Receptor interacting protein-2 contributes to host defense against Anaplasma phagocytophilum infection

FEMS Immunology and Medical Microbiology

Volumn 66, Issue 2, 2012, Pages 211-219

  Sukumaran, Bindu ^a   Ogura, Yasunori ^a,b   Pedra, Joao H F ^a,c   Kobayashi, Koichi S ^a,d   Flavell, Richard A ^a   Fikrig, Erol ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NARA WOMEN'S UNIVERSITY   (Japan)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Anaplasma phagocytophilum; IFN ; NLR; Rip2

Indexed keywords

ADAPTOR PROTEIN; CASPASE RECRUITMENT DOMAIN PROTEIN 4; CXCL1 CHEMOKINE; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 18; MACROPHAGE INFLAMMATORY PROTEIN 2; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR; RECEPTOR INTERACTING PROTEIN 2; UNCLASSIFIED DRUG;

ANAPLASMA PHAGOCYTOPHILUM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL CLEARANCE; BACTERIAL LOAD; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; FEMALE; HOST RESISTANCE; HUMAN; HUMAN CELL; HUMAN GRANULOCYTIC ANAPLASMOSIS; IMMUNE RESPONSE; MALE; MOUSE; NEUTROPHIL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN FUNCTION; SPLEEN CELL; TRANSCRIPTION REGULATION; UPREGULATION;

ANAPLASMA PHAGOCYTOPHILUM; ANIMALS; BACTERIAL LOAD; CYTOKINES; DISEASE MODELS, ANIMAL; EHRLICHIOSIS; FEMALE; HOST-PATHOGEN INTERACTIONS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASES;

EID: 84867734932     PISSN: 09288244     EISSN: 1574695X     Source Type: Journal    
DOI: 10.1111/j.1574-695X.2012.01001.x     Document Type: Article

References (44)

1. Akkoyunlu M & Fikrig E (2000) Gamma interferon dominates the murine cytokine response to the agent of human granulocytic ehrlichiosis and helps to control the degree of early rickettsemia. Infect Immun 68: 1827-1833.
2. Akkoyunlu M, Malawista SE, Anguita J & Fikrig E (2001) Exploitation of interleukin-8-induced neutrophil chemotaxis by the agent of human granulocytic ehrlichiosis. Infect Immun 69: 5577-5588.
3. Archer KA, Ader F, Kobayashi KS, Flavell RA & Roy CR (2010) Cooperation between multiple microbial pattern recognition systems is important for host protection against the intracellular pathogen Legionella pneumophila. Infect Immun 78: 2477-2487.
4. Bakken JS & Dumler JS (2000) Human granulocytic ehrlichiosis. Clinical Infectious Diseases : an official publication of the Infectious Diseases Society of America 31: 554-560.
5. Balamayooran T, Batra S, Balamayooran G, Cai S, Kobayashi KS, Flavell RA & Jeyaseelan S (2011) Receptor-interacting protein 2 controls pulmonary host defense to Escherichia coli infection via the regulation of interleukin-17A. Infect Immun 79: 4588-4599.
6. Banerjee R, Anguita J & Fikrig E (2000) Granulocytic ehrlichiosis in mice deficient in phagocyte oxidase or inducible nitric oxide synthase. Infect Immun 68: 4361-4362.
7. Benko S, Philpott DJ & Girardin SE (2008) The microbial and danger signals that activate Nod-like receptors. Cytokine 43: 368-373.
8. Birkner K, Steiner B, Rinkler C, Kern Y, Aichele P, Bogdan C & von Loewenich FD (2008) The elimination of Anaplasma phagocytophilum requires CD4+ T cells, but is independent of Th1 cytokines and a wide spectrum of effector mechanisms. Eur J Immunol 38: 3395-3410.
9. Borjesson DL & Barthold SW (2002) The mouse as a model for investigation of human granulocytic ehrlichiosis: current knowledge and future directions. Comp Med 52: 403-413.
10. Buchholz KR & Stephens RS (2006) Activation of the host cell proinflammatory interleukin-8 response by Chlamydia trachomatis. Cell Microbiol 8: 1768-1779.
11. Buchholz KR & Stephens RS (2008) The cytosolic pattern recognition receptor NOD1 induces inflammatory interleukin-8 during Chlamydia trachomatis infection. Infect Immun 76: 3150-3155.
12. Bunnell JE, Trigiani ER, Srinivas SR & Dumler JS (1999) Development and distribution of pathologic lesions are related to immune status and tissue deposition of human granulocytic ehrlichiosis agent-infected cells in a murine model system. J Infect Dis 180: 546-550.
13. Carlyon JA & Fikrig E (2003) Invasion and survival strategies of Anaplasma phagocytophilum. Cell Microbiol 5: 743-754.
14. Carlyon JA, Abdel-Latif D, Pypaert M, Lacy P & Fikrig E (2004) Anaplasma phagocytophilum utilizes multiple host evasion mechanisms to thwart NADPH oxidase-mediated killing during neutrophil infection. Infect Immun 72: 4772-4783.
15. Chen GY & Nunez G (2010) Sterile inflammation: sensing and reacting to damage. Nat Rev Immunol 10: 826-837.
16. Chin AI, Dempsey PW, Bruhn K, Miller JF, Xu Y & Cheng G (2002) Involvement of receptor-interacting protein 2 in innate and adaptive immune responses. Nature 416: 190-194.
17. Choi KS, Webb T, Oelke M, Scorpio DG & Dumler JS (2007) Differential innate immune cell activation and proinflammatory response in Anaplasma phagocytophilum infection. Infect Immun 75: 3124-3130.
18. Dumler JS, Trigiani ER, Bakken JS, Aguero-Rosenfeld ME & Wormser GP (2000) Serum cytokine responses during acute human granulocytic ehrlichiosis. Clin Diagn Lab Immunol 7: 6-8.
19. Dumler JS, Choi KS, Garcia-Garcia JC, Barat NS, Scorpio DG, Garyu JW, Grab DJ, Bakken JS (2005) Human granulocytic anaplasmosis and Anaplasma phagocytophilum. Emerg Infect Dis 11: 1828-1834.
20. Dunning Hotopp JC, Lin M, Madupu R et al. (2006) Comparative genomics of emerging human ehrlichiosis agents. PLoS Genet 2: e21.
21. Franchi L, Warner N, Viani K & Nunez G (2009) Function of Nod-like receptors in microbial recognition and host defense. Immunol Rev 227: 106-128.
22. Hodzic E, Ijdo JW, Feng S et al. (1998) Granulocytic ehrlichiosis in the laboratory mouse. J Infect Dis 177: 737-745.
23. Inohara N & Nunez G (2003) NODs: intracellular proteins involved in inflammation and apoptosis. Nat Rev Immunol 3: 371-382.
24. Keestra AM, Winter MG, Klein-Douwel D et al. (2011) A Salmonella virulence factor activates the NOD1/NOD2 signaling pathway. mBio 2(6): e00266-11.
25. Kobayashi K, Inohara N, Hernandez LD et al. (2002) RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems. Nature 416: 194-199.
26. Kobayashi KS, Chamaillard M, Ogura Y, Henegariu O, Inohara N, Nunez G & Flavell RA (2005) Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science 307: 731-734.
27. Lepidi H, Bunnell JE, Martin ME, Madigan JE, Stuen S & Dumler JS (2000) Comparative pathology, and immunohistology associated with clinical illness after Ehrlichia phagocytophila-group infections. The American journal of tropical medicine and hygiene 62: 29-37.
28. Magalhaes JG, Lee J, Geddes K, Rubino S, Philpott DJ & Girardin SE (2011) Essential role of Rip2 in the modulation of innate and adaptive immunity triggered by Nod1 and Nod2 ligands. Eur J Immunol 41: 1445-1455.
29. Martin ME, Bunnell JE & Dumler JS (2000) Pathology, immunohistology, and cytokine responses in early phases of human granulocytic ehrlichiosis in a murine model. J Infect Dis 181: 374-378.
30. Pan Q, Mathison J, Fearns C et al. (2007) MDP-induced interleukin-1beta processing requires Nod2 and CIAS1/NALP3. J Leukoc Biol 82: 177-183.
31. Pedra JH, Sutterwala FS, Sukumaran B et al. (2007a) ASC/PYCARD and caspase-1 regulate the IL-18/IFN-gamma axis during Anaplasma phagocytophilum infection. Journal of immunology 179: 4783-4791.
32. Pedra JH, Tao J, Sutterwala FS et al. (2007b) IL-12/23p40-dependent clearance of Anaplasma phagocytophilum in the murine model of human anaplasmosis. FEMS Immunol Med Microbiol 50: 401-410.
33. Pedra JH, Mattner J, Tao J et al. (2008) c-Jun NH2-terminal kinase 2 inhibits gamma interferon production during Anaplasma phagocytophilum infection. Infect Immun 76: 308-316.
34. Petrilli V, Dostert C, Muruve DA & Tschopp J (2007) The inflammasome: a danger sensing complex triggering innate immunity. Curr Opin Immunol 19: 615-622.
35. Rikihisa Y, Lin M & Niu H (2010) Type IV secretion in the obligatory intracellular bacterium Anaplasma phagocytophilum. Cell Microbiol 12: 1213-1221.
36. Sarkar A, Duncan M, Hart J, Hertlein E, Guttridge DC & Wewers MD (2006) ASC directs NF-kappaB activation by regulating receptor interacting protein-2 (RIP2) caspase-1 interactions. Journal of immunology 176: 4979-4986.
37. Scorpio DG, Akkoyunlu M, Fikrig E & Dumler JS (2004) CXCR2 blockade influences Anaplasma phagocytophilum propagation but not histopathology in the mouse model of human granulocytic anaplasmosis. Clin Diagn Lab Immunol 11: 963-968.
38. Shimada K, Chen S, Dempsey PW et al. (2009) The NOD/RIP2 pathway is essential for host defenses against Chlamydophila pneumoniae lung infection. PLoS Pathog 5: e1000379.
39. Sukumaran B, Carlyon JA, Cai JL, Berliner N & Fikrig E (2005) Early transcriptional response of human neutrophils to Anaplasma phagocytophilum infection. Infect Immun 73: 8089-8099.
40. Sun W, JW IJ, Telford SR 3rd, Hodzic E, Zhang Y, Barthold SW & Fikrig E (1997) Immunization against the agent of human granulocytic ehrlichiosis in a murine model. J Clin Investig 100: 3014-3018.
41. Telford SR 3rd, Dawson JE, Katavolos P, Warner CK, Kolbert CP & Persing DH (1996) Perpetuation of the agent of human granulocytic ehrlichiosis in a deer tick-rodent cycle. Proc Nat Acad Sci USA 93: 6209-6214.
42. von Loewenich FD, Scorpio DG, Reischl U, Dumler JS & Bogdan C (2004) Frontline: control of Anaplasma phagocytophilum, an obligate intracellular pathogen, in the absence of inducible nitric oxide synthase, phagocyte NADPH oxidase, tumor necrosis factor, Toll-like receptor (TLR)2 and TLR4, or the TLR adaptor molecule MyD88. Eur J Immunol 34: 1789-1797.
43. Wang T, Akkoyunlu M, Banerjee R & Fikrig E (2004) Interferon-gamma deficiency reveals that 129Sv mice are inherently more susceptible to Anaplasma phagocytophilum than C57BL/6 mice. FEMS Immunol Med Microbiol 42: 299-305.
44. Yanai H, Ban T, Wang Z et al. (2009) HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses. Nature 462: 99-103.