New findings on anaplasmosis caused by infection with Anaplasma phagocytophilum

Annals of the New York Academy of Sciences

Volumn 1081, Issue , 2006, Pages 360-370

  Lillini, Eugenio ^a   Macrì, Gladia ^a   Proietti, Gabriella ^a   Scarpulla, Manuela ^a  

^a ISTITUTO ZOOPROFILATTICO SPERIMENTALE DELLE REGIONI LAZIO E TOSCANA   (Italy)

Author keywords

Anaplasma phagocytophilum; Anaplasmosis; Dog; Horse; Human; Sheep

Indexed keywords

BACTERIUM ANTIBODY; EHRLICHIA DNA; UNCLASSIFIED DRUG;

ANAPLASMA PHAGOCYTOPHILUM; ANAPLASMOSIS; ANTIBODY DETECTION; CONFERENCE PAPER; DOG; EHRLICHIA CANIS; GRANULOCYTIC EHRLICHIOSIS; HIGH RISK PATIENT; HORSE; HUMAN; IXODES RICINUS; NONHUMAN; PET ANIMAL; POLYMERASE CHAIN REACTION; SEROLOGY; SHEEP; SYMPTOM; TICK BORNE DISEASE;

ACARI; ANAPLASMA PHAGOCYTOPHILUM; ANIMALIA; CANIS FAMILIARIS; EHRLICHIA; EQUIDAE; EQUUS CABALLUS; IXODES RICINUS; IXODIDA; OVIS ARIES;

EID: 33845767346     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1373.053     Document Type: Conference Paper

References (66)

1. DUMLER, J.S., A.F. BARBET, C.P. BEKKER, et al. 2001. Reorganization of genera in the families Rickettsiaceae and Anaplasmataceae in the order Rickettsiales: unification of some species of Ehrlichia with Anaplasma, Cowdria with Ehrlichia and Ehrlichia with Neorickettsia, descriptions of six new species combinations and designation of Ehrlichia equi and 'HGE agent' as subjective synonyms of Ehrlichia phagocytophila. Int. J. Syst. Evol. Microbiol. 51(Pt 6): 2145-2165.
2. MADIGAN, J.E. & N. PUSTERLA. 2000. Ehrlichial diseases. Vet. Clin. North Am. Equine Pract. 16: 487-499.
3. REUBEL, G.H. et al. 1998. Experimental transmission of Ehrlichia equi to horses through naturally infected ticks (Ixodes pacificus) from northern California. J. Clin. Microbiol. 36: 2131-2134.
4. MUNDERLOH, U.G. et al. 1996. Isolation of the equine granulocytic ehrlichiosis agent, Ehrlichia equi, in tick cell culture. J. Clin. Microbiol. 34: 664-670.
5. MADIGAN, J.E. 1993. Equine ehrlichoisis. Vet. Clin. North Am. Equine Pract. 9: 423-428.
6. LIN, M. & Y. RIKIHISA. 2003. Ehrlichia, chaffeensis and Anaplasma phagocytophilum lack genes for lipid A biosynthesis and incorporate cholesterol for their survival. Infect. Immun. 71: 5324-5331.
7. LIN M. Y. RIKIHISA. 2003. Obligatory intracellular parasitism by Ehrlichia chaffeensis and Anaplasma phagocytophilum involves caveolae and glycosyl-phosphatidyilinositol-anchored proteins. Cell. Microbiol. 5: 809-820.
8. MOTT, J., Y. RIKIHISA & S. TSUNAWAKI. 2002. Effect of Anaplasma phagocytophila on NADPH oxidase components in human neutrophils and HL-60 cells. Infect. Immun. 70: 1359-1366.
9. LIN, Q., Y. RIKIHISA, N. OHASHI & N. ZHI. 2003. Mechanism of variable p44 expression by Anaplasma phacytophilum. Infect. Immun. 71: 5650-5661.
10. FAVIA, G., G. CANCRINI, A. CARFI', et al. 2001. Molecular identification of Borrelia valaisiana and HGE-like Ehrlichia in Ixodes ricinus ticks sampled in north-east Italy: first report in Veneto region. Parassitologia 43: 143-146.
11. STRLE, F. 2004. Human granulocytic ehrlichiosis in Europe. Int. J. Med. Microbiol. 293(Suppl 37): 27-35.
12. SIXL, W. et al. 2003. Investigation of Anaplasma phagocytophila infections in Ixodes ricinus and Dermacentor reticulatus ticks in Austria. Ann. N. Y. Acad. Sci. 990: 94-97.
13. GRZESZCZUK, A. et al. 2004. Human anaplasmosis in north-eastern Poland: seroprevalence in humans and prevalence in Ixodes ricinus ticks. Ann. Agric. Environ. Med. 11: 99-103.
14. SPITALSKA, E. & E. KOCIANOVA. 2003. Tick-borne microorganisms in southwestern Slovakia. Ann. N. Y. Acad. Sci. 990: 196-200.
15. CHRISTOVA, I. et al. 2001. High prevalence of granulocytic Ehrlichiae and Borrelia burgdorferi sensu lato in Ixodes ricinus ticks from Bulgaria. J. Clin. Microbiol. 39: 4172-4174.
16. PETROVEC, M., J.W. SUMNER, W.L. NICHOLSON, et al. 1999. Identity of ehrlichial DNA sequences derived from Ixodes ricinus ticks with those obtained from patients with human granulocytic ehrlichiosis in Slovenia. J. Clin. Microbiol. 37: 209-210.
17. VON LOEWENICH, F. D. et al. 2003. High diversity of ankA sequences of Anaplasma phagocytophilum among Ixodes ricinus ticks in Germany. J. Clin. Microbiol. 41: 5033-5040.
18. LIZ, G. et al. 2000. PCR detection of granulocytic ehrlichiae in Ixodes ricinus ticks and wild small mammals in western Switzerland. J. Clin. Microbiol. 38: 1002-1007.
19. SRETER, T. et al. 2004. Anaplasma phagocytophilum: an emerging tick-borne pathogen in Hungary and Central Eastern Europe. Ann. Trop. Med. Parasitol. 98: 401-405.
20. SANTOS, A.S. et al. 2004. Detection of Anaplasma phagocytophilum DNA in Ixodes ticks (Acari: Ixodidae) from Madeira Island and Setubal District, mainland Portugal. Emerg. Infect. Dis. 10: 1643-1648.
21. PETROVEC, M., S. LOTRIC FURLAN, T.A. ZUPANAC, et al. 1997. Human disease in Europe caused by a granulocitic Ehrlichia species. J. Clin.Microbiol. 35: 1556-1559.
22. LOTRIC-FURLAN, S. et al. 1998. Human ehrlichiosis in Central Europe. Wien Klin Wochenschr. 110: 894-897.
23. LOTRIC-FURLAN, S. et al. 2001. Prospective assessment of the etiology of acute febrile illness after a tick bite in Slovenia. Clin. Infect. Dis. 33: 503-510.
24. LOTRIC-FURLAN, S. et al. 2003. Human granulocytic ehrlichiosis in Slovenia. Ann. N. Y. Acad. Sci. 990: 279-284.
25. KARLSSON, U. et al. 2001. Human granulocytic ehrlichosis - a clinical case in Scandinavia. Scand. J. Infect. Dis. 33: 73-74.
26. VAN DOBBENBURGH, A et al. 1999. Human granulocytic ehrlichiosis in western Europe. N. Engl. J. Med. 340: 1214-1216.
27. KRISTIANSEN, B.E. et al. 2001. Human granulocytic ehrlichiosis in Norway. Tidsskr Nor Laegeforen. 121: 805-806.
28. TYLEWSKA-WIERZBANOWSKA, S., T. CHMIELEWSKI, M. KONDRUSIK, et al. 2001. First cases of acute human granulocytic ehrlichiosis in Poland. Eur. J. Clin. Microbiol. Infect. Dis. 20: 196-198.
29. OTEO, J.A., J.R. BLANCO, V. MARTINEZ DE ARTOLA & V. IBARRA. 2000. First report of human granulocytic ehrlichiosis from southern Europe (Spain). Emerg. Infect. Dis. 6: 430-432.
30. WALDER, G., B. FALKENSAMMER, J. AIGNER, et al. 2003. First documented case of human granulocytic ehrlichiosis in Austria. Wien Klin Wochenschr. 115: 263-266.
31. PRUKK, T., K. AINSALU, E. LAJA & A. AIGRO. 2003. Human granulocytic ehrlichiosis in Estonia. Emerg. Infect. Dis. 9: 1499-1500.
32. REMY, V., Y. HANSMANN, S. DE MARTINO, et al. 2003. Human anaplasmosis presenting as atypical pneumonias in France. Clin. Infect. Dis. 37: 846-848.
33. RUSCIO, M. & M. CINCO. 2003. Human granulocytic ehrlichiosis in Italy: first report on two confirmed cases. Ann. N. Y. Acad. Sci. 990: 350-352.
34. NUTI, M., F. RUSSINO, D. GRAZIOLI, et al. 1996. Anticorpi anti-Ehrlichia in soggetti a rischio di zone pedemontane del Veneto. Microbiologia Medica. 11: 492-495.
35. KORBUTIAK, E. & D.H. SNEIDERS. 1994. First confirmed case of equine ehrlichiosis in Great Britain. Equine Vet. Edu. 6: 303-304.
36. SHAW, S. et al. 2001. Equine granulocytic ehrlichiosis in the UK. Vet. Rec. 28: 127-128.
37. MADIGAN, J.E. & N. PUSTERLA. 2000. Ehrlichial diseases. Vet. Clin. North Am. Equine Pract. 16: 487-499.
38. BJOERSDORFF, A. 1990. Ehrlichia equi infection diagnosed in horses. Svensk Vet. Tid. 42: 357-360.
39. BJOERSDORFF, A., B. BAGERT, R.F. MASSUNG, et al. 2002. Isolation and characterization of two European strains of Ehrlichia phagocytophila of equine origin. Clin. Diagn. Lab. Immunol. 9: 341-343.
40. BUSCHER, G., R. GRANDRAS, G. APEL, K.T. FRIEDHOFF. 1984 Der erste Fall von Ehrlichiosis beim Pferd in Deutschland. Dtsch tierarztl.Wschr. 91: 408-409.
41. DAVOUST, B. et al. 1999. Survey of horses from southeast France for antibodies reactives with the agent of human granulocytic ehrlichiosis. International Conference on Rickettsiae and Rickettsiology 14th Sesquiannual Joint Meeting, 12-16 June 1999(Marseille).
42. BERMANN, F. et al. 2002. Ehrlichia equi (Anaplasma phagocytophila) infection in an adult horse in France. Vet. Rec. 150: 787-788.
43. HERMANN, M. 1985. Colitis X in the horse: 9 cases. Schweiz Arch Tierheilkd. 127: 385-396.
44. VON LOEWENICH, F.D., G. STUMPF, B.U. BAUMGARTEN, et al. 2003. Human granulocytic ehrlichiosis in Germany: evidence from serological studies, tick analyses, and a case of equine ehrlichiosis. Ann. N. Y. Acad. Sci. 990: 116-117.
45. VON LOEWENICH, F.D., G. STUMPF, B.U. BAUMGARTEN, et al. 2003. A case of equine granulocytic ehrlichiosis provides molecular evidence for the presence of pathogenic Anaplasma phagocytophilum (HGE agent) in Germany. Eur. J. Clin. Microbiol. Infect. Dis. 22: 303-305.
46. SCARPULLA, M., M.E. CARISTO, G. MACRì & E. LILLINI. 2003. Equine ehrlichiosis in Italy. Ann. N. Y. Acad. Sci. 990: 259-263.
47. CUBEDDU, G.M. et al. 2001. Equine ehrlichiosis in Asmara's Island - Clinical signs. In Proceeding of "7th World Congress of World Equine Veterinary Association." 5-7 October 2001. Sorrento (Naples) - Italy. Ed.: 317.
48. GARCIA-PEREZ, A.L., J. BARANDIKA, B. OPORTO, et al. 2003. Anaplasma phagocytophila as an abortifacient agent in sheep farms from northern Spain. Ann. N. Y. Acad. Sci. 990: 429-432.
49. JUSTE, R.A., A.L. GARCIA-PEREZ & I. POVEDANO-FERNANDEZ. 1986. Estudio experimental de algunos agentes patogenos transimitdos por garrapatas (Babesia, Theileria, Cytoecetes y Anaplasma) en ovejas del Pais Vasco. Med. Vet. 3: 431-439.
50. STUEN, S., S. NEVLAND & T. MOUM. 2003. Fatal cases of tick-borne fever (TBF) in sheep caused by several 16 S rRNA gene variants of Anaplasma phagocytophilum. Ann. N. Y. Acad. Sci. 990: 433-434.
51. WOLDEHIWET, Z., B.K. HORROCKS, H. SCAIFE, et al. 2002. Cultivation of an ovine strain of Ehrlichia phagocytophila in tick cell cultures. J. Comp. Pathol. 127: 142-149.
52. BREITSCHWERDT, E.B. 2000. The rickettsioses. In Ettinger S.J., E.C. Feldman. Eds.: 400-408. Textbook of Veterinary Internal Medicine. W.B. Saunders. Philadelphia.
53. PUSTERLA, N., J.B. PUSTERLA, P. DEPLAZES, et al. 1998. Seroprevalence of Ehrlichia canis and of canine granulocytic Ehrlichia infection in dogs in Switzerland. J. Clin. Microbiol. 36: 3460-3462.
54. SKOTARCZAK, M., M. ADAMSKA & M. SUPRON. 2004. Blood DNA analysis for Ehrlichia (Anaplasma) phagocytophila and Babesia spp of dogs from Northern Poland. Acta Vet. Brno. 73: 347-351.
55. STADTBAUMER, K., M.W. LESCHNIK & B. NELL. 2004. Tick-borne encephalitis virus as a possible cause of optic neuritis in a dog. Vet. Ophthalmol. 7: 271-277.
56. TOZON, N., M. PETROVEC & T. AVSIC-ZUPANC. 2003. Clinical and laboratory features of the first detected cases of A. phagocytophila infections in dogs from Slovenia. Ann. N. Y. Acad. Sci. 990: 424-428.
57. MANNA, L., A. ALBERTI, L.M. PAVONE, et al. 2004. First molecular characterization of a granulocytic Ehrlichia strain isolated from a dog in South Italy. Vet. J. 167: 224-227.
58. GRAVINO, A.E., D. DE CAPRARIIS, L. MANNA, et al. 1997. Preliminary report of infection in dogs related to Ehrlichia equi: description of three cases. New Microbiol. 20: 361-363.
59. EGENVALL, A.E., A.A. HEDHAMMAR & A.I. BJOERSDORFF. 1997. Clinical features and serology of 14 dogs affected by granulocytic ehrlichiosis in Sweden. Vet. Rec. 140: 222-226.
60. MYLONAKIS, M.E., A.F. KOUTINAS, G. BANETH, et al. 2004. Mixed Ehrlichia canis, Hepatozoon canis, and presumptive Anaplasma phagocytophilum infection in a dog. Vet. Clin. Pathol. 33: 249-251.
61. JOHANSSON, K.E., B. PETTERSSON, M. UHLEN, et al. 1995. Identification of the causative agent of granulocytic ehrlichiosis in Swedish dogs and horses by direct solid phase sequencing of PCR products from the 16 S rRNA gene. Res Vet Sci. 58: 109-112.
62. DUMLER, J.S., K.M. ASANOVICH, J.S. BAKKEN, et al. 1995. Serologic cross-reactions among Ehrlichia equi, Ehrlichia phagocytophila and human granulocytic Ehrlichia. J. Clin. Microbiol. 33: 1098-1103.
63. NICHOLSON, W.L., J.A. COMER, J.W. SUMMER, et al. 1997. An indirect immunofluorescence assay using a cell culture-derived antigen for detection of antibodies to the agent of human granulocytic ehrlichiosis. J. Clin. Microbiol. 35: 1510-1516.
64. WANER, T., S. HARRUS, F. JONGEJAN, et al. 2001. Significance of serological testing for ehrlichial disease in dogs with special emphasis on diagnosis of canine monocytic ehrlichiosis caused by Ehrlichia canis. Vet. Parass. 95: 1-15.
65. LIZ, J.S., L. ANDERES, J.W. SUMNER, et al. 2000. PCR detection of granulocytic ehrlichiae in Ixodes ricinus ticks and small mammals in western Switzerland. J. Clin. Microbiol. 38: 1002-1007.
66. WANER, T., G. BANETH, C. STRENGER, et al. 1999. Antibodies reactive with Ehrlichia canis, Ehrlichia phagocytophila genogroup antigens and the spotted fever group rickettsial antigens, in free-ranging jackals (Canis aureus syriacus) from Israel. Vet. Parasitol. 82: 121-128.