Design, synthesis and biological evaluation of heterocyclic azoles derivatives containing pyrazine moiety as potential telomerase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 21, 2012, Pages 6356-6365

  Zhang, Yan Bin ^a   Wang, Xiao Liang ^a   Liu, Wen ^a   Yang, Yu Shun ^a   Tang, Jian Feng ^a   Zhu, Hai Liang ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

Anti tumor activity; Molecular docking; Oxadiazole; Pyrazine; Telomerase; Thiadiazole; Triazole

Indexed keywords

2 (BENZYLTHIO) 5 (PYRAZIN 2 YL) 1,3,4 OXADIAZOLE; 2 (BENZYLTHIO) 5 (PYRAZIN 2 YL) 1,3,4 THIADIAZOLE; 2 [(2 BROMOBENZYL)OXY] 5 (PYRAZIN 2 YL) 1,3,4 OXADIAZOLE; 2 [(2 BROMOBENZYL)THIO] 5 (PYRAZIN 2 YL) 1,3,4 OXADIAZOLE; 2 [(2 BROMOBENZYL)THIO] 5 (PYRAZIN 2 YL) 1,3,4 THIADIAZOLE; 2 [(2 CHLOROBENZYL)THIO] 5 (PYRAZIN 2 YL) 1,3,4 OXADIAZOLE; 2 [(2 CHLOROBENZYL)THIO] 5 (PYRAZIN 2 YL) 1,3,4 THIADIAZOLE; 2 [(2 FLUOROBENZYL)THIO] 5 (PYRAZIN 2 YL) 1,3,4 OXADIAZOLE; 2 [(2 FLUOROBENZYL)THIO] 5 (PYRAZIN 2 YL) 1,3,4 THIADIAZOLE; 2 [(2,4 DIFLUOROBENZYL)THIO] 5 (PYRAZIN 2 YL) 1,3,4 OXADIAZOLE; 2 [(2,4 DIFLUOROBENZYL)THIO] 5 (PYRAZIN 2 YL) 1,3,4 THIADIAZOLE; 2 [(2,6 DIFLUOROBENZYL)THIO] 5 (PYRAZIN 2 YL) 1,3,4 OXADIAZOLE; 2 [(2,6 DIFLUOROBENZYL)THIO] 5 (PYRAZIN 2 YL) 1,3,4 THIADIAZOLE; 2 [(3 BROMOBENZYL)THIO] 5 (PYRAZIN 2 YL) 1,3,4 OXADIAZOLE; 2 [(3 BROMOBENZYL)THIO] 5 (PYRAZIN 2 YL) 1,3,4 THIADIAZOLE; 2 [(3 CHLOROBENZYL)THIO] 5 (PYRAZIN 2 YL) 1,3,4 OXADIAZOLE; 2 [(3 CHLOROBENZYL)THIO] 5 (PYRAZIN 2 YL) 1,3,4 THIADIAZOLE; 2 [(4 BROMOBENZYL)THIO] 5 (PYRAZIN 2 YL) 1,3,4 THIADIAZOLE; 2 [(4 CHLOROBENZYL)THIO] 5 (PYRAZIN 2 YL) 1,3,4 OXADIAZOLE; 2 [(4 CHLOROBENZYL)THIO] 5 (PYRAZIN 2 YL) 1,3,4 THIADIAZOLE; 2 [(4 FLUOROBENZYL)THIO] 5 (PYRAZIN 2 YL) 1,3,4 OXADIAZOLE; 2 [(4 FLUOROBENZYL)THIO] 5 (PYRAZIN 2 YL) 1,3,4 THIADIAZOLE; 2 [5 [(2 BROMOBENZYL)THIO] 4 PHENYL 4H 1,2,4 TRIAZOL 3 YL]PYRAZINE; 2 [5 [(2 CHLOROBENZYL)THIO] 4 PHENYL 4H 1,2,4 TRIAZOL 3 YL]PYRAZINE; 2 [5 [(2 FLUOROBENZYL)THIO] 4 PHENYL 4H 1,2,4 TRIAZOL 3 YL]PYRAZINE; 2 [5 [(3 CHLOROBENZYL)THIO] 4 PHENYL 4H 1,2,4 TRIAZOL 3 YL]PYRAZINE; PYRROLE DERIVATIVE; TELOMERASE; TELOMERASE INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL STRAIN HEPG2; CELL STRAIN SW1116; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; MOLECULAR DOCKING;

ANTINEOPLASTIC AGENTS; APOPTOSIS; AZOLES; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; HEP G2 CELLS; HETEROCYCLIC COMPOUNDS; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PYRAZINES; STRUCTURE-ACTIVITY RELATIONSHIP; TELOMERASE;

EID: 84867571377     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.08.059     Document Type: Article

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