726
    • Frasca, D.1    Nguyen, D.2    Riley, R.L.3    Blomberg, B.B.4
  • 42
    • 0033571526 scopus 로고    scopus 로고
    • E2A activity is induced during B-cell activation to promote immunoglobulin class switch recombination
    • 10.1093/emboj/18.22.6307 10562543 10.1093/emboj/18.22.6307 1:CAS:528:DyaK1MXns1Orsbg%3D
    • Quong MW, Harris DP, Swain SL, Murre C. E2A activity is induced during B-cell activation to promote immunoglobulin class switch recombination. EMBO J. 1999;18(22):6307-18. doi: 10.1093/emboj/18.22.6307.
    • (1999) EMBO J , vol.18 , Issue.22 , pp. 6307-6318
    • Quong, M.W.1    Harris, D.P.2    Swain, S.L.3    Murre, C.4
  • 43
    • 3142721218 scopus 로고    scopus 로고
    • Decreased E47 in senescent B cell precursors is stage specific and regulated posttranslationally by protein turnover
    • 15240668
    • Van der Put E, Frasca D, King AM, Blomberg BB, Riley RL. Decreased E47 in senescent B cell precursors is stage specific and regulated posttranslationally by protein turnover. J Immunol. 2004;173(2):818-27.
    • (2004) J Immunol , vol.173 , Issue.2 , pp. 818-827
    • Van Der Put, E.1    Frasca, D.2    King, A.M.3    Blomberg, B.B.4    Riley, R.L.5
  • 44
    • 33947199706 scopus 로고    scopus 로고
    • Accelerated Notch-dependent degradation of E47 proteins in aged B cell precursors is associated with increased ERK MAPK activation
    • 17339447 1:CAS:528:DC%2BD2sXisVGjs7o%3D
    • King AM, Van der Put E, Blomberg BB, Riley RL. Accelerated Notch-dependent degradation of E47 proteins in aged B cell precursors is associated with increased ERK MAPK activation. J Immunol. 2007;178(6):3521-9.
    • (2007) J Immunol , vol.178 , Issue.6 , pp. 3521-3529
    • King, A.M.1    Van Der Put, E.2    Blomberg, B.B.3    Riley, R.L.4
  • 45
    • 0033213968 scopus 로고    scopus 로고
    • Characterization of the mUBC9-binding sites required for E2A protein degradation
    • 10497239 10.1074/jbc.274.40.28690 1:CAS:528:DyaK1MXmsFWns70%3D
    • Huggins GS, Chin MT, Sibinga NE, Lee SL, Haber E, Lee ME. Characterization of the mUBC9-binding sites required for E2A protein degradation. J Biol Chem. 1999;274(40):28690-6.
    • (1999) J Biol Chem , vol.274 , Issue.40 , pp. 28690-28696
    • Huggins, G.S.1    Chin, M.T.2    Sibinga, N.E.3    Lee, S.L.4    Haber, E.5    Lee, M.E.6
  • 46
    • 0031021877 scopus 로고    scopus 로고
    • Degradation of E2A proteins through a ubiquitin-conjugating enzyme, UbcE2A
    • 9013644 10.1074/jbc.272.6.3845 1:CAS:528:DyaK2sXhtFCgtro%3D
    • Kho CJ, Huggins GS, Endege WO, Hsieh CM, Lee ME, Haber E. Degradation of E2A proteins through a ubiquitin-conjugating enzyme, UbcE2A. J Biol Chem. 1997;272(6):3845-51.
    • (1997) J Biol Chem , vol.272 , Issue.6 , pp. 3845-3851
    • Kho, C.J.1    Huggins, G.S.2    Endege, W.O.3    Hsieh, C.M.4    Lee, M.E.5    Haber, E.6
  • 47
    • 0032493368 scopus 로고    scopus 로고
    • Regulation of hypoxia-inducible factor 1 alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway
    • 9653127 10.1073/pnas.95.14.7987 1:CAS:528:DyaK1cXks1SlsrY%3D
    • Huang LE, Gu J, Schau M, Bunn HF. Regulation of hypoxia-inducible factor 1 alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway. Proc Natl Acad Sci USA. 1998;95(14):7987-92.
    • (1998) Proc Natl Acad Sci USA , vol.95 , Issue.14 , pp. 7987-7992
    • Huang, L.E.1    Gu, J.2    Schau, M.3    Bunn, H.F.4
  • 48
    • 0038185346 scopus 로고    scopus 로고
    • Post-transcriptional regulation of gene expression by degradation of messenger RNAs
    • 10.1002/jcp.10272 12704645 10.1002/jcp.10272 1:CAS:528: DC%2BD3sXjs1yhs70%3D
    • Bevilacqua A, Ceriani MC, Capaccioli S, Nicolin A. Post-transcriptional regulation of gene expression by degradation of messenger RNAs. J Cell Physiol. 2003;195(3):356-72. doi: 10.1002/jcp.10272.
    • (2003) J Cell Physiol , vol.195 , Issue.3 , pp. 356-372
    • Bevilacqua, A.1    Ceriani, M.C.2    Capaccioli, S.3    Nicolin, A.4
  • 49
    • 0028788194 scopus 로고
    • AU-rich elements: Characterization and importance in mRNA degradation
    • 8578590 10.1016/S0968-0004(00)89102-1 1:CAS:528:DyaK2MXpsF2murs%3D
    • Chen CY, Shyu AB. AU-rich elements: characterization and importance in mRNA degradation. Trends Biochem Sci. 1995;20(11):465-70.
    • (1995) Trends Biochem Sci , vol.20 , Issue.11 , pp. 465-470
    • Chen, C.Y.1    Shyu, A.B.2
  • 50
    • 0025001736 scopus 로고
    • A growth factor-inducible nuclear protein with a novel cysteine/histidine repetitive sequence
    • 1699942 1:CAS:528:DyaK3MXhvFKhtA%3D%3D
    • DuBois RN, McLane MW, Ryder K, Lau LF, Nathans D. A growth factor-inducible nuclear protein with a novel cysteine/histidine repetitive sequence. J Biol Chem. 1990;265(31):19185-91.
    • (1990) J Biol Chem , vol.265 , Issue.31 , pp. 19185-19191
    • Dubois, R.N.1    McLane, M.W.2    Ryder, K.3    Lau, L.F.4    Nathans, D.5
  • 51
    • 0025051298 scopus 로고
    • Rapid insulin-stimulated accumulation of an mRNA encoding a proline-rich protein
    • 2204625 1:CAS:528:DyaK3MXls1Smtw%3D%3D
    • Lai WS, Stumpo DJ, Blackshear PJ. Rapid insulin-stimulated accumulation of an mRNA encoding a proline-rich protein. J Biol Chem. 1990;265(27):16556-63.
    • (1990) J Biol Chem , vol.265 , Issue.27 , pp. 16556-16563
    • Lai, W.S.1    Stumpo, D.J.2    Blackshear, P.J.3
  • 52
    • 0032516626 scopus 로고    scopus 로고
    • Feedback inhibition of macrophage tumor necrosis factor-alpha production by tristetraprolin
    • 9703499 10.1126/science.281.5379.1001 1:CAS:528:DyaK1cXlsVCjs74%3D
    • Carballo E, Lai WS, Blackshear PJ. Feedback inhibition of macrophage tumor necrosis factor-alpha production by tristetraprolin. Science. 1998;281(5379):1001-5.
    • (1998) Science , vol.281 , Issue.5379 , pp. 1001-1005
    • Carballo, E.1    Lai, W.S.2    Blackshear, P.J.3
  • 53
    • 16044369031 scopus 로고    scopus 로고
    • A pathogenetic role for TNF alpha in the syndrome of cachexia, arthritis, and autoimmunity resulting from tristetraprolin (TTP) deficiency
    • 8630730 10.1016/S1074-7613(00)80411-2 1:CAS:528:DyaK28Xjt1GhtLw%3D
    • Taylor GA, Carballo E, Lee DM, Lai WS, Thompson MJ, Patel DD, et al. A pathogenetic role for TNF alpha in the syndrome of cachexia, arthritis, and autoimmunity resulting from tristetraprolin (TTP) deficiency. Immunity. 1996;4(5):445-54.
    • (1996) Immunity , vol.4 , Issue.5 , pp. 445-454
    • Taylor, G.A.1    Carballo, E.2    Lee, D.M.3    Lai, W.S.4    Thompson, M.J.5    Patel, D.D.6
  • 54
    • 0035834741 scopus 로고    scopus 로고
    • Decreased sensitivity of tristetraprolin-deficient cells to p38 inhibitors suggests the involvement of tristetraprolin in the p38 signaling pathway
    • 10.1074/jbc.M104953200 11546803 10.1074/jbc.M104953200 1:CAS:528:DC%2BD3MXosVGmtrg%3D
    • Carballo E, Cao H, Lai WS, Kennington EA, Campbell D, Blackshear PJ. Decreased sensitivity of tristetraprolin-deficient cells to p38 inhibitors suggests the involvement of tristetraprolin in the p38 signaling pathway. J Biol Chem. 2001;276(45):42580-7. doi: 10.1074/jbc.M104953200.
    • (2001) J Biol Chem , vol.276 , Issue.45 , pp. 42580-42587
    • Carballo, E.1    Cao, H.2    Lai, W.S.3    Kennington, E.A.4    Campbell, D.5    Blackshear, P.J.6
  • 55
    • 1642332899 scopus 로고    scopus 로고
    • MAPKAP kinase 2 phosphorylates tristetraprolin on in vivo sites including Ser178, a site required for 14-3-3 binding
    • 10.1074/jbc.M310486200 14688255 10.1074/jbc.M310486200 1:CAS:528:DC%2BD2cXhvFCiur4%3D
    • Chrestensen CA, Schroeder MJ, Shabanowitz J, Hunt DF, Pelo JW, Worthington MT, et al. MAPKAP kinase 2 phosphorylates tristetraprolin on in vivo sites including Ser178, a site required for 14-3-3 binding. J Biol Chem. 2004;279(11):10176-84. doi: 10.1074/jbc.M310486200.
    • (2004) J Biol Chem , vol.279 , Issue.11 , pp. 10176-10184
    • Chrestensen, C.A.1    Schroeder, M.J.2    Shabanowitz, J.3    Hunt, D.F.4    Pelo, J.W.5    Worthington, M.T.6
  • 56
    • 58049186804 scopus 로고    scopus 로고
    • Protein phosphatase 2A regulatory subunits and cancer
    • 10.1016/j.bbcan.2008.05.005 18588945 1:CAS:528:DC%2BD1MXhsVyjuw%3D%3D
    • Eichhorn PJ, Creyghton MP, Bernards R. Protein phosphatase 2A regulatory subunits and cancer. Biochim Biophys Acta. 2009;1795(1):1-15. doi: 10.1016/j.bbcan.2008.05.005.
    • (2009) Biochim Biophys Acta , vol.1795 , Issue.1 , pp. 1-15
    • Eichhorn, P.J.1    Creyghton, M.P.2    Bernards, R.3
  • 57
    • 0000714961 scopus 로고    scopus 로고
    • Regulation of protein kinase cascades by protein phosphatase 2A
    • 10322434 10.1016/S0968-0004(99)01375-4 1:CAS:528:DyaK1MXkslSntr8%3D
    • Millward TA, Zolnierowicz S, Hemmings BA. Regulation of protein kinase cascades by protein phosphatase 2A. Trends Biochem Sci. 1999;24(5):186-91.
    • (1999) Trends Biochem Sci , vol.24 , Issue.5 , pp. 186-191
    • Millward, T.A.1    Zolnierowicz, S.2    Hemmings, B.A.3
  • 58
    • 79952610491 scopus 로고    scopus 로고
    • E47 retroviral rescue of intrinsic B-cell defects in senescent mice
    • 10.1111/j.1474-9726.2011.00673.x 21241451 10.1111/j.1474-9726.2011.00673. x 1:CAS:528:DC%2BC3MXksFOru78%3D
    • Landin AM, Frasca D, Harrison P, Scallan M, Riley RL, Blomberg BB. E47 retroviral rescue of intrinsic B-cell defects in senescent mice. Aging Cell. 2011;10(2):327-37. doi: 10.1111/j.1474-9726.2011.00673.x.
    • (2011) Aging Cell , vol.10 , Issue.2 , pp. 327-337
    • Landin, A.M.1    Frasca, D.2    Harrison, P.3    Scallan, M.4    Riley, R.L.5    Blomberg, B.B.6
  • 59
    • 77950857568 scopus 로고    scopus 로고
    • The ageing B cell population: Composition and function
    • 10.1007/s10522-009-9256-9 19937382 10.1007/s10522-009-9256-9
    • Ademokun A, Wu YC, Dunn-Walters D the ageing B cell population: composition and function. Biogerontology. 2010;11(2):125-37. doi: 10.1007/s10522-009-9256-9.
    • (2010) Biogerontology , vol.11 , Issue.2 , pp. 125-137
    • Ademokun, A.1    Wu, Y.C.2    Dunn-Walters, D.3
  • 60
    • 70349412916 scopus 로고    scopus 로고
    • A double-negative (IgD-CD27-) B cell population is increased in the peripheral blood of elderly people
    • 10.1016/j.mad.2009.08.003 19698733 10.1016/j.mad.2009.08.003 1:CAS:528:DC%2BD1MXht1WrsbjK
    • Colonna-Romano G, Bulati M, Aquino A, Pellicano M, Vitello S, Lio D, et al. A double-negative (IgD-CD27-) B cell population is increased in the peripheral blood of elderly people. Mech Ageing Dev. 2009;130(10):681-90. doi: 10.1016/j.mad.2009.08.003.
    • (2009) Mech Ageing Dev , vol.130 , Issue.10 , pp. 681-690
    • Colonna-Romano, G.1    Bulati, M.2    Aquino, A.3    Pellicano, M.4    Vitello, S.5    Lio, D.6
  • 61
    • 79955964506 scopus 로고    scopus 로고
    • Age effects on B cells and humoral immunity in humans
    • 10.1016/j.arr.2010.08.004 20728581 10.1016/j.arr.2010.08.004 1:CAS:528:DC%2BC3MXmtlyrsbw%3D
    • Frasca D, Diaz A, Romero M, Landin AM, Blomberg BB. Age effects on B cells and humoral immunity in humans. Ageing Res Rev. 2011;10(3):330-5. doi: 10.1016/j.arr.2010.08.004.
    • (2011) Ageing Res Rev , vol.10 , Issue.3 , pp. 330-335
    • Frasca, D.1    Diaz, A.2    Romero, M.3    Landin, A.M.4    Blomberg, B.B.5
  • 62
    • 23844467731 scopus 로고    scopus 로고
    • Regulation of aged humoral immune defense against pneumococcal bacteria by IgM memory B cell
    • 16116217 1:CAS:528:DC%2BD2MXos1Ghsbg%3D
    • Shi Y, Yamazaki T, Okubo Y, Uehara Y, Sugane K, Agematsu K. Regulation of aged humoral immune defense against pneumococcal bacteria by IgM memory B cell. J Immunol. 2005;175(5):3262-7.
    • (2005) J Immunol , vol.175 , Issue.5 , pp. 3262-3267
    • Shi, Y.1    Yamazaki, T.2    Okubo, Y.3    Uehara, Y.4    Sugane, K.5    Agematsu, K.6
  • 63
    • 84891486954 scopus 로고    scopus 로고
    • A novel B cell population revealed by a CD38/CD24 gating strategy: CD38(-)CD24 (-) B cells in centenarian offspring and elderly people
    • 10.1007/s11357-012-9488-5 10.1007/s11357-012-9488-5 1:CAS:528: DC%2BC3sXhsV2gtLrM
    • Buffa S, Pellicano M, Bulati M, Martorana A, Goldeck D, Caruso C, et al. A novel B cell population revealed by a CD38/CD24 gating strategy: CD38(-)CD24 (-) B cells in centenarian offspring and elderly people. Age (Dordr). 2013;35(5):2009-24. doi: 10.1007/s11357-012-9488-5.
    • (2013) Age (Dordr) , vol.35 , Issue.5 , pp. 2009-2024
    • Buffa, S.1    Pellicano, M.2    Bulati, M.3    Martorana, A.4    Goldeck, D.5    Caruso, C.6
  • 64
    • 84883817362 scopus 로고    scopus 로고
    • An age-related numerical and functional deficit in CD19(+) CD24(hi) CD38(hi) B cells is associated with an increase in systemic autoimmunity
    • 10.1111/acel.12114 23755918 10.1111/acel.12114 1:CAS:528: DC%2BC3sXhsVektrjM
    • Duggal NA, Upton J, Phillips AC, Sapey E, Lord JM. An age-related numerical and functional deficit in CD19(+) CD24(hi) CD38(hi) B cells is associated with an increase in systemic autoimmunity. Aging Cell. 2013;12(5):873-81. doi: 10.1111/acel.12114.
    • (2013) Aging Cell , vol.12 , Issue.5 , pp. 873-881
    • Duggal, N.A.1    Upton, J.2    Phillips, A.C.3    Sapey, E.4    Lord, J.M.5
  • 65
    • 84871935156 scopus 로고    scopus 로고
    • Cytomegalovirus-associated accumulation of late-differentiated CD4 T-cells correlates with poor humoral response to influenza vaccination
    • 10.1016/j.vaccine.2012.11.041 23196209 10.1016/j.vaccine.2012.11.041 1:CAS:528:DC%2BC38XhvVSlt7zO
    • Derhovanessian E, Theeten H, Hahnel K, Van Damme P, Cools N, Pawelec G. Cytomegalovirus-associated accumulation of late-differentiated CD4 T-cells correlates with poor humoral response to influenza vaccination. Vaccine. 2013;31(4):685-90. doi: 10.1016/j.vaccine.2012.11.041.
    • (2013) Vaccine , vol.31 , Issue.4 , pp. 685-690
    • Derhovanessian, E.1    Theeten, H.2    Hahnel, K.3    Van Damme, P.4    Cools, N.5    Pawelec, G.6
  • 66
    • 79955970125 scopus 로고    scopus 로고
    • Influenza vaccine responses in older adults
    • 10.1016/j.arr.2010.10.008 21055484 10.1016/j.arr.2010.10.008 1:CAS:528:DC%2BC3MXmtlyrsbY%3D
    • McElhaney JE. Influenza vaccine responses in older adults. Ageing Res Rev. 2011;10(3):379-88. doi: 10.1016/j.arr.2010.10.008.
    • (2011) Ageing Res Rev , vol.10 , Issue.3 , pp. 379-388
    • McElhaney, J.E.1
  • 67
    • 0037012001 scopus 로고    scopus 로고
    • Role of humoral and cell-mediated immunity in protection from influenza disease after immunization of healthy elderly
    • 11772530 10.1016/S0531-5565(01)00210-8 1:CAS:528:DC%2BD38XitlKr
    • Murasko DM, Bernstein ED, Gardner EM, Gross P, Munk G, Dran S, et al. Role of humoral and cell-mediated immunity in protection from influenza disease after immunization of healthy elderly. Exp Gerontol. 2002;37(2-3):427-39.
    • (2002) Exp Gerontol , vol.37 , Issue.2-3 , pp. 427-439
    • Murasko, D.M.1    Bernstein, E.D.2    Gardner, E.M.3    Gross, P.4    Munk, G.5    Dran, S.6
  • 68
    • 79961171990 scopus 로고    scopus 로고
    • Aging affects human B cell responses
    • 10.1007/s10875-010-9501-7 21318330 10.1007/s10875-010-9501-7
    • Frasca D, Blomberg BB. Aging affects human B cell responses. J Clin Immunol. 2011;31(3):430-5. doi: 10.1007/s10875-010-9501-7.
    • (2011) J Clin Immunol , vol.31 , Issue.3 , pp. 430-435
    • Frasca, D.1    Blomberg, B.B.2
  • 69
    • 84866902351 scopus 로고    scopus 로고
    • AID activity in B cells strongly correlates with polyclonal antibody affinity maturation in vivo following pandemic 2009-H1N1 vaccination in humans
    • 10.1371/journal.ppat.1002920 23028320 10.1371/journal.ppat.1002920 1:CAS:528:DC%2BC38Xhtl2msb%2FN
    • Khurana S, Frasca D, Blomberg B, Golding H. AID activity in B cells strongly correlates with polyclonal antibody affinity maturation in vivo following pandemic 2009-H1N1 vaccination in humans. PLoS Pathog. 2012;8(9):e1002920. doi: 10.1371/journal.ppat.1002920.
    • (2012) PLoS Pathog , vol.8 , Issue.9 , pp. 1002920
    • Khurana, S.1    Frasca, D.2    Blomberg, B.3    Golding, H.4
  • 70
    • 84875241300 scopus 로고    scopus 로고
    • Immune response to influenza A/H1N1 vaccine in inflammatory bowel disease patients treated with anti TNF-alpha agents: Effects of combined therapy with immunosuppressants
    • 10.1016/j.crohns.2012.05.011 22673636 10.1016/j.crohns.2012.05.011 1:STN:280:DC%2BC38npsFGiug%3D%3D
    • Andrisani G, Frasca D, Romero M, Armuzzi A, Felice C, Marzo M, et al. Immune response to influenza A/H1N1 vaccine in inflammatory bowel disease patients treated with anti TNF-alpha agents: effects of combined therapy with immunosuppressants. J Crohns Colitis. 2013;7(4):301-7. doi: 10.1016/j.crohns. 2012.05.011.
    • (2013) J Crohns Colitis , vol.7 , Issue.4 , pp. 301-307
    • Andrisani, G.1    Frasca, D.2    Romero, M.3    Armuzzi, A.4    Felice, C.5    Marzo, M.6
  • 71
    • 84873696145 scopus 로고    scopus 로고
    • AID in aging and autoimmune diseases
    • 10.3109/08916934.2012.750300 23190037 10.3109/08916934.2012.750300 1:CAS:528:DC%2BC3sXitlWnt7s%3D
    • Frasca D, Andrisani G, Diaz A, Felice C, Guidi L, Blomberg BB. AID in aging and autoimmune diseases. Autoimmunity. 2013;46(2):168-75. doi: 10.3109/08916934.2012.750300.
    • (2013) Autoimmunity , vol.46 , Issue.2 , pp. 168-175
    • Frasca, D.1    Andrisani, G.2    Diaz, A.3    Felice, C.4    Guidi, L.5    Blomberg, B.B.6
  • 72
    • 79953892799 scopus 로고    scopus 로고
    • TLR1/2, TLR7, and TLR9 signals directly activate human peripheral blood naive and memory B cell subsets to produce cytokines, chemokines, and hematopoietic growth factors
    • 10.1007/s10875-010-9456-8 20821041 10.1007/s10875-010-9456-8 1:CAS:528:DC%2BC3MXjvVemtLs%3D
    • Agrawal S, Gupta S. TLR1/2, TLR7, and TLR9 signals directly activate human peripheral blood naive and memory B cell subsets to produce cytokines, chemokines, and hematopoietic growth factors. J Clin Immunol. 2011;31(1):89-98. doi: 10.1007/s10875-010-9456-8.
    • (2011) J Clin Immunol , vol.31 , Issue.1 , pp. 89-98
    • Agrawal, S.1    Gupta, S.2


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