A novel B cell population revealed by a CD38/CD24 gating strategy: CD38-CD24- B cells in centenarian offspring and elderly people

Age

Volumn 35, Issue 5, 2013, Pages 2009-2024

  Buffa, Silvio ^a   Pellicanò, Mariavaleria ^b   Bulati, Matteo ^a   Martorana, Adriana ^a   Goldeck, David ^b   Caruso, Calogero ^a   Pawelec, Graham ^b   Colonna Romano, Giuseppina ^a  

^a UNIVERSITY OF PALERMO   (Italy)

^b UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

B cell; CD180; CD24; CD38; Centenarian offspring; Immunosenescence

Indexed keywords

CD180 RECEPTOR; CD24 ANTIGEN; CD27 ANTIGEN; CD38 ANTIGEN; IMMUNOGLOBULIN D; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

ADULT; AGED; AGING; ARTICLE; CD19+ CD38- CD24- B LYMPHOCYTE; CELL EXPANSION; CELL POPULATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; IMMUNOSENESCENCE; IN VITRO STUDY; MEMORY CELL; NORMAL HUMAN; PROGENY; PROTEIN EXPRESSION; RECEPTOR DOWN REGULATION; SENESCENCE; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; AGING; ANTIGENS, CD24; ANTIGENS, CD38; B-LYMPHOCYTES; CYTOKINES; FEMALE; HUMANS; IMMUNITY, CELLULAR; LONGEVITY; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; PARENTS; REFERENCE VALUES;

EID: 84891486954     PISSN: 01619152     EISSN: 15744647     Source Type: Journal    
DOI: 10.1007/s11357-012-9488-5     Document Type: Article

References (55)

1. Agrawal S, Gupta S (2011) TLR1/2, TLR7, and TLR9 signals directly activate peripheral blood naive and memory B cell subsets to produce cytokines, chemokines, and hematopoietic growth factors. J Clin Immunol 31(1):89-98
2. Allman DM, Ferguson SE, Lentz VM, Cancro MP (1993) Peripheral B cell maturation. II. Heat-stable antigen(hi) splenic B cells are an immature developmental intermediate in the production of long-lived marrow-derived B cells. J Immunol 151(9):4431-4444
3. Allman D, Lindsley RC, DeMuth W, Rudd K, Shinton SA, Hardy RR (2001) Resolution of three nonproliferative immature splenic B cell subsets reveals multiple selection points during peripheral B cell maturation. J Immunol 167(12):6834-6840
4. Allman D, Srivastava B, Lindsley RC (2004) Alternative routes to maturity: branch points and pathways for gene rating follicular and marginal zone B cells. Immunol Rev 197:147-160
5. Anolik JH, Barnard J, Cappione A, Pugh-Bernard AE, Felgar RE, Looney RJ, Sanz I (2004) Rituximab improves peripheral B cell abnormalities in human systemic lupus erythematosus. Arthritis Rheum 50(11):3580-3590
6. Berkowska MA, Driessen GJ, Bikos V, Grosserichter-Wagener C, Stamatopoulos K, Cerutti A, He B, Biermann K, Lange JF, van der Burg M, van Dongen JJ, van Zelm MC (2011) Human memory B cells originate from three distinct germinal center-dependent and -independent maturation pathways. Blood 118(8):2150-2158
7. Blair PA, Noreña LY, Flores-Borja F, Rawlings DJ, Isenberg DA, Ehrenstein MR, Mauri C (2010) CD19(+)CD24 (hi)CD38(hi) B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic lupus erythematosus patients. Immunity 32(1):129-140
8. Buffa S, Bulati M, Pellicanò M, Dunn-Walters DK, Wu YC, Candore G, Vitello S, Caruso C, Colonna-Romano G (2011) B cell immunosenescence: different features of naive and memory B cells in elderly. Biogerontology 12 (5):473-483
9. Bulati M, Buffa S, Candore G, Caruso C, Dunn-Walters DK, Pellicanò M, Wu YC, Colonna Romano G (2011) B cells and immunosenescence: a focus on IgG+IgD-CD27- (DN) B cells in aged humans. Aging Res Rev 10(2):274-284
10. Cagigi A, Du L, Dang LV, Grutzmeier S, Atlas A, Chiodi F, Pan-Hammarström Q, Nilsson A (2009) CD27(-) B-cells produce class switched and somatically hyper-mutated antibodies during chronic HIV-1 infection. PLoS One 4 (5):e5427
11. Cancro MP, Hao Y, Scholz JL, Riley RL, Frasca D, Dunn- Walters DK, Blomberg BB (2009) B cells and ageing: molecules and mechanisms. Trends Immunol 30(7):313-318
12. Carsetti R, Köhler G, Lamers MC (1995) Transitional B cells are the target of negative selection in the B cell compartment. J Exp Med 181(6):2129-2140
13. Carsetti R, Rosado MM, Wardmann H (2004) Peripheral development of B cells in mouse and man. Immunol Rev 197:179-191
14. Cevenini E, Caruso C, Candore G, Capri M, Nuzzo D, Duro G, Rizzo C, Colonna-Romano G, Lio D, Di Carlo D, Palmas MG, Scurti M, Pini E, Franceschi C, Vasto S (2010) Agerelated inflammation: the contribution of different organs, tissues and systems. How to face it for therapeutic approaches. Curr Pharm Des 16:609-618
15. Chaplin JW, Kasahara S, Clark EA, Ledbetter JA (2011) Anti- CD180 (RP105) Activates B cells to rapidly produce polyclonal Ig via a T cell and MyD88-independent pathway. J Immunol 187(8):4199-4209
16. Chong Y, Ikematsu H, Yamaji K, Nishimura M, Nabeshima S, Kashiwagi S, Hayashi J (2005) CD27(+) (memory) B cell decrease and apoptosis-resistant CD27(-) (naive) B cell increase in aged humans: implications for age-related peripheral B cell developmental disturbances. Int Immunol 17(4):383-390
17. Chung JB, Silverman M, Monroe JG (2003) Transitional B cells: step by step towards immune competence. Trends Immunol 24(6):343-349
18. Colonna-Romano G, Bulati M, Aquino A, Vitello S, Lio D, Candore G, Caruso C (2008) B cell immunosenescence in the elderly and in centenarians. Rejuvenation Res 11 (2):433-439
19. Colonna-Romano G, Bulati M, Aquino A, Pellicanò M, Vitello S, Lio D, Candore G, Caruso C (2009) A double-negative (IgD-CD27-) B cell population is increased in the peripheral blood of elderly people. Mech Ageing Develop 130 (10):681-690
20. Colonna-Romano G, Buffa S, Bulati M, Candore G, Lio D, Pellicanò M, Vasto S, Caruso C (2010) B cells compartment in centenarian offspring and old people. Curr Pharm Des 16(6):604-608
21. Dunn-Walters DK, Ademokun AA (2010) B cell repertoire and ageing. Curr Opin Immunol 22(4):514-520
22. Fecteau JF, Côté G, Néron S (2006) A new memory CD27-IgG+B cell population in peripheral blood expressing VH genes with low frequency of somatic mutation. J Immunol 177(6):3728-3736
23. Franceschi C, Bonafè M, Valensin S, Olivieri F, De Luca M, Ottaviani E, De Benedictis G (2000a) Inflamm-aging. An evolutionary perspective on immunosenescence. Ann N Y Acad Sci 908:244-254
24. Franceschi C, Bonafe M, Valensin S (2000b) Human immunosenescence: the prevailing of innate immunity, the failing of clonotypic immunity, and the filling of immunological space. Vaccine 18(16):1717-1720
25. Frasca D, Blomberg BB (2011) Aging affects human B cell responses. J Clin Immunol 31(3):430-435
26. Frasca D, Landin AM, Lechner SC, Ryan JG, Schwartz R, Riley RL, Blomberg BB (2008) Ageing down-regulates the transcription factor E2A, activation-induced cytidine deaminase, and Ig class switch in human B cells. J Immunol 180(8):5283-5290
27. Frasca D, Diaz A, Romero M, Landin AM, Phillips M, Lechner SC, Ryan JG, Blomberg BB (2010) Intrinsic defects in B cell response to seasonal influenza vaccination in elderly humans. Vaccine 28(51):8077-8084
28. Frasca D, Romero M, Diaz A, Alter-Wolf S, Ratliff M, Landin AM, Riley RL, Blomberg BB (2012) A molecular mechanism for TNF-?-mediated downregulation of B cell responses. J Immunol 188(1):279-286
29. Gary-Gouy H, Bruhns P, Schmitt C, Dalloul A, Daëron M, Bismuth G (2000) The pseudo-immunoreceptor tyrosinebased activation motif of CD5 mediates its inhibitory action on B-cell receptor signaling. J Biol Chem 275(1):548-556
30. Gary-Gouy H, Harriague J, Bismuth G, Platzer C, Schmitt C, Dalloul AH (2002) Human CD5 promotes B-cell survival through stimulation of autocrine IL-10 production. Blood 100(13):4537-4543
31. Gibson KL, Wu YC, Barnett Y, Duggan O, Vaughan R, Kondeatis E, Nilsson BO, Wikby A, Kipling D, Dunn- Walters DK (2009) B-cell diversity decreases in old age and is correlated with poor health status. Ageing cell 8 (1):18-25
32. Gupta S, Su H, Bi R, Agrawal S, Gollapudi S (2005) Life and death of lymphocytes: a role of immunosenescence. Immun Ageing 23;2:12
33. Koarada S, Tada Y (2012) RP105-negative B cells in systemic lupus erythematosus. Clin Dev Immunol 2012:259186
34. Koarada S, Tada Y, Ushiyama O, Morito F, Suzuki N, Ohta A, Miyake K, Kimoto M, Nagasawa K (1999) B cells lacking RP105, a novel B cell antigen, in systemic lupus erythematosus. Arthritis Rheum 42(12):2593-2600
35. Kumar R, Burns EA (2008) Age-related decline in immunity: implications for vaccine responsiveness. Expert Rev Vaccines 7(4):467-479
36. LeBien TW, Tedder TF (2008) B lymphocytes: how they develop and function. Blood 112(5):1570-1580
37. Licastro F, Candore G, Lio D, Porcellini E, Colonna-Romano G, Franceschi C, Caruso C (2005) Innate immunity and inflammation in ageing: a key for understanding age-related diseases. Immun Ageing 18:2-8
38. Lio D, Scola L, Crivello A, Colonna-Romano G, Candore G, Bonafé M, Cavallone L, Marchegiani F, Olivieri F, Franceschi C, Caruso C (2003) Inflammation, genetics, and longevity: further studies on the protective effects in men of IL-10-1082 promoter SNP and its interaction with TNF-alpha-308 promoter SNP. J Med Genet 40:296-299
39. Mauri C, Ehrestein MR (2008) The 'short' history of regulatory B cells. Trends Immunol 29(1):34-40
40. McElhaney JE, Zhou X, Talbot HK, Soethout E, Bleackley RC, Granville DJ, PawelecG(2012) The unmet need in the elderly: how immunosenescence, CMV infection, co-morbidities and frailty are a challenge for the development of more effective influenza vaccines. Vaccine 30(12):2060-2067
41. Miller JP, Cancro MP (2007) B cell and ageing: balancing the homeostatic equation. Exp Gerontol 42(5):396-399
42. Morbach H, Eichhorn EM, Liese JG, Girschick HJ (2010) Reference values for B cell subpopulations from infancy to adulthood. Clin Exp Immunol 162(2):271-279
43. Nagai Y, Kobayashi T, Motoi Y, Ishiguro K, Akashi S, Saitoh S, Kusumoto Y, Kaisho T, Akira S, Matsumoto M, Takatsu K, Miyake K (2005) The radioprotective 105/MD-1 complex links TLR2 and TLR4/MD-2 in antibody response to microbial membranes. J Immunol 174(11):7043-7049
44. Ogata H, Su I, Miyake K, Nagai Y, Akashi S, Mecklenbräuker I, Rajewsky K, Kimoto M, Tarakhovsky A (2000) The tolllike receptor protein RP105 regulates lipopolysaccharide signaling in B cells. J Exp Med 192(1):23-29
45. Palanichamy A, Barnard J, Zheng B, Owen T, Quach T, Wei C, Looney RJ, Sanz I, Anolik JH (2009) Novel human transitional B cell populations revealed by B cell depletion therapy. J Immunol 182(10):5982-5993
46. Pawelec G, Akbar A, Caruso C, Solana R, Grubeck-Loebenstein B, Wikby A (2005) Human immunosenescence: is it infectious? Immunol Rev 205:257-268
47. Sanjabi S, Zenewicz LA, Kamanaka M, Flavell RA (2009) Antiinflammatory and proinflammatory roles of TGF-beta, IL- 10, and IL-22 in immunity and autoimmunity. Curr Opin Pharmacol 9(4):447-453
48. Sanz I, Wei C, Lee FE, Anolik J (2008) Phenotypic and functional heterogeneity of human memory B cells. Semin Immunol 20(1):67-82
49. Shi Y, Yamazaki T, Okubo Y, Uehara Y, Sugane K, Agematsu K (2005) Regulation of aged humoral immune defense against pneumococcal bacteria by IgM memory B cell. J Immunol 175(5):3262-3267
50. Terry DF, Wilcox M, McCormick MA, Lawler E, Perls TT (2003) Cardiovascular advantages among the offspring of centenarians. J Gerontol A Biol Sci Med Sci 58(5):M425-M431
51. Terry DF, Wilcox MA, McCormick MA, Perls TT (2004) Cardiovascular disease delay in centenarian offspring. J Gerontol A Biol Sci Med Sci 59(4):385-389
52. Vasto S, Candore G, Balistreri CR, Caruso M, Colonna- Romano G, Grimaldi MP, Listi F, Nuzzo D, Lio D, Caruso C (2007) Inflammatory networks in ageing, age-related diseases and longevity. Mech Ageing Dev 128(1):83-91
53. Veneri D, Ortolani R, Franchini M, Tridente G, Pizzolo G, Vella A (2009) Expression of CD27 and CD23 on peripheral blood B lymphocytes in humans of different ages. Blood Transfus 7(1):29-34
54. Wei C, Anolik J, Cappione A, Zheng B, Pugh-Bernard A, Brooks J, Lee EH, Milner EC, Sanz I (2007) A new population of cells lacking expression of CD27 represents a notable component of the B cell memory compartment in systemic lupus erythematosus. J Immunol 178(10):6624-6633
55. Weller S, Braun MC, Tan BK, Rosenwald A, Cordier C, Conley ME, Plebani A, Kumararatne DS, Bonnet D, Tournilhac O, Tchernia G, Steiniger B, Staudt LM, Casanova JL, Reynaud CA, Weill JC (2004) Human blood IgM "memory" B cells are circulating splenic marginal zone B cells harbouring a pre-diversified immunoglobulin repertoire. Blood 104(12):3647-3654