Immunoglobulin VH gene expression in human aging

Clinical Immunology

Volumn 93, Issue 2, 1999, Pages 132-142

  Wang, Xiaowei ^a   Stollar, B David ^a  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Aging; B cell; cDNA library; Ig repertoire; Single cell PCR; VH domain

Indexed keywords

IMMUNOGLOBULIN;

AGING; ARTICLE; DNA LIBRARY; GENE EXPRESSION; GENE MUTATION; GENE SEQUENCE; HUMAN; IMMUNOGENETICS; MOLECULAR CLONING; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0032694334     PISSN: 15216616     EISSN: None     Source Type: Journal    
DOI: 10.1006/clim.1999.4781     Document Type: Article

References (38)

1. Weksler, M. E., Immune senescence. Ann. Neurol. 35 (Suppl.), S35-S37, 1994.
2. Makinodan, T., Patterns of age-related immunologic changes. Nutr. Rev. 53, S27-S31, 1995.
3. Arreaza, E. E., Gibbons, J. J., Jr., Siskind, G. W., and Weksler, M. E., Lower antibody response to tetanus toxoid associated with higher auto-anti-idiotypic antibody in old compared with young humans. Clin. Exp. Immunol. 92, 169-173, 1993.
4. Goidl, E. A., Michelis, M. A., Siskind, G. W., and Weksler, M. E., Effect of age on the induction of autoantibodies. Clin. Exp. Immunol. 44, 24-30, 1981.
5. Hodes, R. J., Molecular alterations in the aging immune system. J. Exp. Med. 182, 1-3, 1995.
6. Miller, R. A., Aging and the immune response. In "Handbook of the Biology of Aging" (E. L. Schneider and J. W. Rowe, Eds.), pp. 157-180, Academic Press, San Diego, 1990.
7. Pawelec, G., Adibzadeh, M., Pohla, H., and Schaudt, K., Immunosenescence: Ageing of the immune system. Immunol. Today 16, 420-422, 1995.
8. Ershler, W. B., Interleukin-6: A cytokine for gerontologists. J. Am. Geriatr. Soc. 41, 176-181, 1993.
9. LeMaoult, J., Szabo, P., and Weksler, M. E., Effect of age on humoral immunity, selection of the B-cell repertoire and B-cell development. Immunol. Rev. 160, 115-126, 1997.
10. Weksler, M. E., Immune senescence: Deficiency or dysregulation. Nutr. Rev. 53, S3-S7, 1995.
11. Mouthon, L., Lacroix-Desmazes, S., Nobrega, A., Barreau, C., Coutinho, A., and Kazatchkine, M. D., The self-reactive antibody repertoire of normal human serum IgM is acquired in early childhood and remains conserved throughout life. Scand. J. Immunol. 44, 243-251, 1996.
12. Lacroix-Desmazes, S., Mouthon, L., Coutinho, A., and Kazatchkine, M. D., Analysis of the natural human IgG antibody repertoire: Life-long stability of reactivities towards self antigens contrasts with age-dependent diversification of reactivities against bacterial antigens. Eur. J. Immunol. 25, 2598-2604, 1995.
13. Bouanani, M., Dietrich, G., Hurez, V., Kaveri, S. V., Del Rio, M., Pau, B., and Kazatchkine, M. D., Age-related changes in specificity of human natural autoantibodies to thyroglobulin. J. Autoimmun. 6, 639-648, 1993.
14. Radl, J., Sepers, J. M., Skvaril, F., Morell, A., and Hijmans, W., Immunoglobulin patterns in humans over 95 years of age. Clin. Exp. Immunol. 22, 84-90, 1975.
15. Klein, U., Kuppers, R., and Rajewsky, K., Human IgM+IgD+ B cells, the major B cell subset in the peripheral blood, express V kappa genes with no or little somatic mutation throughout life. Eur. J. Immunol. 23, 3272-3277, 1993.
16. Xue, W., Luo, S., Adler, W. H., Schulze, D. H., and Berman, J. E., Immunoglobulin heavy chain junctional diversity in young and aged humans. Hum. Immunol. 57, 80-92, 1997.
17. van Dijk-Hard, I., Soderstrom, I., Feld, S., Holmberg, D., and Lundkvist, I., Age-related impaired affinity maturation and differential D-JH gene usage in human VH6-expressing B lymphocytes from healthy individuals. Eur. J. Immunol. 27, 1381-1386, 1997.
18. Huang, C., and Stollar, B. D., Construction of representative immunoglobulin variable region cDNA libraries from human peripheral blood lymphocytes without in vitro stimulation. J. Immunol. Methods 141, 227-236, 1991.
19. Tomlinson, I. M., Williams, S. C., Corbett, S. J., Cox, J. P. L., and Winter, G., V BASE directory. 1997.
20. Huang, C., and Stollar, B. D., A majority of Ig H chain cDNA of normal human adult blood lymphocytes resembles cDNA for fetal Ig and natural autoantibodies. J. Immunol. 151, 5290-5300, 1993.
21. Klein, U., Kuppers, R., and Rajewsky, K., Evidence for a large compartment of IgM-expressing memory B cells in humans. Blood 89, 1288-1298, 1997.
22. Kraj, P., Friedman, D. F., Stevenson, F., and Silberstein, L. E., Evidence for the overexpression of the VH4-34 (VH4.21) Ig gene segment in the normal adult human peripheral blood B cell repertoire. J. Immunol. 154, 6406-6420, 1995.
23. Demaison, C., David, D., Letourneur, F., Theze, J., Saragosti, S., and Zouali, M., Analysis of human VH gene repertoire expression in peripheral CD19+ B cells. Immunogenetics 42, 342-352, 1995.
24. Matsuda, F., Ishii, K., Bourvagnet, P., Kuma, K., Hayashida, H., Miyata, T., and Honjo, T., The complete nucleotide sequence of the human immunoglobulin heavy chain variable region locus. J. Exp. Med. 188, 2151-2162, 1998.
25. Brezinschek, H. P., Foster, S. J., Brezinschek, R. I., Dorner, T., Domiati-Saad, R., and Lipsky, P. E., Analysis of the human VH gene repertoire. Differential effects of selection and somatic hypermutation on human peripheral CD5(+)/IgM+ and CD5(-)/ IgM+ B cells. J. Clin. Invest. 99, 2488-2501, 1997.
26. Brezinschek, H. P., Foster, S. J., Dorner, T., Brezinschek, R. I., and Lipsky, P. E., Pairing of variable heavy and variable kappa chains in individual naive and memory B cells. J. Immunol. 160, 4762-4767, 1998.
27. Pandey, J. P., Fudenberg, H. H., Ainsworth, S. K., and Loadholt, C. B., Autoantibodies in healthy subjects of different age groups. Mech. Ageing Dev. 10, 399-404, 1979.
28. Goodwin, J. S., Searles, R. P., and Tung, K. S., Immunological responses of healthy elderly population. Clin. Exp. Immunol. 48, 403-410, 1982.
29. Viale, A. C., Chies, J. A., Huetz, F., Malenchere, E., Weksler, M., Freitas, A. A., and Coutinho, A., VH-gene family dominance in ageing mice. Scand. J. Immunol. 39, 184-188, 1994.
30. Brezinschek, H. P., Brezinschek, R. I., and Lipsky, P. E., Analysis of the heavy chain repertoire of human peripheral B cells using single-cell polymerase chain reaction. J. Immunol. 155, 190-202, 1995.
31. Schutte, M. E., van Es, J. H., Silberstein, L. E., and Logtenberg, T., VH4.21-encoded natural autoantibodies with anti-i specificity mirror those associated with cold hemagglutinin disease. J. Immunol. 151, 6569-6576, 1993.
32. Silverman, G. J., and Carson, D. A., Structural characterization of human monoclonal cold agglutinins: Evidence for a distinct primary sequence-defined VH4 idiotype. Eur. J. Immunol. 20, 351-356, 1990.
33. Pascual, V., Victor, K., Spellerberg, M., Hamblin, T. J., Stevenson, F. K., and Capra, J. D., VH restriction among human cold agglutinins. The VH4-21 gene segment is required to encode anti-I and anti-i specificities. J. Immunol. 149, 2337-2344, 1992.
34. Parr, T. B., Johnson, T. A., Silberstein, L. E., and Kipps, T. J., Anti-B cell autoantibodies encoded by VH 4-21 genes in human fetal spleen do not require in vivo somatic selection. Eur. J. Immunol. 24, 2941-2949, 1994.
35. Dube, V. E., Zuckerman, L., and Philipsborn, H. F. J., Variation of cold agglutinin levels. Vox. Sang. 34, 71-76, 1978.
36. Huang, C., Stewart, A. K., Schwartz, R. S., and Stollar, B. D., Immunoglobulin heavy chain gene expression in peripheral blood B lymphocytes. J. Clin. Invest. 89, 1331-1343, 1992.
37. Nunez, C., Nishimoto, N., Gartland, G. L., Billips, L. G., Burrows, P. D., Kubagawa, H., and Cooper, M. D., B cells are generated throughout life in humans. J. Immunol. 156, 866-872, 1996.
38. Corbett, S. J., Tomlinson, I. M., Sonnhammer, E. L., Buck, D., and Winter, G., Sequence of the human immunoglobulin diversity (D) segment locus: A systematic analysis provides no evidence for the use of DIR segments, inverted D segments, "minor" D segments or D-D recombination. J. Mol. Biol. 270, 587-597, 1997.