메뉴 건너뛰기




Volumn 160, Issue , 1997, Pages 115-126

Effect of age on humoral immunity, selection of the B-cell repertoire and B-cell development

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; ANTIGEN; AUTOANTIGEN; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; VACCINE;

EID: 0031436582     PISSN: 01052896     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-065X.1997.tb01032.x     Document Type: Review
Times cited : (176)

References (49)
  • 1
    • 0001192245 scopus 로고
    • Age and antibody production. Qualitative changes in antisera associated with age
    • Baumgartner L. Age and antibody production. Qualitative changes in antisera associated with age. J Immunol 1934;27:407-416.
    • (1934) J Immunol , vol.27 , pp. 407-416
    • Baumgartner, L.1
  • 2
    • 0002679725 scopus 로고
    • The presence of heterophile antibodies in infectious mononucleosis
    • Paul JR, Bunnel WW. The presence of heterophile antibodies in infectious mononucleosis. Am J Med Sci 1932;183-190.
    • (1932) Am J Med Sci , pp. 183-190
    • Paul, J.R.1    Bunnel, W.W.2
  • 3
    • 0002182004 scopus 로고
    • Die stärke der menschlichen Isoagglutinne und entsperchenden Bluktörperchenrezeptoren in verschiedenen Lebensaltern
    • Thomsen O, Kettel K. Die stärke der menschlichen Isoagglutinne und entsperchenden Bluktörperchenrezeptoren in verschiedenen Lebensaltern. Z Immunitatsforsch 1929;63:67-93.
    • (1929) Z Immunitatsforsch , vol.63 , pp. 67-93
    • Thomsen, O.1    Kettel, K.2
  • 5
    • 0018881864 scopus 로고
    • Age influence on the immune system
    • Makinodan T, Kay MM. Age influence on the immune system. Adv Immunol 1980;29:287-330.
    • (1980) Adv Immunol , vol.29 , pp. 287-330
    • Makinodan, T.1    Kay, M.M.2
  • 6
    • 0014404849 scopus 로고
    • Reciprocal change with age in antibody to extrinsic and intrinsic antigens
    • Rowley MJ, Buchanan H, Mackay IR. Reciprocal change with age in antibody to extrinsic and intrinsic antigens. Lancet 1968;2:24-26.
    • (1968) Lancet , vol.2 , pp. 24-26
    • Rowley, M.J.1    Buchanan, H.2    Mackay, I.R.3
  • 7
    • 0019427917 scopus 로고
    • Frequencies of background immunoglobulin-secreting cells in mice as a function of organ, age and immune status
    • Benner R, Rijnbeek AM, Bernabe RR, Martinez-Alonso C, Coutinho A. Frequencies of background immunoglobulin-secreting cells in mice as a function of organ, age and immune status. Immunobiol 1981;158:225-238.
    • (1981) Immunobiol , vol.158 , pp. 225-238
    • Benner, R.1    Rijnbeek, A.M.2    Bernabe, R.R.3    Martinez-Alonso, C.4    Coutinho, A.5
  • 8
    • 0024472597 scopus 로고
    • Peripheral T cells select the B cell repertoire in old mice
    • Weksler ME, Russo C, Siskind GW. Peripheral T cells select the B cell repertoire in old mice. Immunol Rev 1989;110:173-185.
    • (1989) Immunol Rev , vol.110 , pp. 173-185
    • Weksler, M.E.1    Russo, C.2    Siskind, G.W.3
  • 9
    • 0027380352 scopus 로고
    • Effect of age on the expressed B cell repertoire: Role of B cell subsets
    • Hu A, et al. Effect of age on the expressed B cell repertoire: role of B cell subsets. Int Immunol 1993;5:1035-1039.
    • (1993) Int Immunol , vol.5 , pp. 1035-1039
    • Hu, A.1
  • 10
    • 0023850713 scopus 로고
    • Old mice recover the ability to produce IgG and high avidity antibody following irradiation with partial bone marrow shielding
    • Tsuda T, Kim YT, Siskind GW, Weksler ME. Old mice recover the ability to produce IgG and high avidity antibody following irradiation with partial bone marrow shielding. Proc Natl Acad Sci USA 1988;85:1169-1173.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 1169-1173
    • Tsuda, T.1    Kim, Y.T.2    Siskind, G.W.3    Weksler, M.E.4
  • 11
    • 0016769766 scopus 로고
    • Normal function of immunologic stem cells from aged mice
    • Harrison DE, Doubleday JW. Normal function of immunologic stem cells from aged mice. J Immunol 1975;114:1314-1317.
    • (1975) J Immunol , vol.114 , pp. 1314-1317
    • Harrison, D.E.1    Doubleday, J.W.2
  • 12
    • 0021264313 scopus 로고
    • Physiology of B cells in mice with X-linked immunodeficiency. II. Influence of the thymus and mature T cells on B cell differentiation
    • Sprent J, Bruce J. Physiology of B cells in mice with X-linked immunodeficiency. II. Influence of the thymus and mature T cells on B cell differentiation. J Exp Med 1984;160:335-340.
    • (1984) J Exp Med , vol.160 , pp. 335-340
    • Sprent, J.1    Bruce, J.2
  • 13
    • 0017167094 scopus 로고
    • Immunological studies of aging. II. Loss of IgG and high avidity plaque-forming cells and increased suppressor cell activity in aging mice
    • Goidl EA, Innes JB, Weksler ME. Immunological studies of aging. II. Loss of IgG and high avidity plaque-forming cells and increased suppressor cell activity in aging mice. J Exp Med 1976;144:1037-1048.
    • (1976) J Exp Med , vol.144 , pp. 1037-1048
    • Goidl, E.A.1    Innes, J.B.2    Weksler, M.E.3
  • 14
    • 0010994262 scopus 로고
    • Immunological studies of aging IV. The contribution of thymic involution to the immune deficiencies of aging mice
    • Weksler ME, Innes JB, Goldstein G. Immunological studies of aging IV. The contribution of thymic involution to the immune deficiencies of aging mice. J Exp Med 1978;148:966-1006.
    • (1978) J Exp Med , vol.148 , pp. 966-1006
    • Weksler, M.E.1    Innes, J.B.2    Goldstein, G.3
  • 15
    • 0017229486 scopus 로고
    • 3H mice
    • 3H mice. J Immunol 1976;166:469-474.
    • (1976) J Immunol , vol.166 , pp. 469-474
    • Smith, A.M.1
  • 16
    • 0015821513 scopus 로고
    • Lymphocyte phytohemagglutinin responsiveness, immunoglobulins and autoantibodies in aging humans
    • Hallgren HM, Buckley CE, Gilbertsen VA, Yunis EJ. Lymphocyte phytohemagglutinin responsiveness, immunoglobulins and autoantibodies in aging humans. J Immunol 1973;111:1101-1107.
    • (1973) J Immunol , vol.111 , pp. 1101-1107
    • Hallgren, H.M.1    Buckley, C.E.2    Gilbertsen, V.A.3    Yunis, E.J.4
  • 17
    • 0027394331 scopus 로고
    • Lower antibody response to tetanus toxoid associated with higher auto-anti-idiotypic antibody in old compared with young humans
    • Areaza EE, Gibbons JJ, Siskind GW, Weksler ME. Lower antibody response to tetanus toxoid associated with higher auto-anti-idiotypic antibody in old compared with young humans. Clin Exp Immunol 1993;92:169-173.
    • (1993) Clin Exp Immunol , vol.92 , pp. 169-173
    • Areaza, E.E.1    Gibbons, J.J.2    Siskind, G.W.3    Weksler, M.E.4
  • 18
    • 0020691845 scopus 로고
    • Increased frequency of rheumatoid factor precursor B lymphocytes after immunization of normal adults with tetanus toxoid
    • Welch MJ, Fong S, Vaughan J, Carson D. Increased frequency of rheumatoid factor precursor B lymphocytes after immunization of normal adults with tetanus toxoid. Clin Exp Immunol 1983;51:299-304.
    • (1983) Clin Exp Immunol , vol.51 , pp. 299-304
    • Welch, M.J.1    Fong, S.2    Vaughan, J.3    Carson, D.4
  • 19
    • 0025810756 scopus 로고
    • "Cross-wiring" of the immune response in old mice: Increased autoantibody response despite reduced antibody response to nominal antigen
    • Bovbjerg DH, Kim YT, Schwab R, Schmitt K, DeBlasio T, Weksler ME. "Cross-wiring" of the immune response in old mice: increased autoantibody response despite reduced antibody response to nominal antigen. Cell Immunol 1991;135:519-525.
    • (1991) Cell Immunol , vol.135 , pp. 519-525
    • Bovbjerg, D.H.1    Kim, Y.T.2    Schwab, R.3    Schmitt, K.4    DeBlasio, T.5    Weksler, M.E.6
  • 20
    • 0028133043 scopus 로고
    • Global analysis of antibody repertoires. I. An immunoblot method for the quantitative screening of a large number of reactivities
    • Haury M, Grandien A, Sundblad A, Coutinho A, Nobrega A. Global analysis of antibody repertoires. I. An immunoblot method for the quantitative screening of a large number of reactivities. Scand J Immunol 1994;39:79-87.
    • (1994) Scand J Immunol , vol.39 , pp. 79-87
    • Haury, M.1    Grandien, A.2    Sundblad, A.3    Coutinho, A.4    Nobrega, A.5
  • 21
    • 0029825503 scopus 로고    scopus 로고
    • The age-associated increase in autoreactivity reflects a global and progressive expansion of autoreactivity detectable in young mice
    • Nobrega A, Haury M, Guéret R, Coutinho A, Weksler ME. The age-associated increase in autoreactivity reflects a global and progressive expansion of autoreactivity detectable in young mice. Scand J Immunol 1996;44:437-443.
    • (1996) Scand J Immunol , vol.44 , pp. 437-443
    • Nobrega, A.1    Haury, M.2    Guéret, R.3    Coutinho, A.4    Weksler, M.E.5
  • 22
    • 0025346934 scopus 로고
    • Monoclonal gammopathies in human aging: Increased occurrence with age and correlation with health status
    • Ligthart GJ, et al. Monoclonal gammopathies in human aging: increased occurrence with age and correlation with health status. Mech Ageing Dev 1990;52:235-243.
    • (1990) Mech Ageing Dev , vol.52 , pp. 235-243
    • Ligthart, G.J.1
  • 23
    • 0025336906 scopus 로고
    • Age-related monoclonal gammapathies: Clinical lessons from the aging C57BL mouse
    • Radl J. Age-related monoclonal gammapathies: clinical lessons from the aging C57BL mouse. Immunol Today 1990;11:234-236.
    • (1990) Immunol Today , vol.11 , pp. 234-236
    • Radl, J.1
  • 24
    • 0022998764 scopus 로고
    • Monoclonal immunoglobulins with antibody activity in myeloma, macroglobulinemia and related plasma cell dyscrasias
    • Merlini G, Farhangi M, Osserman EF. Monoclonal immunoglobulins with antibody activity in myeloma, macroglobulinemia and related plasma cell dyscrasias. Semin Oncol 1986;13:350-365.
    • (1986) Semin Oncol , vol.13 , pp. 350-365
    • Merlini, G.1    Farhangi, M.2    Osserman, E.F.3
  • 25
    • 0027274836 scopus 로고
    • Evidence for selective pressure in the appearance of monoclonal immunoglobulins during aging: Studies in M54 μ-transgenic mice
    • Guéret R, Grandien A, Anderson J, Coutinho A, Radl J, Weksler ME. Evidence for selective pressure in the appearance of monoclonal immunoglobulins during aging: studies in M54 μ-transgenic mice. Eur J Immunol 1993;23:1735-1738.
    • (1993) Eur J Immunol , vol.23 , pp. 1735-1738
    • Guéret, R.1    Grandien, A.2    Anderson, J.3    Coutinho, A.4    Radl, J.5    Weksler, M.E.6
  • 26
    • 0029737105 scopus 로고    scopus 로고
    • Age related changes in serum immunoglobulin levels, autoantibodies and monoclonal immunoglobulins in Xid and C57BL/6 mice
    • Guéret R, Zhao KS, Weksler ME. Age related changes in serum immunoglobulin levels, autoantibodies and monoclonal immunoglobulins in Xid and C57BL/6 mice. Aging Immunol Infect Dis 1996;6:177-187.
    • (1996) Aging Immunol Infect Dis , vol.6 , pp. 177-187
    • Guéret, R.1    Zhao, K.S.2    Weksler, M.E.3
  • 27
    • 0024677521 scopus 로고
    • Frequency of VH-gene utilization in human EBV-transformed B-cell lines: The most JH-proximal VH segment encodes autoantibodies
    • Logtenberg T, Young FM, van Es J, Gmelig-Meyling FH, Berman JE, Alt FW. Frequency of VH-gene utilization in human EBV-transformed B-cell lines: the most JH-proximal VH segment encodes autoantibodies. J Autoimmun 1989;2 (Suppl): 203-213.
    • (1989) J Autoimmun , vol.2 , Issue.SUPPL. , pp. 203-213
    • Logtenberg, T.1    Young, F.M.2    Van Es, J.3    Gmelig-Meyling, F.H.4    Berman, J.E.5    Alt, F.W.6
  • 28
    • 0028168334 scopus 로고
    • Vh gene family dominance in ageing mice
    • Viale AC, et al. Vh gene family dominance in ageing mice. Scand J Immunol 1994;39:184-188.
    • (1994) Scand J Immunol , vol.39 , pp. 184-188
    • Viale, A.C.1
  • 30
    • 0021709175 scopus 로고
    • Influenza and aging: Age-related changes and the effects of thymosin on the antibody response to influenza vaccine
    • Ershler WB, Moore AL, Socinski MA. Influenza and aging: age-related changes and the effects of thymosin on the antibody response to influenza vaccine. J Clin Immunol 1984;4:445-454.
    • (1984) J Immunol , vol.4 , pp. 445-454
    • Ershler, W.B.1    Moore, A.L.2    Socinski, M.A.3
  • 31
    • 0026042704 scopus 로고
    • The protective efficacy of polyvalent pneumococcal polysaccharide vaccine
    • Shapiro ED, et al. The protective efficacy of polyvalent pneumococcal polysaccharide vaccine. N Engl J Med 1991;325:1453-1460.
    • (1991) N Engl J Med , vol.325 , pp. 1453-1460
    • Shapiro, E.D.1
  • 32
    • 0027252520 scopus 로고
    • Repertoire diversity of antibody response to bacterial antigens in aged mice. III. Phosphorylcholine antibody from young and aged mice differ in structure and protective activity against infection with Streptococcus pneumoniae
    • Nicoletti C, Yang X, Cerny J. Repertoire diversity of antibody response to bacterial antigens in aged mice. III. Phosphorylcholine antibody from young and aged mice differ in structure and protective activity against infection with Streptococcus pneumoniae. J Immunol 1993;150:543-549.
    • (1993) J Immunol , vol.150 , pp. 543-549
    • Nicoletti, C.1    Yang, X.2    Cerny, J.3
  • 33
    • 0015297750 scopus 로고
    • Immunologic deficiencies in senescence. I. Characterization of intrinsic deficiencies
    • Price GB, Makinodan T. Immunologic deficiencies in senescence. I. Characterization of intrinsic deficiencies. J Immunol 1972;108:403-412.
    • (1972) J Immunol , vol.108 , pp. 403-412
    • Price, G.B.1    Makinodan, T.2
  • 34
    • 0029817016 scopus 로고    scopus 로고
    • Increasing doses of purified influenza virus hemagglutinin and subvirion vaccines enhance antibody responses in the elderly
    • Keitel WA, et al. Increasing doses of purified influenza virus hemagglutinin and subvirion vaccines enhance antibody responses in the elderly. Clin Diagn Lab Immunol 1996;3:507-510.
    • (1996) Clin Diagn Lab Immunol , vol.3 , pp. 507-510
    • Keitel, W.A.1
  • 35
    • 0018938289 scopus 로고
    • Effect of age on ease of B-cell tolerance induction
    • Dobken J, Weksler ME, Siskind GW. Effect of age on ease of B-cell tolerance induction. Cell Immunol 1980;55:66-73.
    • (1980) Cell Immunol , vol.55 , pp. 66-73
    • Dobken, J.1    Weksler, M.E.2    Siskind, G.W.3
  • 36
    • 0345279033 scopus 로고
    • Production of auto-anti-idiotypic antibody during the normal immune response: Changes in the auto-anti-idiotypic antibody response and the idiotype repertoire associated with aging
    • Goidl EA, Thorbecke GJ, Weksler ME, Siskind GW. Production of auto-anti-idiotypic antibody during the normal immune response: changes in the auto-anti-idiotypic antibody response and the idiotype repertoire associated with aging. Proc Natl Acad Sci USA 1980;77:6788-6792.
    • (1980) Proc Natl Acad Sci USA , vol.77 , pp. 6788-6792
    • Goidl, E.A.1    Thorbecke, G.J.2    Weksler, M.E.3    Siskind, G.W.4
  • 37
    • 0019196921 scopus 로고
    • Ontogeny of B lymphocyte function. VIII. Failure of thymus cells from aged donors to induce the functional maturation of B lymphocytes from immature donors
    • Szewczuk MR, DeKryuff RH, Goidl EA, Weksler ME, Siskind GW. Ontogeny of B lymphocyte function. VIII. Failure of thymus cells from aged donors to induce the functional maturation of B lymphocytes from immature donors. Eur J Immunol 1980;10:918-923.
    • (1980) Eur J Immunol , vol.10 , pp. 918-923
    • Szewczuk, M.R.1    DeKryuff, R.H.2    Goidl, E.A.3    Weksler, M.E.4    Siskind, G.W.5
  • 38
    • 0024573970 scopus 로고
    • Immunological studies of aging. Normal B-cell repertoire in aged mice: Studies at a clonal level
    • Marcenaro L, Russo C, Kim YT, Siskind GW, Weksler ME. Immunological studies of aging. Normal B-cell repertoire in aged mice: studies at a clonal level. Cell Immunol 1989;119:202-210.
    • (1989) Cell Immunol , vol.119 , pp. 202-210
    • Marcenaro, L.1    Russo, C.2    Kim, Y.T.3    Siskind, G.W.4    Weksler, M.E.5
  • 39
    • 0030022218 scopus 로고    scopus 로고
    • Antibody class switching
    • Stavnezer J. Antibody class switching. Adv Immunol 1996;61:79-146.
    • (1996) Adv Immunol , vol.61 , pp. 79-146
    • Stavnezer, J.1
  • 40
    • 0028983212 scopus 로고
    • Ig VH hypermutation is absent in the germinal centers of aged mice
    • Miller C, Kelsoe G. Ig VH hypermutation is absent in the germinal centers of aged mice. J Immunol 1995;155:3377-3384.
    • (1995) J Immunol , vol.155 , pp. 3377-3384
    • Miller, C.1    Kelsoe, G.2
  • 41
    • 0029918498 scopus 로고    scopus 로고
    • Relative contribution of T and B cells to hypermutation and selection of the antibody repertoire in germinal centers of aged mice
    • Yang X, Stedra J, Cerny J. Relative contribution of T and B cells to hypermutation and selection of the antibody repertoire in germinal centers of aged mice. J Exp Med 1996;183:959-970.
    • (1996) J Exp Med , vol.183 , pp. 959-970
    • Yang, X.1    Stedra, J.2    Cerny, J.3
  • 42
    • 0030018560 scopus 로고    scopus 로고
    • Treatment of old mice with Il-2 corrects dysregulated Il-2 and Il-4 production
    • Kirman I, et al. Treatment of old mice with Il-2 corrects dysregulated Il-2 and Il-4 production. Int Immunol 1996;8:1009-1015.
    • (1996) Int Immunol , vol.8 , pp. 1009-1015
    • Kirman, I.1
  • 43
    • 0025346853 scopus 로고
    • Cellular basis for the age-associated increase in autoimmune reactions
    • Weksler ME, Schwab R, Huetz F, Kim YT, Coutinho A. Cellular basis for the age-associated increase in autoimmune reactions. Int Immunol 1990;2:329-335.
    • (1990) Int Immunol , vol.2 , pp. 329-335
    • Weksler, M.E.1    Schwab, R.2    Huetz, F.3    Kim, Y.T.4    Coutinho, A.5
  • 44
    • 0345590220 scopus 로고
    • Ly-1 B-cell clones similar to human chronic lymphocytic leukemias routinely develop in older normal mice and young autoimmune (New Zealand Black-related) animals
    • Stall AM, et al. Ly-1 B-cell clones similar to human chronic lymphocytic leukemias routinely develop in older normal mice and young autoimmune (New Zealand Black-related) animals. Proc Natl Acad Sci USA 1988;85:7312-7316.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 7312-7316
    • Stall, A.M.1
  • 46
    • 0001613414 scopus 로고
    • Collagen induced arthritis and aging: Influence of age on arthritis susceptibility and acute phase responses
    • von Rollenhoven RP, et al. Collagen induced arthritis and aging: influence of age on arthritis susceptibility and acute phase responses. Aging Immunol Infect Dis 1988;1:159-176.
    • (1988) Aging Immunol Infect Dis , vol.1 , pp. 159-176
    • Von Rollenhoven, R.P.1
  • 47
    • 0028020494 scopus 로고
    • Bone marrow declines as a site of B cell precursor differentiation with age: Relationship to thymus involution
    • Ben-Yehuda A, Szabo P, Dyall R, Weksler ME. Bone marrow declines as a site of B cell precursor differentiation with age: relationship to thymus involution. Proc Natl Acad Sci USA 1994;91:11988-11992.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 11988-11992
    • Ben-Yehuda, A.1    Szabo, P.2    Dyall, R.3    Weksler, M.E.4
  • 48
    • 0029966724 scopus 로고    scopus 로고
    • Specific alterations in murine B lymphopoiesis with age
    • Stephan RP, Sanders VM, Witte PL. Specific alterations in murine B lymphopoiesis with age. Int Immunol 1996;8:509-518.
    • (1996) Int Immunol , vol.8 , pp. 509-518
    • Stephan, R.P.1    Sanders, V.M.2    Witte, P.L.3
  • 49
    • 0025762004 scopus 로고
    • B cell precursors are decreased in senescent BALB/c mice, but retain normal mitotic activity in vivo and in vitro
    • Riley RL, Kruger MG, Elia J. B cell precursors are decreased in senescent BALB/c mice, but retain normal mitotic activity in vivo and in vitro. Clin Immunol Immunopathol 1991;59:301-313.
    • (1991) Clin Immunol Immunopathol , vol.59 , pp. 301-313
    • Riley, R.L.1    Kruger, M.G.2    Elia, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.