Discovery of vinylogous carbamates as a novel class of β-ketoacyl-acyl carrier protein synthase III (FabH) inhibitors

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 15, 2011, Pages 4454-4459

  Li, Huan Qiu ^a   Luo, Yin ^b   Zhu, Hai Liang ^b  

^a SOOCHOW UNIVERSITY   (China)

^b NANJING UNIVERSITY   (China)

Author keywords

Antibiotics; FabH; Structure activity relationship; Vinylogous carbamates

Indexed keywords

3 OXOACYL ACYL CARRIER PROTEIN SYNTHASE; 3 OXOACYL ACYL CARRIER PROTEIN SYNTHASE III INHIBITOR; ANTIBIOTIC AGENT; CARBAMIC ACID DERIVATIVE; ENZYME INHIBITOR; ETHYL 2 [4 (BENZYLOXY)PHENYL] 3 (2 CHLOROPHENYLAMINO)ACRYLATE; ETHYL 2 [4 (BENZYLOXY)PHENYL] 3 (2 FLUOROPHENYLAMINO)ACRYLATE; ETHYL 2 [4 (BENZYLOXY)PHENYL] 3 (2,4 DIBROMOPHENYLAMINO)ACRYLATE; ETHYL 2 [4 (BENZYLOXY)PHENYL] 3 (2,4 DICHLOROPHENYLAMINO)ACRYLATE; ETHYL 2 [4 (BENZYLOXY)PHENYL] 3 (2,4 DIFLUOROPHENYLAMINO)ACRYLATE; ETHYL 2 [4 (BENZYLOXY)PHENYL] 3 (4 BROMOPHENYLAMINO)ACRYLATE; ETHYL 2 [4 (BENZYLOXY)PHENYL] 3 (4 CHLOROPHENYLAMINO)ACRYLATE; ETHYL 2 [4 (BENZYLOXY)PHENYL] 3 (4 FLUOROPHENYLAMINO)ACRYLATE; ETHYL 2 [4 (BENZYLOXY)PHENYL] 3 (4 ISOPROPYLPHENYLAMINO)ACRYLATE; ETHYL 2 [4 (BENZYLOXY)PHENYL] 3 (4 NITROPHENYLAMINO)ACRYLATE; ETHYL 2 [4 (BENZYLOXY)PHENYL] 3 (PHENYLAMINO)ACRYLATE; ETHYL 3 (PARA TOLUIDINO) 2 [4 (BENZYLOXY)PHENYL]ACRYLATE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; BINDING AFFINITY; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG BINDING; DRUG SYNTHESIS; DRUG TARGETING; ENZYME ASSAY; ENZYME INHIBITION; ENZYME PURIFICATION; ESCHERICHIA COLI; IC 50; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DOCKING; NONHUMAN; PSEUDOMONAS FLUORESCENS; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

3-OXOACYL-(ACYL-CARRIER-PROTEIN) SYNTHASE; ANTI-BACTERIAL AGENTS; CARBAMATES; DRUG DESIGN; ENZYME INHIBITORS; ESCHERICHIA COLI; ESCHERICHIA COLI INFECTIONS; GRAM-NEGATIVE BACTERIA; GRAM-NEGATIVE BACTERIAL INFECTIONS; HUMANS; MODELS, MOLECULAR; STRUCTURE-ACTIVITY RELATIONSHIP;

ESCHERICHIA COLI; NEGIBACTERIA;

EID: 79960564902     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.06.048     Document Type: Article

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