-
1
-
-
10644260423
-
Discovery and applications of small molecule probes for studying biological processes
-
J.S. Potuzak, S.B. Moilanen, D.S Tan, Discovery and applications of small molecule probes for studying biological processes, Biotechnol. Genet. Eng. Rev. 2004, 21, 11-77.
-
(2004)
Biotechnol. Genet. Eng. Rev.
, vol.21
, pp. 11-77
-
-
Potuzak, J.S.1
Moilanen, S.B.2
Tan, D.S.3
-
2
-
-
33644839988
-
Diversity-oriented synthesis: exploring the intersections between chemistry and biology
-
D.S. Tan, Diversity-oriented synthesis: exploring the intersections between chemistry and biology, Nat. Chem. Biol., 2005, 1, 74-84.
-
(2005)
Nat. Chem. Biol.
, vol.1
, pp. 74-84
-
-
Tan, D.S.1
-
3
-
-
20744456789
-
Solid phase peptide synthesis. I. The synthesis of a tetrapeptide
-
R.B. Merrifield, Solid phase peptide synthesis. I. The synthesis of a tetrapeptide, J. Am. Chem. Soc. 1963, 85, 2149-2154.
-
(1963)
J. Am. Chem. Soc.
, vol.85
, pp. 2149-2154
-
-
Merrifield, R.B.1
-
4
-
-
0033683359
-
Linkers and cleavage strategies in solid-phase organic synthesis and combinatorial chemistry
-
F. Guillier, D. Orain, M. Bradley, Linkers and cleavage strategies in solid-phase organic synthesis and combinatorial chemistry, Chem. Rev. 2000, 100, 2091-2157.
-
(2000)
Chem. Rev.
, vol.100
, pp. 2091-2157
-
-
Guillier, F.1
Orain, D.2
Bradley, M.3
-
5
-
-
0037021091
-
Modern separation techniques for efficient workup in organic synthesis
-
C.C. Tzschucke, C. Markert, W. Bannwarth, S. Roller, A. Hebel, R. Haag, Modern separation techniques for efficient workup in organic synthesis, Angew. Chem. Int. Ed. Engl. 2002, 41, 3964-4000.
-
(2002)
Angew. Chem. Int. Ed. Engl.
, vol.41
, pp. 3964-4000
-
-
Tzschucke, C.C.1
Markert, C.2
Bannwarth, W.3
Roller, S.4
Hebel, A.5
Haag, R.6
-
6
-
-
0035804384
-
Functionalized polymers-emerging versatile tools for solution-phase chemistry and automated parallel synthesis
-
A. Kirschning, H. Monenschein, R. Wittenberg, Functionalized polymers-emerging versatile tools for solution-phase chemistry and automated parallel synthesis, Angew. Chem. Int. Ed. Engl. 2001, 40, 650-679.
-
(2001)
Angew. Chem. Int. Ed. Engl.
, vol.40
, pp. 650-679
-
-
Kirschning, A.1
Monenschein, H.2
Wittenberg, R.3
-
7
-
-
0347478195
-
Scavenger resins in solution-phase combichem
-
J.G. Garcia, Scavenger resins in solution-phase combichem, Methods Enzymol. 2003, 369, 391-412.
-
(2003)
Methods Enzymol.
, vol.369
, pp. 391-412
-
-
Garcia, J.G.1
-
8
-
-
4544357020
-
DNA-templated organic synthesis: Nature's strategy for controlling chemical reactivity applied to synthetic molecules
-
X. Li, D.R. Liu, DNA-templated organic synthesis: Nature's strategy for controlling chemical reactivity applied to synthetic molecules, Angew. Chem. Int. Ed. Engl. 2004, 43, 4848-4870.
-
(2004)
Angew. Chem. Int. Ed. Engl.
, vol.43
, pp. 4848-4870
-
-
Li, X.1
Liu, D.R.2
-
9
-
-
0000951677
-
Use of peptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid
-
H.M. Geysen, R.H. Meloen, S.J Barteling, Use of peptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid, Proc. Natl. Acad. Sei. U. S. A. 1984, 81, 3998-4002.
-
(1984)
Proc. Natl. Acad. Sei. U. S. A.
, vol.81
, pp. 3998-4002
-
-
Geysen, H.M.1
Meloen, R.H.2
Barteling, S.J.3
-
10
-
-
0000478940
-
General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids
-
R.A. Houghten, General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids, Proc. Natl. Acad. Sei. U. S. A. 1985, 82, 5131-5135.
-
(1985)
Proc. Natl. Acad. Sei. U. S. A.
, vol.82
, pp. 5131-5135
-
-
Houghten, R.A.1
-
11
-
-
0025893762
-
General method for rapid synthesis of multicomponent peptide mixtures
-
A. Furka, F. Sebestyén, M. Asgedom, G. Dibó, General method for rapid synthesis of multicomponent peptide mixtures, Int.], Pept. Protein Res. 1991, 37, 487-493.
-
(1991)
Int.], Pept. Protein Res.
, vol.37
, pp. 487-493
-
-
Furka, A.1
Sebestyén, F.2
Asgedom, M.3
Dibó, G.4
-
12
-
-
0026419328
-
A new type of synthetic peptide library for identifying ligand-binding activity
-
K.S. Lam, S.E. Salmon, E.M. Hersh, V.J. Hruby, W.M. Kazmierski, R.J Knapp, A new type of synthetic peptide library for identifying ligand-binding activity, Nature 1991, 354, 82-84.
-
(1991)
Nature
, vol.354
, pp. 82-84
-
-
Lam, K.S.1
Salmon, S.E.2
Hersh, E.M.3
Hruby, V.J.4
Kazmierski, W.M.5
Knapp, R.J.6
-
13
-
-
0035358555
-
Solutions for library encoding to create collections of discrete compounds
-
R.L. Affleck, Solutions for library encoding to create collections of discrete compounds, Curr. Opin. Chem. Biol. 2001, 5, 257-263.
-
(2001)
Curr. Opin. Chem. Biol.
, vol.5
, pp. 257-263
-
-
Affleck, R.L.1
-
14
-
-
0000478940
-
General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids
-
R.A. Houghten, General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids, Proc. Natl. Acad. Sei. U. S. A. 1985, 82, 5131-5135.
-
(1985)
Proc. Natl. Acad. Sei. U. S. A.
, vol.82
, pp. 5131-5135
-
-
Houghten, R.A.1
-
15
-
-
2842561522
-
Design, synthesis, and evaluation of small-molecule libraries
-
J.A. EUman, Design, synthesis, and evaluation of small-molecule libraries, Acc. Chem. Res. 1996, 29, 132-143.
-
(1996)
Acc. Chem. Res.
, vol.29
, pp. 132-143
-
-
Euman, J.A.1
-
16
-
-
0027202613
-
"Diversomers": an approach to nonpeptide, nonoligomeric chemical diversity
-
S. Hobbs DeWitt, J.S. Kiely, C.J. Stankovic, M.C. Schroeder, D.M. Reynolds Cody, M.R. Pavia, "Diversomers": an approach to nonpeptide, nonoligomeric chemical diversity, Proc. Natl. Acad. Sei. U. S. A. 1993, 90, 6909-6913.
-
(1993)
Proc. Natl. Acad. Sei. U. S. A.
, vol.90
, pp. 6909-6913
-
-
Hobbs Dewitt, S.1
Kiely, J.S.2
Stankovic, C.J.3
Schroeder, M.C.4
Reynolds Cody, D.M.5
Pavia, M.R.6
-
17
-
-
0032569205
-
Stereoselective synthesis of over two million compounds having structural features both reminiscent of natural products and compatible with miniaturized cell-based assays
-
D.S. Tan, M.A. Foley, M.D. Shair, S.L Schreiber, Stereoselective synthesis of over two million compounds having structural features both reminiscent of natural products and compatible with miniaturized cell-based assays, J. Am. Chem. Soc. 1998, 120, 8565-8566.
-
(1998)
J. Am. Chem. Soc.
, vol.120
, pp. 8565-8566
-
-
Tan, D.S.1
Foley, M.A.2
Shair, M.D.3
Schreiber, S.L.4
-
18
-
-
0031549105
-
Synthetic design for combinatorial chemistry. Solution and polymer-supported synthesis of polycyclic lactams by intramolecular cyclization of azomethine ylides
-
M.A. Marx, A.-L. Grillot, C.T. Louer, K.A. Beaver, P.A Bartlett, Synthetic design for combinatorial chemistry. Solution and polymer-supported synthesis of polycyclic lactams by intramolecular cyclization of azomethine ylides, J. Am. Chem. Soc. 1997, 119, 6153-6167.
-
(1997)
J. Am. Chem. Soc.
, vol.119
, pp. 6153-6167
-
-
Marx, M.A.1
Grillot, A.-L.2
Louer, C.T.3
Beaver, K.A.4
Bartlett, P.A.5
-
19
-
-
0029963887
-
Postcondensation modifications of ugi four-component condensation products: 1-isocyanocyclohexene as a convertible isocyanide. Mechanism of conversion, synthesis of diverse structures, and demonstration of resin capture
-
T.A. Keating, R.W Armstrong, Postcondensation modifications of ugi four-component condensation products: 1-isocyanocyclohexene as a convertible isocyanide. Mechanism of conversion, synthesis of diverse structures, and demonstration of resin capture, J. Am. Chem. Soc. 1996, 118, 2574-2583.
-
(1996)
J. Am. Chem. Soc.
, vol.118
, pp. 2574-2583
-
-
Keating, T.A.1
Armstrong, R.W.2
-
20
-
-
0030762990
-
Cyclobutenedione derivatives on solid support: toward multiple core structure libraries
-
P.A. Tempest, R.W Armstrong, Cyclobutenedione derivatives on solid support: toward multiple core structure libraries, J. Am. Chem. Soc. 1997, 119, 7607-7608.
-
(1997)
J. Am. Chem. Soc.
, vol.119
, pp. 7607-7608
-
-
Tempest, P.A.1
Armstrong, R.W.2
-
21
-
-
3042689621
-
Fragment-based drug discovery
-
D.A. Erlanson, R.S. McDowell, T. O'Brien, Fragment-based drug discovery, J. Med. Chem. 2004, 47, 3463-3482.
-
(2004)
J. Med. Chem.
, vol.47
, pp. 3463-3482
-
-
Erlanson, D.A.1
McDowell, R.S.2
O'Brien, T.3
-
22
-
-
11144323163
-
Virtual screening of chemical libraries
-
B.K. Shoichet, Virtual screening of chemical libraries, Nature 2004, 432, 862-865.
-
(2004)
Nature
, vol.432
, pp. 862-865
-
-
Shoichet, B.K.1
-
23
-
-
8844263008
-
Docking and scoring in virtual screening for drug discovery: methods and applications
-
D.B. Kitchen, H. Decornez, J.R. Furr, J. Bajorath, Docking and scoring in virtual screening for drug discovery: methods and applications, Nat. Rev. Drug Diseov. 2004, 3, 935-949.
-
(2004)
Nat. Rev. Drug Diseov.
, vol.3
, pp. 935-949
-
-
Kitchen, D.B.1
Decornez, H.2
Furr, J.R.3
Bajorath, J.4
-
24
-
-
11144341956
-
Chemical space and biology
-
C.M. Dobson, Chemical space and biology, Nature 2004, 432, 824-828.
-
(2004)
Nature
, vol.432
, pp. 824-828
-
-
Dobson, C.M.1
-
25
-
-
0024239320
-
Methods for drug discovery: development of potent, selective, orally effective cholecystokinin antagonists
-
B.E. Evans, K.E. Rittie, M.G. Bock, R.M. DiPardo, R.M. Freidinger, W.L. Whitter, G.F. Lundell, D.F. Veber, P.S Anderson, et al. Methods for drug discovery: development of potent, selective, orally effective cholecystokinin antagonists, J. Med. Chem. 1988, 32, 2235-2246.
-
(1988)
J. Med. Chem.
, vol.32
, pp. 2235-2246
-
-
Evans, B.E.1
Rittie, K.E.2
Bock, M.G.3
DiPardo, R.M.4
Freidinger, R.M.5
Whitter, W.L.6
Lundell, G.F.7
Veber, D.F.8
Anderson, P.S.9
-
26
-
-
4243159924
-
Privileged structures: applications in drug discovery
-
R.W. DeSimone, K.S. Currie, S.A. Mitchell, J.W. Darrow, D.A Pippin, Privileged structures: applications in drug discovery, Comb. Chem. High Throughput Screen. 2004, 7, 473-493.
-
(2004)
Comb. Chem. High Throughput Screen.
, vol.7
, pp. 473-493
-
-
DeSimone, R.W.1
Currie, K.S.2
Mitchell, S.A.3
Darrow, J.W.4
Pippin, D.A.5
-
27
-
-
0141828504
-
Protein structure similarity as guiding principle for combinatorial library design
-
M.A. Koch, R. Breinbauer, H. Waldmann, Protein structure similarity as guiding principle for combinatorial library design, Biol. Chem. 2003, 384, 1265-1272.
-
(2003)
Biol. Chem.
, vol.384
, pp. 1265-1272
-
-
Koch, M.A.1
Breinbauer, R.2
Waldmann, H.3
-
28
-
-
0037208308
-
Property distributions: differences between drugs, natural products, and molecules from combinatorial chemistry
-
M. Feher, J.M Schmidt, Property distributions: differences between drugs, natural products, and molecules from combinatorial chemistry, J. Chem. Inf. Comput. Sei. 2003, 43, 218-227.
-
(2003)
J. Chem. Inf. Comput. Sei.
, vol.43
, pp. 218-227
-
-
Feher, M.1
Schmidt, J.M.2
-
29
-
-
0037366605
-
The combinatorial synthesis of bicyclic privileged structures or privileged substructures
-
D.A. Horton, G.T. Bourne, M.L Smythe, The combinatorial synthesis of bicyclic privileged structures or privileged substructures, Chem. Rev. 2003, 103, 893-930.
-
(2003)
Chem. Rev.
, vol.103
, pp. 893-930
-
-
Horton, D.A.1
Bourne, G.T.2
Smythe, M.L.3
-
30
-
-
4644301831
-
Molecular properties that influence oral drug-like behavior
-
M.S. Lajiness, M. Vieth, J. Erickson, Molecular properties that influence oral drug-like behavior, Curr. Opin. Drug Diseov. Devel. 2004, 7, 470-477.
-
(2004)
Curr. Opin. Drug Diseov. Devel.
, vol.7
, pp. 470-477
-
-
Lajiness, M.S.1
Vieth, M.2
Erickson, J.3
-
31
-
-
2942564021
-
Pursuing the leadlikeness concept in pharmaceutical research
-
M.M. Hann, T.I Oprea, Pursuing the leadlikeness concept in pharmaceutical research, Curr. Opin. Chem. Biol., 2004, 8, 255-263.
-
(2004)
Curr. Opin. Chem. Biol.
, vol.8
, pp. 255-263
-
-
Hann, M.M.1
Oprea, T.I.2
-
32
-
-
3142781225
-
Small-molecule inhibitors of protein-protein interactions: progressing towards the dream
-
M.R. Arkin, J.A. Wells, Small-molecule inhibitors of protein-protein interactions: progressing towards the dream, Nat. Rev. Drug Diseov. 2004, 3, 301-317.
-
(2004)
Nat. Rev. Drug Diseov.
, vol.3
, pp. 301-317
-
-
Arkin, M.R.1
Wells, J.A.2
-
33
-
-
3342908718
-
Emerging classes of protein-protein interaction inhibitors and new tools for their development
-
L. Pagliaro, J. Felding, K. Audouze, S.J. Nielsen, R.B. Terry, C. Krog-Jensen, S. Butcher, Emerging classes of protein-protein interaction inhibitors and new tools for their development, Curr. Opin. Chem. Biol. 2004, 8, 442-449.
-
(2004)
Curr. Opin. Chem. Biol.
, vol.8
, pp. 442-449
-
-
Pagliaro, L.1
Felding, J.2
Audouze, K.3
Nielsen, S.J.4
Terry, R.B.5
Krog-Jensen, C.6
Butcher, S.7
-
34
-
-
20444410443
-
Advancing chemistry and biology through diversity-oriented synthesis of natural product-like libraries
-
S. Shang, D.S Tan, Advancing chemistry and biology through diversity-oriented synthesis of natural product-like libraries, Curr. Opin. Chem. Biol. 2005, 9, 248-258.
-
(2005)
Curr. Opin. Chem. Biol.
, vol.9
, pp. 248-258
-
-
Shang, S.1
Tan, D.S.2
-
35
-
-
5644294669
-
Current progress in natural product-like libraries for discovery screening
-
D.S. Tan, Current progress in natural product-like libraries for discovery screening, Comb. Chem. High Throughput. Screen. 2004, 7, 631-643.
-
(2004)
Comb. Chem. High Throughput. Screen.
, vol.7
, pp. 631-643
-
-
Tan, D.S.1
-
36
-
-
0034678033
-
Target-oriented and diversity-oriented organic synthesis in drug discovery
-
S.L. Schreiber, Target-oriented and diversity-oriented organic synthesis in drug discovery, Science 2000, 287, 1964-1969.
-
(2000)
Science
, vol.287
, pp. 1964-1969
-
-
Schreiber, S.L.1
-
37
-
-
3042799070
-
A planning strategy for diversity-oriented synthesis
-
M.D. Burke, S.L Schreiber, A planning strategy for diversity-oriented synthesis, Angew. Chem. Int. Ed. Engl. 2004, 43, 46-58.
-
(2004)
Angew. Chem. Int. Ed. Engl.
, vol.43
, pp. 46-58
-
-
Burke, M.D.1
Schreiber, S.L.2
-
38
-
-
20444402286
-
Complex molecules: do they add value?
-
P. Selzer, H.-J. Roth, P. Ertl, A. Schuffenhauer, Complex molecules: do they add value? Curr. Opin. Chem. Biol. 2005, 9, 310-316.
-
(2005)
Curr. Opin. Chem. Biol.
, vol.9
, pp. 310-316
-
-
Selzer, P.1
Roth, H.-J.2
Ertl, P.3
Schuffenhauer, A.4
-
39
-
-
0037181078
-
A combinatorial scaffold approach toward kinase-directed heterocycle libraries
-
S. Ding, N.S. Gray, X. Wu, Q. Ding, P.G Schultz, A combinatorial scaffold approach toward kinase-directed heterocycle libraries, J. Am Chem. Soc. 2002, 124, 1594-1596.
-
(2002)
J. Am Chem. Soc.
, vol.124
, pp. 1594-1596
-
-
Ding, S.1
Gray, N.S.2
Wu, X.3
Ding, Q.4
Schultz, P.G.5
-
40
-
-
0037073206
-
Skeletal diversity via a branched pathway: efficient synthesis of 29, 400 discrete, polycyclic compounds and their arraying into stock solutions
-
O. Kwon, S.B. Park, S.L Schreiber, Skeletal diversity via a branched pathway: efficient synthesis of 29, 400 discrete, polycyclic compounds and their arraying into stock solutions, J. Am. Chem. Soc. 2002, 124, 13402-13404.
-
(2002)
J. Am. Chem. Soc.
, vol.124
, pp. 13402-13404
-
-
Kwon, O.1
Park, S.B.2
Schreiber, S.L.3
-
41
-
-
0142147275
-
Generating diverse skeletons of small molecules combinatorially
-
M.D. Burke, E.M. Berger, S.L Schreiber, Generating diverse skeletons of small molecules combinatorially, Science 2003, 302, 613-618.
-
(2003)
Science
, vol.302
, pp. 613-618
-
-
Burke, M.D.1
Berger, E.M.2
Schreiber, S.L.3
-
42
-
-
3242697253
-
Cell-based partitioning
-
L. Xue, F.L. Stahura, J. Bajorath, Cell-based partitioning, Methods MoL Biol. 2004, 275, 279-289.
-
(2004)
Methods MoL Biol.
, vol.275
, pp. 279-289
-
-
Xue, L.1
Stahura, F.L.2
Bajorath, J.3
-
43
-
-
0034609833
-
Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties
-
P. Ertl, B. Rohde, P. Selzer, Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties, J. Med. Chem. 2000, 43, 3714-3717.
-
(2000)
J. Med. Chem.
, vol.43
, pp. 3714-3717
-
-
Ertl, P.1
Rohde, B.2
Selzer, P.3
-
44
-
-
0037061492
-
Dissecting glucose signalling with diversity-oriented synthesis and small-molecule microarrays
-
F.G. Kuruvilla, A.F. Shamji, S.M. Sternson, P.J. Hergenrother, S.L Schreiber, Dissecting glucose signalling with diversity-oriented synthesis and small-molecule microarrays, Nature 2002, 416, 653-657.
-
(2002)
Nature
, vol.416
, pp. 653-657
-
-
Kuruvilla, F.G.1
Shamji, A.F.2
Sternson, S.M.3
Hergenrother, P.J.4
Schreiber, S.L.5
-
45
-
-
0038522853
-
Multidimensional chemical genetic analysis of diversity-oriented synthesis-derived deacetylase inhibitors using cell-based assays
-
S.J. Haggarty, K.M. Koeller, J.C. Wong, R.A. Butcher, S.L Schreiber, Multidimensional chemical genetic analysis of diversity-oriented synthesis-derived deacetylase inhibitors using cell-based assays, Chem. Biol. 2003, 10, 383-396.
-
(2003)
Chem. Biol.
, vol.10
, pp. 383-396
-
-
Haggarty, S.J.1
Koeller, K.M.2
Wong, J.C.3
Butcher, R.A.4
Schreiber, S.L.5
-
46
-
-
0038274087
-
Structural biasing elements for in-cell histone deacetylase paralog selectivity
-
J.C. Wong, R. Hong, S.L Schreiber, Structural biasing elements for in-cell histone deacetylase paralog selectivity, J. Am Chem. Soc. 2003, 125, 5586-5587.
-
(2003)
J. Am Chem. Soc.
, vol.125
, pp. 5586-5587
-
-
Wong, J.C.1
Hong, R.2
Schreiber, S.L.3
-
47
-
-
0037596751
-
Synthetic small molecules that control stem cell fate
-
S. Ding, T.Y.H. Wu, A. Brinker, E.C. Peters, W. Hur, N.S. Gray, P.G Schultz, Synthetic small molecules that control stem cell fate, Proc. Natl. Acad. Sei. U. S.A. 2003, 100, 7632-7637.
-
(2003)
Proc. Natl. Acad. Sei. U. S.A.
, vol.100
, pp. 7632-7637
-
-
Ding, S.1
Wu, T.Y.H.2
Brinker, A.3
Peters, E.C.4
Hur, W.5
Gray, N.S.6
Schultz, P.G.7
-
48
-
-
1242336840
-
Small molecules that induce cardiomyogenesis in embryonic stem cells
-
X. Wu, S. Ding, Q. Ding, N.S. Gray, P.G Schultz, Small molecules that induce cardiomyogenesis in embryonic stem cells, J. Am Chem. Soc. 2004, 126, 1590-1591.
-
(2004)
J. Am Chem. Soc.
, vol.126
, pp. 1590-1591
-
-
Wu, X.1
Ding, S.2
Ding, Q.3
Gray, N.S.4
Schultz, P.G.5
-
49
-
-
0037065356
-
A small molecule with osteogenesis-inducing activity in multipotent mesenchymal progenitor cells
-
X. Wu, S. Ding, Q. Ding, N.S. Gray, P.G Schultz, A small molecule with osteogenesis-inducing activity in multipotent mesenchymal progenitor cells, J. Am Chem. Soc. 2002, 124, 14520-14521.
-
(2002)
J. Am Chem. Soc.
, vol.124
, pp. 14520-14521
-
-
Wu, X.1
Ding, S.2
Ding, Q.3
Gray, N.S.4
Schultz, P.G.5
-
50
-
-
0347717672
-
Dedifferentiation of lineage-committed cells by a small molecule
-
S. Chen, Q. Zhang, X. Wu, P.G. Schultz, S. Ding, Dedifferentiation of lineage-committed cells by a small molecule, J. Am Chem. Soc. 2004, 126, 410-411.
-
(2004)
J. Am Chem. Soc.
, vol.126
, pp. 410-411
-
-
Chen, S.1
Zhang, Q.2
Wu, X.3
Schultz, P.G.4
Ding, S.5
-
51
-
-
0037738531
-
A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR
-
M. Downes, M.A. Verdecia, A.J. Roecker, R. Hughes, J.B. Hogenesch, H.R. Kast-Woelbern, M.E. Bowman, J.-L. Ferrer, A.M. Anisfeld, P.A. Edwards, J.M. Rosenfeld, J.G.A. Alvarez, J.P. Noel, K.C. Nicolaou, R.M Evans, A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR, Mol. Cell 2003, 11, 1079-1092.
-
(2003)
Mol. Cell
, vol.11
, pp. 1079-1092
-
-
Downes, M.1
Verdecia, M.A.2
Roecker, A.J.3
Hughes, R.4
Hogenesch, J.B.5
Kast-Woelbern, H.R.6
Bowman, M.E.7
Ferrer, J.-L.8
Anisfeld, A.M.9
Edwards, P.A.10
Rosenfeld, J.M.11
Alvarez, J.G.A.12
Noel, J.P.13
Nicolaou, K.C.14
Evans, R.M.15
-
52
-
-
0037133575
-
Small-molecule antagonists of Myc/Max dimerization inhibit Myc-induced transformation of chicken embryo fibroblasts
-
T. Berg, S.B. Cohen, J. Desharnais, C. Sonderegger, D.J. Maslyar, J. Goldberg, D.L. Boger, P.K. Vogt, Small-molecule antagonists of Myc/Max dimerization inhibit Myc-induced transformation of chicken embryo fibroblasts, Proc. Natl. Acad. Sei. U. S. A. 2002, 99, 3830-3835.
-
(2002)
Proc. Natl. Acad. Sei. U. S. A.
, vol.99
, pp. 3830-3835
-
-
Berg, T.1
Cohen, S.B.2
Desharnais, J.3
Sonderegger, C.4
Maslyar, D.J.5
Goldberg, J.6
Boger, D.L.7
Vogt, P.K.8
-
53
-
-
0344640906
-
Domain-selective small-molecule inhibitor of histone deacetylase 6 (H.DAC6)-mediated tubulin deacetylation
-
S.J. Haggarty, K.M. Koeller, J.C. Wong, C.M. Grozinger, S.L. Schreiber, Domain-selective small-molecule inhibitor of histone deacetylase 6 (H.DAC6)-mediated tubulin deacetylation, Proc. Natl. Acad. Sei. U.S.A. 2003, 100, 4389-4394.
-
(2003)
Proc. Natl. Acad. Sei. U.S.A.
, vol.100
, pp. 4389-4394
-
-
Haggarty, S.J.1
Koeller, K.M.2
Wong, J.C.3
Grozinger, C.M.4
Schreiber, S.L.5
-
54
-
-
0037161744
-
HDAC6 is a microtubule-associated deacetylase
-
C. Hubbert, A. Guardiola, R. Shao, Y. Kawaguchi, A. Ito, A. Nixon, M. Yoshida, X.-F. Wang, T.-P. Yao, HDAC6 is a microtubule-associated deacetylase, Nature 2002, 417, 455-458.
-
(2002)
Nature
, vol.417
, pp. 455-458
-
-
Hubbert, C.1
Guardiola, A.2
Shao, R.3
Kawaguchi, Y.4
Ito, A.5
Nixon, A.6
Yoshida, M.7
Wang, X.-F.8
Yao, T.-P.9
-
55
-
-
3042744026
-
A role for chemistry in stem cell biology
-
S. Ding, P.G Schultz, A role for chemistry in stem cell biology, Nat. Biotechnol. 2004, 22, 833-840.
-
(2004)
Nat. Biotechnol.
, vol.22
, pp. 833-840
-
-
Ding, S.1
Schultz, P.G.2
-
56
-
-
0038274333
-
Discovery and optimization of non-steroidal FXR agonists from natural product-like libraries
-
K.C. Nicolaou, R.M. Evans, A.J. Roecker, R. Hughes, M. Downes, J.A Pfefferkorn, Discovery and optimization of non-steroidal FXR agonists from natural product-like libraries, Org. Biomol. Chem. 2003, 2, 908-920.
-
(2003)
Org. Biomol. Chem.
, vol.2
, pp. 908-920
-
-
Nicolaou, K.C.1
Evans, R.M.2
Roecker, A.J.3
Hughes, R.4
Downes, M.5
Pfefferkorn, J.A.6
-
57
-
-
0141633672
-
Solution-phase combinatorial libraries: modulating cellular signaling by targeting protein-protein or protein-DNA interactions
-
D.L. Boger, J. Desharnais, K. Capps, Solution-phase combinatorial libraries: modulating cellular signaling by targeting protein-protein or protein-DNA interactions, Angew. Chem., Int. Ed. Engl. 2003, 42, 4138-4176.
-
(2003)
Angew. Chem., Int. Ed. Engl.
, vol.42
, pp. 4138-4176
-
-
Boger, D.L.1
Desharnais, J.2
Capps, K.3
-
58
-
-
8444225024
-
Policy forum: molecular biology: NIH molecular libraries initiative
-
C.P. Austin, L.S. Brady, T.R. Insel, F.S Collins, Policy forum: molecular biology: NIH molecular libraries initiative, Science 2004, 306, 1138-1139.
-
(2004)
Science
, vol.306
, pp. 1138-1139
-
-
Austin, C.P.1
Brady, L.S.2
Insel, T.R.3
Collins, F.S.4
-
59
-
-
0037835827
-
Fluorous technologies for solution-phase high-throughput organic-synthesis
-
W. Zang, Fluorous technologies for solution-phase high-throughput organic-synthesis, Tetrahedron, 2003, 59, 4475-4489.
-
(2003)
Tetrahedron
, vol.59
, pp. 4475-4489
-
-
Zang, W.1
-
60
-
-
20844435806
-
Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma
-
T. Hideshima, J.E. Bradner, J. Wong, D. Chauhan, P. Richardson, S.L. Schreiber, K.C. Anderson, Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma, Proc. Natl. Acad. Sei. U. S. A. 2005, 202, 8567-8572.
-
(2005)
Proc. Natl. Acad. Sei. U. S. A.
, vol.202
, pp. 8567-8572
-
-
Hideshima, T.1
Bradner, J.E.2
Wong, J.3
Chauhan, D.4
Richardson, P.5
Schreiber, S.L.6
Anderson, K.C.7
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