메뉴 건너뛰기




Volumn 2, Issue FEB, 2011, Pages

Global proteomic analysis of two tick-borne emerging zoonotic agents: Anaplasma phagocytophilum and Ehrlichia chaffeensis

Author keywords

Anaplasma phagocytophilum; Ehrlichia chaffeensis; Human granulocytic anaplasmosis; Human leukocytes; Human monocytic ehrlichiosis; Proteomic analysis

Indexed keywords


EID: 79960140462     PISSN: None     EISSN: 1664302X     Source Type: Journal    
DOI: 10.3389/fmicb.2011.00024     Document Type: Article
Times cited : (58)

References (90)
  • 2
    • 58149490639 scopus 로고    scopus 로고
    • Four VirB6 paralogs and VirB9 are expressed and interact in Ehrlichia chaffeensis-containing vacuoles
    • Bao, W., Kumagai, Y., Niu, H., Yamaguchi, M., Miura, K., and Rikihisa, Y. (2009). Four VirB6 paralogs and VirB9 are expressed and interact in Ehrlichia chaffeensis-containing vacuoles. J. Bacteriol. 191, 278-286.
    • (2009) J. Bacteriol. , vol.191 , pp. 278-286
    • Bao, W.1    Kumagai, Y.2    Niu, H.3    Yamaguchi, M.4    Miura, K.5    Rikihisa, Y.6
  • 3
    • 0032900986 scopus 로고    scopus 로고
    • Ehrlichia chaffeensis and E. sennetsu, but not the human granulocytic ehrlichiosis agent, colocalize with transferrin receptor and up-regulate transferrin receptor mRNA by activating iron-responsive protein 1
    • Barnewall, R. E., Ohashi, N., and Rikihisa, Y. (1999). Ehrlichia chaffeensis and E. sennetsu, but not the human granulocytic ehrlichiosis agent, colocalize with transferrin receptor and up-regulate transferrin receptor mRNA by activating iron-responsive protein 1. Infect. Immun. 67, 2258-2265.
    • (1999) Infect. Immun. , vol.67 , pp. 2258-2265
    • Barnewall, R.E.1    Ohashi, N.2    Rikihisa, Y.3
  • 5
    • 18744367006 scopus 로고    scopus 로고
    • Insights into pathogen immune evasion mechanisms: Anaplasma phagocytophilum fails to induce an apoptosis differentiation program in human neutrophils
    • Borjesson, D. L., Kobayashi, S. D., Whitney, A. R., Voyich, J. M., Argue, C. M., and Deleo, F. R. (2005). Insights into pathogen immune evasion mechanisms: Anaplasma phagocytophilum fails to induce an apoptosis differentiation program in human neutrophils. J. Immunol. 174, 6364-6372.
    • (2005) J. Immunol. , vol.174 , pp. 6364-6372
    • Borjesson, D.L.1    Kobayashi, S.D.2    Whitney, A.R.3    Voyich, J.M.4    Argue, C.M.5    Deleo, F.R.6
  • 6
    • 4544321685 scopus 로고    scopus 로고
    • Phages and the evolution of bacterial pathogens: From genomic rearrangements to lysogenic conversion
    • Brussow, H., Canchaya, C., and Hardt, W. D. (2004). Phages and the evolution of bacterial pathogens: from genomic rearrangements to lysogenic conversion. Microbiol. Mol. Biol. Rev. 68, 560-602.
    • (2004) Microbiol. Mol. Biol. Rev. , vol.68 , pp. 560-602
    • Brussow, H.1    Canchaya, C.2    Hardt, W.D.3
  • 8
    • 3342959166 scopus 로고    scopus 로고
    • Anaplasma phagocytophilum utilizes multiple host evasion mechanisms to thwart NADPH oxidase-mediated killing during neutrophil infection
    • Carlyon, J. A., Abdel-Latif, D., Pypaert, M., Lacy, P., and Fikrig, E. (2004). Anaplasma phagocytophilum utilizes multiple host evasion mechanisms to thwart NADPH oxidase-mediated killing during neutrophil infection. Infect. Immun. 72, 4772-4783.
    • (2004) Infect. Immun. , vol.72 , pp. 4772-4783
    • Carlyon, J.A.1    Abdel-Latif, D.2    Pypaert, M.3    Lacy, P.4    Fikrig, E.5
  • 9
    • 0142217173 scopus 로고    scopus 로고
    • Invasion and survival strategies of Anaplasma phagocytophilum
    • Carlyon, J. A., and Fikrig, E. (2003). Invasion and survival strategies of Anaplasma phagocytophilum. Cell. Microbiol. 5, 743-754.
    • (2003) Cell. Microbiol. , vol.5 , pp. 743-754
    • Carlyon, J.A.1    Fikrig, E.2
  • 10
    • 33644836708 scopus 로고    scopus 로고
    • Mechanisms of evasion of neutrophil killing by Anaplasma phagocytophilum
    • Carlyon, J. A., and Fikrig, E. (2006). Mechanisms of evasion of neutrophil killing by Anaplasma phagocytophilum. Curr. Opin. Hematol. 13, 28-33.
    • (2006) Curr. Opin. Hematol. , vol.13 , pp. 28-33
    • Carlyon, J.A.1    Fikrig, E.2
  • 11
    • 0033850294 scopus 로고    scopus 로고
    • ankA: an Ehrlichia phagocytophila group gene encoding a cytoplasmic protein antigen with ankyrin repeats
    • Caturegli, P., Asanovich, K. M., Walls, J. J., Bakken, J. S., Madigan, J. E., Popov, V. L., and Dumler, J. S. (2000). ankA: an Ehrlichia phagocytophila group gene encoding a cytoplasmic protein antigen with ankyrin repeats. Infect. Immun. 68, 5277-5283.
    • (2000) Infect. Immun. , vol.68 , pp. 5277-5283
    • Caturegli, P.1    Asanovich, K.M.2    Walls, J.J.3    Bakken, J.S.4    Madigan, J.E.5    Popov, V.L.6    Dumler, J.S.7
  • 12
    • 0028047345 scopus 로고
    • Identification of a granulocytotropic Ehrlichia species as the etiologic agent of human disease
    • Chen, S. M., Dumler, J. S., Bakken, J. S., and Walker, D. H. (1994). Identification of a granulocytotropic Ehrlichia species as the etiologic agent of human disease. J. Clin. Microbiol. 32, 589-595.
    • (1994) J. Clin. Microbiol. , vol.32 , pp. 589-595
    • Chen, S.M.1    Dumler, J.S.2    Bakken, J.S.3    Walker, D.H.4
  • 13
    • 33745771590 scopus 로고    scopus 로고
    • Intra-leukocyte expression of two-component systems in Ehrlichia chaffeensis and Anaplasma phagocytophilum and effects of the histidine kinase inhibitor closantel
    • Cheng, Z., Kumagai, Y., Lin, M., Zhang, C., and Rikihisa, Y. (2006). Intra-leukocyte expression of two-component systems in Ehrlichia chaffeensis and Anaplasma phagocytophilum and effects of the histidine kinase inhibitor closantel. Cell. Microbiol. 8, 1241-1252.
    • (2006) Cell. Microbiol. , vol.8 , pp. 1241-1252
    • Cheng, Z.1    Kumagai, Y.2    Lin, M.3    Zhang, C.4    Rikihisa, Y.5
  • 14
    • 40449139085 scopus 로고    scopus 로고
    • Regulation of type IV secretion apparatus genes during Ehrlichia chaffeensis intracellular development by a previously unidentified protein
    • Cheng, Z., Wang, X., and Rikihisa, Y. (2008). Regulation of type IV secretion apparatus genes during Ehrlichia chaffeensis intracellular development by a previously unidentified protein. J. Bacteriol. 190, 2096-2105.
    • (2008) J. Bacteriol. , vol.190 , pp. 2096-2105
    • Cheng, Z.1    Wang, X.2    Rikihisa, Y.3
  • 15
    • 34848903282 scopus 로고    scopus 로고
    • Intracellular pathogens go extreme: Genome evolution in the Rickettsiales
    • Darby, A. C., Cho, N. H., Fuxelius, H. H., Westberg, J., and Andersson, S. G. (2007). Intracellular pathogens go extreme: genome evolution in the Rickettsiales. Trends Genet. 23, 511-520.
    • (2007) Trends Genet , vol.23 , pp. 511-520
    • Darby, A.C.1    Cho, N.H.2    Fuxelius, H.H.3    Westberg, J.4    Andersson, S.G.5
  • 17
    • 15944425755 scopus 로고    scopus 로고
    • Gene expression profiling of human promyelocytic cells in response to infection with Anaplasma phagocytophilum
    • De la Fuente, J., Ayoubi, P., Blouin, E. F., Almazan, C., Naranjo, V., and Kocan, K. M. (2005). Gene expression profiling of human promyelocytic cells in response to infection with Anaplasma phagocytophilum. Cell. Microbiol. 7, 549-559.
    • (2005) Cell. Microbiol. , vol.7 , pp. 549-559
    • De la Fuente, J.1    Ayoubi, P.2    Blouin, E.F.3    Almazan, C.4    Naranjo, V.5    Kocan, K.M.6
  • 18
    • 0035192367 scopus 로고    scopus 로고
    • Reorganization of genera in the families Rickettsiaceae and Anaplasmataceae in the order Rickettsiales: unification of some species of Ehrlichia with Anaplasma, Cowdria with Ehrlichia and Ehrlichia with Neorickettsia, descriptions of six new species combinations and designation of Ehrlichia equi and "HGE agent" as subjective synonyms of Ehrlichia phagocytophila
    • Dumler, J. S., Barbet, A. F., Bekker, C. P., Dasch, G. A., Palmer, G. H., Ray, S. C., Rikihisa, Y., and Rurangirwa, F. R. (2001). Reorganization of genera in the families Rickettsiaceae and Anaplasmataceae in the order Rickettsiales: unification of some species of Ehrlichia with Anaplasma, Cowdria with Ehrlichia and Ehrlichia with Neorickettsia, descriptions of six new species combinations and designation of Ehrlichia equi and "HGE agent" as subjective synonyms of Ehrlichia phagocytophila. Int. J. Syst. Evol. Microbiol. 51, 2145-2165.
    • (2001) Int. J. Syst. Evol. Microbiol. , vol.51 , pp. 2145-2165
    • Dumler, J.S.1    Barbet, A.F.2    Bekker, C.P.3    Dasch, G.A.4    Palmer, G.H.5    Ray, S.C.6    Rikihisa, Y.7    Rurangirwa, F.R.8
  • 20
    • 0000857494 scopus 로고
    • An approach to correlate tandem mass-spectral data of peptides with amino-acid-sequences in a protein database
    • Eng, J. K., Mccormack, A. L., and Yates, J. R. (1994). An approach to correlate tandem mass-spectral data of peptides with amino-acid-sequences in a protein database. J. Am. Soc. Mass Spectrom. 5, 976-989.
    • (1994) J. Am. Soc. Mass Spectrom. , vol.5 , pp. 976-989
    • Eng, J.K.1    Mccormack, A.L.2    Yates, J.R.3
  • 22
    • 0345490693 scopus 로고    scopus 로고
    • On dynamics of overlapping genes in bacterial genomes
    • Fukuda, Y., Nakayama, Y., and Tomita, M. (2003). On dynamics of overlapping genes in bacterial genomes. Gene 323, 181-187.
    • (2003) Gene , vol.323 , pp. 181-187
    • Fukuda, Y.1    Nakayama, Y.2    Tomita, M.3
  • 24
    • 67650886021 scopus 로고    scopus 로고
    • Epigenetic silencing of host cell defense genes enhances intracellular survival of the rickettsial pathogen Anaplasma phagocytophilum
    • doi: 10.1371/journal.ppat.1000488
    • Garcia-Garcia, J. C., Barat, N. C., Trembley, S. J., and Dumler, J. S. (2009). Epigenetic silencing of host cell defense genes enhances intracellular survival of the rickettsial pathogen Anaplasma phagocytophilum. PLoS Pathog. 5, e1000488. doi: 10.1371/ journal.ppat.1000488
    • (2009) PLoS Pathog , vol.5
    • Garcia-Garcia, J.C.1    Barat, N.C.2    Trembley, S.J.3    Dumler, J.S.4
  • 25
    • 0038649210 scopus 로고    scopus 로고
    • National surveillance for the human ehrlichioses in the United States, 1997-2001, and proposed methods for evaluation of data quality
    • Gardner, S. L., Holman, R. C., Krebs, J. W., Berkelman, R., and Childs, J. E. (2003). National surveillance for the human ehrlichioses in the United States, 1997-2001, and proposed methods for evaluation of data quality. Ann. N. Y. Acad. Sci. 990, 80-89.
    • (2003) Ann. N. Y. Acad. Sci. , vol.990 , pp. 80-89
    • Gardner, S.L.1    Holman, R.C.2    Krebs, J.W.3    Berkelman, R.4    Childs, J.E.5
  • 26
    • 35648974248 scopus 로고    scopus 로고
    • Identification of novel surface proteins of Anaplasma phagocytophilum by affinity purification and proteomics
    • Ge, Y., and Rikihisa, Y. (2007a). Identification of novel surface proteins of Anaplasma phagocytophilum by affinity purification and proteomics. J. Bacteriol. 189, 7819-7828.
    • (2007) J. Bacteriol. , vol.189 , pp. 7819-7828
    • Ge, Y.1    Rikihisa, Y.2
  • 27
    • 34547640142 scopus 로고    scopus 로고
    • Surfaceexposed proteins of Ehrlichia chaffeensis
    • Ge, Y., and Rikihisa, Y. (2007b). Surfaceexposed proteins of Ehrlichia chaffeensis. Infect. Immun. 75, 3833-3841.
    • (2007) Infect. Immun. , vol.75 , pp. 3833-3841
    • Ge, Y.1    Rikihisa, Y.2
  • 30
    • 77955427023 scopus 로고    scopus 로고
    • The Anaplasma phagocytophilum-occupied vacuole selectively recruits Rab-GTPases that are predominantly associated with recycling endosomes
    • Huang, B., Hubber, A., McDonough, J. A., Roy, C. R., Scidmore, M. A., and Carlyon, J. A. (2010a). The Anaplasma phagocytophilum-occupied vacuole selectively recruits Rab-GTPases that are predominantly associated with recycling endosomes. Cell. Microbiol. 12, 1292-1307.
    • (2010) Cell. Microbiol , vol.12 , pp. 1292-1307
    • Huang, B.1    Hubber, A.2    McDonough, J.A.3    Roy, C.R.4    Scidmore, M.A.5    Carlyon, J.A.6
  • 31
    • 77955427703 scopus 로고    scopus 로고
    • Anaplasma phagocytophilum APH_0032 is expressed late during infection and localizes to the pathogen-occupied vacuolar membrane
    • Huang, B., Troese, M. J., Howe, D., Ye, S., Sims, J. T., Heinzen, R. A., Borjesson, D. L., and Carlyon, J. A. (2010b). Anaplasma phagocytophilum APH_0032 is expressed late during infection and localizes to the pathogen-occupied vacuolar membrane. Microb. Pathog. 49, 273-284.
    • (2010) Microb. Pathog. , vol.49 , pp. 273-284
    • Huang, B.1    Troese, M.J.2    Howe, D.3    Ye, S.4    Sims, J.T.5    Heinzen, R.A.6    Borjesson, D.L.7    Carlyon, J.A.8
  • 32
    • 77951215124 scopus 로고    scopus 로고
    • Anaplasma phagocytophilum APH_1387 is expressed throughout bacterial intracellular development and localizes to the pathogen-occupied vacuolar membrane
    • Huang, B., Troese, M. J., Ye, S., Sims, J. T., Galloway, N. L., Borjesson, D. L., and Carlyon, J. A. (2010c). Anaplasma phagocytophilum APH_1387 is expressed throughout bacterial intracellular development and localizes to the pathogen-occupied vacuolar membrane. Infect. Immun. 78, 1864-1873.
    • (2010) Infect. Immun. , vol.78 , pp. 1864-1873
    • Huang, B.1    Troese, M.J.2    Ye, S.3    Sims, J.T.4    Galloway, N.L.5    Borjesson, D.L.6    Carlyon, J.A.7
  • 33
    • 33947410383 scopus 로고    scopus 로고
    • Porin activity of Anaplasma phagocytophilum outer membrane fraction and purified P44
    • Huang, H., Wang, X., Kikuchi, T., Kumagai, Y., and Rikihisa, Y. (2007). Porin activity of Anaplasma phagocytophilum outer membrane fraction and purified P44. J. Bacteriol. 189, 1998-2006.
    • (2007) J. Bacteriol. , vol.189 , pp. 1998-2006
    • Huang, H.1    Wang, X.2    Kikuchi, T.3    Kumagai, Y.4    Rikihisa, Y.5
  • 34
    • 34147154867 scopus 로고    scopus 로고
    • Anaplasma phagocytophilum AnkA is tyrosine phosphorylated at EPIYA motifs and recruits SHP-1 during early infection
    • IJdo, J. W., Carlson, A. C., and Kennedy, E. L. (2007). Anaplasma phagocytophilum AnkA is tyrosine phosphorylated at EPIYA motifs and recruits SHP-1 during early infection. Cell. Microbiol. 9, 1284-1296.
    • (2007) Cell. Microbiol. , vol.9 , pp. 1284-1296
    • Ijdo, J.W.1    Carlson, A.C.2    Kennedy, E.L.3
  • 35
    • 23944445530 scopus 로고    scopus 로고
    • Disruption of rpmJ encoding ribosomal protein L36 decreases the expression of secY upstream of the spc operon and inhibits protein translocation in Escherichia coli
    • Ikegami, A., Nishiyama, K., Matsuyama, S., and Tokuda, H. (2005). Disruption of rpmJ encoding ribosomal protein L36 decreases the expression of secY upstream of the spc operon and inhibits protein translocation in Escherichia coli. Biosci. Biotechnol. Biochem. 69, 1595-1602.
    • (2005) Biosci. Biotechnol. Biochem. , vol.69 , pp. 1595-1602
    • Ikegami, A.1    Nishiyama, K.2    Matsuyama, S.3    Tokuda, H.4
  • 36
    • 33748045474 scopus 로고    scopus 로고
    • Biochemical activities of three pairs of Ehrlichia chaffeensis two-component regulatory system proteins involved in inhibition of lysosomal fusion
    • Kumagai, Y., Cheng, Z., Lin, M., and Rikihisa, Y. (2006). Biochemical activities of three pairs of Ehrlichia chaffeensis two-component regulatory system proteins involved in inhibition of lysosomal fusion. Infect. Immun. 74, 5014-5022.
    • (2006) Infect. Immun. , vol.74 , pp. 5014-5022
    • Kumagai, Y.1    Cheng, Z.2    Lin, M.3    Rikihisa, Y.4
  • 37
    • 47049114343 scopus 로고    scopus 로고
    • Expression and porin activity of P28 and OMP-1F during intracellular Ehrlichia chaffeensis development
    • Kumagai, Y., Huang, H., and Rikihisa, Y. (2008). Expression and porin activity of P28 and OMP-1F during intracellular Ehrlichia chaffeensis development. J. Bacteriol. 190, 3597-3605.
    • (2008) J. Bacteriol. , vol.190 , pp. 3597-3605
    • Kumagai, Y.1    Huang, H.2    Rikihisa, Y.3
  • 38
    • 33748876775 scopus 로고    scopus 로고
    • Anaplasma phagocytophilum causes global induction of antiapoptosis in human neutrophils
    • Lee, H. C., and Goodman, J. L. (2006). Anaplasma phagocytophilum causes global induction of antiapoptosis in human neutrophils. Genomics 88, 496-503.
    • (2006) Genomics , vol.88 , pp. 496-503
    • Lee, H.C.1    Goodman, J.L.2
  • 39
    • 49349091054 scopus 로고    scopus 로고
    • Anaplasma phagocytophilum-induced gene expression in both human neutrophils and HL-60 cells
    • Lee, H. C., Kioi, M., Han, J., Puri, R. K., and Goodman, J. L. (2008). Anaplasma phagocytophilum-induced gene expression in both human neutrophils and HL-60 cells. Genomics 92, 144-151.
    • (2008) Genomics , vol.92 , pp. 144-151
    • Lee, H.C.1    Kioi, M.2    Han, J.3    Puri, R.K.4    Goodman, J.L.5
  • 40
    • 77958474246 scopus 로고    scopus 로고
    • Proteomic analyses of a variety of intracellular bacterial species infecting different host cell lines
    • Li, Q., and Lostumbo, G. (2010). Proteomic analyses of a variety of intracellular bacterial species infecting different host cell lines. Curr. Proteomics 7, 222-232.
    • (2010) Curr. Proteomics , vol.7 , pp. 222-232
    • Li, Q.1    Lostumbo, G.2
  • 41
    • 34848862803 scopus 로고    scopus 로고
    • Anaplasma phagocytophilum AnkA secreted by type IV secretion system is tyrosine phosphorylated by Abl-1 to facilitate infection
    • Lin, M., Den Dulk-Ras, A., Hooykaas, P. J., and Rikihisa, Y. (2007). Anaplasma phagocytophilum AnkA secreted by type IV secretion system is tyrosine phosphorylated by Abl-1 to facilitate infection. Cell. Microbiol. 9, 2644-2657.
    • (2007) Cell. Microbiol. , vol.9 , pp. 2644-2657
    • Lin, M.1    Den Dulk-Ras, A.2    Hooykaas, P.J.3    Rikihisa, Y.4
  • 42
    • 1642473014 scopus 로고    scopus 로고
    • Ehrlichia chaffeensis downregulates surface Toll-like receptors 2/4, CD14 and transcription factors PU.1 and inhibits lipopolysaccharide activation of NF-kB
    • Lin, M., and Rikihisa, Y. (2004). Ehrlichia chaffeensis downregulates surface Toll-like receptors 2/4, CD14 and transcription factors PU.1 and inhibits lipopolysaccharide activation of NF-kB, ERK 1/2 and p38 MAPK in host monocytes. Cell. Microbiol. 6, 175-186.
    • (2004) ERK 1/2 and p38 MAPK in host monocytes. Cell. Microbiol. , vol.6 , pp. 175-186
    • Lin, M.1    Rikihisa, Y.2
  • 43
    • 70350653834 scopus 로고    scopus 로고
    • Analysis of complete genome sequence of Neorickettsia risticii: causative agent of Potomac horse fever
    • Lin, M., Zhang, C., Gibson, K., and Rikihisa, Y. (2009). Analysis of complete genome sequence of Neorickettsia risticii: causative agent of Potomac horse fever. Nucleic Acids Res. 37, 6076-6091.
    • (2009) Nucleic Acids Res , vol.37 , pp. 6076-6091
    • Lin, M.1    Zhang, C.2    Gibson, K.3    Rikihisa, Y.4
  • 44
    • 0036150092 scopus 로고    scopus 로고
    • Rapid activation of protein tyrosine kinase and phospholipase C-gamma2 and increase in cytosolic free calcium are required by Ehrlichia chaffeensis for internalization and growth in THP-1 cells
    • Lin, M., Zhu, M. X., and Rikihisa, Y. (2002). Rapid activation of protein tyrosine kinase and phospholipase C-gamma2 and increase in cytosolic free calcium are required by Ehrlichia chaffeensis for internalization and growth in THP-1 cells. Infect. Immun. 70, 889-898.
    • (2002) Infect. Immun. , vol.70 , pp. 889-898
    • Lin, M.1    Zhu, M.X.2    Rikihisa, Y.3
  • 45
    • 23444434654 scopus 로고    scopus 로고
    • Establishment of cloned Anaplasma phagocytophilum and analysis of p44 gene conversion within an infected horse and infected SCID mice
    • Lin, Q., and Rikihisa, Y. (2005). Establishment of cloned Anaplasma phagocytophilum and analysis of p44 gene conversion within an infected horse and infected SCID mice. Infect. Immun. 73, 5106-5114.
    • (2005) Infect. Immun. , vol.73 , pp. 5106-5114
    • Lin, Q.1    Rikihisa, Y.2
  • 46
    • 4644298611 scopus 로고    scopus 로고
    • Polymorphism and transcription at the p44-1/p44-18 genomic locus in Anaplasma phagocytophilum strains from diverse geographic regions
    • Lin, Q., Rikihisa, Y., Massung, R. F., Woldehiwet, Z., and Falco, R. C. (2004). Polymorphism and transcription at the p44-1/p44-18 genomic locus in Anaplasma phagocytophilum strains from diverse geographic regions. Infect. Immun. 72, 5574-5581.
    • (2004) Infect. Immun. , vol.72 , pp. 5574-5581
    • Lin, Q.1    Rikihisa, Y.2    Massung, R.F.3    Woldehiwet, Z.4    Falco, R.C.5
  • 47
    • 0141669063 scopus 로고    scopus 로고
    • Mechanisms of variable p44 expression by Anaplasma phagocytophilum
    • Lin, Q., Rikihisa, Y., Ohashi, N., and Zhi, N. (2003). Mechanisms of variable p44 expression by Anaplasma phagocytophilum. Infect. Immun. 71, 5650-5661.
    • (2003) Infect. Immun. , vol.71 , pp. 5650-5661
    • Lin, Q.1    Rikihisa, Y.2    Ohashi, N.3    Zhi, N.4
  • 48
    • 33645547831 scopus 로고    scopus 로고
    • Analysis of involvement of the RecF pathway in p44 recombination in Anaplasma phagocytophilum and in Escherichia coli by using a plasmid carrying the p44 expression and p44 donor loci
    • Lin, Q., Zhang, C., and Rikihisa, Y. (2006). Analysis of involvement of the RecF pathway in p44 recombination in Anaplasma phagocytophilum and in Escherichia coli by using a plasmid carrying the p44 expression and p44 donor loci. Infect. Immun. 74, 2052-2062.
    • (2006) Infect. Immun. , vol.74 , pp. 2052-2062
    • Lin, Q.1    Zhang, C.2    Rikihisa, Y.3
  • 49
    • 74549203487 scopus 로고    scopus 로고
    • Molecular characterization of antibody epitopes of Ehrlichia chaffeensis ankyrin protein 200 and tandem repeat protein 47 and evaluation of synthetic immunodeterminants for serodiagnosis of human monocytotropic ehrlichiosis
    • Luo, T., Zhang, X., Nicholson, W. L., Zhu, B., and McBride, J. W. (2010). Molecular characterization of antibody epitopes of Ehrlichia chaffeensis ankyrin protein 200 and tandem repeat protein 47 and evaluation of synthetic immunodeterminants for serodiagnosis of human monocytotropic ehrlichiosis. Clin. Vaccine Immunol. 17, 87-97.
    • (2010) Clin. Vaccine Immunol. , vol.17 , pp. 87-97
    • Luo, T.1    Zhang, X.2    Nicholson, W.L.3    Zhu, B.4    McBride, J.W.5
  • 52
    • 0033009747 scopus 로고    scopus 로고
    • Human granulocytic ehrlichiosis agent and Ehrlichia chaffeensis reside in different cytoplasmic compartments in HL-60 cells
    • Mott, J., Barnewall, R. E., and Rikihisa, Y. (1999). Human granulocytic ehrlichiosis agent and Ehrlichia chaffeensis reside in different cytoplasmic compartments in HL-60 cells. Infect. Immun. 67, 1368-1378.
    • (1999) Infect. Immun. , vol.67 , pp. 1368-1378
    • Mott, J.1    Barnewall, R.E.2    Rikihisa, Y.3
  • 54
    • 50849100137 scopus 로고    scopus 로고
    • Whole genome transcription profiling of Anaplasma phagocytophilum in human and tick host cells by tiling array analysis
    • doi: 10.1186/1471-2164-9-364
    • Nelson, C. M., Herron, M. J., Felsheim, R. F., Schloeder, B. R., Grindle, S. M., Chavez, A. O., Kurtti, T. J., and Munderloh, U. G. (2008). Whole genome transcription profiling of Anaplasma phagocytophilum in human and tick host cells by tiling array analysis. BMC Genomics 9, 364. doi: 10.1186/1471-2164-9-364
    • (2008) BMC Genomics , vol.9 , pp. 364
    • Nelson, C.M.1    Herron, M.J.2    Felsheim, R.F.3    Schloeder, B.R.4    Grindle, S.M.5    Chavez, A.O.6    Kurtti, T.J.7    Munderloh, U.G.8
  • 55
    • 0347479229 scopus 로고    scopus 로고
    • Molecular basis of bacterial outer membrane permeability revisited
    • Nikaido, H. (2003). Molecular basis of bacterial outer membrane permeability revisited. Microbiol. Mol. Biol. Rev. 67, 593-656.
    • (2003) Microbiol. Mol. Biol. Rev. , vol.67 , pp. 593-656
    • Nikaido, H.1
  • 56
    • 0021989093 scopus 로고
    • Molecular basis of bacterial outer membrane permeability
    • Nikaido, H., and Vaara, M. (1985). Molecular basis of bacterial outer membrane permeability. Microbiol. Rev. 49, 1-32.
    • (1985) Microbiol. Rev. , vol.49 , pp. 1-32
    • Nikaido, H.1    Vaara, M.2
  • 57
    • 77649251212 scopus 로고    scopus 로고
    • Anaplasma phagocytophilum Ats-1 is imported into host cell mitochondria and interferes with apoptosis induction
    • doi: 10.1371/journal. ppat.1000774
    • Niu, H., Kozjak-Pavlovic, V., Rudel, T., and Rikihisa, Y. (2010). Anaplasma phagocytophilum Ats-1 is imported into host cell mitochondria and interferes with apoptosis induction. PLoS Pathog. 6, e1000774. doi: 10.1371/journal. ppat.1000774
    • (2010) PLoS Pathog , vol.6
    • Niu, H.1    Kozjak-Pavlovic, V.2    Rudel, T.3    Rikihisa, Y.4
  • 58
    • 0036640957 scopus 로고    scopus 로고
    • Distinguishing the ORFs from the ELFs: short bacterial genes and the annotation of genomes
    • Ochman, H. (2002). Distinguishing the ORFs from the ELFs: short bacterial genes and the annotation of genomes. Trends Genet. 18, 335-337.
    • (2002) Trends Genet , vol.18 , pp. 335-337
    • Ochman, H.1
  • 59
    • 0031874241 scopus 로고    scopus 로고
    • Cloning and characterization of multigenes encoding the immunodominant 30-kilodalton major outer membrane proteins of Ehrlichia canis and application of the recombinant protein for serodiagnosis
    • Ohashi, N., Unver, A., Zhi, N., and Rikihisa, Y. (1998a). Cloning and characterization of multigenes encoding the immunodominant 30-kilodalton major outer membrane proteins of Ehrlichia canis and application of the recombinant protein for serodiagnosis. J. Clin. Microbiol. 36, 2671-2680.
    • (1998) J. Clin. Microbiol. , vol.36 , pp. 2671-2680
    • Ohashi, N.1    Unver, A.2    Zhi, N.3    Rikihisa, Y.4
  • 60
    • 0031976047 scopus 로고    scopus 로고
    • Immunodominant major outer membrane proteins of Ehrlichia chaffeensis are encoded by a polymorphic multigene family
    • Ohashi, N., Zhi, N., Zhang, Y., and Rikihisa, Y. (1998b). Immunodominant major outer membrane proteins of Ehrlichia chaffeensis are encoded by a polymorphic multigene family. Infect. Immun. 66, 132-139.
    • (1998) Infect. Immun. , vol.66 , pp. 132-139
    • Ohashi, N.1    Zhi, N.2    Zhang, Y.3    Rikihisa, Y.4
  • 61
    • 0036126936 scopus 로고    scopus 로고
    • Characterization and transcriptional analysis of gene clusters for a type IV secretion machinery in human granulocytic and monocytic ehrlichiosis agents
    • Ohashi, N., Zhi, N., Lin, Q., and Rikihisa, Y. (2002). Characterization and transcriptional analysis of gene clusters for a type IV secretion machinery in human granulocytic and monocytic ehrlichiosis agents. Infect. Immun. 70, 2128-2138.
    • (2002) Infect. Immun. , vol.70 , pp. 2128-2138
    • Ohashi, N.1    Zhi, N.2    Lin, Q.3    Rikihisa, Y.4
  • 63
    • 0037240533 scopus 로고    scopus 로고
    • Ehrlichia chaffeensis: A prototypical emerging pathogen
    • Paddock, C. D., and Childs, J. E. (2003). Ehrlichia chaffeensis: a prototypical emerging pathogen. Clin. Microbiol. Rev. 16, 37-64.
    • (2003) Clin. Microbiol. Rev. , vol.16 , pp. 37-64
    • Paddock, C.D.1    Childs, J.E.2
  • 64
    • 23344451806 scopus 로고    scopus 로고
    • Modulation of NB4 promyelocytic leukemic cell machinery by Anaplasma phagocytophilum
    • Pedra, J. H., Sukumaran, B., Carlyon, J. A., Berliner, N., and Fikrig, E. (2005). Modulation of NB4 promyelocytic leukemic cell machinery by Anaplasma phagocytophilum. Genomics 86, 365-377.
    • (2005) Genomics , vol.86 , pp. 365-377
    • Pedra, J.H.1    Sukumaran, B.2    Carlyon, J.A.3    Berliner, N.4    Fikrig, E.5
  • 65
    • 14844360847 scopus 로고    scopus 로고
    • Probability-based evaluation of peptide and protein identifications from tandem mass spectrometry and SEQUEST analysis: The human proteome
    • Qian, W. J., Liu, T., Monroe, M. E., Strittmatter, E. F., Jacobs, J. M., Kangas, L. J., Petritis, K., Camp, D. G. II, and Smith, R. D. (2005). Probability-based evaluation of peptide and protein identifications from tandem mass spectrometry and SEQUEST analysis: the human proteome. J. Proteome Res. 4, 53-62.
    • (2005) J. Proteome Res. , vol.4 , pp. 53-62
    • Qian, W.J.1    Liu, T.2    Monroe, M.E.3    Strittmatter, E.F.4    Jacobs, J.M.5    Kangas, L.J.6    Petritis, K.7    Camp II, D.G.8    Smith, R.D.9
  • 66
    • 0025777206 scopus 로고
    • The tribe Ehrlichieae and ehrlichial diseases
    • Rikihisa, Y. (1991). The tribe Ehrlichieae and ehrlichial diseases. Clin. Microbiol. Rev. 4, 286-308.
    • (1991) Clin. Microbiol. Rev. , vol.4 , pp. 286-308
    • Rikihisa, Y.1
  • 67
    • 77951097433 scopus 로고    scopus 로고
    • Anaplasma phagocytophilum and Ehrlichia chaffeensis: subversive manipulators of host cells
    • Rikihisa, Y. (2010a). Anaplasma phagocytophilum and Ehrlichia chaffeensis: subversive manipulators of host cells. Nat. Rev. Microbiol. 8, 328-339.
    • (2010) Nat. Rev. Microbiol. , vol.8 , pp. 328-339
    • Rikihisa, Y.1
  • 68
    • 74449083802 scopus 로고    scopus 로고
    • Molecular events involved in cellular invasion by Ehrlichia chaffeensis and Anaplasma phagocytophilum
    • Rikihisa, Y. (2010b). Molecular events involved in cellular invasion by Ehrlichia chaffeensis and Anaplasma phagocytophilum. Vet. Parasitol. 167, 155-166.
    • (2010) Vet. Parasitol. , vol.167 , pp. 155-166
    • Rikihisa, Y.1
  • 69
    • 0031015273 scopus 로고    scopus 로고
    • Ultrastructural and antigenic characterization of a granulocytic ehrlichiosis agent directly isolated and stably cultivated from a patient in New York state
    • Rikihisa, Y., Zhi, N., Wormser, G. P., Wen, B., Horowitz, H. W., and Hechemy, K. E. (1997). Ultrastructural and antigenic characterization of a granulocytic ehrlichiosis agent directly isolated and stably cultivated from a patient in New York state. J. Infect. Dis. 175, 210-213.
    • (1997) J. Infect. Dis. , vol.175 , pp. 210-213
    • Rikihisa, Y.1    Zhi, N.2    Wormser, G.P.3    Wen, B.4    Horowitz, H.W.5    Hechemy, K.E.6
  • 70
    • 55849087243 scopus 로고    scopus 로고
    • Total, membrane, and immunogenic proteomes of macrophageand tick cell-derived Ehrlichia chaffeensis evaluated by liquid chromatography-tandem mass spectrometry and MALDI-TOF methods
    • Seo, G. M., Cheng, C., Tomich, J., and Ganta, R. R. (2008). Total, membrane, and immunogenic proteomes of macrophageand tick cell-derived Ehrlichia chaffeensis evaluated by liquid chromatography-tandem mass spectrometry and MALDI-TOF methods. Infect. Immun. 76, 4823-4832.
    • (2008) Infect. Immun. , vol.76 , pp. 4823-4832
    • Seo, G.M.1    Cheng, C.2    Tomich, J.3    Ganta, R.R.4
  • 73
    • 11044231152 scopus 로고    scopus 로고
    • Ehrlichia chaffeensis expresses macrophageand tick cellspecific 28-kilodalton outer membrane proteins
    • Singu, V., Liu, H., Cheng, C., and Ganta, R. R. (2005). Ehrlichia chaffeensis expresses macrophageand tick cellspecific 28-kilodalton outer membrane proteins. Infect. Immun. 73, 79-87.
    • (2005) Infect. Immun. , vol.73 , pp. 79-87
    • Singu, V.1    Liu, H.2    Cheng, C.3    Ganta, R.R.4
  • 74
    • 0035424711 scopus 로고    scopus 로고
    • On the total number of genes and their length distribution in complete microbial genomes
    • Skovgaard, M., Jensen, L. J., Brunak, S., Ussery, D., and Krogh, A. (2001). On the total number of genes and their length distribution in complete microbial genomes. Trends Genet. 17, 425-428.
    • (2001) Trends Genet , vol.17 , pp. 425-428
    • Skovgaard, M.1    Jensen, L.J.2    Brunak, S.3    Ussery, D.4    Krogh, A.5
  • 76
    • 28444446702 scopus 로고    scopus 로고
    • Early transcriptional response of human neutrophils to Anaplasma phagocytophilum infection
    • Sukumaran, B., Carlyon, J. A., Cai, J. L., Berliner, N., and Fikrig, E. (2005). Early transcriptional response of human neutrophils to Anaplasma phagocytophilum infection. Infect. Immun. 73, 8089-8099.
    • (2005) Infect. Immun. , vol.73 , pp. 8089-8099
    • Sukumaran, B.1    Carlyon, J.A.2    Cai, J.L.3    Berliner, N.4    Fikrig, E.5
  • 78
    • 77955361364 scopus 로고    scopus 로고
    • Anaplasma phagocytophilum induces actin phosphorylation to selectively regulate gene transcription in Ixodes scapularis ticks
    • Sultana, H., Neelakanta, G., Kantor, F. S., Malawista, S. E., Fish, D., Montgomery, R. R., and Fikrig, E. (2010). Anaplasma phagocytophilum induces actin phosphorylation to selectively regulate gene transcription in Ixodes scapularis ticks. J. Exp. Med. 207, 1727-1743.
    • (2010) J. Exp. Med. , vol.207 , pp. 1727-1743
    • Sultana, H.1    Neelakanta, G.2    Kantor, F.S.3    Malawista, S.E.4    Fish, D.5    Montgomery, R.R.6    Fikrig, E.7
  • 79
    • 70350468702 scopus 로고    scopus 로고
    • Current management of human granulocytic anaplasmosis, human monocytic ehrlichiosis and Ehrlichia ewingii ehrlichiosis
    • Thomas, R. J., Dumler, J. S., and Carlyon, J. A. (2009). Current management of human granulocytic anaplasmosis, human monocytic ehrlichiosis and Ehrlichia ewingii ehrlichiosis. Expert Rev. Anti. Infect. Ther. 7, 709-722.
    • (2009) Expert Rev. Anti. Infect. Ther. , vol.7 , pp. 709-722
    • Thomas, R.J.1    Dumler, J.S.2    Carlyon, J.A.3
  • 80
    • 0036070770 scopus 로고    scopus 로고
    • The omp-1 major outer membrane multigene family of Ehrlichia chaffeensis is differentially expressed in canine and tick hosts
    • Unver, A., Rikihisa, Y., Stich, R. W., Ohashi, N., and Felek, S. (2002). The omp-1 major outer membrane multigene family of Ehrlichia chaffeensis is differentially expressed in canine and tick hosts. Infect. Immun. 70, 4701-4704.
    • (2002) Infect. Immun. , vol.70 , pp. 4701-4704
    • Unver, A.1    Rikihisa, Y.2    Stich, R.W.3    Ohashi, N.4    Felek, S.5
  • 81
    • 65449163095 scopus 로고    scopus 로고
    • An Ehrlichia chaffeensis tandem repeat protein interacts with multiple host targets involved in cell signaling, transcriptional regulation, and vesicle trafficking
    • Wakeel, A., Kuriakose, J. A., and McBride, J. W. (2009). An Ehrlichia chaffeensis tandem repeat protein interacts with multiple host targets involved in cell signaling, transcriptional regulation, and vesicle trafficking. Infect. Immun. 77, 1734-1745.
    • (2009) Infect. Immun , vol.77 , pp. 1734-1745
    • Wakeel, A.1    Kuriakose, J.A.2    McBride, J.W.3
  • 82
    • 77949723101 scopus 로고    scopus 로고
    • Mass spectrometric analysis of Ehrlichia chaffeensis tandem repeat proteins reveals evidence of phosphorylation and absence of glycosylation
    • doi: 10.1371/journal.pone.0009552
    • Wakeel, A., Zhang, X., and McBride, J. W. (2010). Mass spectrometric analysis of Ehrlichia chaffeensis tandem repeat proteins reveals evidence of phosphorylation and absence of glycosylation. PLoS ONE 5, e9552. doi: 10.1371/journal.pone.0009552
    • (2010) PLoS ONE , vol.5
    • Wakeel, A.1    Zhang, X.2    McBride, J.W.3
  • 83
    • 36749006069 scopus 로고    scopus 로고
    • Anaplasma phagocytophilum p44 mRNA expression is differentially regulated in mammalian and tick host cells: Involvement of the DNA binding protein ApxR
    • Wang, X., Cheng, Z., Zhang, C., Kikuchi, T., and Rikihisa, Y. (2007). Anaplasma phagocytophilum p44 mRNA expression is differentially regulated in mammalian and tick host cells: involvement of the DNA binding protein ApxR. J. Bacteriol. 189, 8651-8659.
    • (2007) J. Bacteriol. , vol.189 , pp. 8651-8659
    • Wang, X.1    Cheng, Z.2    Zhang, C.3    Kikuchi, T.4    Rikihisa, Y.5
  • 84
    • 9344261822 scopus 로고    scopus 로고
    • Rapid sequential changeover of expressed p44 genes during the acute phase of Anaplasma phagocytophilum infection in horses
    • Wang, X., Rikihisa, Y., Lai, T. H., Kumagai, Y., Zhi, N., and Reed, S. M. (2004). Rapid sequential changeover of expressed p44 genes during the acute phase of Anaplasma phagocytophilum infection in horses. Infect. Immun. 72, 6852-6859.
    • (2004) Infect. Immun. , vol.72 , pp. 6852-6859
    • Wang, X.1    Rikihisa, Y.2    Lai, T.H.3    Kumagai, Y.4    Zhi, N.5    Reed, S.M.6
  • 85
    • 0035106351 scopus 로고    scopus 로고
    • Large-scale analysis of the yeast proteome by multidimensional protein identification technology
    • Washburn, M. P., Wolters, D., and Yates, J. R. III. (2001). Large-scale analysis of the yeast proteome by multidimensional protein identification technology. Nat. Biotechnol. 19, 242-247.
    • (2001) Nat. Biotechnol. , vol.19 , pp. 242-247
    • Washburn, M.P.1    Wolters, D.2    Yates III, J.R.3
  • 86
    • 3342964429 scopus 로고    scopus 로고
    • Expression of members of the 28-kilodalton major outer membrane protein family of Ehrlichia chaffeensis during persistent infection
    • Zhang, J. Z., Guo, H., Winslow, G. M., and Yu, X. J. (2004). Expression of members of the 28-kilodalton major outer membrane protein family of Ehrlichia chaffeensis during persistent infection. Infect. Immun. 72, 4336-4343.
    • (2004) Infect. Immun. , vol.72 , pp. 4336-4343
    • Zhang, J.Z.1    Guo, H.2    Winslow, G.M.3    Yu, X.J.4
  • 87
    • 0036175313 scopus 로고    scopus 로고
    • Transcript heterogeneity of the p44 multigene family in a human granulocytic ehrlichiosis agent transmitted by ticks
    • Zhi, N., Ohashi, N., Tajima, T., Mott, J., Stich, R. W., Grover, D., Telford, S. R. III, Lin, Q., and Rikihisa, Y. (2002). Transcript heterogeneity of the p44 multigene family in a human granulocytic ehrlichiosis agent transmitted by ticks. Infect. Immun. 70, 1175-1184.
    • (2002) Infect. Immun. , vol.70 , pp. 1175-1184
    • Zhi, N.1    Ohashi, N.2    Tajima, T.3    Mott, J.4    Stich, R.W.5    Grover, D.6    Telford III, S.R.7    Lin, Q.8    Rikihisa, Y.9
  • 88
    • 70349417835 scopus 로고    scopus 로고
    • Nuclear translocated Ehrlichia chaffeensis ankyrin protein interacts with the mid a-stretch of host promoter and intronic Alu elements
    • Zhu, B., Nethery, K. A., Kuriakose, J. A., Wakeel, A., Zhang, X., and McBride, J. W. (2009). Nuclear translocated Ehrlichia chaffeensis ankyrin protein interacts with the mid a-stretch of host promoter and intronic Alu elements. Infect. Immun. 77, 4243-4255.
    • (2009) Infect. Immun. , vol.77 , pp. 4243-4255
    • Zhu, B.1    Nethery, K.A.2    Kuriakose, J.A.3    Wakeel, A.4    Zhang, X.5    McBride, J.W.6
  • 89
    • 10344264978 scopus 로고    scopus 로고
    • Metabolic interdependence of obligate intracellular bacteria and their insect hosts
    • Zientz, E., Dandekar, T., and Gross, R. (2004). Metabolic interdependence of obligate intracellular bacteria and their insect hosts. Microbiol. Mol. Biol. Rev. 68, 745-770.
    • (2004) Microbiol. Mol. Biol. Rev. , vol.68 , pp. 745-770
    • Zientz, E.1    Dandekar, T.2    Gross, R.3
  • 90
    • 33646264529 scopus 로고    scopus 로고
    • Advances in proteomics data analysis and display using an accurate mass and time tag approach
    • Zimmer, J. S., Monroe, M. E., Qian, W. J., and Smith, R. D. (2006). Advances in proteomics data analysis and display using an accurate mass and time tag approach. Mass Spectrom. Rev. 25, 450-482.
    • (2006) Mass Spectrom. Rev. , vol.25 , pp. 450-482
    • Zimmer, J.S.1    Monroe, M.E.2    Qian, W.J.3    Smith, R.D.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.