Novel E. coli β-ketoacyl-acyl carrier protein synthase III inhibitors as targeted antibiotics

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 4, 2009, Pages 1506-1513

  Lee, Jee Young ^a   Jeong, Ki Woong ^a   Lee, Ju Un ^a   Kang, Dong Il ^a   Kim, Yangmee ^a  

^a Konkuk University   (South Korea)

Author keywords

Antibiotics; In silico screening; KAS; STD NMR

Indexed keywords

3 OXOACYL ACYL CARRIER PROTEIN SYNTHASE; 4 CYCLOHEXYLIMINOMETHYLBENZENE 1,3 DIOL; ANTIBIOTIC AGENT; BETA KETOACYL ACYL CARRIER PROTEIN SYNTHASE III INHIBITOR; UNCLASSIFIED DRUG; YKAS 3003;

ARTICLE; DRUG SCREENING; ENZYME STRUCTURE; ESCHERICHIA COLI; FATTY ACID SYNTHESIS; MINIMUM INHIBITORY CONCENTRATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHARMACOPHORE;

3-OXOACYL-(ACYL-CARRIER-PROTEIN) SYNTHASE; ANTI-BACTERIAL AGENTS; BINDING SITES; ENTEROCOCCUS FAECALIS; ESCHERICHIA COLI; KLEBSIELLA PNEUMONIAE; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; SPECTROMETRY, FLUORESCENCE; STAPHYLOCOCCUS AUREUS;

ESCHERICHIA COLI;

EID: 60049089356     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.01.004     Document Type: Article

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