1,2-Dithiole-3-ones as potent inhibitors of the bacterial 3-ketoacyl acyl carrier protein synthase III (FabH)

Antimicrobial Agents and Chemotherapy

Volumn 48, Issue 8, 2004, Pages 3093-3102

  He, Xin ^a   Reeve, Anne McElwee ^a,b   Desai, Umesh R ^a   Kellogg, Glen E ^a   Reynolds, Kevin A ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b LYNCHBURG COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2 DITHIOLE 3 THIONE DERIVATIVE; 4,5 DICHLORO 1,2 DITHIOL 3 ONE DERIVATIVE; 5 CHLORO 1,2 DITHIOL 3 ONE DERIVATIVE; 5 CHLORO 1,2 DITHIOLE 3 THIONE DERIVATIVE; ACYL CARRIER PROTEIN SYNTHASE 3; ANTIINFECTIVE AGENT; ANTIPARASITIC AGENT; BACTERIAL ENZYME; FATTY ACID; METHYL GROUP; NATURAL PRODUCT; THIOLACTOMYCIN; TRIFLUOROMETHYL DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BINDING AFFINITY; CHLORINATION; DISSOCIATION; DRUG EFFICACY; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME INHIBITOR COMPLEX; ENZYME MECHANISM; ESCHERICHIA COLI; FATTY ACID SYNTHESIS; IC 50; INCUBATION TIME; INHIBITION KINETICS; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS; SUBSTITUTION REACTION;

ANTI-BACTERIAL AGENTS; BACTERIA; DATABASES, FACTUAL; ESCHERICHIA COLI; LIGANDS; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; PROTEIN SYNTHESIS INHIBITORS; SPECTROMETRY, FLUORESCENCE; STAPHYLOCOCCUS AUREUS; THIONES; THIOPHENES; TRANSFERASES (OTHER SUBSTITUTED PHOSPHATE GROUPS);

EID: 3342944977     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.48.8.3093-3102.2004     Document Type: Article

References (68)

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