Design, synthesis and biological evaluation of novel thiazole derivatives as potent FabH inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 23, 2009, Pages 6750-6754

  Lv, Peng Cheng ^a   Wang, Kai Rui ^a   Yang, Ying ^a   Mao, Wen Jun ^a   Chen, Jin ^a   Xiong, Jing ^a   Zhu, Hai Liang ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

Design; FabH inhibitors; Synthesis; Thiazole derivatives

Indexed keywords

ANTIINFECTIVE AGENT; FATTY ACID SYNTHASE; FATTY ACID SYNTHASE INHIBITOR; KANAMYCIN B; PENICILLIN G; SCHIFF BASE; THIAZOLE DERIVATIVE;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; ENTEROBACTER CLOACAE; ENTEROCOCCUS FAECALIS; ENZYME INHIBITION; ESCHERICHIA COLI; IC 50; NONHUMAN; PSEUDOMONAS AERUGINOSA; SIMULATION; STAPHYLOCOCCUS AUREUS;

3-OXOACYL-(ACYL-CARRIER-PROTEIN) SYNTHASE; ANTI-BACTERIAL AGENTS; DRUG DESIGN; ENZYME INHIBITORS; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; STEREOISOMERISM; THIAZOLES;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; POSIBACTERIA;

EID: 71749107173     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.09.111     Document Type: Article

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