Anaplasma phagocytophilum infection in dogs: 34 cases (2000-2007)

Journal of the American Veterinary Medical Association

Volumn 234, Issue 12, 2009, Pages 1559-1565

  Granick, Jennifer L ^a,b,d   Armstrong, P Jane ^a,b   Bender, Jeff B ^a,c  

^a Departments of Veterinary Clinical Sciences

^b Veterinary Population Medicine   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANAPLASMA PHAGOCYTOPHILUM; ANIMALIA; CANIS FAMILIARIS; IXODIDA;

ANTIINFECTIVE AGENT; BACTERIUM ANTIBODY; DOXYCYCLINE;

ANAPLASMA PHAGOCYTOPHILUM; ANIMAL; ANIMAL DISEASE; ARTICLE; BLOOD; DEMOGRAPHY; DIFFERENTIAL DIAGNOSIS; DOG; DOG DISEASE; EHRLICHIOSIS; FEMALE; IMMUNOLOGY; INFESTATION; ISOLATION AND PURIFICATION; IXODES; MALE; MICROBIOLOGY; RETROSPECTIVE STUDY; RISK FACTOR; SEASON; TRAVEL; TREATMENT OUTCOME; UNITED STATES;

ANAPLASMA PHAGOCYTOPHILUM; ANIMALS; ANTI-BACTERIAL AGENTS; ANTIBODIES, BACTERIAL; DEMOGRAPHY; DIAGNOSIS, DIFFERENTIAL; DOG DISEASES; DOGS; DOXYCYCLINE; EHRLICHIOSIS; FEMALE; IXODES; MALE; MINNESOTA; RETROSPECTIVE STUDIES; RISK FACTORS; SEASONS; TICK INFESTATIONS; TRAVEL; TREATMENT OUTCOME; WISCONSIN;

EID: 67651068961     PISSN: 00031488     EISSN: None     Source Type: Journal    
DOI: 10.2460/javma.234.12.1559     Document Type: Article

References (32)

1. Demma LJ, Holman RC, McQuiston JH, et al. Epidemiology of human ehrlichiosis and anaplasmosis in the United States, 2001-2002. Am J Trop Med Hyg 2005;73:400-409.
2. Egenvall A.E. Hedhammar A.A. Bjoersdorff A.I. Clinical features and serology of 14 dogs affected by granulocytic ehrlichiosis in Sweden Veterinary Record 1997 140 9 222-226 2. Egenvall AE, Hedhammar AA, Bjoersdorff AA. Clinical features and serology of 14 dogs affected by granulocytic ehrlichiosis in Sweden. Vet Rec 1997;140:222-226. (Pubitemid 27113153)
3. Foley J. Drazenovich N. Leutenegger C.M. Chomel B.B. Association between polyarthritis and thrombocytopenia and increased prevalence of vectorborne pathogens in Californian dogs Veterinary Record 2007 160 5 159-162 3. Foley J, Drazenovich N, Leutenegger CM, et al. Association between polyarthritis and thrombocytopenia and increased prevalence of vectorborne pathogens in Californian dogs. Vet Rec 2007;160:159-162. (Pubitemid 46264473)
4. Greig B. Asanovich K.M. Jane Armstrong P. Stephen Dumler J. Geographic, clinical, serologic, and molecular evidence of granulocytic ehrlichiosis, a likely zoonotic disease, in minnesota and wisconsin dogs Journal of Clinical Microbiology 1996 34 1 44-48 4. Greig B, Asanovich KM, Armstrong PJ, et al. Geographic, clinical, serologic, and molecular evidence of granulocytic ehrlichiosis, a likely zoonotic disease, in Minnesota and Wisconsin dogs. J Clin Microbiol 1996;34:44-48. (Pubitemid 126506890)
5. Jensen J, Simon D, Murua Escobar H, et al. Anaplasma phagocytophilum in dogs in Germany. Zoonoses Public Health 2007;54:94-101.
6. Dumler JS, Barbet AF, Bekker CP, et al. Reorganization of genera in the families Rickettsiaceae and Anaplasmataceae in the order Rickettsiales: unification of some species of Ehrlichia with Anaplasma, Cowdria with Ehrlichia and Ehrlichia with Neorickettsia, descriptions of six new species combinations and designation of Ehrlichia equi and 'HGE agent' as subjective synonyms of Ehrlichia phagocytophila. Int J Syst Evol Microbiol 2001;51:2145-2165.
7. Goodman J.L. Nelson C.M. Klein M.B. Hayes S.F. Weston B.W. Leukocyte infection by the granulocytic ehrlichiosis agent is linked to expression of a selectin ligand Journal of Clinical Investigation 1999 103 3 407-412 7. Goodman JL, Nelson CM, Klein MB, et al. Leukocyte infection by the granulocytic ehrlichiosis agent is linked to expression of a selectin ligand. J Clin Invest 1999;103:407-412. (Pubitemid 29069991)
8. Herron M.J. Nelson C.M. Larson J. Snapp K.R. Kansas G.S. Goodman J.L. Intracellular parasitism by the human granulocytic ehrlichiosis bacterium through the P-selectin ligand, PSGL-1 Science 2000 288 5471 1653-1656 DOI 10.1126/science.288.5471.1653 8. Herron MJ, Nelson CM, Larson J, et al. Intracellular parasitism by the human granulocytic ehrlichiosis bacterium through the P-selectin ligand, PSGL-I. Science 2000;288:1653-1656. (Pubitemid 30387433)
9. Webster P. IJdo J.W. Chicoine L.M. Fikrig E. The agent of human granulocytic ehrlichiosis resides in an endosomal compartment Journal of Clinical Investigation 1998 101 9 1932-1941 9. Webster P, IJdo JW, Chicoine LM, et al. The agent of human granulocytic ehrlichiosis resides in an endosomal compartment. J Clin Invest 1998;101:1932-1941. (Pubitemid 28226113)
10. Lilliehook I. Egenvall A. Tvedten H.W. Hematopathology in Dogs Experimentally Infected with a Swedish Granulocytic Ehrlichia Species Veterinary Clinical Pathology 1998 27 4 116-122 10. Lilliehöök I, Egenvall A, Tvedten HW. Hematopathology in dogs experimentally infected with a Swedish granulocytic Ehrlichia species. Vet Clin Pathol 1998;27:116-122. (Pubitemid 128464072)
11. Bexfield N.H. Villiers E.J. Herrtage M.E. Immune-mediated haemolytic anaemia and thrombocytopenia associated with Anaplasma phagocytophilum in a dog Journal of Small Animal Practice 2005 46 11 543-548 DOI 10.1111/j.1748-5827. 2005.tb00284.x 11. Bexfield NH, Villiers EJ, Herrtage ME. Immune-mediated haemolytic anaemia and thrombocytopenia associated with Anaplasma phagocytophilum in a dog. J Small Anim Pract 2005;46:543-548. (Pubitemid 41634753)
12. MacDonald KA, Chomel BB, Kittleson MD, et al. A prospective study of canine infective endocarditis in northern California (1999-2001): emergence of Bartonella as a prevalent etiologic agent. J Vet Intern Med 2004;18:56-64.
13. Tozon N. Petrovec M. Avsic-Zupanc T. Clinical and laboratory features of the first detected cases of A. phagocytophila infections in dogs from Slovenia Annals of the New York Academy of Sciences 2003 990 424-428 13. Tozon N, Petrovec M, Avsic-Zupanc T. Clinical and laboratory features of the first detected cases of A. phagocytophila infections in dogs from Slovenia. Ann N Y Acad Sci 2003;990:424-428. (Pubitemid 36814026)
14. Bexfield MJ, Chandrashekar R, Eberts MD, et al. Serological and molecular prevalence of Borrelia burgdorferi, Anaplasma phagocytophilum, and Ehrlichia species in dogs from Minnesota. Vector Borne Zoonotic Dis 2008;8:455-464.
15. De Laforcade A.M. Freeman L.M. Shaw S.P. Brooks M.B. Rozanski E.A. Rush J.E. Hemostatic changes in dogs with naturally occurring sepsis Journal of Veterinary Internal Medicine 2003 17 5 674-679 DOI 10.1892/0891-6640(2003) 017<0674:HCIDWN>2.3.CO;2 15. de Laforcade AM, Freeman LM, Shaw SP, et al. Hemostatic changes in dogs with naturally occurring sepsis. J Vet Intern Med 2003;17:674-679. (Pubitemid 37229847)
16. Goldman EE, Breitschwerdt EB, Grindem CB, et al. Granulocytic ehrlichiosis in dogs from North Carolina and Virginia. J Vet Intern Med 1998;12:61-70.
17. Goodman R.A. Hawkins E.C. Olby N.J. Grindem C.B. Hegarty B. Breitschwerdt E.B. Molecular identification of Ehrlichia ewingii infection in dogs: 15 Cases (1997-2001) Journal of the American Veterinary Medical Association 2003 222 8 1102-1107 DOI 10.2460/javma.2003.222.1102 17. Goodman RA, Hawkins EC, Olby NJ, et al. Molecular identification of Ehrlichia ewingii infection in dogs: 15 cases (19972001). J Am Vet Med Assoc 2003;222:1102-1107. (Pubitemid 36452318)
18. Liddell A.M. Stockham S.L. Scott M.A. Sumner J.W. Paddock C.D. Gaudreault-Keener M. Arens M.Q. Storch G.A. Predominance of Ehrlichia ewingii in Missouri dogs Journal of Clinical Microbiology 2003 41 10 4617-4622 DOI 10.1128/JCM.41.10.4617-4622.2003 18. Liddell AM, Stockham SL, Scott MA, et al. Predominance of Ehrlichia ewingii in Missouri dogs. J Clin Microbiol 2003;41:4617-4622. (Pubitemid 37264955)
19. Minnesota Department of Health. Expansion of range of vector-borne disease in Minnesota. Disease Control Newsletter 2006;34:15-17.
20. Daniels T.J. Falco R.C. Curran K.L. Fish D. Timing of Ixodes scapularis (Acari: Ixodidae) Oviposition and Larval Activity in Southern New York Journal of Medical Entomology 1996 33 1 140-147 20. Daniels TJ, Falco RC, Curran KL, et al. Timing of Ixodes scapularis (Acari: Ixodidae) oviposition and larval activity in southern New York. J Med Entomol 1996;33:140-147. (Pubitemid 126429351)
21. Bakken J.S. Aguero-Rosenfeld M.E. Tilden R.L. Wormser G.P. Horowitz H.W. Raffalli J.T. Baluch M. Riddell D. Walls J.J. Dumler J.S. Serial measurements of hematologic counts during the active phase of human granulocytic ehrlichiosis Clinical Infectious Diseases 2001 32 6 862-870 DOI 10.1086/319350 21. Bakken JS, Aguero-Rosenfeld ME, Tilden RL, et al. Serial measurements of hematologic counts during the active phase of human granulocytic ehrlichiosis. Clin Infect Dis 2001;32:862-870. (Pubitemid 32524819)
22. Greene CE. Infectious diseases of the dog and cat. 3rd ed. St Louis: Elsevier, 2006.
23. Borjesson D.L. Simon S.I. Tablin F. Barthold S.W. Thrombocytopenia in a mouse model of human granulocytic ehrlichiosis Journal of Infectious Diseases 2001 184 11 1475-1479 DOI 10.1086/324518 23. Borjesson DL, Simon SI, Tablin F, et al. Thrombocytopenia in a mouse model of human granulocytic ehrlichiosis. J Infect Dis 2001;184:1475-1479. (Pubitemid 33108865)
24. Munderloh UG, Lynch MJ, Herron MJ, et al. Infection of endothelial cells with Anaplasma marginale and A. phagocytophilum. Vet Microbiol 2004;101:53-64.
25. Schwan TG, Piesman J, Golde WT, et al. Induction of an outer surface protein on Borrelia burgdorferi during tick feeding. Proc Natl Acad Sci USA 1995;92:2909-2913.
26. Granick JL, Reneer DV, Carlyon JA, et al. Anaplasma phagocytophilum infects cells of the megakaryocytic lineage through sialylated ligands but fails to alter platelet production. J Med Microbiol 2008;57:416-423.
27. Scorpio DG, Von Loewenich FD, Bogdan C, et al. Innate immune tissue injury and murine HGA: tissue injury in the murine model of granulocytic anaplasmosis relates to host innate immune response and not pathogen load. Ann N Y Acad Sci 2005;1063:425-428.
28. Bakken J.S. Krueth J. Wilson-Nordskog C. Tilden R.L. Asanovich K. Dumler J.S. Clinical and laboratory characteristics of human granulocytic ehrlichiosis Journal of the American Medical Association 1996 275 3 199-205 DOI 10.1001/jama.275.3.199 28. Bakken JS, Krueth J, Wilson-Nordskog C, et al. Clinical and laboratory characteristics of human granulocytic ehrlichiosis. JAMA 1996;275:199-205. (Pubitemid 26028560)
29. Bakken JS, Dumler JS, Chen SM, et al. Human granulocytic ehrlichiosis in the upper Midwest United States. A new species emerging? JAMA 1994;272:212-218.
30. Aguero-Rosenfeld M.E. Horowitz H.W. Wormser G.P. McKenna D.F. Nowakowski J. Munoz J. Dumler J.S. Human granulocytic ehrlichiosis: A case series from a medical center in New York State Annals of Internal Medicine 1996 125 11 904-908 30. Aguero-Rosenfeld ME, Horowitz HW, Wormser GP, et al. Human granulocytic ehrlichiosis: a case series from a medical center in New York State. Ann Intern Med 1996;125:904-908. (Pubitemid 126506763)
31. Zeidner N.S. Dolan M.C. Massung R. Piesman J. Fish D. Coinfection with Borrelia burgdorferi and the agent of human granulocytic ehrlichiosis suppresses IL-2 and IFNγ production and promotes an IL-4 response in C3H/HeJ mice Parasite Immunology 2000 22 11 581-588 DOI 10.1046/j.1365-3024.2000.00339.x 31. Zeidner NS, Dolan MC, Massung R, et al. Coinfection with Borrelia burgdorferi and the agent of human granulocytic ehrlichiosis suppresses IL-2 and IFN gamma production and promotes an IL-4 response in C3H/HeJ mice. Parasite Immunol 2000;22:581-588. (Pubitemid 30829205)
32. Thomas V. Anguita J. Barthold S.W. Fikrig E. Coinfection with Borrelia burgdorferi and the agent of human granulocytic ehrlichiosis alters murine immune responses, pathogen burden, and severity of lyme arthritis Infection and Immunity 2001 69 5 3359-3371 DOI 10.1128/IAI.69.5.3359-3371.2001 32. Thomas V, Anguita J, Barthold SW, et al. Coinfection with Borrelia burgdorferi and the agent of human granulocytic ehrlichiosis alters murine immune responses, pathogen burden, and severity of Lyme arthritis. Infect Immun 2001;69:3359-3371. (Pubitemid 32332235)