A molecular mechanism for TNF-α-mediated downregulation of B cell responses

Journal of Immunology

Volumn 188, Issue 1, 2012, Pages 279-286

  Frasca, Daniela ^a   Romero, Maria ^a   Diaz, Alain ^a   Alter Wolf, Sarah ^a   Ratliff, Michelle ^a   Landin, Ana Marie ^a   Riley, Richard L ^a   Blomberg, Bonnie B ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTIDINE DEAMINASE; LIPOPOLYSACCHARIDE; MESSENGER RNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR E47; TRISTETRAPROLIN; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA ANTIBODY; UNCLASSIFIED DRUG;

AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; FEMALE; HUMORAL IMMUNITY; IMMUNOREGULATION; IN VIVO STUDY; LYMPHOCYTE ACTIVATION; LYMPHOCYTE FUNCTION; MALE; MOLECULAR MECHANICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA STABILITY;

AGING; ANIMALS; AUTOCRINE COMMUNICATION; B-LYMPHOCYTES; CELLS, CULTURED; CYTIDINE DEAMINASE; DOWN-REGULATION; FEMALE; IMMUNOGLOBULIN CLASS SWITCHING; LIPOPOLYSACCHARIDES; MALE; MICE; MICE, INBRED BALB C; RNA STABILITY; RNA, MESSENGER; TRANSCRIPTION FACTOR 3; TRISTETRAPROLIN; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84855408862     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1003964     Document Type: Article

References (45)

1. Feldmann, M., and R. N. Maini. 2010. Anti-TNF therapy, from rationale to standard of care: what lessons has it taught us? J. Immunol. 185: 791-794.
2. Sethi, G., B. Sung, A. B. Kunnumakkara, and B. B. Aggarwal. 2009. Targeting TNF for Treatment of Cancer and Autoimmunity. Adv. Exp. Med. Biol. 647: 37-51.
3. Tincani, A., L. Andreoli, C. Bazzani, D. Bosiso, and S. Sozzani. 2007. Inflammatory molecules: a target for treatment of systemic autoimmune diseases. Autoimmun. Rev. 7: 1-7. (Pubitemid 47633384)
4. Ferrucci, L., A. Corsi, F. Lauretani, S. Bandinelli, B. Bartali, D. D. Taub, J. M. Guralnik, and D. L. Longo. 2005. The origins of age-related proinflammatory state. Blood 105: 2294-2299. (Pubitemid 40387022)
5. Fülöp, T., A. Larbi, K. Hirokawa, E. Mocchegiani, B. Lesourds, S. Castle, A. Wikby, C. Franceschi, and G. Pawelec. 2007. Immunosupportive therapies in aging. Clin. Interv. Aging 2: 33-54.
6. Harris, T. B., L. Ferrucci, R. P. Tracy, M. C. Corti, S. Wacholder, W. H. Ettinger, Jr., H. Heimovitz, H. J. Cohen, and R. Wallace. 1999. Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly. Am. J. Med. 106: 506-512. (Pubitemid 29231100)
7. Wikby, A., B. O. Nilsson, R. Forsey, J. Thompson, J. Strindhall, S. Löfgren, J. Ernerudh, G. Pawelec, F. Ferguson, and B. Johansson. 2006. The immune risk phenotype is associated with IL-6 in the terminal decline stage: findings from the Swedish NONA immune longitudinal study of very late life functioning. Mech. Ageing Dev. 127: 695-704. (Pubitemid 43949280)
8. Fahey, J. L., J. F. Schnelle, J. Boscardin, J. K. Thomas, M. E. Gorre, N. Aziz, H. Sadeghi, and P. Nishanian. 2000. Distinct categories of immunologic changes in frail elderly. Mech. Ageing Dev. 115: 1-20. (Pubitemid 30347434)
9. Franceschi, C., S. Valensin, M. Bonafè, G. Paolisso, A. I. Yashin, D. Monti, and G. De Benedictis. 2000. The network and the remodeling theories of aging: historical background and new perspectives. Exp. Gerontol. 35: 879-896.
10. Sansoni, P., R. Vescovini, F. Fagnoni, C. Biasini, F. Zanni, L. Zanlari, A. Telera, G. Lucchini, G. Passeri, D. Monti, et al. 2008. The immune system in extreme longevity. Exp. Gerontol. 43: 61-65.
11. Menard, L. C., L. A. Minns, S. Darche, D. W. Mielcarz, D. M. Foureau, D. Roos, F. Dzierszinski, L. H. Kasper, and D. Buzoni-Gatel. 2007. B cells amplify IFN-gamma production by T cells via a TNF-alpha-mediated mechanism. J. Immunol. 179: 4857-4866.
12. Lund, F. E., M. Hollifield, K. Schuer, J. L. Lines, T. D. Randall, and B. A. Garvy. 2006. B cells are required for generation of protective effector and memory CD4 cells in response to Pneumocystis lung infection. J. Immunol. 176: 6147-6154.
13. Wojciechowski, W., D. P. Harris, F. Sprague, B. Mousseau, M. Makris, K. Kusser, T. Honjo, K. Mohrs, M. Mohrs, T. Randall, and F. E. Lund. 2009. Cytokine-producing effector B cells regulate type 2 immunity to H. polygyrus. Immunity 30: 421-433.
14. Lund, F. E., and T. D. Randall. 2010. Effector and regulatory B cells: modulators of CD4(+) T cell immunity. Nat. Rev. Immunol. 10: 236-247.
15. Frasca, D., E. Van der Put, R. L. Riley, and B. B. Blomberg. 2004. Reduced Ig class switch in aged mice correlates with decreased E47 and activation-induced cytidine deaminase. J. Immunol. 172: 2155-2162. (Pubitemid 38182361)
16. Frasca, D., A. M. Landin, R. L. Riley, and B. B. Blomberg. 2008. Mechanisms for decreased function of B cells in aged mice and humans. J. Immunol. 180: 2741-2746.
17. Frasca, D., E. Van der Put, A. M. Landin, D. Gong, R. L. Riley, and B. B. Blomberg. 2005. RNA stability of the E2A-encoded transcription factor E47 is lower in splenic activated B cells from aged mice. J. Immunol. 175: 6633-6644. (Pubitemid 41598906)
18. Frasca, D., A. M. Landin, J. P. Alvarez, P. J. Blackshear, R. L. Riley, and B. B. Blomberg. 2007. Tristetraprolin, a negative regulator of mRNA stability, is increased in old B cells and is involved in the degradation of E47 mRNA. J. Immunol. 179: 918-927.
19. Cao, H., F. Dzineku, and P. J. Blackshear. 2003. Expression and purification of recombinant tristetraprolin that can bind to tumor necrosis factor-alpha mRNA and serve as a substrate for mitogen-activated protein kinases. Arch. Biochem. Biophys. 412: 106-120. (Pubitemid 36324370)
20. Lai, W. S., J. S. Parker, S. F. Grissom, D. J. Stumpo, and P. J. Blackshear. 2006. Novel mRNA targets for tristetraprolin (TTP) identified by global analysis of stabilized transcripts in TTP-deficient fibroblasts. Mol. Cell. Biol. 26: 9196-9208. (Pubitemid 44904416)
21. Sherwood, E. M., B. B. Blomberg, W. Xu, C. A. Warner, and R. L. Riley. 1998. Senescent BALB/c mice exhibit decreased expression of lambda5 surrogate light chains and reduced development within the pre-B cell compartment. J. Immunol. 161: 4472-4475. (Pubitemid 28492013)
22. Van der Put, E., E. M. Sherwood, B. B. Blomberg, and R. L. Riley. 2003. Aged mice exhibit distinct B cell precursor phenotypes differing in activation, proliferation and apoptosis. Exp. Gerontol. 38: 1137-1147.
23. Van der Put, E., D. Frasca, A. M. King, B. B. Blomberg, and R. L. Riley. 2004. Decreased E47 in senescent B cell precursors is stage specific and regulated posttranslationally by protein turnover. J. Immunol. 173: 818-827. (Pubitemid 38924256)
24. Birjandi, S. Z., J. A. Ippolito, A. K. Ramadorai, and P. L. Witte. 2011. Alterations in marginal zone macrophages and marginal zone B cells in old mice. J. Immunol. 186: 3441-3451.
25. Johnson, S. A., S. J. Rozzo, and J. C. Cambier. 2002. Aging-dependent exclusion of antigen-inexperienced cells from the peripheral B cell repertoire. J. Immunol. 168: 5014-5023. (Pubitemid 34495964)
26. Green, M. R., S. Monti, R. Dalla-Favera, L. Pasqualucci, N. C. Walsh, M. Schmidt-Supprian, J. L. Kutok, S. J. Rodig, D. S. Neuberg, K. Rajewsky, et al. 2011. Signatures of murine B-cell development implicate Yy1 as a regulator of the germinal center-specific program. Proc. Natl. Acad. Sci. USA 108: 2873-2878.
27. Hao, Y., P. J. O'Neill, M. S. Naradikian, J. L. Scholz, and M. P. Cancro. 2011. A B-cell subset uniquely responsive to innate stimuli accumulates in aged mice. Blood. 118: 1294-1304.
28. + B-cell population is important for the development of autoimmunity. Blood. 118: 1305-1315.
29. Chorinchath, B. B., L. Y. Kong, L. Mao, and R. E. McCallum. 1996. Age-associated differences in TNF-alpha and nitric oxide production in endotoxic mice. J. Immunol. 156: 1525-1530.
30. Rahhal, R. M., T. J. Vanden Bush, M. K. McLendon, M. A. Apicella, and G. A. Bishop. 2007. Differential effects of Francisella tularensis lipopolysaccharide on B lymphocytes. J. Leukoc. Biol. 82: 813-820. (Pubitemid 47511041)
31. Boehmer, E. D., J. Goral, D. E. Faunce, and E. J. Kovacs. 2004. Age-dependent decrease in Toll-like receptor 4-mediated proinflammatory cytokine production and mitogen-activated protein kinase expression. J. Leukoc. Biol. 75: 342-349. (Pubitemid 38174592)
32. Boehmer, E. D., M. J. Meehan, B. T. Cutro, and E. J. Kovacs. 2005. Aging negatively skews macrophage TLR2- and TLR4-mediated pro-inflammatory responses without affecting the IL-2-stimulated pathway. Mech. Ageing Dev. 126: 1305-1313. (Pubitemid 41572248)
33. Frasca, D., A. Diaz, M. Romero, A. M. Landin, M. Phillips, S. C. Lechner, J. G. Ryan, and B. B. Blomberg. 2010. Intrinsic defects in B cell response to seasonal influenza vaccination in elderly humans. Vaccine. 28: 8077-8084.
34. Balkwill, F. 2009. Tumour necrosis factor and cancer. Nat. Rev. Cancer 9: 361-371.
35. Lindholm, E., E. Bakhtadze, C. Cilio, E. Agardh, L. Groop, and C. D. Agardh. 2008. Association between LTA, TNF and AGER polymorphisms and late diabetic complications. PLoS ONE 3: e2546.
36. Mundy, G. R. 2007. Osteoporosis and inflammation. Nutr. Rev. 65: S147-S151.
37. Holmes, C., C. Cunningham, E. Zotova, J. Woolford, C. Dean, S. Kerr, D. Culliford, and V. H. Perry. 2009. Systemic inflammation and disease progression in Alzheimer disease. Neurology 73: 768-774.
38. Isaacs, J. D. 2009. Therapeutic agents for patients with rheumatoid arthritis and an inadequate response to tumour necrosis factor-alpha antagonists. Expert Opin. Biol. Ther. 9: 1463-1475.
39. Sarzi-Puttini, P., F. Atzeni, A. Doria, L. Iaccarino, and M. Turiel. 2005. Tumor necrosis factor-alpha, biologic agents and cardiovascular risk. Lupus 14: 780-784. (Pubitemid 41413311)
40. Carballo, E., W. S. Lai, and P. J. Blackshear. 1998. Feedback inhibition of macrophage tumor necrosis factor-alpha production by tristetraprolin. Science 281: 1001-1005. (Pubitemid 28399252)
41. Carballo, E., W. S. Lai, and P. J. Blackshear. 2000. Evidence that tristetraprolin is a physiological regulator of granulocyte-macrophage colony-stimulating factor messenger RNA deadenylation and stability. Blood 95: 1891-1899. (Pubitemid 30151623)
42. Chen, Y. L., Y. L. Huang, N. Y. Lin, H. C. Chen, W. C. Chiu, and C. J. Chang. 2006. Differential regulation of ARE-mediated TNFalpha and IL-1beta mRNA stability by lipopolysaccharide in RAW264.7 cells. Biochem. Biophys. Res. Commun. 346: 160-168.
43. Ogilvie, R. L., M. Abelson, H. H. Hau, I. Vlasova, P. J. Blackshear, and P. R. Bohjanen. 2005. Tristetraprolin down-regulates IL-2 gene expression through AU-rich element-mediated mRNA decay. J. Immunol. 174: 953-961. (Pubitemid 40094291)
44. Stoecklin, G., X. F. Ming, R. Looser, and C. Moroni. 2000. Somatic mRNA turnover mutants implicate tristetraprolin in the interleukin-3 mRNA degradation pathway. Mol. Cell. Biol. 20: 3753-3763. (Pubitemid 30314475)
45. Franceschi, C., M. Capri, D. Monti, S. Giunta, F. Olivieri, F. Sevini, M. P. Panourgia, L. Invidia, L. Celani, M. Scurti, et al. 2007. Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans. Mech. Ageing Dev. 128: 92-105. (Pubitemid 46073065)