Design, synthesis and antibacterial activities of 5-(pyrazin-2-yl)-4H-1,2, 4-triazole-3-thiol derivatives containing Schiff base formation as FabH inhibitory

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 1, 2014, Pages 90-95

  Zhang, Fei ^a   Wen, Qing ^a   Wang, She Feng ^a   Shahla Karim, Baloch ^a   Yang, Yu Shun ^a   Liu, Jia Jia ^a   Zhang, Wei Ming ^a   Zhu, Hai Liang ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

1,2,4 Triazole; Antibacterial; FabH inhibitor; Schiff base; Structure activity relationship

Indexed keywords

3 OXOACYL ACYL CARRIER PROTEIN SYNTHASE; ANTIBIOTIC AGENT; KANAMYCIN B; SCHIFF BASE; THIOL DERIVATIVE; 1,2,4 TRIAZOLE DERIVATIVE; ACYLTRANSFERASE INHIBITOR; ANTIINFECTIVE AGENT; BETA KETOACYL ACYL CARRIER PROTEIN SYNTHASE III INHIBITOR; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACILLUS AMYLOLIQUEFACIENS; BACILLUS SUBTILIS; BACTERIAL STRAIN; CONTROLLED STUDY; DRUG BINDING SITE; DRUG CONFORMATION; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; ESCHERICHIA COLI; IC 50; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DOCKING; NONHUMAN; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION; IC50;

BACILLUS AMYLOLIQUEFACIENS; BACILLUS SUBTILIS; BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS;

1,2,4-TRIAZOLE; ANTIBACTERIAL; FABH INHIBITOR; SCHIFF BASE; STRUCTURE-ACTIVITY RELATIONSHIP;

ACETYLTRANSFERASES; ANTI-BACTERIAL AGENTS; BACILLUS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; FATTY ACID SYNTHASE, TYPE II; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; PSEUDOMONAS AERUGINOSA; PYRAZINES; SCHIFF BASES; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

EID: 84891485767     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.11.079     Document Type: Article

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