Age-related impaired affinity maturation and differential D-JH gene usage in human VH6-expressing B lymphocytes from healthy individuals

European Journal of Immunology

Volumn 27, Issue 6, 1997, Pages 1381-1386

  Van Dijk Härd, Iris ^a   Söderström, Ingegerd ^b   Feld, Sari ^a   Holmberg, Dan ^b   Lundkvist, Inger ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b UMEÅ UNIVERSITY   (Sweden)

Author keywords

Affinity maturation; CDR3 variability; Ontogeny; Senescence; VH6 gene

Indexed keywords

NUCLEOTIDE;

ARTICLE; B LYMPHOCYTE; BLOOD; CELL MATURATION; CONTROLLED STUDY; GENE MUTATION; GENE REARRANGEMENT; HUMAN; HUMAN CELL; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNE RESPONSE GENE; MOLECULAR BIOLOGY; MUTATION RATE; NUCLEOTIDE SEQUENCE; ONTOGENY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SENESCENCE; SPLEEN; UMBILICAL CORD BLOOD;

ADULT; AGED; AGING; ANTIBODY AFFINITY; B-LYMPHOCYTES; CELL DIFFERENTIATION; GENE REARRANGEMENT, B-LYMPHOCYTE; GENES, IMMUNOGLOBULIN; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN JOINING REGION; IMMUNOGLOBULIN VARIABLE REGION; MIDDLE AGED; ORGAN SPECIFICITY; VARIATION (GENETICS);

EID: 0037849072     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.1830270613     Document Type: Article

References (30)

1. Grandien, A., Modigliani, Y., Freitas, A., Andersson, J. and Coutinho, A., Immunol. Rev. 1994. 137: 35.
2. Tarlinton, D., Immunol. Rev. 1994. 137: 203.
3. Tonegawa, S., Nature 1983. 502: 575.
4. Alt, F. W., Blackwell, T. K. and Yancopoulos, G. D., Science 1987. 238: 1079.
5. Kirkham, P. M., Mortari, F., Newton, J. A. and Schroeder, H. W. Jr., EMBO 1992. 11: 603.
6. Cuisinier, A. M., Guigou, V., Boubli, L., Fougereau, M. and Tonnelle, C., Scan. J. Immunol. 1989. 30: 493.
7. Hillson, J. L., Oppliger, I. R., Sasso, E. H., Milner, E. C. and Wener, M. H., J. Immunol. 1992. 149: 3741.
8. Schroeder, H. W. Jr. and Wang, J. Y, Proc. Natl. Acad. Sci. USA 1990. 87: 6146.
9. Raaphorst, F. M., Timmers, E., Kenter, M. J., Van Tol, M. J., Vossen, J. M. and Schuurman, R. K., Eur. J. Immunol. 1992. 22: 247.
10. Berman, J. E., Nickerson, K. G., Pollock, R. R., Barth, J. E., Schuurman, R. K. B., Knowles, D. M., Chess, L. and Alt, F. W., Eur. J. Immunol. 1991. 21: 1311.
11. Fumoux, F, Guigou, Y, Biaise, D., Maraninchi, D., Fougereau, M. and Schiff, C., Blood 1993. 81: 3153.
12. Storek, J., King, L., Ferrara, S., Marcelo, D., Saxon, A. and Braun, J., Bone Marrow Transplant. 1994. 14: 783.
13. Näsman, I. and Lundkvist, I., Blood 1996. 87: 2795.
14. Davidkova, G., Pettersson, S., Holmberg, D. and Lundkvist, I., Scand. J. Immunol. 1997. 45: 62.
15. Logtenberg, T., Young, F. M., Van Es, J. H., Gmelig-Meyling, F. H. and Alt, F. W., J. Exp. Med. 1989. 170: 1347.
16. Kearney, J. F. and Vakil, M., Immunol Rev. 1986. 94: 39.
17. Hodes, R. J., J. Exp. Med. 1995. 182: 1.
18. Pawelec, G., Adibzadeh, M., Pohla, H. and Schaudt, K., Immunol. Today 1995. 16: 420.
19. Viale, A. C., Chies, J. A., Huetz, F., Malenchere, E., Weksler, M., Freitas, A. A. and Coutinho, A., Scand. J. Immunol. 1994. 39: 184.
20. Miller, C. and Kelsoe, G., J. Immunol. 1995. 155: 3377.
21. Schroeder, H. W. Jr., Hillson, J. L. and Perlmutter, R. M., Science 1987. 238: 791.
22. Kabat, E. A., Wu, T. T., Perry, H. M., Gottesman, D. S. and Foeller, C., Sequences of proteins of immunological interest, 5th Edn., NIH Publication 91-3242, Bethesda 1991.
23. Ravetch, J. V, Siebenlist, U., Korsmeyer, S., Waldmann, T. and Leder, P., Cell 1981. 27: 583.
24. Huang, C., Stewart, K., Schwanz, R. S. and Stollar, D., J. Clin. Invest. 1992. 89: 1331.
25. Nuñez, C., Nishimoto, N., Gartland, G. L., Billips, L. G., Burrows, P. D., Kubagawa, H. and Cooper, M. D., J. lmmunol. 1996. 156: 866.
26. Jukes,T. H. and King, J. L., Nature 1979. 281: 605.
27. Stenzel-Poore, M. P, Bruderer, U. and Rittenberg, M. B., Immunol. Rev. 1988. 105: 113.
28. Brezinschek, H. P., Brezinschek, R. I. and Lipsky, P. E., J. Immunol. 1995. 155: 190.
29. Mortari, F., Newton, J. A., Wang, J. Y. and Schroeder, H. Jr., Eur. J. Immunol. 1992. 22: 241.
30. Yamada, M., Wasserman, R., Reichard, B. A., Shane, S., Caton, A. J. and Rovera, G., J. Exp. Med. 1991. 173: 395.