Clinical diagnosis and treatment of human granulocytotropic anaplasmosis

Annals of the New York Academy of Sciences

Volumn 1078, Issue , 2006, Pages 236-247

  Bakken, Johan S ^a,b,d   Dumler, J Stephen ^c  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b St Luke's Hospital of Duluth   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d St Luke's Infectious Disease Associates   (United States)

Author keywords

Doxycycline; Human granulocytotropic anaplasmosis; Rifampicin; Tick borne infections; Zoonosis

Indexed keywords

AMINOTRANSFERASE; ANTIBIOTIC AGENT; BACTERIUM ANTIBODY; C REACTIVE PROTEIN; DOXYCYCLINE HYCLATE; LEVOFLOXACIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT; RIFAMPICIN; TETRACYCLINE; TETRACYCLINE DERIVATIVE; TROVAFLOXACIN;

ACUTE DISEASE; AMINOTRANSFERASE BLOOD LEVEL; ANALYTICAL PARAMETERS; ANAPLASMA PHAGOCYTOPHILUM; ANAPLASMOSIS; ANTIBIOTIC THERAPY; ANTIBODY DETECTION; BACTERIUM IDENTIFICATION; BLOOD ANALYSIS; BORRELIA BURGDORFERI; CLINICAL FEATURE; CONFERENCE PAPER; CONVALESCENCE; CYTOPLASM; DELAYED DIAGNOSIS; DISEASE COURSE; DISEASE DURATION; DISEASE MARKER; ENDEMIC DISEASE; EPIDEMIOLOGICAL DATA; ERYTHROCYTE SEDIMENTATION RATE; FEVER; FLU LIKE SYNDROME; FLUORESCENT ANTIBODY TECHNIQUE; GRANULOCYTE; GRANULOCYTOSIS; HEADACHE; HUMAN; HUMAN GRANULOCYTOTROPIC ANAPLASMOSIS; IMMUNE DEFICIENCY; IMMUNOCOMPROMISED PATIENT; INCIDENCE; IXODES PERSULCATUS; LABORATORY TEST; LEUKOCYTE COUNT; LYME DISEASE; LYMPHOCYTOPENIA; MYALGIA; NONHUMAN; PARASITE VECTOR; PERIPHERAL LYMPHOCYTE; POLYMERASE CHAIN REACTION; RASH; RECOMMENDED DRUG DOSE; RIGOR; SEROCONVERSION; SEROEPIDEMIOLOGY; SEX DIFFERENCE; SEX RATIO; SKIN MANIFESTATION; THROMBOCYTE COUNT; TICK BITE; TICK BORNE DISEASE;

ACARI; ANAPLASMA; ANAPLASMA PHAGOCYTOPHILUM; ARTHROPODA; BORRELIA BURGDORFERI; EHRLICHIA; IXODES PERSULCATUS; IXODIDA; MAMMALIA; RICKETTSIACEAE;

EID: 33845739682     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1374.042     Document Type: Conference Paper

References (61)

1. DUMLER, J.S., A.F. BARBET, C.P. BEKKER, et al. 2001. Reorganization of genera in the families Rickettsiaceae and Anaplasmataceae in the order Rickettsiales: unification of some species of Ehrlichia with Anaplasma, Cowdria with Ehrlichia and Ehrlichia with Neorickettsia, descriptions of six new species combinations and designation of Ehrlichia equi and 'HGE agent' as subjective synonyms of Ehrlichia phagocytophila. Int. J. Syst. Evol. Microbiol. 51: 2145-2165.
2. ANONYMOUS. 2002. International Classification of Diseases. The World Wide Web 9th Revision, Clinical Modification[6th]. PMIC, Los Angeles, CA. [electronic citation].
3. BAKKEN, J.S., J.S. DUMLER, S.M. CHEN, et al. 1994. Human granulocytic ehrlichiosis in the upper Midwest United States: a new species emerging? JAMA 272: 212-218.
4. DUMLER, J.S., K.M. ASANOVICH, J.S. BAKKEN, et al. 1995. Serologic cross-reactions among Ehrlichia equi, Ehrlichia phagocytophila, and human granulocytic ehrlichia. J. Clin. Microbiol. 33: 1098-1103.
5. AGUERO-ROSENFELD, M.E., H.W. HOROWITZ, G.P. WORMSER, et al. 1996. Human granulocytic ehrlichiosis: a case series from a medical center in New York State. Ann. Intern. Med. 125: 904-908.
6. BAKKEN, J.S. & J.S. DUMLER. 1996. Human granulocytic ehrlichiosis in the United States. Infect. Med. October: 877-912.
7. ANDERSON, J.F. 2002. The natural history of ticks. Med. Clin. North Am. 86: 205-218.
8. BAKKEN, J.S. & J.S. DUMLER. 2000. Human granulocytic ehrlichiosis. Clin. Infect. Dis. 31: 554-560.
9. KRAUSE, P.J., K. MCKAY, C.A. THOMPSON, et al. 2002. Disease-specific diagnosis of coinfecting tickborne zoonoses: babesiosis, human granulocytic ehrlichiosis, and Lyme disease. Clin. Infect. Dis. 34: 1184-1191.
10. CASTRO, M.B., W.L. NICHOLSON, V.L. KRAMER & J.E. CHILDS. 2001. Persistent infection in Neotoma fuscipes (Muridae: Sigmodontinae) with Ehrlichia phagocytophila sensu lato. Am. J. Trop. Med. Hyg. 65: 261-267.
11. TELFORD, S.R., III, J.E. DAWSON, P. KATAVOLOS, et al. 1996. Perpetuation of the agent of human granulocytic ehrlichiosis in a deer tick-rodent cycle. Proc. Natl. Acad. Sci. USA 93: 6209-6214.
12. BAKKEN, J.S. 2003. Human anaplasmosis: epidemiological, clinical, laboratory, and therapeutic aspects of a new emerging tick-borne infectious disease. Department of Microbiology, University of Tromsø, Norway.
13. KATAVOLOS, P., P.M. ARMSTRONG, J.E. DAWSON & S.R. TELFORD, III. 1998. Duration of tick attachment required for transmission of granulocytic ehrlichiosis. J. Infect. Dis. 177: 1422-1425.
14. MCQUISTON, J.H., C.L. MCCALL & W.L. NICHOLSON. 2003. Ehrlichiosis and related infections. J. Am. Vet. Med. Assoc. 223: 1750-1756.
15. BLANCO, J.R. & J.A. OTEO. 2002. Human granulocytic ehrlichiosis in Europe. Clin. Microbiol. Infect. 8: 763-772.
16. AGUERO-ROSENFELD, M.E., L. DONNARUMMA, L. ZENTMAIER, et al. 2002. Seroprevalence of antibodies that react with Anaplasma phagocytophila, the agent of human granulocytic ehrlichiosis, in different populations in Westchester County, New York. J. Clin. Microbiol. 40: 2612-2615.
17. BAKKEN, J.S., P. GOELLNER, M. VAN ETTEN, et al. 1998. Seroprevalence of human granulocytic ehrlichiosis among permanent residents of northwestern Wisconsin. Clin. Infect. Dis. 27: 1491-1496.
18. HILTON, E., J. DEVOTI, J.L. BENACH, et al. 1999. Seroprevalence and seroconversion for tick-borne diseases in a high-risk population in the northeast United States. Am. J. Med. 106: 404-409.
19. WOESSNER, R., B.C. GAERTNER, M.T. GRAUER, et al. 2001. Incidence and prevalence of infection with human granulocytic ehrlichiosis agent in Germany: a prospective study in young healthy subjects. Infection 29: 271-273.
20. BAKKEN, J.S., I. HALLER, D. RIDDELL, et al. 2002. The serological response of patients infected with the agent of human granulocytic ehrlichiosis. Clin. Infect. Dis. 34: 22-27.
21. BAKKEN, J.S., J. KRUETH, C. WILSON-NORDSKOG, et al. 1996. Clinical and laboratory characteristics of human granulocytic ehrlichiosis. JAMA 275: 199-205.
22. BAKKEN, J.S. & J.S. DUMLER. 2002. Ehrlichia and Anaplasma species. In Antimicrobial Therapy and Vaccine. V. YU, R. Weber, D. Raoult, Eds.: 875-882. Apple Trees Productions, LLC. New York.
23. CIZMAN, M., T. AVSIC-ZUPANC, M. PETROVEC, et al. 2000. Seroprevalence of ehrlichiosis, Lyme borreliosis and tick-borne encephalitis infections in children and young adults in Slovenia. Wien. Klin. Wochenschr. 112: 842-845.
24. MCQUISTON, J.H., C.D. PADDOCK, R.C. HOLMAN & J.E. CHILDS. 1999. The human ehrlichioses in the United States. Emerg. Infect. Dis. 5: 635-642.
25. LEIBY, D.A., A.P. CHUNG, R.G. CABLE, et al. 2002. Relationship between tick bites and the seroprevalence of Babesia microti and Anaplasma phagocytophila (previously Ehrlichia, sp.) in blood donors. Transfusion 42: 1585-1591.
26. LEPIDI, H., J.E. BUNNELL, M.E. MARTIN, et al. 2000. Comparative pathology, and immunohistology associated with clinical illness after Ehrlichia phagocytophila-group infections. Am. J. Trop. Med. Hyg. 62: 29-37.
27. DUMLER, J.S., E.R. TRIGIANI, J.S. BAKKEN, et al. 2000. Serum cytokine responses during acute human granulocytic ehrlichiosis. Clin. Diagn. Lab. Immunol. 7: 6-8.
28. MARTIN, M.E., K. CASPERSEN & J.S. DUMLER. 2001. Immunopathology and ehrlichial propagation are regulated by interferon-gamma and interleukin-10 in a murine model of human granulocytic ehrlichiosis. Am. J. Pathol. 158: 1881-1888.
29. WALLACE, B.J., G. BRADY, D.M. ACKMAN, et al. 1998. Human granulocytic ehrlichiosis in New York. Arch. Intern. Med. 158: 769-773.
30. BAKKEN, J.S., R.L. TILDEN, J.J. WALLS & J.S. DUMLER. 1999. Influence of occupation, preexisting illness, and chronic medication use on the severity of illness of human granulocytic ehrlichiosis. In Rickettsia and Rickettsial Diseases at the Turn of the Third Millenium. D. RAOULT & P. BROUQUI, Eds.: 195-198. Elsevier. Marseilles, France.
31. BAKKEN, J.S., S.A. ERLEMEYER, R.J. KANOFF, et al. 1998. Demyelinating polyneuropathy associated with human granulocytic ehrlichiosis. Clin. Infect. Dis. 27: 1323-1324.
32. HOROWITZ, H.W., S.J. MARKS, M. WEINTRAUB & J.S. DUMLER. 1996. Brachial plexopathy associated with human granulocytic ehrlichiosis. Neurology 46: 1026-1029.
33. JAHANGIR, A., C. KOLBERT, W. EDWARDS, et al. 1998. Fatal pancarditis associated with human granulocytic ehrlichiosis in a 44-year-old man. Clin. Infect. Dis. 27: 1424-1427.
34. BAKKEN, J.S., M.E. AGUERO-ROSENFELD, R.L. TILDEN, et al. 2001. Serial measurements of hematologic counts during the active phase of human granulocytic ehrlichiosis. Clin. Infect. Dis. 32: 862-870.
35. DUMLER, J.S. & D.H. WALKER. 2001. Tick-borne ehrlichioses. Lancet Inf. Dis. 1: 21-28.
36. MASSUNG, R.F. & K.G. SLATER. 2003. Comparison of PCR assays for detection of the agent of human granulocytic ehrlichiosis, Anaplasma phagocytophilum. J. Clin. Microbiol. 41: 717-722.
37. GOODMAN, J.L., C. NELSON, B. VITALE, et al. 1996. Direct cultivation of the causative agent of human granulocytic ehrlichiosis. N. Engl. J. Med. 334: 209-215.
38. AGUERO-ROSENFELD, M.E. 2002. Diagnosis of human granulocytic ehrlichiosis: state of the art. Vect. Borne Zoon. Dis. 2: 233-239.
39. BELONGIA, E.A., K.D. REED, P.D. MITCHELL, et al. 2001. Tickborne infections as a cause of nonspecific febrile illness in Wisconsin. Clin. Infect. Dis. 32: 1434-1439.
40. WALLS, J.J., M. AGUERO-ROSENFELD, J.S. BAKKEN, et al. 1999. Inter- and intralaboratory comparison of Ehrlichia equi and human granulocytic ehrlichiosis (HGE) agent strains for serodiagnosis of HGE by the immunofluorescent-antibody test. J. Clin. Microbiol. 37: 2968-2973.
41. HOROWITZ, H.W., T.C. HSIEH, M.E. AGUERO-ROSENFELD, et al. 2001. Antimicrobial susceptibility of Ehrlichia phagocytophila. Antimicrob. Agents Chemother. 45: 786-788.
42. KLEIN, M.B., C.M. NELSON & J.L. GOODMAN. 1997. Antibiotic susceptibility of the newly cultivated agent of human granulocytic ehrlichiosis: promising activity of quinolones and rifamycins. Antimicrob. Agents Chemother. 41: 76-79.
43. MAURIN, M., J.S. BAKKEN & J.S. DUMLER. 2003. Antibiotic susceptibilities of Anaplasma (Ehrlichia) phagocytophilum strains from various geographic areas in the United States. Antimicrob. Agents Chemother. 47: 413-415.
44. FISHBEIN, D.B., J.E. DAWSON & L.E. ROBINSON. 1994. Human ehrlichiosis in the United States, 1985 to 1990. Ann. Intern. Med. 120: 736-743.
45. OLANO, J.P. & D.H. WALKER. 2002. Human ehrlichioses. Med. Clin. North Am. 86: 375-392.
46. PADDOCK, C.D., S.M. FOLK, G.M. SHORE, et al. 2001. Infections with Ehrlichia chaffeensis and Ehrlichia ewingii in persons coinfected with human immunodeficiency virus. Clin. Infect. Dis. 33: 1586-1594.
47. PADDOCK, C.D. & J.E. CHILDS. 2003. Ehrlichia chaffeensis: a prototypical emerging pathogen. Clin. Microbiol. Rev. 16: 37-64.
48. ANONYMOUS. 2003. Ehrlichia infections (human ehrlichioses). In 2003 Report of the Committee of Infectious Diseases. L.K. Pickering, Ed.: 266-269. Red Book, American Academy of Pediatrics. Elk Grove Village, IL.
49. HOROWITZ, H.W., M. AGUERO-ROSENFELD, J.S. DUMLER, et al. 1998. Reinfection with the agent of human granulocytic ehrlichiosis. Ann. Intern. Med. 129: 461-463.
50. ANONYMOUS. 2004. Tetracyclines. In AHFS Drug Information. G.K. McEvoy, Ed.: 433-457. American Society of Health-System Pharmacists. Bethesda, MD.
51. BROUQUI, P. & D. RAOULT. 1992. In vitro antibiotic susceptibility of the newly recognized agent of ehrlichiosis in humans, Ehrlichia chaffeensis. Antimicrob. Agents Chemother. 36: 2799-2803.
52. BUITRAGO, M.I., J.W. IJDO, P. RINAUDO, et al. 1998. Human granulocytic ehrlichiosis during pregnancy treated successfully with rifampin. Clin. Infect. Dis. 27: 213-215.
53. ELSTON, D.M. 1998. Perinatal transmission of human granulocytic ehrlichiosis. N. Engl. J. Med. 39: 1941-1942.
54. KRAUSE, P.J., C.L. CORROW & J.S. BAKKEN. 2003. Successful treatment of human granulocytic ehrlichiosis in children using rifampin. Pediatrics 112: e252-e253.
55. EVERETT, E.D., K.A. EVANS, R.B. HENRY & G. MCDONALD. 1994. Human ehrlichiosis in adults after tick exposure. Diagnosis using polymerase chain reaction. Ann. Intern. Med. 120: 730-735.
56. OLANO, J.P., W. HOGREFE, B. SEATON & D.H. WALKER. 2003. Clinical manifestations, epidemiology, and laboratory diagnosis of human monocytotropic ehrlichiosis in a commercial laboratory setting. Clin. Diagn. Lab. Immunol. 10: 891-896.
57. BELONGIA, E.A., K.D REED, P.D. MITCHELL, et al. 1999. Clinical and epidemiological features of early Lyme disease and human granulocytic ehrlichiosis in Wisconsin. Clin. Infect. Dis. 29: 1472-1477.
58. HOROWITZ, H.W., M.E. AGUERO-ROSENFELD, D.F. MCKENNA, et al. 1998. Clinical and laboratory spectrum of culture-proven human granulocytic ehrlichiosis: comparison with culture-negative cases. Clin. Infect. Dis. 27: 1314-1317.
59. WALKER, D.H., J.S. BAKKEN, P. BROUQUI, et al. 2000. Diagnosing human ehrlichioses: current status and recommendations. Am. Soc. Microbiol. News 5: 287-293.
60. AGUERO-ROSENFELD, M.E., F. KALANTARPOUR, M. BALUCH, et al. 2000. Serology of culture-confirmed cases of human granulocytic ehrlichiosis. J. Clin. Microbiol. 38: 635-638.
61. DUMLER, J.S. & J.S. BAKKEN. 1998. Human ehrlichioses: newly recognized infections transmitted by ticks. Annu. Rev. Med. 49: 201-213.