Anaplasma phagocytophilum-a widespread multi-host pathogen with highly adaptive strategies

Frontiers in Cellular and Infection Microbiology

Volumn 4, Issue JUL, 2013, Pages

  Stuen, Snorre ^a   Granquist, Erik G ^a   Silaghi, Cornelia ^b  

^a NORWEGIAN UNIVERSITY OF LIFE SCIENCES   (Norway)

^b UNIVERSITY OF MUNICH   (Germany)

Author keywords

Anaplasma phagocytophilum; Distribution; Ecology; Epidemiology; Hosts; Vectors

Indexed keywords

DOXYCYCLINE HYCLATE; GAVAC; RECOMBINANT 64TRP; RECOMBINANT BA86; RECOMBINANT BM; RECOMBINANT BM86; RECOMBINANT BM91; RECOMBINANT VACCINE; RIFAMPICIN; TICKGARD PLUS; UNCLASSIFIED DRUG;

ANAPLASMA PHAGOCYTOPHILUM; BACTERIAL COLONIZATION; BACTERIAL TRANSMISSION; BACTERIUM IDENTIFICATION; BOVIDS; DISEASE CARRIER; DOMESTIC ANIMAL; ECOLOGY; GENE SEQUENCE; GENETIC VARIABILITY; GEOGRAPHIC DISTRIBUTION; HUMAN; HUMAN GRANULOCYTIC ANAPLASMOSIS; IMMUNIZATION; INSECTIVORE; NONHUMAN; PATHOLOGY; POLYMERASE CHAIN REACTION; PREVALENCE; REVIEW; SEROLOGY; SYMPTOM; TICK BORNE DISEASE; ANIMAL; CLASSIFICATION; DISEASE TRANSMISSION; DISTRIBUTION; EHRLICHIOSIS; EPIDEMIOLOGY; GENETICS; HOSTS; ISOLATION AND PURIFICATION; IXODES; MICROBIOLOGY; PARASITE VECTOR; PATHOGENICITY; TICK; VECTORS; ZOONOSIS; TICK-BORNE DISEASES; TRANSMISSION; ZOONOSES;

ANAPLASMA PHAGOCYTOPHILUM; DISTRIBUTION; ECOLOGY; EPIDEMIOLOGY; HOSTS; VECTORS;

ANAPLASMA PHAGOCYTOPHILUM; ANIMALS; ARTHROPOD VECTORS; EHRLICHIOSIS; HUMANS; IXODES; TICK-BORNE DISEASES; TICKS; ZOONOSES;

EID: 84891418391     PISSN: None     EISSN: 22352988     Source Type: Journal    
DOI: 10.3389/fcimb.2013.00031     Document Type: Review

References (412)

1. Adaszek, L., Klimiuk, P., Skrzypczak, M., Gorna, M., Zietek, J., and Winiarczyk, S. (2012). The identification of Anaplasma spp. isolated from fallow deer (Dama dama) on a free-range farm in eastern Poland. Pol. J. Vet. Sci. 15, 393-394. doi: 10.2478/v10181-012-0060-0
2. Adelson, M. E., Rao, R. V., Tilton, R. C., Cabets, K., Eskow, E., Fein, L., et al. (2004). Prevalence of Borrelia burgdorferi, Bartonella spp., Babesia microti, and Anaplasma phagocytophila in Ixodes scapularis ticks collected in Northern New Jersey. J. Clin. Microbiol. 42, 2799-2801. doi: 10.1128/JCM.42.6.2799-2801.2004
3. Akkoyunlu, M., Malawista, S. E., Anguita, J., and Fikrig, E. (2001). Exploitation of interleukin-8-induced neutrophil chemotaxis by the agent of human granulocytic ehrlichiosis. Infect. Immun. 69, 5577-5588. doi: 10.1128/IAI.69.9.5577-5588.2001
4. Alberdi, M. P., Walker, A. R., and Urquhart, K. A. (2000). Field evidence that roe deer (Capreolus capreolus) are a natural host for Ehrlichia phagocytophila. Epidemiol. Infect. 124, 315-323. doi: 10.1017/S0950268899003684
5. Alberdi, M. P., Walker, A. R., Paxton, E. A., and Sumption, K. J. (1998). Natural prevalence of infection with Ehrlichia (Cytoecetes) phagocytophila of Ixodes ricinus ticks in Scotland. Vet. Parasitol. 78, 203-213. doi: 10.1016/S0304-4017(98)00138-1
6. Alberti, A., Zobba, R., Chessa, B., Addis, M. F., Sparagano, O., Pinna Parpagliam, M. L., et al. (2005a). Equine and canine Anaplasma phagocytophilum strains isolated on the island of Sardinia (Italy) are phylogenetically related to pathogenic strains from the United States. Appl. Environ. Microbiol. 71, 6418-6422. doi: 10.1128/AEM.71.10.6418-6422.2005
7. Alberti, A., Addis, M. F., Sparagano, O., Zobba, R., Chessa, B., Cubeddu, T., et al. (2005b). Anaplasma phagocytophilum, Sardinia, Italy. Emerg. Infect. Dis. 11, 1322-1324. doi: 10.3201/eid1108.050085
8. Alekseev, A. N., Dubinina, H. V., Van De Pol, I., and Schouls, L. M. (2001a). Identification of Ehrlichia spp. and Borrelia burgdorferi in Ixodes ticks in the Baltic regions of Russia. J. Clin. Microbiol. 39, 2237-2242. doi: 10.1128/JCM.39.6.2237-2242.2001
9. Alekseev, A. N., Dubinina, H. V., Semenov, A. V., and Bolshakov, C. V. (2001b). Evidence of ehrlichiosis agents found in ticks (Acari: Ixodidae) collected from migratory birds. J. Med. Entomol. 38, 471-474. doi: 10.1603/0022-2585-38.4.471
10. Al-Khedery, B., Lundgren, A. M., Stuen, S., Granquist, E. G., Munderloh, U. G., Nelson, C. M., et al. (2012). Structure of the type IV secretion system in different strains of Anaplasma phagocytophilum. BMC Genomics 13:678. doi: 10.1186/1471-2164-13-678
11. Alleman, A. R., Barbet, A. F., Sorenson, H. L., Strik, N. I., Wamsley, H. L., Wong, S. J., et al. (2006). Cloning and expression of the gene encoding the major surface protein 5 (MSP5) of Anaplasma phagocytophilum and potential application for serodiagnosis. Vet. Clin. Pathol. 35, 418-425. doi: 10.1111/j.1939-165X.2006.tb00158.x
12. Anderson, B. E., Dawson, J. E., Jones, D. C., and Wilson, K. H. (1991). Ehrlichia chaffeensis, a new species associated with human ehrlichiosis. J. Clin. Microbiol. 29, 2838-2842.
13. Anonymous. (2002). Notification that new names and new combinations have appeared in volume 51, part 6, of the IJSEM. Int. J. Syst. Evol. Microbiol. 52, 5-6.
14. Aureli, S., Foley, J. E., Galuppi, R., Rejmanek, D., Bonoli, C., and Tampieri, M. P. (2012). Anaplasma phagocytophilum in ticks from parks in the Emilia-Romagna region of northern Italy. Vet. Ital. 48, 413-423.
15. Bakken, J. S., and Dumler, J. S. (2006). Clinical diagnosis and treatment of human granulocytic anaplasmosis. Ann. N.Y. Acad. Sci. 1078, 236-247. doi: 10.1196/annals.1374.042
16. Bakken, J. S., and Dumler, J. S. (2008). Human granulocytic anaplasmosis. Infect. Dis. Clin. North Am. 22, 433-448. doi: 10.1016/j.idc.2008.03.011
17. Bakken, J. S., Dumler, J. S., Chen, S. M., Eckman, M. R., Van Etta, L. L., and Walker, D. H. (1994). Human granulocytic ehrlichiosis in the upper Midwest United States. A new species emerging? J. Am. Med. Assoc. 272, 212-218. doi: 10.1001/jama.1994.03520030054028
18. Baldridge, G. D., Scoles, G. A., Burkhardt, N. Y., Schloeder, B., Kurtti, T. J., and Munderloh, U. G. (2009). Transovarial transmission of Francisella-like endosymbionts and Anaplasma phagocytophilum variants in Dermacentor albipictus (Acari: Ixodidae). J. Med. Entomol. 46, 625-632. doi: 10.1603/033.046.0330
19. Barandika, J. F., Hurtado, A., García-Esteban, C., Gil, H., Escudero, R., Barral, M., et al. (2007). Tick-borne zoonotic bacteria in wild and domestic small mammals in northern spain. J. Appl. Environ. Microbiol. 73, 6166-6171.
20. Barbet, A. F., Lundgren, A., Yi, J., Rurangirwa, F. R., and Palmer, G. H. (2000). Antigenic variation of Anaplasma marginale by expression of MSP2 mosaics. Infect. Immun. 68, 6133-6138. doi: 10.1128/IAI.68.11.6133-6138.2000
21. Barbet, A. F., Meeus, P. F. M., Belanger, M., Bowie, M. V., Yi, J., Lundgren, A. M., et al. (2003). Expression of multiple outer membrane protein sequence variants from a single genomic locus of Anaplasma phagocytophilum. Infect. Immun. 71, 1706-1718. doi: 10.1128/IAI.71.4.1706-1718.2003
22. Barlough, J. E., Madigan, J. E., Kramer, V. L., Clover, J. R., Hui, L. T., Webb, J. P., et al. (1997a). Ehrlichia phagocytophila genogroup rickettsiae in ixodid ticks from California collected in 1995 and 1996. J. Clin. Microbiol. 35, 2018-2021.
23. Barlough, J. E., Madigan, J. E., Turoff, D. R., Clover, J. R., Shelly, S. M., and Dumler, J. S. (1997b). An Ehrlichia strain from a llama (Lama glama) and Llama-associated ticks (Ixodes pacificus). J. Clin. Microbiol. 35, 1005-1007.
24. Bayard-Mc Neeley, M., Bansal, A., Chowdhury, I., Girao, G., Small, C. B., Seiter, K., et al. (2004). In vivo and in vitro studies on Anaplasma phagocytophilum infection of the myeloid cells of a patient with chronic myelogenous leukaemia and human granulocytic ehrlichiosis. J. Clin. Pathol. 57, 499-503. doi: 10.1136/jcp.2003.011775
25. Beall, M. J., Chandrashekar, R., Eberts, M. D., Cyr, K. E., Diniz, P. P., Mainville, C., et al. (2008). Serological and molecular prevalence of Borrelia burgdorferi, Anaplasma phagocytophilum, and Ehrlichia species in dogs from Minnesota. Vector Borne Zoonotic Dis. 8, 455-464. doi: 10.1089/vbz.2007.0236
26. Beaufays, J., Adam, B., Menten-Dedoyart, C., Fievez, L., Grosjean, A., Decrem, Y., et al. (2008). Ir-LBP, an Ixodes ricinus tick salivary LTB4-binding lipocalin, interferes with host neutrophil function. PLoS ONE 3:e3987. doi: 10.1371/journal.pone.0003987
27. Bell, D. R., Berghaus, R. D., Patel, S., Beavers, S., Fernandez, I., and Sanchez, S. (2012). Seroprevalence of tick-borne infections in military working dogs in the republic of Korea. Vector Borne Zoonotic Dis. 12, 1023-1030. doi: 10.1089/vbz.2011.0864
28. Belongia, E. A., Reed, K. D., Mitchell, P. D., Kolbert, C. P., Persing, D. H., Gill, J. S., et al. (1997). Prevalence of granulocytic Ehrlichia infection among white-tailed deer in Wisconsin. J. Clin. Microbiol. 35, 1465-1468.
29. Beninati, T., Piccolo, G., Rizzoli, A., Genchi, C., and Bandi, C. (2006). Anaplasmataceae in wild rodents and roe deer from Trento Province (northern Italy). Eur. J. Clin. Microbiol. Infect. Dis. 25, 677-678. doi: 10.1007/s10096-006-0196-x
30. Billeter, S. A., Spencer, J. A., Griffin, B., Dykstra, C. C., and Blagburn, B. L. (2007). Prevalence of Anaplasma phagocytophilum in domestic felines in the United States. Vet. Parasitol. 147, 194-198. doi: 10.1016/j.vetpar.2007.03.028
31. Bjöersdorff, A., Bagert, B., Massung, R. F., Gusa, A., and Eliasson, I. (2002). Isolation and characterization of two European strains of Ehrlichia phagocytophila of equine origin. Clin. Diagn. Lab. Immunol. 9, 341-343.
32. Bjöersdorff, A., Bergström, S., Massung, R. F., Haeming, P. D., and Olsen, B. (2001). Ehrlichia -infected ticks on migrating birds. Emerg. Infect. Dis. 7, 877-879.
33. Bjöersdorff, A., Svendenius, L., Owens, J. H., and Massung, R. F. (1999). Feline granulocytic ehrlichiosis - a report of a new clinical entity and characterisation of the infectious agent. J. Small Anim. Pract. 40, 20-24. doi: 10.1111/j.1748-5827.1999.tb03249.x
34. Bowman, D., Little, S. E., Lorentzen, L., Shields, J., Sullivan, M. P., and Carlin, E. P. (2009). Prevalence and geographic distribution of Dirofilaria immitis, Borrelia burgdorferi, Ehrlichia canis, and Anaplasma phagocytophilum in dogs in the United States: results of a national clinic-based serologic survey. Vet. Parasitol. 160, 138-148. doi: 10.1016/j.vetpar.2008.10.093
35. Bown, K. J., Begon, M., Bennett, M., Birtles, R. J., Burthe, S., Lambin, X., et al. (2006). Sympatric Ixodes trianguliceps and Ixodes ricinus ticks feeding on field voles (Microtus agrestis): potential for increased risk of Anaplasma phagocytophilum in the United Kingdom. Vector Borne Zoonotic Dis. 6, 404-410. doi: 10.1089/vbz.2006.6.404
36. Bown, K. J., Begon, M., Bennett, M., Woldehiwet, Z., and Ogden, N. H. (2003). Seasonal dynamics of Anaplasma phagocytophila in a rodent-tick (Ixodes trianguliceps) system, United Kingdom. Emerg. Infect. Dis. 9, 63-70. doi: 10.3201/eid0901.020169
37. Bown, K. J., Lambin, X., Ogden, N. H., Begon, M., Telford, G., Woldehiwet, Z., et al. (2009). Delineating Anaplasma phagocytophilum ecotypes in coexisting, discrete enzootic cycles. Emerg. Infect. Dis. 15, 1948-1954. doi: 10.3201/eid1512.090178
38. Bown, K. J., Lambin, X., Ogden, N. H., Petrovec, M., Shaw, S. E., Woldehiwet, Z., et al. (2007). High-resolution genetic fingerprinting of European strains of Anaplasma phagocytophilum by use of multilocus variable-number tandem-repeat analysis. J. Clin. Microbiol. 45, 1771-1776. doi: 10.1128/JCM.00365-07
39. Bown, K. J., Lambin, X., Telford, G., Heyder-Bruckner, D., Ogden, N. H., and Birtles, R. J. (2011). The common shrew (Sorex araneus): a neglected host of tick-borne infections. Vector Borne Zoonotic Dis. 11, 947-953. doi: 10.1089/vbz.2010.0185
40. Bown, K. J., Lambin, X., Telford, G. R., Ogden, N. H., Telfer, S., Woldehiwet, Z., et al. (2008). Relative importance of Ixodes ricinus and Ixodes trianguliceps as vectors for Anaplasma phagocytophilum and Babesia microti in field vole (Microtus agrestis) populations. Appl. Environ. Microbiol. 74, 7118-7125. doi: 10.1128/AEM.00625-08
41. Bray, D. P., Bown, K. J., Stockley, P., Hurst, J. L., Bennett, M., and Birtles, R. J. (2007). Haemoparasites of common shrews (Sorex araneus) in Northwest England. Parasitology 134, 819-826. doi: 10.1017/S0031182007002302
42. Brodie, T. A., Holmes, P. H., and Urquhart, G. M. (1986). Some aspects of tick-borne diseases of British sheep. Vet. Rec. 118, 415-418. doi: 10.1136/vr.118.15.415
43. Brouqui, P., and Matsumoto, K. (2007). "Bacteriology and phylogeny of Anaplasmataceae," in Rickettsial Diseases, eds D. Raoult and P. Parola (New York, NY: Informa Healthcare, USA, Inc.), 179-198. doi: 10.3109/9781420019971.013
44. Burri, C., Dupasquier, C., Bastic, V., and Gern, L. (2011). Pathogens of emerging tick-borne diseases, Anaplasma phagocytophilum, Rickettsia spp., and Babesia spp., in Ixodes ticks collected from rodents at four sites in Switzerland (Canton of Bern). Vector Borne Zoonotic Dis. 11, 939-944. doi: 10.1089/vbz.2010.0215
45. Butler, C. M., Nijhof, A. M., Jongejan, F., and Van Der Kolk, J. H. (2008). Anaplasma phagocytophilum infection in horses in the Netherlands. Vet. Rec. 162, 216-217. doi: 10.1136/vr.162.7.216
46. Campbell, R. S. F., Rowland, A. C., and Scott, G. R. (1994). Sequential pathology of tick-borne fever. J. Comp. Pathol. 111, 303-313. doi: 10.1016/S0021-997580009-X
47. Canales, M., Labruna, M. B., Soares, J. F., Prudencio, C. R., and de la Fuente, J. (2009). Protective efficacy of bacterial membranes containing surface-exposed BM95 antigenic peptides for the control of cattle tick infestations. Vaccine 27, 7244-7248. doi: 10.1016/j.vaccine.2009.09.123
48. Cao, W. C., Zhan, L., He, J., Foley, J. E., Sj, D. E. V., Wu, X. M., et al. (2006). Natural Anaplasma phagocytophilum infection of ticks and rodents from a forest area of Jilin Province, China. Am. J. Trop. Med. Hyg. 75, 664-668.
49. Cao, W. C., Zhao, Q. M., Zhang, P. H., Dumler, J. S., Zhang, X. T., Fang, L. Q., et al. (2000). Granulocytic Ehrlichiae in Ixodes persulcatus ticks from an area in China where Lyme disease is endemic. J. Clin. Microbiol. 38, 4208-4210.
50. Cao, W. C., Zhao, Q. M., Zhang, P. H., Yang, H., Wu, X. M., Wen, B. H., et al. (2003). Prevalence of Anaplasma phagocytophila and Borrelia burgdorferi in Ixodes persulcatus ticks from northeastern China. Am. J. Trop. Med. Hyg. 68, 547-550.
51. Capelli, G., Ravagnan, S., Montarsi, F., Ciocchetta, S., Cazzin, S., Porcellato, E., et al. (2012). Occurrence and identification of risk areas of Ixodes ricinus-borne pathogens: a cost-effectiveness analysis in north-eastern Italy. Parasit. Vectors 5:61. doi: 10.1186/1756-3305-5-61
52. Carlyon, J. A., Akkoyunlu, M., Xia, L. J., Yago, T., Wang, T., Cummings, R. D., et al. (2003). Murine neutrophils require alpha 1, 3-fucosylation but not PSGL-1 for productive infection with Anaplasma phagocytophilum. Blood 102, 3387-3395. doi: 10.1182/blood-2003-02-0621
53. Carpi, G., Cagnacci, F., Neteler, M., and Rizzoli, A. (2008). Tick infestation on roe deer in relation to geographic and remotely sensed climatic variables in a tick-borne encephalitis endemic area. Epidemiol. Infect. 136, 1416-1424. doi: 10.1017/S0950268807000039
54. Castellaw, A. H., Chenney, E. F., and Varela-Stokes, A. S. (2011). Tick-borne disease agents in various wildlife from Mississippi. Vector Borne Zoonotic Dis. 11, 439-442. doi: 10.1089/vbz.2009.0221
55. Castro, M. B., Nicholson, W. L., Kramer, V. L., and Childs, J. E. (2001). Persistent infection in Neotoma fuscipes (Muridae: Sigmodontinae) with Ehrlichia phagocytophila sensu lato. Am. J. Trop. Med. Hyg. 65, 261-267.
56. Chae, J. S., Yu do, H., Shringi, S., Klein, T. A., Kim, H. C., Chong, S. T., et al. (2008). Microbial pathogens in ticks, rodents and a shrew in northern Gyeonggi-do near the DMZ, Korea. J. Vet. Sci. 9, 285-293. doi: 10.4142/jvs.2008.9.3.285
57. Chen, G., Severo, M. S., Sohail, M., Sakhon, O. S., Wikel, S. K., Kotsyfakis, M., et al. (2012). Ixodes scapularis saliva mitigates inflammatory cytokine secretion during Anaplasma phagocytophilum stimulation of immune cells. Parasit. Vectors 5:229. doi: 10.1186/1756-3305-5-229
58. Chen, S.M., Dumler, J. S., Bakken, J. S., and Walker, D. H. (1994). Identification of a granulocytic Ehrlichia species as the etiologic agent of human disease. J. Clin. Microbiol. 32, 589-595.
59. Chmielewska-Badora, J., Zwolinski, J., Cisak, E., Wojcik-Fatla, A., Buczek, A., and Dutkiewicz, J. (2007). Prevalence of Anaplasma phagocytophilum in Ixodes ricinus ticks determined by polymerase chain reaction with two pairs of primers detecting 16S rRNA and ankA genes. Ann. Agric. Environ. Med. 14, 281-285.
60. Choi, K. S., Garyu, J., Park, J., and Dumler, J. S. (2003). Diminished adhesion of Anaplasma phagocytophilum-infected neutrophils to endothelial cells is associated with reduced expression of leukocyte surface selectin. Infect. Immun. 71, 4586-4594. doi: 10.1128/IAI.71.8.4586-4594.2003
61. Choi, K. S., Grab, D. J., and Dumler, J. S. (2004). Anaplasma phagocytophilum infection induces protracted neutrophil degranulation. Infect. Immun. 72, 3680-3683. doi: 10.1128/IAI.72.6.3680-3683.2004
62. Choi, K. S., Park, J. T., and Dumler, J. S. (2005). Anaplasma phagocytophilum delay of neutrophil apoptosis through the p38 mitogen-activated protein kinase signal pathway. Infect. Immun. 73, 8209-8218. doi: 10.1128/IAI.73.12.8209-8218.2005
63. Christová, I., and Gladnishka, T. (2005). Prevalence of infection with Francisella tularensis, Borrelia burgdorferi sensu lato and Anaplasma phagocytophilum in rodents from an endemic focus of tularemia in Bulgaria. Ann. Agric. Environ. Med. 12, 149-152.
64. Christová, I., Schouls, L. van De Pol, I., Park, J., Panayotov, S., Lefterová, V., et al. (2001). High prevalence of granulocytic Ehrlichiae and Borrelia burgdorferi sensu lato in Ixodes ricinus ticks from Bulgaria. J. Clin. Microbiol. 39, 4172-4174. doi: 10.1128/JCM.39.11.4172-4174.2001
65. Cinco, M., Padovan, D., Murgia, R., Maroli, M., Frusteri, L., Heldtander, M., et al. (1997). Coexistence of Ehrlichia phagocytophila and Borrelia burgdorferi sensu lato in Ixodes ricinus ticks from Italy as determined by 16S rRNA gene sequencing. J. Clin. Microbiol. 35, 3365-3366.
66. Clark, K. L. (2012). Anaplasma phagocytophilum in small mammals and ticks in northeast Florida. J. Vector Ecol. 37, 262-268. doi: 10.1111/j.1948-7134.2012.00226.x
67. Cockwill, K. R., Taylor, S. M., Snead, E. C., Dickinson, R., Cosford, K., Malek, S., et al. (2009). Granulocytic anaplasmosis in three dogs from Saskatoon, Saskatchewan. Can. Vet. J. 50, 835-840.
68. Cohn, L. A. (2003). Ehrlichiosis and related infections. Vet. Clin. North Am. Small Anim. Pract. 33, 863-884. doi: 10.1016/S0195-561600031-7
69. Cotté, V., Bonnet, S., Cote, M., and Vayssier-Taussat, M. (2010). Prevalence of five pathogenic agents in questing Ixodes ricinus ticks from western France. Vector Borne Zoonotic Dis. 10, 723-730. doi: 10.1089/vbz.2009.0066
70. Courtney, J. W., Dryden, R. L., Montgomery, J., Schneider, B. S., Smith, G., and Massung, R. F. (2003). Molecular characterization of Anaplasma phagocytophilum and Borrelia burgdorferi in Ixodes scapularis ticks from Pennsylvania. J. Clin. Microbiol. 41, 1569-1573. doi: 10.1128/JCM.41.4.1569-1573.2003
71. Courtney, J. W., Kostelnik, L. M., Zeidner, N. S., and Massung, R. F. (2004). Multiplex real-time PCR for detection of Anaplasma phagocytophilum and Borrelia burgdorferi. J. Clin. Microbiol. 42, 3164-3168. doi: 10.1128/JCM.42.7.3164-3168.2004
72. Daniel, M. (1993). Influence of the microclimate on the vertical distribution of the tick Ixodes ricinus (L.) in central Europe. Acarologia 34, 105-113.
73. Daniels, T. J., Battaly, G. R., Liveris, D., Falco, R. C., and Schwartz, I. (2002). Avian reservoirs of the agent of human granulocytic ehrlichiosis. Emerg. Infect. Dis. 8, 1524-1525. doi: 10.3201/eid0812.010527
74. Dark, M. J., Lundgren, A. M., and Barbet, A. F. (2012). Determining the repertoire of immunodominant proteins via whole-genome amplification of intracellular pathogens. PLoS ONE 7:e36456. doi: 10.1371/journal.pone.0036456
75. de Carvalho, I. L., Milhano, N., Santos, A. S., Almeida, V., Barros, S. C., De Sousa, R., et al. (2008). Detection of Borrelia lusitaniae, Rickettsia sp. IRS3, Rickettsia monacensis, and Anaplasma phagocytophilum in Ixodes ricinus collected in Madeira Island, Portugal. Vector Borne Zoonotic Dis. 8, 575-579. doi: 10.1089/vbz.2007.0245
76. de la Fuente, J., Ayoubi, P., Blouin, E. F., Almazán, C., Naranjo, V., and Kocan, K. M. (2006a). Anaplasmosis: focusing on host-vector-pathogen interactions for vaccine development. Ann. N.Y. Acad. Sci. 1078, 416-423. doi: 10.1196/annals.1374.081
77. de la Fuente, J., Almazán, C., Blas-Machado, U., Naranjo, V., Mangold, A. J., Blouin, E. F., et al. (2006b). The tick protective antigen, 4D8, is a conserved protein involved in modulation of tick blood ingestion and reproduction. Vaccine 24, 4082-4095.
78. de la Fuente, J., Almazán, C., Blouin, E. F., Naranjo, V., and Kocan, K. M. (2006c). Reduction of tick infections with Anaplasma marginale and A. phagocytophilum by targeting the tick protective antigen subolesin. Parasitol. Res. 100, 85-91. doi: 10.1007/s00436-006-0244-6
79. de la Fuente, J., Blouin, E. F., Manzano-Roman, R., Naranjo, V., Almazán, C. Pérez de la Lastra, J. M., et al. (2007). Functional genomic studies of tick cells in response to infection with the cattle pathogen, Anaplasma marginale. Genomics 90, 712-722. doi: 10.1016/j.ygeno.2007.08.009
80. de la Fuente, J., and Kocan, K. M. (2006). Strategies for development of vaccines for control of ixodid ticks species. Parasite Immunol. 28, 275-283. doi: 10.1111/j.1365-3024.2006.00828.x
81. de la Fuente, J., Massung, R. F., Wong, S. J., Chu, F. K., Lutz, H., Meli, M., et al. (2005a). Sequence analysis of the msp4 gene of Anaplasma phagocytophilum strains. J. Clin. Microbiol. 43, 1309-1317. doi: 10.1128/JCM.43.3.1309-1317.2005
82. de la Fuente, J., Naranjo, V., Ruiz-Fons, F., Hofle, U., Fernandez De Mera, I. G., Villanua, D., et al. (2005b). Potential vertebrate reservoir hosts and invertebrate vectors of Anaplasma marginale and A. phagocytophilum in central Spain. Vector Borne Zoonotic Dis. 5, 390-401. doi: 10.1089/vbz.2005.5.390
83. de la Fuente, J., Ruiz-Fons, F., Naranjo, V., Torina, A., Rodriguez, O., and Gortazar, C. (2008). Evidence of Anaplasma infections in European roe deer (Capreolus capreolus) from southern Spain. Res. Vet. Sci. 84, 382-386. doi: 10.1016/j.rvsc.2007.05.018
84. DeNatale, C. E., Burkot, T. R., Schneider, B. S., and Zeidner, N. S. (2002). Novel potential reservoirs for Borrelia sp. and the agent of human granulocytic ehrlichiosis in Colorado. J. Wildl. Dis. 38, 478-482.
85. Derdáková, M., Halanová, M., Stanko, M., Štefanèíková, A., Cislaková, L., and Pet'ko, B. (2003). Molecular evidence for Anaplasma phagocytophilum and Borrelia burgdorferi sensu lato in Ixodes ricinus ticks from eastern Slovakia. Ann. Agric. Environ. Med. 10, 269-271.
86. Derdáková, M., Štefanèíková, A., Špitalská, E., Taragel'ová, V., Košt'álová, T., Hrkl'ová, G., et al. (2011). Emergence and genetic variability of Anaplasma species in small ruminants and ticks from Central Europe. Vet. Microbiol. 153, 293-298. doi: 10.1016/j.vetmic.2011.05.044
87. Des Vignes, F., Levin, M. L., and Fish, D. (1999). Comparative vector competence of Dermacentor variabilis and Ixodes scapularis (Acari: Ixodidae) for the agent of human granulocytic ehrlichiosis. J. Med. Entomol. 36, 182-185.
88. Drazenovich, N., Foley, J., and Brown, R. N. (2006). Use of real-time quantitative PCR targeting the msp2 protein gene to identify cryptic Anaplasma phagocytophilum infections in wildlife and domestic animals. Vector Borne Zoonotic Dis. 6, 83-90. doi: 10.1089/vbz.2006.6.83
89. Dubska, L., Literak, I., Kverek, P., Roubalova, E., Kocianova, E., and Taragelova, V. (2012). Tick-borne zoonotic pathogens in ticks feeding on the common nightingale including a novel strain of Rickettsia sp. Ticks Tick Borne Dis. 3, 265-268. doi: 10.1016/j.ttbdis.2012.06.001
90. Dugan, V. G., Yabsley, M. J., Tate, C. M., Mead, D. G., Munderloh, U. G., Herron, M. J., et al. (2006). Evaluation of white-tailed deer (Odocoileus virginianus) as natural sentinels for Anaplasma phagocytophilum. Vector Borne Zoonotic Dis. 6, 192-207. doi: 10.1089/vbz.2006.6.192
91. Dumler, J. S. (1996). "Human ehrlichiosis: clinical, laboratory, epidemiologic, and pathologic considerations," in Rickettsiae and Rickettsial Diseases, eds J. Kazár and R. Toman (Bratislava: Veda), 287-302.
92. Dumler, J. S. (2012). The biological basis of severe outcomes in Anaplasma phagocytophilum infection. FEMS Immunol. Med. Microbiol. 64, 13-20. doi: 10.1111/j.1574-695X.2011.00909.x
93. Dumler, J. S., Asanovich, K. M., and Bakken, J. S. (2003). Analysis of genetic identity of North American Anaplasma phagocytophilum strains by pulsed-field gel electrophoresis. J. Clin. Microbiol. 41, 3392-3394. doi: 10.1128/JCM.41.7.3392-3394.2003
94. Dumler, J. S., Barbet, A. F., Bekker, C. P., Dasch, G. A., Palmer, G. H., Ray, S. C., et al. (2001). Reorganization of genera in the families Rickettsiaceae and Anaplasmataceae in the order Rickettsiales; unification of some species of Ehrlichia with Anaplasma, Cowdria with Ehrlichia and Ehrlichia with Neorickettsia, descriptions of six new species combinations and designation of Ehrlichia equi and "HGE agent" as subjective synonyms of Ehrlichia phagocytophila. Int. J. Syst. Evol. Microbiol. 51, 2145-2165. doi: 10.1099/00207713-51-6-2145
95. Dumler, J. S., Madigan, J. E., Pusterla, N., and Bakken, J. S. (2007). Ehrlichiosis in humans: epidemiology, clinical presentation, diagnosis, and treatment. Clin. Infect. Dis. 15, 45(SUPPL.1), S45-S51.
96. Ebani, V. V., Verin, R., Fratini, F., Poli, A., and Cerri, D. (2011). Molecular survey of Anaplasma phagocytophilum and Ehrlichia canis in red foxes (Vulpes vulpes) from central Italy. J. Wildl. Dis. 47, 699-703.
97. Egenvall, A., Lilliehook, I., Bjoersdorff, A., Engvall, E. O., Karlstam, E., Artursson, K., et al. (2000). Detection of granulocytic Ehrlichia species DNA by PCR in persistently infected dogs. Vet. Rec. 146, 186-190. doi: 10.1136/vr.146.7.186
98. Egenvall, A. E., Hedhammar, A. A., and Bjöersdorff, A. (1997). Clinical features and serology of 14 dogs affected by granulocytic ehrlichiosis in Sweden. Vet. Rec. 140, 222-226. doi: 10.1136/vr.140.9.222
99. Egyed, L., Elo, P., Sreter-Lancz, Z., Szell, Z., Balogh, Z., and Sreter, T. (2012). Seasonal activity and tick-borne pathogen infection rates of Ixodes ricinus ticks in Hungary. Ticks Tick Borne Dis. 3, 90-94. doi: 10.1016/j.ttbdis.2012.01.002
100. Eremeeva, M. E., Oliveira, A., Robinson, J. B., Ribakova, N., Tokarevich, N. K., and Dasch, G. A. (2006). Prevalence of bacterial agents in Ixodes persulcatus ticks from the Vologda Province of Russia. Ann. N.Y. Acad. Sci. 1078, 291-298. doi: 10.1196/annals.1374.054
101. Ferquel, E., Garnier, M., Marie, J., Bernede-Bauduin, C., Baranton, G., Perez-Eid, C., et al. (2006). Prevalence of Borrelia burgdorferi sensu lato and Anaplasmataceae members in Ixodes ricinus ticks in Alsace, a focus of Lyme borreliosis endemicity in France. Appl. Environ. Microbiol. 72, 3074-3078. doi: 10.1128/AEM.72.4.3074-3078.2006
102. Fingerle, V., Munderloh, U. G., Liegl, G., and Wilske, B. (1999). Coexistence of ehrlichiae of the phagocytophila group with Borrelia burgdorferi in Ixodes ricinus from Southern Germany. Med. Microbiol. Immunol. 188, 145-149. doi: 10.1007/s004300050117
103. Foggie, A. (1951). Studies on the infectious agent of tick-borne fever in sheep. J. Pathol. Bacteriol. 63, 1-15. doi: 10.1002/path.1700630103
104. Foggie, A. (1962). Studies on tick pyaemia and tick-borne fever. Symp. Zoo. Soc. Lond. 6, 51-58.
105. Foley, J. E., Barlough, J. E., Kimsey, R. B., Madigan, J. E., Derock, E., and Poland, A. (1998). Ehrlichia spp. in cervids from California. J. Wildl. Dis. 34, 731-737.
106. Foley, J. E., Clueit, S. B., and Brown, R. N. (2008a). Differential exposure to Anaplasma phagocytophilum in rodent species in northern California. Vector Borne Zoonotic Dis. 8, 49-55. doi: 10.1089/vbz.2007.0175
107. Foley, J. E., Nieto, N. C., Adjemian, J., Dabritz, H., and Brown, R. N. (2008b). Anaplasma phagocytophilum infection in small mammal hosts of Ixodes ticks, western United States. Emerg. Infect. Dis. 14, 1147-1150. doi: 10.3201/eid1407.071599
108. Foley, J. E., Foley, P., Jecker, M., Swift, P. K., and Madigan, J. E. (1999). Granulocytic ehrlichiosis and tick infestation in mountain lions in California. J. Wildl. Dis. 35, 703-709.
109. Foley, J. E., and Nieto, N. C. (2011). The ecology of tick-transmitted infections in the redwood chipmunk (Tamias ochrogenys). Ticks Tick Borne Dis. 2, 88-93. doi: 10.1016/j.ttbdis.2010.11.003
110. Foley, J. E., Nieto, N. C., Clueit, S. B., Foley, P., Nicholson, W. N., and Brown, R. N. (2007). Survey for zoonotic rickettsial pathogens in northern flying squirrels, Glaucomys sabrinus, in California. J. Wildl. Dis. 43, 684-689.
111. Foley, J. E., Rejmanek, D., Fleer, K., and Nieto, N. (2011). Nidicolous ticks of small mammals in Anaplasma phagocytophilum-enzootic sites in northern California. Ticks Tick Borne Dis. 2, 75-80. doi: 10.1016/j.ttbdis.2011.03.003
112. Franke, J., Meier, F., Moldenhauer, A., Straube, E., Dorn, W., and Hildebrandt, A. (2010). Established and emerging pathogens in Ixodes ricinus ticks collected from birds on a conservation island in the Baltic Sea. Med. Vet. Entomol. 24, 425-432. doi: 10.1111/j.1365-2915.2010.00905.x
113. Franzén, P., Aspan, A., Egenvall, A., Gunnarsson, A., Aberg, L., and Pringle, J. (2005). Acute clinical, hematologic, serologic, and polymerase chain reaction findings in horses experimentally infected with a European strain of Anaplasma phagocytophilum. J. Vet. Intern. Med. 9, 232-239.
114. Franzén, P., Aspan, A., Egenvall, A., Gunnarsson, A., Karlstam, E., and Pringle, J. (2009). Molecular evidence for persistence of Anaplasma phagocytophilum in the absence of clinical abnormalities in horses after recovery from acute experimental infection. J. Vet. Intern. Med. 23, 636-642. doi: 10.1111/j.1939-1676.2009.0317.x
115. Franzén, P., Berg, A. L., Aspan, A., Gunnarsson, A., and Pringle, J. (2007). Death of a horse infected experimentally with Anaplasma phagocytophilum. Vet. Rec. 160, 122-125. doi: 10.1136/vr.160.4.122
116. Futse, J. E., Brayton, K. A., Dark, M. J., Knowles, D. P., and Palmer, G. H. (2008). Superinfection as a driver of genomic diversification in antigenically variant pathogens. Proc. Natl. Acad. Sci. U.S.A. 105, 2123-2127. doi: 10.1073/pnas.0710333105
117. Gabriel, M. W., Brown, R. N., Foley, J. E., Higley, J. M., and Botzler, R. G. (2009). Ecology of Anaplasma phagocytophilum infection in gray foxes (Urocyon cinereoargenteus) in northwestern California. J. Wildl. Dis. 45, 344-354.
118. Galindo, R. C., Ayllon, N. Strasek Smrdel, K., Boadella, M., Beltran, B., Mazariegos, M., et al. (2012). Gene expression profile suggests that pigs (Sus scrofa) are susceptible to Anaplasma phagocytophilum but control infection. Parasit. Vectors 5:181. doi: 10.1186/1756-3305-5-181
119. Ge, Y., and Rikihisa, Y. (2006). Anaplasma phagocytophilum delays spontaneous human neutrophil apoptosis by modulation of multiple apoptotic pathways. Cell. Microbiol. 8, 1406-1416. doi: 10.1111/j.1462-5822.2006.00720.x
120. Giudice, E., Giannetto, C., Furco, V., Alongi, A., and Torina, A. (2012). Anaplasma phagocytophilum seroprevalence in equids: a survey in Sicily (Italy). Parasitol. Res. 111, 951-955. doi: 10.1007/s00436-012-2854-5
121. Goethert, H. K., and Telford, S. R. 3rd. (2003). Enzootic transmission of the agent of human granulocytic ehrlichiosis among cottontail rabbits. Am. J. Trop. Med. Hyg. 68, 633-637.
122. Goodman, J. L., Nelson, C., Vitale, B., Madigan, J. E., Dumler, J. S., Kurtti, T. J., et al. (1996). Direct cultivation of the causative agent of human granulocytic ehrlichiosis. N. Engl. J. Med. 334, 209-215. doi: 10.1056/NEJM199601253340401
123. Gordon, W. S., Brownlee, A., and Wilson, D. R. (1940). "Studies in louping-ill, tick-borne fever and scrapie," in Proceedings: 3rd International Congress of Microbiology, (New York, NY), 362-363.
124. Gordon, W. S., Brownlee, A., Wilson, D. R., and MacLeod, J. (1932). "Tick-borne fever" (A hitherto undescribed disease of sheep.). J. Comp. Pathol. 45, 301-307.
125. Granick, J. L., Armstrong, P. J., and Bender, J. B. (2009). Anaplasma phagocytophilum infection in dogs: 34 cases (2000-2007). J. Am. Vet. Med. Assoc. 234, 1559-1565. doi: 10.2460/javma.234.12.1559
126. Granick, J. L., Reneer, D. V., Carlyon, J. A., and Borjesson, D. L. (2008). Anaplasma phagocytophilum infects cells of the megakaryocytic lineage through sialylated ligands but falls to alter platelet production. J. Med. Microbiol. 57, 416-423. doi: 10.1099/jmm.0.47551-0
127. Granquist, E. G., Aleksandersen, M., Bergstrom, K., Dumler, S. J., Torsteinbo, W. O., and Stuen, S. (2010a). A morphological and molecular study of Anaplasma phagocytophilum transmission events at the time of Ixodes ricinus tick bite. Acta Vet. Scand. 52
128. Granquist, E. G., Bardsen, K., Bergstrom, K., and Stuen, S. (2010b). Variant -and individual dependent nature of persistent Anaplasma phagocytophilum infection. Acta Vet. Scand. 52.
129. Granquist, E. G., Stuen, S., Crosby, L., Lundgren, A. M., Alleman, A. R., and Barbet, A. F. (2010c). Variant-specific and diminishing immune responses towards the highly variable MSP2(P44) outer membrane protein of Anaplasma phagocytophilum during persistent infection in lambs. Vet. Immunol. Immunopathol. 133, 117-124. doi: 10.1016/j.vetimm.2009.07.009
130. Granquist, E. G., Stuen, S., Lundgren, A. M., Braten, M., and Barbet, A. F. (2008). Outer membrane protein sequence variation in lambs experimentally infected with Anaplasma phagocytophilum. Infect. Immun. 76, 120-126. doi: 10.1128/IAI.01206-07
131. Gribble, D. H. (1969). Equine ehrlichiosis. J. Am. Vet. Med. Assoc. 155, 462-469.
132. Grøva, L., Olesen, I., Steinshamn, H., and Stuen, S. (2011). Prevalence of Anaplasma phagocytophilum infection and effect on lamb growth. Acta Vet. Scand. 53:30. doi: 10.1186/1751-0147-53-30
133. Grzeszczuk, A., Karbowiak, G., Ziarko, S., and Kovalchuk, O. (2006). The root-vole Microtus oeconomus (Pallas, 1776): a new potential reservoir of Anaplasma phagocytophilum. Vector Borne Zoonotic Dis. 6, 240-243. doi: 10.1089/vbz.2006.6.240
134. Grzeszczuk, A., and Stanczak, J. (2006). Highly variable year-to-year prevalence of Anaplasma phagocytophilum in Ixodes ricinus ticks in northeastern Poland: a 4-year follow-up. Ann. N.Y. Acad. Sci. 1078, 309-311. doi: 10.1196/annals.1374.057
135. Güner, E. S., Watanabe, M., Kadosaka, T., Polat, E., Gargili, A., Gulanber, A., et al. (2005). Seroepidemiology of Borrelia burgdorferi sensu lato and Anaplasma phagocytophilum in wild mice captured in northern Turkey. Epidemiol. Infect. 133, 331-336. doi: 10.1017/S0950268804003309
136. Guo, X. Y., Booth, C. J., Paley, M. A., Wang, X. M., DePonte, K., Fikrig, E., et al. (2009). Inhibition of neutrophil function by two tick salivary proteins. Infect. Immun. 77, 2320-2329. doi: 10.1128/IAI.01507-08
137. Guy, E., Tasker, S., and Joynson, D. H. (1998). Detection of the agent of human granulocytic ehrlichiosis (HGE) in UK ticks using polymerase chain reaction. Epidemiol. Infect. 121, 681-683. doi: 10.1017/S0950268898001708
138. Halos, L., Bord, S., Cotté, V., Gasqui, P., Abrial, D., Barnouin, J., et al. (2010). Ecological factors characterizing the prevalence of bacterial tick-borne pathogens in Ixodes ricinus ticks in pastures and woodlands. Appl. Environ. Microbiol. 76, 4413-4420. doi: 10.1128/AEM.00610-10
139. Halos, L., Vourc'h, G., Cotté, V., Gasqui, P., Barnouin, J., Boulous, H. J., et al. (2006). Prevalence of Anaplasma phagocytophilum, Rickettsia sp. and Borrelia burgdorferi sensu lato DNA in questing Ixodes ricinus ticks from France. Ann. N.Y. Acad. Sci. 1078, 316-319. doi: 10.1196/annals.1374.059
140. Hamel, D., Bondarenko, A., Silaghi, C., Nolte, I., and Pfister, K. (2012a). Seroprevalence and bacteremia [corrected] of Anaplasma phagocytophilum in cats from Bavaria and Lower Saxony (Germany). Berl. Munch. Tierarztl. Wochenschr. 125, 163-167.
141. Hamel, D., Silaghi, C., Lescai, D., and Pfister, K. (2012b). Epidemiological aspects on vector-borne infections in stray and pet dogs from Romania and Hungary with focus on Babesia spp. Parasitol. Res. 110, 1537-1545. doi: 10.1007/s00436-011-2659-y
142. Hansen, M. G., Christoffersen, M., Thuesen, L. R., Petersen, M. R., and Bojesen, A. M. (2010). Seroprevalence of Borrelia burgdorferi sensu lato and Anaplasma phagocytophilum in Danish horses. Acta Vet. Scand. 52:3. doi: 10.1186/1751-0147-52-53
143. Hapunik, J., Vichova, B., Karbowiak, G., Wita, I., Bogdaszewski, M., and Pet'ko, B. (2011). Wild and farm breeding cervids infections with Anaplasma phagocytophilum. Ann. Agric. Environ. Med. 18, 73-77.
144. Hartelt, K., Oehme, R., Frank, H., Brockmann, S. O., Hassler, D., and Kimmig, P. (2004). Pathogens and symbionts in ticks: prevalence of Anaplasma phagocytophilum (Ehrlichia sp.), Wolbachia sp., Rickettsia sp., and Babesia sp. in Southern Germany. Int. J. Med. Microbiol. 293(SUPPL. 37), 86-92.
145. Hartelt, K., Pluta, S., Oehme, R., and Kimmig, P. (2008). Spread of ticks and tick-borne diseases in Germany due to global warming. Parasitol. Res. 103(SUPPL. 1), S109-S116. doi: 10.1007/s00436-008-1059-4
146. Heikkilä, H. M., Bondarenko, A., Mihalkov, A., Pfister, K., and Spillmann, T. (2010). Anaplasma phagocytophilum infection in a domestic cat in Finland: case report. Acta Vet. Scand. 52:62. doi: 10.1186/1751-0147-52-62
147. Heine, S., Thiet, W., and Liebisch, G. (2007). Anaplasmose beim Hund - Fallbericht. Prakt. Tierarzt 88, 20-27.
148. Heinze, D. M., Carmical, J. R., Aronson, J. F., and Thangamani, S. (2012), Early immunologic events at the tick-host interface. PLoS ONE 7:e47301. doi:10.1371/journal.pone.0047301
149. Henn, J. B., Gabriel, M. W., Kasten, R. W., Brown, R. N., Theis, J. H., Foley, J. E., et al. (2007). Gray foxes (Urocyon cinereoargenteus) as a potential reservoir of a Bartonella clarridgeiae-like bacterium and domestic dogs as part of a sentinel system for surveillance of zoonotic arthropod-borne pathogens in northern California. J. Clin. Microbiol. 45, 2411-2418. doi: 10.1128/JCM.02539-06
150. Herron, M. J., Ericson, M. E., Kurtti, T. J., and Munderloh, U. G. (2005). The interactions of Anaplasma phagocytophilum, endothelial cells, and human neutrophils. Rickettsioses: from Genome to Proteome, Pathobiology, and Rickettsiae As An International Threat 1063, 374-382.
151. Herron, M. J., Nelson, C. M., Larson, J., Snapp, K. R., Kansas, G. S., and Goodman, J. L. (2000). Intracellular parasitism by the human granulocytic ehrlichiosis bacterium through the P-selectin ligand, PSGL-1. Science 288, 1653-1656. doi: 10.1126/science.288.5471.1653
152. Hildebrandt, A., Franke, J., Meier, F., Sachse, S., Dorn, W., and Straube, E. (2010a). The potential role of migratory birds in transmission cycles of Babesia spp., Anaplasma phagocytophilum, and Rickettsia spp. Ticks Tick Borne Dis. 1, 105-107. doi: 10.1016/j.ttbdis.2009.12.003
153. Hildebrandt, A., Kramer, A., Sachse, S., and Straube, E. (2010b). Detection of Rickettsia spp. and Anaplasma phagocytophilum in Ixodes ricinus ticks in a region of Middle Germany (Thuringia). Ticks Tick Borne Dis. 1, 52-56. doi: 10.1016/j.ttbdis.2009.11.005
154. Hildebrandt, A., Schmidt, K. H., Fingerle, V., Wilske, B., and Straube, E. (2002). Prevalence of granulocytic Ehrlichiae in Ixodes ricinus ticks in Middle Germany (Thuringia) detected by PCR and sequencing of a 16S ribosomal DNA fragment. FEMS Microbiol. Lett. 211, 225-230. doi: 10.1111/j.1574-6968.2002.tb11229.x
155. Hofmann-Lehmann, R., Meli, M. L., Dreher, U. M., Gonczi, E., Deplazes, P., Braun, U., et al. (2004). Concurrent infections with vector-borne pathogens associated with fatal hemolytic anemia in a cattle herd in Switzerland. J. Clin. Microbiol. 42, 3775-3780. doi: 10.1128/JCM.42.8.3775-3780.2004
156. Holden, K., Boothby, J. T., Anand, S., and Massung, R. F. (2003). Detection of Borrelia burgdorferi, Ehrlichia chaffeensis, and Anaplasma phagocytophilum in ticks (Acari: Ixodidae) from a coastal region of California. J. Med. Entomol. 40, 534-539. doi: 10.1603/0022-2585-40.4.534
157. Holden, K., Boothby, J. T., Kasten, R. W., and Chomel, B. B. (2006). Co-detection of Bartonella henselae, Borrelia burgdorferi, and Anaplasma phagocytophilum in Ixodes pacificus ticks from California, USA. Vector Borne Zoonotic Dis. 6, 99-102. doi: 10.1089/vbz.2006.6.99
158. Holman, M. S., Caporale, D. A., Goldberg, J., Lacombe, E., Lubelczyk, C., Rand, P. W., et al. (2004). Anaplasma phagocytophilum, Babesia microti, and Borrelia burgdorferi in Ixodes scapularis, southern coastal Maine. Emerg. Infect. Dis. 10, 744-746. doi: 10.3201/eid1004.030566
159. Hornok, S., Csörgö, T., de la Fuente, J., Gyuranecz, M., Privigyei, C., Meli, M. L., et al. (2013). Synanthropic birds associated with high prevalence of tick-borne rickettsiae and with the first detection of Rickettsia aeschlimannii in Hungary. Vector Borne Zoonotic Dis. 13, 77-83. doi: 10.1089/vbz.2012.1032
160. Horowitz, H. W., Kilchevsky, E., Haber, S., Aguero-Rosenfeldt, M., Kranwinkel, R., James, E. K., et al. (1998). Perinatal transmission of the agent of human granulocytic ehrlichiosis. N. Engl. J. Med. 339, 375-378. doi: 10.1056/NEJM199808063390604
161. Hotopp, J. C. D., Lin, M. Q., Madupu, R., Crabtree, J., Angiuoli, S. V., Eisen, J., et al. (2006). Comparative Genomics of emerging human ehrlichiosis agents. PLoS Genet. 2:e21. doi: 10.1371/journal.pgen.0020021
162. Hulínská, D., Langøová, K., Pejèoch, M., and Pavlásek, I. (2004). Detection of Anaplasma phagocytophilum in animals by real-time polymerase chain reaction. APMIS 112, 239-247. doi: 10.1111/j.1600-0463.2004.apm11204-0503.x
163. Ijdo, J. W., Sun, W., Zhang, Y., Magnarelli, L. A., and Fikrig, E. (1998). Cloning of the gene encoding the 44-kilodalton antigen of the agent of human granulocytic ehrlichiosis and characterization of the humoral response. Infect. Immun. 66, 3264-3269.
164. Jaenson, T. G., Jaenson, D. G., Eisen, L., Petersson, E., and Lindgren, E. (2012). Changes in the geographical distribution and abundance of the tick Ixodes ricinus during the past 30 years in Sweden. Parasit. Vectors 5:8. doi: 10.1186/1756-3305-5-8
165. Jenkins, A., Kristiansen, B. E., Allum, A. G., Aakre, R. K., Strand, L., Kleveland, E. J., et al. (2001). Borrelia burgdorferi sensu lato and Ehrlichia spp. in Ixodes ticks from southern Norway. J. Clin. Microbiol. 39, 3666-3671. doi: 10.1128/JCM.39.10.3666-3671.2001
166. Jensen, J., Simon, D. Murua Escobar, H., Soller, J. T., Bullerdiek, J., Beelitz, P., et al. (2007). Anaplasma phagocytophilum in dogs in Germany. Zoonoses Public Health 54, 94-101. doi: 10.1111/j.1863-2378.2007.01028.x
167. Jensen, P. M., Hansen, H., and Frandsen, F. (2000). Spatial risk assessment for Lyme borreliosis in Denmark. Scand. J. Infect. Dis. 32, 545-550. doi: 10.1080/003655400458857
168. Jilintai, Seino, N., Hayakawa, D., Suzuki, M., Hata, H., Kondo, S., et al. (2009). Molecular survey for Anaplasma bovis and Anaplasma phagocytophilum infection in cattle in a pastureland where sika deer appear in Hokkaido, Japan. Jpn. J. Infect. Dis. 62, 73-75.
169. Johnson, R. C., Kodner, C., Jarnefeld, J., Eck, D. K., and Xu, Y. (2011). Agents of human anaplasmosis and Lyme disease at Camp Ripley, Minnesota. Vector Borne Zoonotic Dis. 11, 1529-1534. doi: 10.1089/vbz.2011.0633
170. Johnston, E., Tsao, J. I., Muñoz, J. D., and Owen, J. (2013). Anaplasma phagocytophilum infection in American robins and gray catbirds: an assessment of reservoir competence and disease in captive wildlife. J. Med. Entomol. 50, 163-170.
171. Jordan, R. A., Schulze, T. L., and Jahn, M. B. (2007). Effects of reduced deer density on the abundance of Ixodes scapularis (Acari: Ixodidae) and Lyme disease incidence in a northern New Jersey endemic area. J. Med. Entomol. 44, 752-757. doi: 10.1603/0022-258544[752:EORDDO]2.0.CO;2
172. Jore, S., Viljugrein, H., Hofshagen, M., Brun-Hansen, H., Kristoffersen, A. B., Nygård, K., et al. (2011). Multi-source analysis reveals latitudinal and altitudinal shifts in range of Ixodes ricinus at its northern distribution limit. Parasit. Vectors 4:84. doi: 10.1186/1756-3305-4-84
173. Kahl, O., Gern, L., Eisen, L., and Lane, R. S. (2002). "Ecological research on Borrelia burgdorferi sensu lato: terminology and some methodological pitfalls," in Lyme borreliosis Biology, Epidemiology and Control, eds J. S. Gray, O. Kahl, R. S. Lane, and G. Stanek (Oxon: CABI Publishing), 29-46. doi: 10.1079/9780851996325.0029
174. Kahlon, A., Ojogun, N., Ragland, S. A., Seidman, D., Troese, M. J., Ottens, A. K., et al. (2013). Anaplasma phagocytophilum Asp14 is an invasin that interacts with mammalian host cells via its C terminus to facilitate infection. Infect. Immun. 81, 65-79. doi: 10.1128/IAI.00932-12
175. Kang, J. G., Kim, H. C., Choi, C. Y., Nam, H. Y., Chae, H. Y., Chong, S. T., et al. (2013). Molecular detection of Anaplasma, Bartonella, and Borrelia species in ticks collected from migratory birds from Hong-do Island, Republic of Korea. Vector Borne Zoonotic Dis. 13, 215-225. doi: 10.1089/vbz.2012.1149
176. Kang, J. G., Ko, S., Kim, Y. J., Yang, H. J., Lee, H., Shin, N. S., et al. (2011). New genetic variants of Anaplasma phagocytophilum and Anaplasma bovis from Korean water deer (Hydropotes inermis argyropus). Vector Borne Zoonotic Dis. 11, 929-938. doi: 10.1089/vbz.2010.0214
177. Karbowiak, G., Vichova, B., Majlathova, V., Hapunik, J., and Petko, B. (2009). Anaplasma phagocytophilum infection of red foxes (Vulpes vulpes). Ann. Agric. Environ. Med. 16, 299-300.
178. Katargina, O., Geller, J., Alekseev, A., Dubinina, H., Efremova, G., Mishaeva, N., et al. (2012). Identification of Anaplasma phagocytophilum in tick populations in Estonia, the European part of Russia and Belarus. Clin. Microbiol. Infect. 18, 40-46. doi: 10.1111/j.1469-0691.2010.03457.x
179. Kawahara, M., Rikihisa, Y., Lin, Q., Isogai, E., Tahara, K., Itagaki, A., et al. (2006). Novel genetic variants of Anaplasma phagocytophilum, Anaplasma bovis, Anaplasma centrale, and a novel Ehrlichia sp. in wild deer and ticks on two major islands in Japan. Appl. Environ. Microbiol. 72, 1102-1109. doi: 10.1128/AEM.72.2.1102-1109.2006
180. Kiffner, C., Vor, T., Hagedorn, P., Niedrig, M., and Rühe, F. (2011). Factors affecting patterns of tick parasitism on forest rodents in tick-borne encephalitis risk areas, Germany. Parasitol. Res. 108, 323-335. doi: 10.1007/s00436-010-2065-x
181. Kiilerich, A. M., Christensen, H., and Thamsborg, S. M. (2009). Anaplasma phagocytophilum in Danish sheep: confirmation by DNA sequencing. Acta Vet. Scand. 51:55. doi: 10.1186/1751-0147-51-55
182. Kim, C. M., Yi, Y. H., Yu, D. H., Lee, M. J., Cho, M. R., Desai, A. R., et al. (2006). Tick-borne rickettsial pathogens in ticks and small mammals in Korea. Appl. Environ. Microbiol. 72, 5766-5776. doi: 10.1128/AEM.00431-06
183. Klein, M. B., Miller, J. S., Nelson, C. M., and Goodman, J. L. (1997). Primary bone marrow progenitors of both granulocytic and monocytic lineages are susceptible to infection with the agent of human granulocytic ehrlichiosis. J. Infect. Dis. 176, 1405-1409. doi: 10.1086/517332
184. Koèi, J., Movila, A., Taragel'ová, V., Toderas, I., Uspenskaia, I., Derdáková, M., et al. (2007). First report of Anaplasma phagocytophilum and its co-infections with Borrelia burgdorferi sensu lato in Ixodes ricinus ticks (Acari: Ixodidae) from Republic of Moldova. Exp. Appl. Acarol. 41, 147-152. doi: 10.1007/s10493-007-9048-3
185. Kohn, B., Silaghi, C., Galke, D., Arndt, G., and Pfister, K. (2011). Infections with Anaplasma phagocytophilum in dogs in Germany. Res. Vet. Sci. 91, 71-76. doi: 10.1016/j.rvsc.2010.08.008
186. Kramer, V. L., Randolph, M. P., Hui, L. T., Irwin, W. E., Gutierrez, A. G., and Vugia, D. J. (1999). Detection of the agents of human ehrlichioses in ixodid ticks from California. Am. J. Trop. Med. Hyg. 60, 62-65.
187. Kybicová, K., Schánilec, P., Hulínská, D., Uherková, L., Kurzová, Z., and Spejchalová, S. (2009). Detection of Anaplasma phagocytophilum and Borrelia burgdorferi sensu lato in dogs in the Czech Republic. Vector Borne Zoonotic Dis. 9, 655-661. doi: 10.1089/vbz.2008.0127
188. Labuda, M., Trimnell, A. R., Licková, M., Kazimírová, M., Davies, G. M., Lissina, O., et al. (2006). An antivector vaccine protects against a lethal vector-borne pathogen. PLoS Pathog. 2:e27. doi: 10.1371/journal.ppat.0020027
189. Ladbury, G. A. F., Stuen, S., Thomas, R., Bown, K. J., Woldehiwet, Z., Granquist, E. G., et al. (2008). Dynamic transmission of numerous Anaplasma phagocytophilum genotypes among lambs in an infected sheep flock in an area of anaplasmosis endemicity. J. Clin. Microbiol. 46, 1686-1691. doi: 10.1128/JCM.02068-07
190. Laloy, E., Petit, E., Boulouis, H. J., Gandoin, C., Bouillin, C., Gounot, G., et al. (2009). Dynamics of natural infection by Anaplasma phagocytophilum in a dairy cattle herd in Brittany, France. Clin. Microbiol. Infect. 15(SUPPL. 2), 24-25. doi: 10.1111/j.1469-0691.2008.02142.x
191. Lane, R. S., Foley, J. E., Eisen, L., Lennette, E. T., and Peot, M. A. (2001). Acarologic risk of exposure to emerging tick-borne bacterial pathogens in a semirural community in northern California. Vector Borne Zoonotic Dis. 1, 197-210. doi: 10.1089/153036601753552567
192. Lane, R. S., Mun, J., Peribáñez, M. A., and Fedorova, N. (2010). Differences in prevalence of Borrelia burgdorferi and Anaplasma spp. infection among host-seeking Dermacentor occidentalis, Ixodes pacificus, and Ornithodoros coriaceus ticks in northwestern California. Ticks Tick Borne Dis. 1, 159-167.
193. Lane, R. S., Steinlein, D. B., and Mun, J. (2004). Human behaviors elevating exposure to Ixodes pacificus (Acari: Ixodidae) nymphs and their associated bacterial zoonotic agents in a hardwood forest. J. Med. Entomol. 41, 239-248. doi: 10.1603/0022-2585-412.239
194. Larson, L.-G., Aspan, A., and Bergström, K. (2006). Persistence of Anaplasma phagocytophilum in naturally infected Swedish cattle. (in Swedish). Svensk Vet. Tidn. 58, 13-19.
195. Lascola, K., Vandis, M., Bain, P., and Bedenice, D. (2009). Concurrent Infection with Anaplasma phagocytophilum and Mycoplasma haemolamae in a young alpaca. J. Vet. Intern. Med. 23, 379-382. doi: 10.1111/j.1939-1676.2008.0268.x
196. Laus, F., Veronesi, F., Passamonti, F., Paggi, E., Cerquetella, M., Hyatt, D., et al. (2013). Prevalence of tick borne pathogens in horses from Italy. J. Vet. Med. Sci. 75, 715-720. doi: 10.1292/jvms.12-0449
197. Lee, H. C., and Goodman, J. L. (2006). Anaplasma phagocytophilum causes global induction of antiapoptosis in human neutrophils. Genomics 88, 496-503. doi: 10.1016/j.ygeno.2006.06.002
198. Lempereur, L., Lebrun, M., Cuvelier, P., Sepult, G., Caron, Y., Saegerman, C., et al. (2012). Longitudinal field study on bovine Babesia spp. and Anaplasma phagocytophilum infections during a grazing season in Belgium. Parasitol. Res. 110, 1525-1530. doi: 10.1007/s00436-011-2657-0
199. Lepidi, H., Bunnell, J. E., Martin, M. E., Madigan, J. E., Stuen, S., and Dumler, J. S. (2000). Comparative pathology and immunohistology associated with clinical illness after Ehrlichia phagocytophila-group infections. Am. J. Trop. Med. Hyg. 62, 29-37.
200. Leschnik, M., Kirtz, G., Virányi, Z., Wille-Piazzai, W., and Duscher, G. (2012). Acute granulocytic anaplasmosis in a captive timber wolf (Canis lupus occidentalis). J. Zoo. Wildl. Med. 43, 645-648. doi: 10.1638/2011-0224R.1
201. Leutenegger, C. M., Pusterla, N., Mislin, C. N., Weber, R., and Lutz, H. (1999). Molecular evidence of coinfection of ticks with Borrelia burgdorferi sensu lato and the human granulocytic ehrlichiosis agent in Switzerland. J. Clin. Microbiol. 37, 3390-3391.
202. Levin, M. L. des Vignes, F., and Fish, D. (1999). Disparity in the natural cycles of Borrelia burgdorferi and the agent of human granulocytic ehrlichiosis. Emerg. Infect. Dis. 5, 204-208. doi: 10.3201/eid0502.990203
203. Levin, M. L., Nicholson, W. L., Massung, R. F., Sumner, J. W., and Fish, D. (2002). Comparison of the reservoir competence of medium-sized mammals and Peromyscus leucopus for Anaplasma phagocytophilum in Connecticut. Vector Borne Zoonotic Dis. 2, 125-136. doi: 10.1089/15303660260613693
204. Li, H., Zhou, Y., Wang, W., Guo, D., Huang, S., and Jie, S. (2011). The clinical characteristics and outcomes of patients with human granulocytic anaplasmosis in China. Int. J. Infect. Dis. 15, 859-866. doi: 10.1016/j.ijid.2011.09.008
205. Lillini, E., Macri, G., Proietti, G., and Scarpulla, M. (2006). New findings on anaplasmosis caused by infection with Anaplasma phagocytophilum. Ann. N.Y. Acad. Sci. 1081, 360-370. doi: 10.1196/annals.1373.053
206. Lin, M., Kikuchi, T., Brewer, H. M., Norbeck, A. D., and Rikihisa, Y. (2011). Global proteomic analysis of two tick-borne emerging zoonotic agents: Anaplasma phagocytophilum and Ehrlichia chaffeensis. Front. Microbiol. 2:24. doi: 10.3389/fmicb.2011.00024
207. Lin, M. Q., and Rikihisa, Y. (2003a). Ehrlichia chaffeensis and Anaplasma phagocytophilum lack genes for lipid a biosynthesis and incorporate cholesterol for their survival. Infect. Immun. 71, 5324-5331. doi: 10.1128/IAI.71.9.5324-5331.2003
208. Lin, M. Q., and Rikihisa, Y. (2003b). Obligatory intracellular parasitism by Ehrlichia chaffeensis and Anaplasma phagocytophilum involves caveolae and glycosylphosphatidylinositol-anchored proteins. Cell. Microbiol. 5, 809-820. doi: 10.1046/j.1462-5822.2003.00322.x
209. Lin, Q., Rikihisa, Y., Ohashi, N., and Zhi, N. (2003). Mechanisms of variable p44 expression by Anaplasma phagocytophilum. Infect. Immun. 71, 5650-5661. doi: 10.1128/IAI.71.10.5650-5661.2003
210. Liu, Z., Ma, M., Wang, Z., Wang, J., Peng, Y., Li, Y., et al. (2012). Molecular survey and genetic identification of Anaplasma species in goats from central and southern China. Appl. Environ. Microbiol. 78, 464-470. doi: 10.1128/AEM.06848-11
211. Liz, J. S., Anderes, L., Sumner, J. W., Massung, R. F., Gern, L., Rutti, B., et al. (2000). PCR detection of granulocytic ehrlichiae in Ixodes ricinus ticks and wild small mammals in western Switzerland. J. Clin. Microbiol. 38, 1002-1007.
212. Liz, J. S., Sumner, J. W., Pfister, K., and Brossard, M. (2002). PCR detection and serological evidence of granulocytic ehrlichial infection in roe deer (Capreolus capreolus) and chamois (Rupicapra rupicapra). J. Clin. Microbiol. 40, 892-897. doi: 10.1128/JCM.40.3.892-897.2002
213. Lommano, E., Bertaiola, L., Dupasquier, C., and Gern, L. (2012). Infections and co-infections of questing Ixodes ricinus ticks by emerging zoonotic pathogens in Western Switzerland. Appl. Environ. Microbiol. 78, 4606-4612. doi: 10.1128/AEM.07961-11
214. Lovrich, S. D., Jobe, D. A., Kowalski, T. J., Policepatil, S. M., and Callister, S. M. (2011). Expansion of the Midwestern focus for human granulocytic anaplasmosis into the region surrounding La Crosse, Wisconsin. J. Clin. Microbiol. 49, 3855-3859. doi: 10.1128/JCM.05025-11
215. Maeda, K., Markowitz, N., Hawley, R. C., Ristic, M., Cox, D., and McDade, J. E. (1987). Human infection with Ehrlichia canis, a leucocytic rickettsia. N. Engl. J. Med. 316, 853-856. doi: 10.1056/NEJM198704023161406
216. Magnarelli, L. A., Ijdo, J. W., Shermant, B. A., Bushmich, S. L., Levy, S. A., and Fikrig, E. (2002). Antibodies to granulocytic ehrlichiae in cattle from Connecticut. J. Med. Microbiol. 51, 326-331.
217. Magnarelli, L. A., Ijdo, J. W., Stafford, K. C. 3rd., and Fikrig, E. (1999). Infections of granulocytic ehrlichiae and Borrelia burgdorferi in white-tailed deer in Connecticut. J. Wildl. Dis. 35, 266-274.
218. Magnarelli, L. A., Ijdo, J. W., Van Andel, A. E., Wu, C., and Fikrig, E. (2001). Evaluation of a polyvalent enzyme-linked immunosorbent assay incorporating a recombinant p44 antigen for diagnosis of granulocytic ehrlichiosis in dogs and horses. Am. J. Vet. Res. 62, 29-32. doi: 10.2460/ajvr.2001.62.29
219. Magnarelli, L. A., Stafford, K. C. 3rd., Mather, T. N., Yeh, M. T., Horn, K. D., and Dumler, J. S. (1995). Hemocytic rickettsia-like organisms in ticks: serologic reactivity with antisera to Ehrlichiae and detection of DNA of agent of human granulocytic ehrlichiosis by PCR. J. Clin. Microbiol. 33, 2710-2714.
220. Mäkinen, J., Vuorinen, I., Oksi, J., Peltomaa, M., He, Q., Marjamäki, M., et al. (2003). Prevalence of granulocytic Ehrlichia and Borrelia burgdorferi sensu lato in Ixodes ricinus ticks collected from Southwestern Finland and from Vormsi Island in Estonia. APMIS 111, 355-362. doi: 10.1034/j.1600-0463.2003.1110209.x
221. Mantelli, B., Pecchioli, E., Hauffe, H. C., Rosa, R., and Rizzoli, A. (2006). Prevalence of Borrelia burgdorferi s.l. and Anaplasma phagocytophilum in the wood tick Ixodes ricinus in the Province of Trento, Italy. Eur. J. Clin. Microbiol. Infect. Dis. 25, 737-739. doi: 10.1007/s10096-006-0208-x
222. Massung, R. F., Courtney, J. W., Hiratzka, S. L., Pitzer, V. E., Smith, G., and Dryden, R. L. (2005). Anaplasma phagocytophilum in white-tailed deer. Emerg. Infect. Dis. 11, 1604-1606. doi: 10.3201/eid1110.041329
223. Massung, R. F., Lee, K., Mauel, M., and Gusa, A. (2002). Characterization of the rRNA genes of Ehrlichia chaffeensis and Anaplasma phagocytophila. DNA Cell Biol. 21, 587-596. doi: 10.1089/104454902320308960
224. Massung, R. F., Levin, M. L., Munderloh, U. G., Silverman, D. J., Lynch, M. J., Gaywee, J. K., et al. (2007). Isolation and propagation of the Ap-Variant 1 Strain of Anaplasma phagocytophilum in a tick cell line. J. Clin. Microbiol. 45, 2138-2143.
225. Massung, R. F., Mather, T. N., and Levin, M. L. (2006). Reservoir competency of goats for the Ap-variant 1 strain of Anaplasma phagocytophilum. Infect. Immun. 74, 1373-1375. doi: 10.1128/IAI.74.2.1373-1375.2006
226. Massung, R. F., Mauel, M. J., Owens, J. H., Allan, N., Courtney, J. W. Stafford, K. C. 3rd., et al. (2002). Genetic variants of Ehrlichia phagocytophila, Rhode Island and Connecticut. Emerg. Infect. Dis. 8, 467-472. doi: 10.3201/eid0805.010251
227. Massung, R. F., Owens, J. H., Ross, D., Reed, K. D., Petrovec, M., Bjoersdorff, A., et al. (2000). Sequence analysis of the ank gene of granulocytic ehrlichiae. J. Clin. Microbiol. 38, 2917-2922.
228. Massung, R. F., Priestley, R. A., Miller, N. J., Mather, T. N., and Levin, M. L. (2003). Inability of a variant strain of Anaplasma phagocytophilum to infect mice. J. Infect. Dis. 188, 1757-1763. doi: 10.1086/379725
229. Mastronunzio, J. E., Kurscheid, S., and Fikrig, E. (2012). Postgenomic analyses reveal development of infectious Anaplasma phagocytophilum during transmission from ticks to mice. J. Bacteriol. 194, 2238-2247. doi: 10.1128/JB.06791-11
230. Masuzawa, T., Kharitonenkov, I. G., Okamoto, Y., Fukui, T., and Ohashi, N. (2008). Prevalence of Anaplasma phagocytophilum and its coinfection with Borrelia afzelii in Ixodes ricinus and Ixodes persulcatus ticks inhabiting Tver Province (Russia) - a sympatric region for both tick species. J. Med. Microbiol. 57, 986-991. doi: 10.1099/jmm.0.47721-0
231. Masuzawa, T., Uchishima, Y., Fukui, T., Okamoto, Y., Muto, M., Koizumi, N., et al. (2011). Detection of Anaplasma phagocytophilum from wild boars and deer in Japan. Jpn. J. Infect. Dis. 64, 333-336.
232. Materna, J., Daniel, M., and Danielová, V. (2005). Altitudinal distribution limit of the tick Ixodes ricinus shifted considerably towards higher altitudes in central Europe: results of three years monitoring in the Krkonose Mts. (Czech Republic). Cent. Eur. J. Public Health. 13, 24-28.
233. Matsumoto, K., Grzeszczuk, A., Brouqui, P., and Raoult, D. (2009). Rickettsia raoultii and Anaplasma phagocytophilum in Dermacentor reticulatus ticks collected from Bialowieza Primeval Forest European bison (Bison bonasus bonasus), Poland. Clin. Microbiol. Infect. 15(SUPPL. 2), 286-287. doi: 10.1111/j.1469-0691.2008.02238.x
234. Matsumoto, K., Joncour, G., Lamanda, P., Inokuma, H., and Brouqui, P. (2007). Detection of Anaplasma phagocytophilum and Ehrlichia sp. HF strains in Ixodes ricinus ticks in Brittany, France. Clin. Microbiol. Infect. 13, 338-341. doi: 10.1111/j.1469-0691.2006.01630.x
235. Medlock, J. M., Hansford, K. M., Bormane, A., Derdakova, M., Estrada-Peña, A., George, J. C., et al. (2013). Driving forces for changes in geographical distribution of Ixodes ricinus ticks in Europe. Parasit. Vectors 6:1. doi: 10.1186/1756-3305-6-1
236. M'Ghirbi, Y., Ghorbel, A., Amouri, M., Nebaoui, A., Haddad, S., and Bouattour, A. (2009). Clinical, serological, and molecular evidence of ehrlichiosis and anaplasmosis in dogs in Tunisia. Parasitol. Res. 104, 767-774. doi: 10.1007/s00436-008-1253-4
237. M'Ghirbi, Y., Yaich, H., Ghorbel, A., and Bouattour, A. (2012). Anaplasma phagocytophilum in horses and ticks in Tunisia. Parasit. Vectors 5:180. doi: 10.1186/1756-3305-5-180
238. Michalik, J., Stanczak, J., Cieniuch, S., Racewicz, M., Sikora, B., and Dabert, M. (2012). Wild boars as hosts of human-pathogenic Anaplasma phagocytophilum variants. Emerg. Infect. Dis. 18, 998-1001. doi: 10.3201/eid1806.110997
239. Michalik, J., Stanczak, J., Racewicz, M., Cieniuch, S., Sikora, B., Szubert-Kruszynska, A., et al. (2009). Molecular evidence of Anaplasma phagocytophilum infection in wild cervids and feeding Ixodes ricinus ticks from west-central Poland. Clin. Microbiol. Infect. 15(SUPPL. 2), 81-83. doi: 10.1111/j.1469-0691.2008.02240.x
240. Michalski, M., Rosenfield, C., Erickson, M., Selle, R., Bates, K., Essar, D., et al. (2006). Anaplasma phagocytophilum in central and western Wisconsin: a molecular survey. Parasitol. Res. 99, 694-699. doi: 10.1007/s00436-006-0217-9
241. Moreno, C. X., Moy, F., Daniels, T. J., Godfrey, H. P., and Cabello, F. C. (2006). Molecular analysis of microbial communities identified in different developmental stages of Ixodes scapularis ticks from Westchester and Dutchess Counties, New York. Environ. Microbiol. 8, 761-772. doi: 10.1111/j.1462-2920.2005.00955.x
242. Morgenthal, D., Hamel, D., Arndt, G., Silaghi, C., Pfister, K., Kempf, V. A., et al. (2012). Prevalence of haemotropic Mycoplasma spp., Bartonella spp. and Anaplasma phagocytophilum in cats in Berlin/Brandenburg (Northeast Germany). Berl. Munch. Tierarztl. Wochenschr. 125, 418-427.
243. Movila, A., Rolain, J. M., Podavalenko, A., Toderas, I., Tkachenco, L., Naglov, V., et al. (2009). Detection of spotted fever group rickettsiae and family Anaplasmataceae in Ixodes ricinus ticks from Republic of Moldova and Eastern Ukraine. Clin. Microbiol. Infect. 15(SUPPL. 2), 32-33. doi: 10.1111/j.1469-0691.2008.02152.x
244. Munderloh, U. G., Jauron, S. D., Fingerle, V., Leitritz, L., Hayes, S. F., Hautman, J. M., et al. (1999). Invasion and intracellular development of the human granulocytic ehrlichiosis agent in tick cell culture. J. Clin. Microbiol. 37, 2518-2524.
245. Munderloh, U. G., Lynch, M. J., Herron, M. J., Palmer, A. T., Kurtti, T. J., Nelson, R. D., et al. (2004). Infection of endothelial cells with Anaplasma marginale and A. phagocytophilum. Vet. Microbiol. 101, 53-64. doi: 10.1016/j.vetmic.2004.02.011
246. Munderloh, U. G., Madigan, J. E., Dumler, J. S., Goodman, J. L., Hayes, S. F., Barlough, J. E., et al. (1996). Isolation of the equine granulocytic ehrlichiosis agent, Ehrlichia equi, in tick cell culture. J. Clin. Microbiol. 34, 664-670.
247. Munro, R., Hunter, A. R., MacKenzie, G., and McMartin, D. A. (1982). Pulmonary lesions in sheep following experimental infection by Ehrlichia phagocytophila and Chlamydia psittaci. J. Comp. Pathol. 92, 117-129. doi: 10.1016/0021-997590047-0
248. Murase, Y., Konnai, S., Hidano, A., Githaka, N. W., Ito, T., Takano, A., et al. (2011). Molecular detection of Anaplasma phagocytophilum in cattle and Ixodes persulcatus ticks. Vet. Microbiol. 149, 504-507. doi: 10.1016/j.vetmic.2010.11.025
249. Naranjo, V., Ruiz-Fons, F., Hofle, U., Fernandez De Mera, I. G., Villanua, D., Almazan, C., et al. (2006). Molecular epidemiology of human and bovine anaplasmosis in southern Europe. Ann. N.Y. Acad. Sci. 1078, 95-99. doi: 10.1196/annals.1374.013
250. Nicholson, W. L., Castro, M. B., Kramer, V. L., Sumner, J. W., and Childs, J. E. (1999). Dusky-footed wood rats (Neotoma fuscipes) as reservoirs of granulocytic Ehrlichiae (Rickettsiales: Ehrlichieae) in northern California. J. Clin. Microbiol. 37, 3323-3327.
251. Nieto, N. C., and Foley, J. E. (2008). Evaluation of squirrels (Rodentia: Sciuridae) as ecologically significant hosts for Anaplasma phagocytophilum in California. J. Med. Entomol. 45, 763-769. doi: 10.1603/0022-258545[763:EOSRSA]2.0.CO;2
252. Nieto, N. C., Foley, J. E., Bettaso, J., and Lane, R. S. (2009). Reptile infection with Anaplasma phagocytophilum, the causative agent of granulocytic anaplasmosis. J. Parasitol. 95, 1165-1170. doi: 10.1645/GE-1983.1
253. Nieto, N. C., Leonhard, S., Joley, J. E., and Lane, R. S. (2010). Coinfection of Western Gray Squirrel (Sciurus griseus) and other Sciurid rodents with Borrelia burgdorferi sensu strictu and Anaplasma phagocytophilum in California. J. Wildl. Dis. 46, 291-296
254. Oehme, R., Hartelt, K., Backe, H., Brockmann, S., and Kimmig, P. (2002). Foci of tick-borne diseases in southwest Germany. Int. J. Med. Microbiol. 291(SUPPL. 33), 22-29. doi: 10.1016/S1438-422180005-4
255. Ogden, N. H., Bown, K., Horrocks, B. K., Woldehiwet, Z., and Bennett, M. (1998). Granulocytic Ehrlichia infection in ixodid ticks and mammals in woodlands and uplands of the U.K. Med. Vet. Entomol. 12, 423-429. doi: 10.1046/j.1365-2915.1998.00133.x
256. Ogden, N. H., Lindsay, L. R., Hanincová, K., Barker, I. K., Bigras-Poulin, M., Charron, D. F., et al. (2008). Role of migratory birds in introduction and range expansion of Ixodes scapularis ticks and of Borrelia burgdorferi and Anaplasma phagocytophilum in Canada. Appl. Environ. Microbiol. 74, 1780-1790. doi: 10.1128/AEM.01982-07
257. Ohashi, N., Inayoshi, M., Kitamura, K., Kawamori, F., Kawaguchi, D., Nishimura, Y., et al. (2005). Anaplasma phagocytophilum-infected ticks, Japan. Emerg. Infect. Dis. 11, 1780-1783. doi: 10.3201/eid1111.050407
258. Ojogun, N., Kahlon, A., Ragland, S. A., Troese, M. J., Mastronunzio, J. E., Walker, N. J., et al. (2012). Anaplasma phagocytophilum outer membrane protein A interacts with sialylated glycoproteins to promote infection of mammalian host cells. Infect. Immun. 80, 3748-3760. doi: 10.1128/IAI.00654-12
259. Ooshiro, M., Zakimi, S., Matsukawa, Y., Katagiri, Y., and Inokuma, H. (2008). Detection of Anaplasma bovis and Anaplasma phagocytophilum from cattle on Yonaguni Island, Okinawa, Japan. Vet. Parasitol. 154, 360-364. doi: 10.1016/j.vetpar.2008.03.028
260. Oporto, B., Gil, H., Barral, M., Hurtado, A., Juste, R. A., and García-Pérez, A. L. (2003). A survey on Anaplasma phagocytophila in wild small mammals and roe deer (Capreolus capreolus) in Northern Spain. Ann. N.Y. Acad. Sci. 990, 98-102. doi: 10.1111/j.1749-6632.2003.tb07344.x
261. Øverås, J., Lund, A., Ulvund, M. J., and Waldeland, H. (1993). Tick-borne fever as a possible predisposing factor in septicaemic pasteurellosis in lambs. Vet. Rec. 133, 398.
262. Overzier, E., Pfister, K., Herb, I., Mahling, M., Böck, G. Jr., and Silaghi, C. (2013a). Detection of tick-borne pathogens in roe deer (Capreolus capreolus), questing ticks (Ixodes ricinus) and ticks infesting roe deer in southern Germany. Ticks Tick Borne Dis. 4, 320-328. doi: 10.1016/j.ttbdis.2013.01.004
263. Overzier, E., Pfister, K., Thiel, C., Herb, I., Mahling, M., and Silaghi, C. (2013b). Anaplasma phagocytophilum in questing Ixodes ricinus Ticks: comparison of prevalences and partial 16S rRNA gene variants in urban, pasture, and natural habitats. Appl. Environ. Microbiol. 79, 1730-1734. doi: 10.1128/AEM.03300-12
264. Palomar, A. M., Santibáñez, P., Mazuelas, D., Roncero, L., Santibáñez, S., Portillo, A., et al. (2012). Role of birds in dispersal of etiologic agents of tick-borne zoonoses, Spain. Emerg. Infect. Dis. 18, 1188-1191.
265. Park, J., Choi, K. S., and Dumler, J. S. (2003). Major surface protein 2 of Anaplasma phagocytophilum facilitates adherence to granulocytes. Infect. Immun. 71, 4018-4025. doi: 10.1128/IAI.71.7.4018-4025.2003
266. Passamonti, F., Veronesi, F., Cappelli, K., Capomaccio, S., Coppola, G., Marenzoni, M. L., et al. (2010). Anaplasma phagocytophilum in horses and ticks: a preliminary survey of Central Italy. Comp. Immunol. Microbiol. Infect. Dis. 33, 73-83. doi: 10.1016/j.cimid.2008.08.002
267. Paulauskas, A., Radzijevskaja, J., and Rosef, O. (2012). Molecular detection and characterization of Anaplasma phagocytophilum strains. Comp. Immunol. Microbiol. Infect. Dis. 35, 187-195. doi: 10.1016/j.cimid.2012.01.001
268. Paxton, E. A., and Scott, G. R. (1989). Detection of antibodies to the agent of tick-borne fever by indirect immunofluorescence. Vet. Microbiol. 21, 133-138. doi: 10.1016/0378-113590025-4
269. Petrovec, M., Sumner, J. W., Nicholson, W. L., Childs, J. E., Strle, F., Barlic, J., et al. (1999). Identity of ehrlichial DNA sequences derived from Ixodes ricinus ticks with those obtained from patients with human granulocytic ehrlichiosis in Slovenia. J. Clin. Microbiol. 37, 209-210.
270. Philip, C. B. (1974) "Tribe, I. I. Ehrlichieae Philip 1957," in Bergey's Manual of Determinative Bacteriology 8th Edn., eds R. E. Buchanan, N. E. Gibbons (Baltimore, MD: The Williams and Wilkins Company) 893-897.
271. Piccolin, G., Benedetti, G., Doglioni, C., Lorenzato, C., Mancuso, S., Papa, N., et al. (2006). A study of the presence of B. burgdorferi, Anaplasma (previously Ehrlichia) phagocytophilum, Rickettsia, and Babesia in Ixodes ricinus collected within the territory of Belluno, Italy. Vector Borne Zoonotic Dis. 6, 24-31. doi: 10.1089/vbz.2006.6.24
272. Pichon, B., Kahl, O., Hammer, B., and Gray, J. S. (2006). Pathogens and host DNA in Ixodes ricinus nymphal ticks from a German forest. Vector Borne Zoonotic Dis. 6, 382-387. doi: 10.1089/vbz.2006.6.382
273. Polin, H., Hufnagl, P., Haunschmid, R., Gruber, F., and Ladurner, G. (2004). Molecular evidence of Anaplasma phagocytophilum in Ixodes ricinus ticks and wild animals in Austria. J. Clin. Microbiol. 42, 2285-2286. doi: 10.1128/JCM.42.5.2285-2286.2004
274. Portillo, A., Pérez-Martínez, L., Santibáñez, S., Santibáñez, P., Palomar, A. M., and Oteo, J. A. (2011). Anaplasma spp. in wild mammals and Ixodes ricinus from the north of Spain. Vector Borne Zoonotic Dis. 11, 3-8.
275. Portillo, A., Santos, A. S., Santibanez, S., Pérez-Martinez, L., Blanco, J. R., Ibarra, V., et al. (2005). Detection of a non-pathogenic variant of Anaplasma phagocytophilum in Ixodes ricinus from La Rioja, Spain. Ann. N.Y. Acad. Sci. 1063, 333-336. doi: 10.1196/annals.1355.053
276. Pusterla, N., Leutenegger, C. M., Huder, J. B., Weber, R., Braun, U., and Lutz, H. (1999). Evidence of the human granulocytic ehrlichiosis agent in Ixodes ricinus ticks in Switzerland. J. Clin. Microbiol. 37, 1332-1334.
277. Radzijevskaja, J., Paulauskas, A., and Rosef, O. (2008). Prevalence of Anaplasma phagocytophilum and Babesia divergens in Ixodes ricinus from Lithuania and Norway. Int. J. Med. Microbiol. 298, 218-221. doi: 10.1016/j.ijmm.2008.01.008
278. Rand, P. W., Lubelczyk, C., Lavigne, G. R., Elias, S., Holman, M. S., Lacombe, E. H., et al. (2003). Deer density and the abundance of Ixodes scapularis (Acari: Ixodidae). J. Med. Entomol. 40, 179-184. doi: 10.1603/0022-2585-40.2.179
279. Rar, V. A., Epikhina, T. I., Livanova, N. N., Panov, V. V., Doroschenko, E. K., Pukhovskaya, N. M., et al. (2011). Genetic variability of Anaplasma phagocytophilum in Ixodes persulcatus ticks and small mammals in the Asian part of Russia. Vector Borne Zoonotic Dis. 11, 1013-1021. doi: 10.1089/vbz.2010.0266
280. Rar, V. A., Fomenko, N. V., Dobrotvorsky, A. K., Livanova, N. N., Rudakova, S. A., Fedorov, E. G., et al. (2005). Tickborne pathogen detection, Western Siberia, Russia. Emerg. Infect. Dis. 11, 1708-1715. doi: 10.3201/eid1111.041195
281. Ravyn, M. D., Goodman, J. L., Kodner, C. B., Westad, D. K., Coleman, L. A., Engstrom, S. M., et al. (1998). Immunodiagnosis of human granulocytic ehrlichiosis by using culture-derived human isolates. J. Clin. Microbiol. 36, 1480-1488.
282. Reichard, M. V., Roman, R. M., Kocan, K. M., Blouin, E. F., de la Fuente, J., Snider, T. A., et al. (2009). Inoculation of white-tailed deer (Odocoileus virginianus) with Ap-V or NY-18 strains of Anaplasma phagocytophilum and microscopic demonstration of Ap-V1 in Ixodes scapularis adults that acquired infection from deer as nymphs. Vector Borne Zoonotic Dis. 9, 565-568. doi: 10.1089/vbz.2008.0106
283. Reis, C., Cote, M., Paul, R. E., and Bonnet, S. (2011). Questing ticks in suburban forest are infected by at least six tick-borne pathogens. Vector Borne Zoonotic Dis. 11, 907-916. doi: 10.1089/vbz.2010.0103
284. Rejmanek, D., Foley, P., Barbet, A., and Foley, J. (2012). Evolution of antigen variation in the tick-borne pathogen Anaplasma phagocytophilum. Mol. Biol. Evol. 29, 391-400. doi: 10.1093/molbev/msr229
285. Rejmanek, D., Nieto, N. C., Barash, N., and Foley, J. E. (2011). Temporal patterns of tick-borne granulocytic anaplasmosis in California. Ticks Tick Borne Dis. 2, 81-87. doi: 10.1016/j.ttbdis.2010.12.003
286. Reneer, D. V., Kearns, S. A., Yago, T., Sims, J., Cummings, R. D., Mcever, R. P., et al. (2006). Characterization of a sialic acid- and P-selectin glycoprotein ligand-1-independent adhesin activity in the granulocytotropic bacterium Anaplasma phagocytophilum. Cell. Microbiol. 8, 1972-1984. doi: 10.1111/j.1462-5822.2006.00764.x
287. Reneer, D. V., Troese, M. J., Huang, B., Kearns, S. A., and Carlyon, J. A. (2008). Anaplasma phagocytophilum PSGL-1-independent infection does not require Syk and leads to less efficient AnkA delivery. Cell. Microbiol. 10, 1827-1838. doi: 10.1111/j.1462-5822.2008.01168.x
288. Reye, A. L., Hübschen, J. M., Sausy, A., and Müller, C. P. (2010). Prevalence and seasonality of tick-borne pathogens in questing Ixodes ricinus ticks from Luxembourg. Appl. Environ. Microbiol. 76, 2923-2931. doi: 10.1128/AEM.03061-09
289. Reye, A. L., Stegniy, V., Mishaeva, N. P., Velhin, S., Hübschen, J. M., Ignatyev, G., et al. (2013). Prevalence of tick-borne pathogens in Ixodes ricinus and Dermacentor reticulatus ticks from different geographical locations in Belarus. PLoS ONE 8:e54476. doi: 10.1371/journal.pone.0054476
290. Richter, D., and Matuschka, F. R. (2012). "Candidatus Neoehrlichia mikurensis," Anaplasma phagocytophilum, and lyme disease spirochetes in questing european vector ticks and in feeding ticks removed from people. J. Clin. Microbiol. 50, 943-947. doi: 10.1128/JCM.05802-11
291. Rikihisa, Y. (1991). The tribe Ehrlichieae and ehrlichial diseases. Clin. Microbiol. Rev. 4, 286-308.
292. Rikihisa, Y. (2003). Mechanisms to create a safe haven by members of the family Anaplasmataceae. Ann. N.Y. Acad. Sci. 990, 548-555.
293. Rikihisa, Y. (2011). Mechanisms of obligatory intracellular infection with Anaplasma phagocytophilum. Clin. Microbiol. Rev. 24, 469-489. doi: 10.1128/CMR.00064-10
294. Rizzoli, A., Hauffe, H. C., Tagliapietra, V., Neteler, M., and Rosà, R. (2009). Forest structure and roe deer abundance predict tick-borne encephalitis risk in Italy. PLoS ONE 4:e4336. doi: 10.1371/journal.pone.0004336
295. Robinson, M. T., Shaw, S. E., and Morgan, E. R. (2009). Anaplasma phagocytophilum infection in a multi-species deer community in the New Forest, England. Eur. J. Wildl. Res. 55, 439-442. doi: 10.1007/s10344-009-0261-8
296. Rodriguez, J. L., Palmer, G. H., Knowles, D. P., and Brayton, K. A. (2005). Distinctly different msp2 pseudogene repertoires in Anaplasma marginale strains that are capable of superinfection. Gene 361, 127-132. doi: 10.1016/j.gene.2005.06.038
297. Roellig, D. M., and Fang, Q. Q. (2012). Detection of Anaplasma phagocytophilum in ixodid ticks from equine-inhabited sites in the Southeastern United States. Vector Borne Zoonotic Dis. 12, 330-332. doi: 10.1089/vbz.2011.0757
298. Rosef, O., Paulauskas, A., and Radzijevskaja, J. (2009). Prevalence of Borrelia burgdorferi sensu lato and Anaplasma phagocytophilum in questing Ixodes ricinus ticks in relation to the density of wild cervids. Acta Vet. Scand. 51:47. doi: 10.1186/1751-0147-51-47
299. Ruiz-Fons, F., Fernández-de-Mera, I. G., Acevedo, P., Gortázar, C., and de la Fuente, J. (2012). Factors driving the abundance of Ixodes ricinus Ticks and the prevalence of zoonotic, I. ricinus-borne pathogens in natural foci. Appl. Environ. Microbiol. 78, 2669-2676. doi: 10.1128/AEM.06564-11
300. Rymaszewska, A. (2005). Identification of Anaplasma phagocytophilum on the basis of a fragment of the 16S rDNA gene. Folia Biol. (Krakow) 53, 199-203. doi: 10.3409/173491605775142765
301. Rymaszewska, A. (2008). Divergence within the marker region of the groESL operon in Anaplasma phagocytophilum. Eur. J. Clin. Microbiol. Infect. Dis. 27, 1025-1036. doi: 10.1007/s10096-008-0539-x
302. Rymaszewska, A., and Adamska, M. (2011). Molecular evidence of vector-borne pathogens coinfecting dogs from Poland. Acta Vet. Hung. 59, 215-223. doi: 10.1556/AVet.2011.008
303. Samish, M., Ginsberg, H., and Glazer, I. (2004). Biological control of ticks. Parasitology 129, S389-S403. doi: 10.1017/S0031182004005219
304. Santos, A. S., Santos-Silva, M. M., Almeida, V. C., Bacellar, F., and Dumler, J. S. (2004). Detection of Anaplasma phagocytophilum DNA in Ixodes ticks (Acari: Ixodidae) from Madeira island and Setubal district, mainland Portugal. Emerg. Infect. Dis. 10, 1643-1648. doi: 10.3201/eid1009.040276
305. Santos, H. A., Pires, M. S., Vilela, J. A. R., Santos, T. M., Faccini, J. L. H., Baldani, C. D., et al. (2011). Detection of Anaplasma phagocytophilum in Brazilian dogs by real-time polymerase chain reaction. J. Vet. Diagn. Invest. 23, 770. doi: 10.1177/1040638711406974
306. Sarkar, A., Hellberg, L., Bhattacharyya, A., Behnen, M., Wang, K. Q., Lord, J. M., et al. (2012). Infection with Anaplasma phagocytophilum activates the phosphatidylinositol 3-kinase/Akt and NF-kappa B survival pathways in neutrophil granulocytes. Infect. Immun. 80, 1615-1623. doi: 10.1128/IAI.05219-11
307. Scharf, W., Schauer, S., Freyburger, F., Petrovec, M., Schaarschmidt-Kiener, D., Liebisch, G., et al. (2011). Distinct host species correlate with Anaplasma phagocytophilum ankA gene clusters. J. Clin. Microbiol. 49, 790-796. doi: 10.1128/JCM.02051-10
308. Schicht, S., Junge, S., Schnieder, T., and Strube, C. (2011). Prevalence of Anaplasma phagocytophilum and coinfection with Borrelia burgdorferi Sensu Lato in the hard tick Ixodes ricinus in the City of Hanover (Germany). Vector Borne Zoonotic Dis. 11, 1595-1597. doi: 10.1089/vbz.2011.0699
309. Schorn, S., Pfister, K., Reulen, H., Mahling, M., Manitz, J., Thiel, C., et al. (2011). Prevalence of Anaplasma phagocytophilum in Ixodes ricinus in Bavarian public parks, Germany. Ticks Tick Borne Dis. 2, 196-203. doi: 10.1016/j.ttbdis.2011.09.009
310. Scorpio, D. G., Akkoyunlu, M., Fikrig, E., and Dumler, J. S. (2004). CXCR2 blockade influences Anaplasma phagocytophilum propagation but not histopathology in the mouse model of human granulocytic anaplasmosis. Clin. Diag. Lab. Immun. 11, 963-968.
311. Sen, E., Uchishima, Y., Okamoto, Y., Fukui, T., Kadosaka, T., Ohashi, N., et al. (2011). Molecular detection of Anaplasma phagocytophilum and Borrelia burgdorferi in Ixodes ricinus ticks from Istanbul metropolitan area and rural Trakya (Thrace) region of north-western Turkey. Ticks Tick Borne Dis. 2, 94-98. doi: 10.1016/j.ttbdis.2011.03.004
312. Severinsson, K., Jaenson, T. G., Pettersson, J., Falk, K., and Nilsson, K. (2010). Detection and prevalence of Anaplasma phagocytophilum and Rickettsia helvetica in Ixodes ricinus ticks in seven study areas in Sweden. Parasit. Vectors 3, 66. doi: 10.1186/1756-3305-3-66
313. Shaw, S. E., Binns, S. H., Birtles, R. J., Day, M. J., Smithson, R., and Kenny, M. J. (2005). Molecular evidence of tick-transmitted infections in dogs and cats in the United Kingdom. Vet. Rec. 157, 645-648.
314. Shpynov, S., Fournier, P.-E., Rudakov, N., Tarasevich, I., and Raoult, D. (2006). Detection of members of the genera Rickettsia, Anaplasma, and Ehrlichia in ticks collected in the Asiatic part of Russia. Ann. N.Y. Acad. Sci. 1078, 378-383. doi: 10.1196/annals.1374.075
315. Shukla, S. K., Vandermause, M. F., Belongia, E. A., Reed, K. D., Paskewitz, S. M., and Kazmierczak, J. (2003). Importance of primer specificity for PCR detection of Anaplasma phagocytophila among Ixodes scapularis ticks from Wisconsin. J. Clin. Microbiol. 41, 4006. doi: 10.1128/JCM.41.8.4006.2003
316. Silaghi, C., Gilles, J., Höhle, M., Fingerle, V., Just, F. T., and Pfister, K. (2008). Anaplasma phagocytophilum infection in Ixodes ricinus, Bavaria, Germany. Emerg. Infect. Dis. 14, 972-974. doi: 10.3201/eid1406.071095
317. Silaghi, C., Hamel, D., Pfister, K., and Rehbein, S. (2011a). Babesia species and co-infection with Anaplasma phagocytophilum in free-ranging ungulates from Tyrol, Austria. Wien. Tierärztl. Monatsschr. 98, 268-274.
318. Silaghi, C., Hamel, D., Thiel, C., Pfister, K., Passos, L. M., and Rehbein, S. (2011b). Genetic variants of Anaplasma phagocytophilum in wild caprine and cervid ungulates from the Alps in Tyrol, Austria. Vector Borne Zoonotic Dis. 11, 355-362. doi: 10.1089/vbz.2010.0051
319. Silaghi, C., Kauffmann, M., Passos, L. M. F., Pfister, K., and Zweygarth, E. (2011c). Isolation, propagation and preliminary characterisation of Anaplasma phagocytophilum from roe deer (Capreolus capreolus) in the tick cell line IDE8. Ticks Tick Borne Dis. 2, 204-208. doi: 10.1016/j.ttbdis.2011.09.002
320. Silaghi, C., Liebisch, G., and Pfister, K. (2011d). Genetic variants of Anaplasma phagocytophilum from 14 equine granulocytic anaplasmosis cases. Parasit. Vectors. 4:161. doi: 10.1186/1756-3305-4-161
321. Silaghi, C., Scheuerle, M. C., Friche Passos, L. M., Thiel, C., and Pfister, K. (2011e). PCR detection of Anaplasma phagocytophilum in goat flocks in an area endemic for tick-borne fever in Switzerland. Parasite 18, 57-62. doi: 10.1051/parasite/2011181057
322. Silaghi, C., Skuballa, J., Thiel, C., Pfister, K., Petney, T., Pfäffle, M., et al. (2012a). The European hedgehog (Erinaceus europaeus) - a suitable reservoir for variants of Anaplasma phagocytophilum. Ticks Tick Borne Dis. 3, 49-54. doi: 10.1016/j.ttbdis.2011.11.005
323. Silaghi, C., Woll, D., Hamel, D., Pfister, K., Mahling, M., and Pfeffer, M. (2012b). Babesia spp. and Anaplasma phagocytophilum in questing ticks, ticks parasitizing rodents and the parasitized rodents - Analyzing the host-pathogen-vector interface in a metropolitan area. Parasit. Vectors 5:191. doi: 10.1186/1756-3305-5-191
324. Sixl, W., Petrovec, M., Marth, E., Wust, G., Stunzner, D., Schweiger, R., et al. (2003). Investigation of Anaplasma phagocytophila infections in Ixodes ricinus and Dermacentor reticulatus ticks in Austria. Ann. N.Y. Acad. Sci. 990, 94-97. doi: 10.1111/j.1749-6632.2003.tb07343.x
325. Skarphedinsson, S., Jensen, P. M., and Kristiansen, K. (2005). Survey of tickborne infections in Denmark. Emerg. Infect. Dis. 11, 1055-1061. doi: 10.3201/eid1107.041265
326. Skarphedinsson, S., Lyholm, B. F., Ljungberg, M., Sogaard, P., Kolmos, H. J., and Nielsen, L. P. (2007). Detection and identification of Anaplasma phagocytophilum, Borrelia burgdorferi, and Rickettsia helvetica in Danish Ixodes ricinus ticks. APMIS 115, 225-230. doi: 10.1111/j.1600-0463.2007.apm_256.x
327. Skotarczak, B., Rymaszewska, A., Wodecka, B., and Sawczuk, M. (2003). Molecular evidence of coinfection of Borrelia burgdorferi sensu lato, human granulocytic ehrlichiosis agent, and Babesia microti in ticks from northwestern Poland. J. Parasitol. 89, 194-196. doi: 10.1645/0022-3395089[0194:MEOCOB]2.0.CO;2
328. Skotarczak, B., Rymaszewska, A., Wodecka, B., Sawczuk, M., Adamska, M., and Maciejewska, A. (2006). PCR detection of granulocytic Anaplasma and Babesia in Ixodes ricinus ticks and birds in west-central Poland. Ann. Agric. Environ. Med. 13, 21-23.
329. Skuballa, J., Petney, T., Pfäffle, M., and Taraschewski, H. (2010). Molecular detection of Anaplasma phagocytophilum in the European hedgehog (Erinaceus europaeus) and its ticks. Vector Borne Zoonotic Dis. 10, 1055-1057. doi: 10.1089/vbz.2009.0150
330. Smetanová, K., Schwarzová, K., and Kocianová, E. (2006). Detection of Anaplasma phagocytophilum, Coxiella burnetii, Rickettsia spp., and Borrelia burgdorferi s. l. in Ticks, and wild-living animals in western and middle Slovakia. Ann. N.Y. Acad. Sci. 1078, 312-315. doi: 10.1196/annals.1374.058
331. Smrdel, K. S., Serdt, M., Duh, D., Knap, N., and Županc, T. A. (2010). Anaplasma phagocytophilum in ticks in Slovenia. Parasit. Vectors 3:102. doi: 10.1186/1756-3305-3-102
332. Soleng, A., and Kjelland, V. (2013). Borrelia burgdorferi sensu lato and Anaplasma phagocytophilum in Ixodes ricinus ticks in Bronnoysund in northern Norway. Ticks Tick Borne Dis. 4, 218-221. doi: 10.1016/j.ttbdis.2012.11.006
333. Sonenshine, D. E. (1993). Biology of Ticks. Vol 2. New York, NY: Oxford University Press.
334. Spielman, A., Wilson, M. L., Levine, J. F., and Piesman, J. (1985). Ecology of Ixodes dammini-borne human babesiosis and Lyme disease. Annu. Rev. Entomol. 30, 439-460.
335. Špitalská, E., Boldis, V., Kostanová, Z., Kocianová, E., and Stefanidesová, K. (2008). Incidence of various tick-borne microorganisms in rodents and ticks of central Slovakia. Acta Virol. 52, 175-179.
336. Stafford, K. C. 3rd., Massung, R. F., Magnarelli, L. A., Ijdo, J. W., and Anderson, J. F. (1999). Infection with agents of human granulocytic ehrlichiosis, lyme disease, and babesiosis in wild white-footed mice (Peromyscus leucopus) in Connecticut. J. Clin. Microbiol. 37, 2887-2892.
337. Stanczak, J., Gabre, R. M., Kruminis-Lozowska, W., Racewicz, M., and Kubica-Biernat, B. (2004). Ixodes ricinus as a vector of Borrelia burgdorferi sensu lato, Anaplasma phagocytophilum and Babesia microti in urban and suburban forests. Ann. Agric. Environ. Med. 11, 109-114.
338. Stanczak, J., Racewicz, M., Kruminis-Lozowska, W., and Kubica-Biernat, B. (2002). Coinfection of Ixodes ricinus (Acari: Ixodidae) in northern Poland with the agents of Lyme borreliosis (LB) and human granulocytic ehrlichiosis (HGE). Int. J. Med. Microbiol. 291(SUPPL. 33), 198-201. doi: 10.1016/S1438-422180045-5
339. Stefanidesová, K., Kocianová, E., Boldis, V., Kostanová, Z., Kanka, P., Nemethová, D., et al. (2008). Evidence of Anaplasma phagocytophilum and Rickettsia helvetica infection in free-ranging ungulates in central Slovakia. Euro. J. Wildl. Res. 54, 519-524. doi: 10.1007/s10344-007-0161-8
340. Steiner, F. E., Pinger, R. R., Vann, C. N., Abley, M. J., Sullivan, B., Grindle, N., et al. (2006). Detection of Anaplasma phagocytophilum and Babesia odocoilei DNA in Ixodes scapularis (Acari: Ixodidae) collected in Indiana. J. Med. Entomol. 43, 437-442. doi: 10.1603/0022-2585043[0437:DOAPAB]2.0.CO;2
341. Steiner, F. E., Pinger, R. R., Vann, C. N., Grindle, N., Civitello, D., Clay, K., et al. (2008). Infection and co-infection rates of Anaplasma phagocytophilum variants, Babesia spp., Borrelia burgdorferi, and the rickettsial endosymbiont in Ixodes scapularis (Acari: Ixodidae) from sites in Indiana, Maine, Pennsylvania, and Wisconsin. J. Med. Entomol. 45, 289-297. doi: 10.1603/0022-258545[289:IACROA]2.0.CO;2
342. Stuen, S. (2003). Anaplasma Phagocytophilum (Formerly Ehrlichia phagocytophila) Infection in Sheep and Wild Ruminants in Norway. A study on clinical manifestation, distribution and persistence. Dr Philos thesis, Norwegian School of Veterinary Science, Oslo.
343. Stuen, S., Artursson, K., and Olsson Engvall, E. (1998). Experimental infection of lambs with an equine granulocytic Ehrlichia species resembling the agent that causes human granulocytic ehrlichiosis (HGE). Acta Vet. Scand. 39, 491-497.
344. Stuen, S., Handeland, K., Frammarsvik, T., and Bergstrom, K. (2001). Experimental Ehrlichia phagocytophila infection in red deer (Cervus elaphus). Vet. Rec. 149, 390-392. doi: 10.1136/vr.149.13.390
345. Stuen, S., Hardeng, F., and Larsen, H. J. (1992). Resistance to tick-borne fever in young lambs. Res. Vet. Sci. 52, 211-216. doi: 10.1016/0034-528890012-Q
346. Stuen, S., Pettersen, K. S., Granquist, E. G., Bergström, K., Bown, K. J., and Birtles, R. J. (2013). Anaplasma phagocytophilum variants in sympatric red deer (Cervus elaphus) and sheep in southern Norway. Ticks Tick Borne Dis. 4, 197-201. doi: 10.1016/j.ttbdis.2012.11.014
347. Stuen, S., Scharf, W., Schauer, S., Freyburger, F., Bergstrom, K., and von Loewenich, F. D. (2010). Experimental infection in lambs with a red deer (Cervus elaphus) isolate of Anaplasma phagocytophilum. J. Wildl. Dis. 46, 803-809.
348. Stuen, S., Torsteinbo, W. O., Bergstrom, K., and Bardsen, K. (2009). Superinfection occurs in Anaplasma phagocytophilum infected sheep irrespective of infection phase and protection status. Acta Vet. Scand. 51:41. doi: 10.1186/1751-0147-51-41
349. Stuen, S., Van De Pol, I., Bergström, K., and Schouls, L. M. (2002). Identification of Anaplasma phagocytophila (formerly Ehrlichia phagocytophila) variants in blood from sheep in Norway. J. Clin. Microbiol. 40, 3192-3197. doi: 10.1128/JCM.40.9.3192-3197.2002
350. Subramanian, G., Sekeyova, Z., Raoult, D., and Mediannikov, O. (2012). Multiple tick-associated bacteria in Ixodes ricinus from Slovakia. Ticks Tick Borne Dis. 3, 406-410. doi: 10.1016/j.ttbdis.2012.10.001
351. Sukumaran, B., Ogura, Y., Pedra, J. H. F., Kobayashi, K. S., Flavell, R. A., and Fikrig, E. (2012). Receptor interacting protein-2 contributes to host defense against Anaplasma phagocytophilum infection. FEMS Immunol. Med. Microbiol. 66, 211-219. doi: 10.1111/j.1574-695X.2012.01001.x
352. Swanson, K. I., and Norris, D. E. (2007). Co-circulating microorganisms in questing Ixodes scapularis nymphs in Maryland. J. Vector Ecol. 32, 243-251. doi: 10.3376/1081-171032[243:CMIQIS]2.0.CO;2
353. Sytykiewicz, H., Karbowiak, G., Hapunik, J., Szpechcinski, A., Supergan-Marwicz, M., Golawska, S., et al. (2012). Molecular evidence of Anaplasma phagocytophilum and Babesia microti co-infections in Ixodes ricinus ticks in central-eastern region of Poland. Ann. Agri. Environ. Med. 19, 45-49.
354. Taylor, S. M., and Kenny, J. (1980). The effects of tick-borne fever (Ehrlichia phagocytophila) on the growth rate of fattening cattle. Brit. Vet. J. 136, 364-370.
355. Teglas, M. B., and Foley, J. (2006). Differences in the transmissibility of two Anaplasma phagocytophilum strains by the North American tick vector species, Ixodes pacificus and Ixodes scapularis (Acari: Ixodidae). Exp. Appl. Acarol. 38, 47-58. doi: 10.1007/s10493-005-5293-5
356. Teglas, M., Matern, E., Lein, S., Foley, P., Mahan, S. M., and Foley, J. (2005). Ticks and tick-borne disease in Guatemalan cattle and horses. Vet. Parasitol. 131, 119-127. doi: 10.1016/j.vetpar.2005.04.033
357. Telford, S. R. 3rd., Dawson, J. E., Katavolos, P., Warner, C. K., Kolbert, C. P., and Persing, D. H. (1996). Perpetuation of the agent of human granulocytic ehrlichiosis in a deer tick-rodent cycle. Proc. Natl. Acad. Sci. U.S.A. 93, 6209-6214. doi: 10.1073/pnas.93.12.6209
358. Tomanovic, S., Chochlakis, D., Radulovic, Z., Milutinovic, M., Cakic, S., Mihaljica, D., et al. (2013). Analysis of pathogen co-occurrence in host-seeking adult hard ticks from Serbia. Exp. Appl. Acarol. 59, 367-376. doi: 10.1007/s10493-012-9597-y
359. Tomanovic, S., Radulovic, Z., Masuzawa, T., and Milutinovic, M. (2010). Coexistence of emerging bacterial pathogens in Ixodes ricinus ticks in Serbia. Parasite 17, 211-217. doi: 10.1051/parasite/2010173211
360. Tomasiewicz, K., Modrzewska, R., Buczek, A., Stanczak, J., and Maciukajc, J. (2004). The risk of exposure to Anaplasma phagocytophilum infection in Mid-Eastern Poland. Ann. Agric. Environ. Med. 11, 261-264.
361. Torina, A., Alongi, A., Naranjo, V., Estrada-Pena, A., Vicente, J., Scimeca, S., et al. (2008a). Prevalence and genotypes of Anaplasma species and habitat suitability for ticks in a Mediterranean ecosystem. Appl. Environ. Microbiol. 74, 7578-7584. doi: 10.1128/AEM.01625-08
362. Torina, A., Alongi, A., Naranjo, V., Scimeca, S., Nicosia, S., Di Marco, V., et al. (2008b). Characterization of Anaplasma infections in Sicily, Italy. Ann. N.Y. Acad. Sci. 1149, 90-93. doi: 10.1196/annals.1428.065
363. Torina, A., Galindo, R. C., Vicente, J., Di Marco, V., Russo, M., Aronica, V., et al. (2010). Characterization of Anaplasma phagocytophilum and A. ovis infection in a naturally infected sheep flock with poor health condition. Trop. Anim. Health Prod. 42, 1327-1331. doi: 10.1007/s11250-010-9580-8
364. Troese, M. J., Kahlon, A., Ragland, S. A., Ottens, A. K., Ojogun, N., Nelson, K. T., et al. (2011). Proteomic analysis of Anaplasma phagocytophilum during infection of human myeloid cells identifies a protein that is pronouncedly upregulated on the infectious dense-cored cell. Infect. Immun. 79, 4696-4707. doi: 10.1128/IAI.05658-11
365. Tuomi, J. (1967a). Experimental studies on bovine tick-borne fever. 1. Clinical and haematological data, some properties of the causative agent, and homologous immunity. Acta Pathol. Microbiol. Scand. 70, 429-445. doi: 10.1111/j.1699-0463.1967.tb01311.x
366. Tuomi, J. (1967b). Experimental studies on bovine tick-borne fever. 2. Differences in virulence of strains in cattle and sheep. Acta Pathol. Microbiol. Scand. 70, 577-589. doi: 10.1111/j.1699-0463.1967.tb01327.x
367. Tuomi, J., and von Bonsdorff, C. H. (1966). Electron microscopy of tick-borne fever agent in bovine and ovine phagocytizing leukocytes. J. Bacteriol. 92, 1478-1492.
368. Tyzzer, E. E. (1938). Cytoecetes microti, n.g., n.sp., a parasite developing in granulocytes and infective for small rodents. Parasitology 30, 242-257. doi: 10.1017/S0031182000025774
369. Uehlinger, F. D., Clancey, N. P., and Lofstedt, J. (2011). Granulocytic anaplasmosis in a horse from Nova Scotia caused by infection with Anaplasma phagocytophilum. Can. Vet. J. 52, 537-540.
370. Vázquez, L., Panadero, R., Dacal, V., Pato, F. J., López, C., Díaz, P., et al. (2011). Tick infestation (Acari: Ixodidae) in roe deer (Capreolus capreolus) from northwestern Spain: population dynamics and risk stratification. Exp. Appl. Acarol. 53, 399-409.
371. Veronesi, F., Galuppi, R., Tampieri, M. P., Bonoli, C., Mammoli, R., and Piergili Fioretti, D. (2011). Prevalence of Anaplasma phagocytophilum in fallow deer (Dama dama) and feeding ticks from an Italy preserve. Res. Vet. Sci. 90, 40-43. doi: 10.1016/j.rvsc.2010.05.019
372. Vichová, B., Majlathová, V., Nováková, M., Straka, M., and Pet'ko, B. (2010). First molecular detection of Anaplasma phagocytophilum in European brown bear (Ursus arctos). Vector Borne Zoonotic Dis. 10, 543-545. doi: 10.1089/vbz.2009.0103
373. Villeneuve, A., Goring, J., Marcotte, L., and Overvelde, S. (2011). Seroprevalence of Borrelia burgdorferi, Anaplasma phagocytophilum, Ehrlichia canis, and Dirofilaria immitis among dogs in Canada. Can. Vet. J. 52, 527-530.
374. von Loewenich, F. D., Baumgarten, B. U., Schroppel, K., Geissdorfer, W., Rollinghoff, M., and Bogdan, C. (2003). High diversity of ankA sequences of Anaplasma phagocytophilum among Ixodes ricinus ticks in Germany. J. Clin. Microbiol. 41, 5033-5040. doi: 10.1128/JCM.41.11.5033-5040.2003
375. von Stedingk, L. V., Gurtelschmid, M., Hanson, H. S., Gustafson, R., Dotevall, L., Engvall, E. O., et al. (1997). The human granulocytic ehrlichiosis (HGE) agent in Swedish ticks. Clin. Microbiol. Infect. 3, 573-574. doi: 10.1111/j.1469-0691.1997.tb00311.x
376. Vor, T., Kiffner, C., Hagedorn, P., Niedrig, M., and Rühe, F. (2010). Tick burden on European roe deer (Capreolus capreolus). Exp. Appl. Acarol. 51, 405-417. doi: 10.1007/s10493-010-9337-0
377. Walk, S. T., Xu, G., Stull, J. W., and Rich, S. M. (2009). Correlation between tick density and pathogen endemicity, New Hampshire. Emerg. Infect. Dis. 15, 585-587. doi: 10.3201/eid1504.080940
378. Walker, A. R., Alberdi, M. P., Urquhart, K. A., and Rose, H. (2001). Risk factors in habitats of the tick Ixodes ricinus influencing human exposure to Ehrlichia phagocytophila bacteria. Med. Vet. Entomol. 15, 40-49. doi: 10.1046/j.1365-2915.2001.00271.x
379. Walls, J. J., Greig, B., Neitzel, D. F., and Dumler, J. S. (1997). Natural infection of small mammal species in Minnesota with the agent of human granulocytic ehrlichiosis. J. Clin. Microbiol. 35, 853-855.
380. Wang, X. Q., Kikuchi, T., and Rikihisa, Y. (2006). Two monoclonal antibodies with defined epitopes of P44 major surface proteins neutralize Anaplasma phagocytophilum by distinct mechanisms. Infect. Immun. 74, 1873-1882. doi: 10.1128/IAI.74.3.1873-1882.2006
381. Webster, K. A., and Mitchell, G. B. B. (1988). Use of counter immunoelectrophoresis in detection of antibodies to tickborne fever. Res. Vet. Sci. 45, 28-30.
382. Wicki, R., Sauter, P., Mettler, C., Natsch, A., Enzler, T., Pusterla, N., et al. (2000). Swiss Army Survey in Switzerland to determine the prevalence of Francisella tularensis, members of the Ehrlichia phagocytophila genogroup, Borrelia burgdorferi sensu lato, and tick-borne encephalitis virus in ticks. Eur. J. Clin. Microbiol. Infect. Dis. 19, 427-432. doi: 10.1007/s100960000283
383. Wielinga, P. R., Gaasenbeek, C., Fonville, M., de Boer, A., de Vries, A., Dimmers, W., et al. (2006). Longitudinal analysis of tick densities and Borrelia, Anaplasma, and Ehrlichia infections of Ixodes ricinus ticks in different habitat areas in The Netherlands. Appl. Environ. Microbiol. 72, 7594-7601. doi: 10.1128/AEM.01851-06
384. Willardsen, P. (2004). Anti-tick vaccines. Parasitology 129, S367-S387. doi: 10.1017/S0031182003004657
385. Wilson, M. L., Telford, S. R., Piesman, J., and Spielman, A. (1988). Reduced abundance of immature Ixodes dammini (Acari: Ixodidae) following elimination of deer. J. Med. Entomol. 25, 224-228.
386. Wójcik-Fatla, A., Szymañska, J., Wdowiak, L., Buczek, A., and Dutkiewicz, J. (2009). Coincidence of three pathogens (Borrelia burgdorferi sensu lato, Anaplasma phagocytophilum and Babesia microti) in Ixodes ricinus ticks in the Lublin macroregion. Ann. Agric. Environ. Med. 16, 151-158.
387. Woldehiwet, Z. (2007). "Tick-borne diseases," in Diseases of Sheep, 4th Edn. ed I. D. Aitken (Oxford: Blackwell publishing), 347-355.
388. Woldehiwet, Z. (2010). The natural history of Anaplasma phagocytophilum. Vet. Parasitol. 167, 108-122. doi: 10.1016/j.vetpar.2009.09.013
389. Woldehiwet, Z., Horrocks, B. K., Scaife, H., Ross, G., Munderloh, U. G., Bown, K., et al. (2002). Cultivation of an ovine strain of Ehrlichia phagocytophila in tick cell cultures. J. Comp. Pathol. 127, 142-149. doi: 10.1053/jcpa.2002.0574
390. Woldehiwet, Z., and Scott, G. R. (1993). "Tick-borne (pasture) fever," in Rickettsial and Chlamydial Diseases of Domestic Animals, eds Z. Woldehiwet and M. Ristic (Oxford: Pergamon Press), 233-254.
391. Woldehiwet, Z., and Yavari, C. (2012). Evaluation of an indirect enzyme-linked immunosorbent assay (ELISA) for the detection of antibodies against Anaplasma phagocytophilum in sheep. J. Comp. Pathol. 146, 116-121. doi: 10.1016/j.jcpa.2011.04.004
392. Wuritu, Ozawa, Y. Gaowa, Kawamori, F., Masuda, T., Masuzawa, T., et al. (2009). Structural analysis of a p44/msp2 expression site of Anaplasma phagocytophilum in naturally infected ticks in Japan. J. Med. Microbiol. 58, 1638-1644. doi: 10.1099/jmm.0.011775-0
393. Xiong, Q. M., Wang, X. Q., and Rikihisa, Y. (2007). High-cholesterol diet facilitates Anaplasma phagocytophilum infection and up-regulates macrophage inflammatory protein-2 and CXCR2 expression in apolipoprotein E-deficient mice. J. Infect. Dis. 195, 1497-1503. doi: 10.1086/514819
394. Yabsley, M. J., Murphy, S. M., Luttrell, M. P., Little, S. E., Massung, R. F., Stallknecht, D. E., et al. (2008). Experimental and field studies on the suitability of raccoons (Procyon lotor) as hosts for tick-borne pathogens. Vector Borne Zoonotic Dis. 8, 491-503. doi: 10.1089/vbz.2007.0240
395. Yago, T., Leppanen, A., Carlyon, J. A., Akkoyunlu, M., Karmakar, S., Fikrig, E., et al. (2003). Structurally distinct requirements for binding of P-selectin glycoprotein ligand-1 and sialyl Lewis x to Anaplasma phagocytophilum and P-selectin. J. Biol. Chem. 278, 37987-37997. doi: 10.1074/jbc.M305778200
396. Yang, J., Liu, Z., Guan, G., Liu, Q., Li, Y., Chen, Z., et al. (2013). Prevalence of Anaplasma phagocytophilum in ruminants, rodents and ticks in Gansu, north-western China. J. Med. Microbiol. 62, 254-258. doi: 10.1099/jmm.0.046771-0
397. Yaxue, Z., Hongtao, J., Qiuyue, W., Zhixin, F., Hongwei, G., Pengpeng, L., et al. (2011). Molecular detection of Anaplasma phagocytophilum in Ixodid ticks in Hebei Province, China. Vector Borne Zoonotic Dis. 11, 1323-1327. doi: 10.1089/vbz.2010.0253
398. Ybañez, A. P., Matsumoto, K., Kishimoto, T., Yokoyama, N., and Inokuma, H. (2012). Dual presence of Anaplasma phagocytophilum and its closely related Anaplasma sp. in ixodid ticks in Hokkaido, Japan, and their specific molecular detection. J. Vet. Med. Sci. 74, 1551-1560.
399. Ybañez, A. P., Tagawa, M., Matsumoto, K., Kishimoto, T., Yokoyama, N., and Inokuma, H. (2013). Specific molecular detection of Anaplasma sp. closely related to Anaplasma phagocytophilum in Ixodid ticks and cattle in a pastureland in Hokkaido, Japan. Vector Borne Zoonotic Dis. 13, 6-11.
400. Yoshiie, K., Kim, H. Y., Mott, J., and Rikihisa, Y. (2000). Intracellular infection by the human granulocytic ehrlichiosis agent inhibits human neutrophil apoptosis. Infect. Immun. 68, 1125-1133. doi: 10.1128/IAI.68.3.1125-1133.2000
401. Yoshimoto, K., Matsuyama, Y., Matsuda, H., Sakamoto, L., Matsumoto, K., Yokoyama, N., et al. (2010). Detection of Anaplasma bovis and Anaplasma phagocytophilum DNA from Haemaphysalis megaspinosa in Hokkaido, Japan. Vet. Parasitol. 168, 170-172. doi: 10.1016/j.vetpar.2009.10.008
402. Zeidner, N. S., Burkot, T. R., Massung, R., Nicholson, W. L., Dolan, M. C., Rutherford, J. S., et al. (2000). Transmission of the agent of human granulocytic ehrlichiosis by Ixodes spinipalpis ticks: evidence of an enzootic cycle of dual infection with Borrelia burgdorferi in Northern Colorado. J. Infect. Dis. 182, 616-619. doi: 10.1086/315715
403. Zele, D., Avbersek, J., Gruntar, I., Ocepek, M., and Vengust, G. (2012). Evidence of Anaplasma phagocytophilum in game animals from Slovenia. Acta Vet. Hung. 60, 441-448. doi: 10.1556/AVet.2012.038
404. Zeman, P., and Pecha, M. (2008). Segregation of genetic variants of Anaplasma phagocytophilum circulating among wild ruminants within a Bohemian forest (Czech Republic). Int. J. Med. Microbiol. 298, 203-210. doi: 10.1016/j.ijmm.2008.03.003
405. Zhan, L., Cao, W. C., Chu, C. Y., Jiang, B. G., Zhang, F., Liu, W., et al. (2009a). Tick-borne agents in rodents, China, 2004-2006. Emerg. Infect. Dis. 15, 1904-1908. doi: 10.3201/eid1512.081141
406. Zhan, L., Chu, C. Y., Zuo, S. Q., Wu, X. M., Dumler, J. S., Jia, N., et al. (2009b). Anaplasma phagocytophilum and Borrelia burgdorferi in rabbits from southeastern China. Vet. Parasitol. 162, 354-356. doi: 10.1016/j.vetpar.2009.03.003
407. Zhan, L., Cao, W. C., de Vlas, S., Xie, S. Y., Zhang, P. H., Wu, X. M., et al. (2008). A newly discovered Anaplasma phagocytophilum variant in rodents from southeastern China. Vector Borne Zoonotic Dis. 8, 369-380. doi: 10.1089/vbz.2007.0211
408. Zhan, L., Cao, W. C., Jiang, J. F., Zhang, X. A., Wu, X. M., Zhang, W. Y., et al. (2010). Anaplasma phagocytophilum in livestock and small rodents. Vet. Microbiol. 144, 405-408. doi: 10.1016/j.vetmic.2010.02.018
409. Zhang, L., Liu, H., Xu, B., Lu, Q., Li, L., Chang, L., et al. (2012a). Anaplasma phagocytophilum infection in domestic animals in ten provinces/cities of China. Am. J. Trop. Med. Hyg. 87, 185-189. doi: 10.4269/ajtmh.2012.12-0005
410. Zhang, X. C., Zhang, L. X., Li, W. H., Wang, S. W., Sun, Y. L., Wang, Y. Y., et al. (2012b). Ehrlichiosis and zoonotic anaplasmosis in suburban areas of Beijing, China. Vector Borne Zoonotic Dis. 12, 932-937. doi: 10.1089/vbz.2012.0961
411. Zhang, L., Wang, G., Liu, Q., Chen, C., Li, J., Long, B., et al. (2013). Molecular Analysis of Anaplasma phagocytophilum isolated from patients with febrile diseases of unknown etiology in china. PLoS ONE 8:e57155. doi: 10.1371/journal.pone.0057155
412. Zygner, W., Górski, P., and Wedrychowicz, H. (2009). Detection of the DNA of Borrelia afzelii, Anaplasma phagocytophilum and Babesia canis in blood samples from dogs in Warsaw. Vet. Rec. 164, 465-467. doi: 10.1136/vr.164.15.465