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Volumn 8, Issue 4, 2006, Pages 513-529

Kernicterus and the molecular mechanisms of bilirubin-induced CNS injury in newborns

Author keywords

Apoptosis; Bilirubin; Excitotoxic injury; Kernicterus; Necrosis; Neurotoxicity

Indexed keywords

BILIRUBIN; CALCIUM; MITOGEN ACTIVATED PROTEIN KINASE;

EID: 33749636448     PISSN: 15351084     EISSN: None     Source Type: Journal    
DOI: 10.1385/NMM:8:4:513     Document Type: Review
Times cited : (122)

References (123)
  • 1
    • 0345426033 scopus 로고
    • Neonatal kernicterus: Neuropathologic diagnosis
    • Levine R. L., Maisels M. J., eds., Ross Laboratories, Columbus, OH
    • Ahdab-Barmada M. (1983) Neonatal kernicterus: neuropathologic diagnosis, in Hyperbilirubinemia in the Newborn, Levine R. L., Maisels M. J., eds., Ross Laboratories, Columbus, OH, pp. 2-10.
    • (1983) Hyperbilirubinemia in the Newborn , pp. 2-10
    • Ahdab-Barmada, M.1
  • 2
    • 0011324203 scopus 로고    scopus 로고
    • The neuropathology of kernicterus: Definitions and debate
    • Maisels M. J., Watchko J. F., eds., Harwood Academic Publishers, Amsterdam
    • Ahdab-Barmada M. (2000) The neuropathology of kernicterus: definitions and debate, in Neonatal Jaundice, Maisels M. J., Watchko J. F., eds., Harwood Academic Publishers, Amsterdam, pp. 75-88.
    • (2000) Neonatal Jaundice , pp. 75-88
    • Ahdab-Barmada, M.1
  • 3
    • 0021321793 scopus 로고
    • The neuropathology of kernicterus in the premature neonate: Diagnostic problems
    • Ahdab-Barmada M. and Moossy J. (1984) The neuropathology of kernicterus in the premature neonate: Diagnostic problems. J. Neuropathol. Exp. Neurol. 43, 45-52.
    • (1984) J. Neuropathol. Exp. Neurol. , vol.43 , pp. 45-52
    • Ahdab-Barmada, M.1    Moossy, J.2
  • 4
    • 0037192399 scopus 로고    scopus 로고
    • Bilirubin produces apoptosis in cultured bovine brain endothelial cells
    • Akin E., Clower B., Tibbs R., Tang J., and Zhang J. (2002) Bilirubin produces apoptosis in cultured bovine brain endothelial cells. Brain Res. 931, 168-175.
    • (2002) Brain Res. , vol.931 , pp. 168-175
    • Akin, E.1    Clower, B.2    Tibbs, R.3    Tang, J.4    Zhang, J.5
  • 5
    • 1942426424 scopus 로고    scopus 로고
    • Kernicterus: Epidemiological strategies for its prevention through systems-based approaches
    • Bhutani V. K., Johnson L. H., Maisels M. J., et al. (2004) Kernicterus: epidemiological strategies for its prevention through systems-based approaches. J. Perinatol. 24, 650-662.
    • (2004) J. Perinatol. , vol.24 , pp. 650-662
    • Bhutani, V.K.1    Johnson, L.H.2    Maisels, M.J.3
  • 6
    • 0029153913 scopus 로고
    • Apoptosis and necrosis: Two distinct events induced, respectively, by mild and intense insults with N-Methyl-D-Aspartate or nitric-oxide superoxide in cortical cell-cultures
    • Bonfoco E., Krainc D., Ankarcrona M., Nicotera P., and Lipton S. A. (1995) Apoptosis and necrosis: Two distinct events induced, respectively, by mild and intense insults with N-Methyl-D-Aspartate or nitric-oxide superoxide in cortical cell-cultures. Proc. Natl. Acad. Sci. USA 92, 7162-7166.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 7162-7166
    • Bonfoco, E.1    Krainc, D.2    Ankarcrona, M.3    Nicotera, P.4    Lipton, S.A.5
  • 7
    • 5044220926 scopus 로고    scopus 로고
    • A link between hyperbilirubinemia, oxidative stress and injury to neocortical synaptosomes
    • Brito M.A., Brites D., and Butterfield D. A. (2004) A link between hyperbilirubinemia, oxidative stress and injury to neocortical synaptosomes. Brain Res. 1026, 33-43.
    • (2004) Brain Res. , vol.1026 , pp. 33-43
    • Brito, M.A.1    Brites, D.2    Butterfield, D.A.3
  • 8
    • 0018396166 scopus 로고
    • Bilirubin: Solubility and interactions with albumin and phospholipid
    • Brodersen R. (1979) Bilirubin: solubility and interactions with albumin and phospholipid. J. Biol. Chem. 254, 2364-2369.
    • (1979) J. Biol. Chem. , vol.254 , pp. 2364-2369
    • Brodersen, R.1
  • 9
    • 0002547347 scopus 로고
    • Physical chemistry of bilirubin: Binding to macromolecules and membranes
    • Heirwegh K. P. M. and Brown S. B., eds., CRC Press, Inc., Boca Raton
    • Brodersen R. (1982) Physical chemistry of bilirubin: binding to macromolecules and membranes, in Bilirubin Chemistry, Heirwegh K. P. M. and Brown S. B., eds., CRC Press, Inc., Boca Raton, pp. 75-123.
    • (1982) Bilirubin Chemistry , pp. 75-123
    • Brodersen, R.1
  • 10
    • 0002069912 scopus 로고    scopus 로고
    • Loss of concern about jaundice and the reemergence of kernicterus in full term infants in the era of managed care
    • Fanaroff A. A., Klaus M. H., eds., Mosby Yearbook, St Louis, Missouri
    • Brown A. K. and Johnson L. (1996) Loss of concern about jaundice and the reemergence of kernicterus in full term infants in the era of managed care, in Yearbook of Neonatal and Perinatal Medicine, Fanaroff A. A., Klaus M. H., eds., Mosby Yearbook, St Louis, Missouri, pp. xvii-xxviii.
    • (1996) Yearbook of Neonatal and Perinatal Medicine
    • Brown, A.K.1    Johnson, L.2
  • 11
    • 0000888577 scopus 로고
    • Extrapyramidal cerebral palsy and hearing loss following erthroblastosis
    • Byers R. K., Paine R. S., and Crothers B. (1955) Extrapyramidal cerebral palsy and hearing loss following erthroblastosis. Pediatrics 15, 248-254.
    • (1955) Pediatrics , vol.15 , pp. 248-254
    • Byers, R.K.1    Paine, R.S.2    Crothers, B.3
  • 13
    • 0034028479 scopus 로고    scopus 로고
    • 2+/ calmodulin kinase II in the cerebellum of jaundiced Gunn rats during development: A quantitative light microscopic analysis
    • 2+/calmodulin kinase II in the cerebellum of jaundiced Gunn rats during development: a quantitative light microscopic analysis. Acta Neuropathol. (Berl.) 99, 393-401.
    • (2000) Acta Neuropathol. (Berl.) , vol.99 , pp. 393-401
    • Conlee, J.W.1    Shapiro, S.M.2    Churn, S.B.3
  • 14
    • 20344386955 scopus 로고    scopus 로고
    • Hyperintense globus pallidus on T1-weighted MR imaging in acute kernicterus: Is it common or rare?
    • Coskun A., Yikilmaz A., Kumandas S., Karahan O. I., Akcakus M., and Manav A. (2005) Hyperintense globus pallidus on T1-weighted MR imaging in acute kernicterus: is it common or rare? Eur. Radiol. 15, 1263-1267.
    • (2005) Eur. Radiol. , vol.15 , pp. 1263-1267
    • Coskun, A.1    Yikilmaz, A.2    Kumandas, S.3    Karahan, O.I.4    Akcakus, M.5    Manav, A.6
  • 15
    • 0015008690 scopus 로고
    • Mechanisms of bilirubin toxicity on tissue culture cells: Factors that affect toxicity, reversibility by albumin, and comparison with other respiratory poisons and surfactants
    • Cowger M. L. (1971) Mechanisms of bilirubin toxicity on tissue culture cells: factors that affect toxicity, reversibility by albumin, and comparison with other respiratory poisons and surfactants. Biochem. Med. 5, 1-6.
    • (1971) Biochem. Med. , vol.5 , pp. 1-6
    • Cowger, M.L.1
  • 16
    • 0032253897 scopus 로고    scopus 로고
    • Decline in US cesarean delivery rate appears to stall
    • Curtin S. C. and Kozak L. J. (1998) Decline in US cesarean delivery rate appears to stall. Birth 25, 259-262.
    • (1998) Birth , vol.25 , pp. 259-262
    • Curtin, S.C.1    Kozak, L.J.2
  • 17
    • 33748041670 scopus 로고    scopus 로고
    • Calculated in vivo free bilirubin levels in the central nervous system of Gunn rat pups
    • in press
    • Daood M. J. and Watchko J. F. (2006) Calculated in vivo free bilirubin levels in the central nervous system of Gunn rat pups. Pediatr. Res. in press.
    • (2006) Pediatr. Res.
    • Daood, M.J.1    Watchko, J.F.2
  • 18
    • 0343960889 scopus 로고
    • Inhibition of brain respiration in vitro by bilirubin. Reversal of inhibition by various means
    • Day R. L. (1954) Inhibition of brain respiration in vitro by bilirubin. Reversal of inhibition by various means. Proc. Soc. Exper. Biol. Med. 85, 261-264.
    • (1954) Proc. Soc. Exper. Biol. Med. , vol.85 , pp. 261-264
    • Day, R.L.1
  • 19
    • 0014197871 scopus 로고
    • Oxidative phosphorylation in experimental bilirubin encephalpathy
    • Diamond I. and Schmid R. (1967) Oxidative phosphorylation in experimental bilirubin encephalpathy. Science 155, 1288-1289.
    • (1967) Science , vol.155 , pp. 1288-1289
    • Diamond, I.1    Schmid, R.2
  • 20
    • 0030982798 scopus 로고    scopus 로고
    • Evidence that the early loss in membrane protein kinase C is a necessary step in the excitatory amino acid-induced death of primary cortical neurons
    • Durkin J. P., Tremblay R., Chakravarthy B., Mealing G., Morley P., and Song D. (1997) Evidence that the early loss in membrane protein kinase C is a necessary step in the excitatory amino acid-induced death of primary cortical neurons. J. Neurochem. 68, 1400-1412.
    • (1997) J. Neurochem. , vol.68 , pp. 1400-1412
    • Durkin, J.P.1    Tremblay, R.2    Chakravarthy, B.3    Mealing, G.4    Morley, P.5    Song, D.6
  • 21
    • 0030045253 scopus 로고    scopus 로고
    • An early loss in membrane protein kinase C activity precedes the excitatory amino acid-induced death of primary cortical neurons
    • Durkin J. P., Tremblay R., Buchan A., et al. (1996) An early loss in membrane protein kinase C activity precedes the excitatory amino acid-induced death of primary cortical neurons. J. Neurochem. 66, 951-962.
    • (1996) J. Neurochem. , vol.66 , pp. 951-962
    • Durkin, J.P.1    Tremblay, R.2    Buchan, A.3
  • 22
    • 0020044401 scopus 로고
    • Low reserve albumin for binding of bilirubin in neonates with deficiency of bilirubin excretion and bronze baby syndrome
    • Ebbesen F. (1982) Low reserve albumin for binding of bilirubin in neonates with deficiency of bilirubin excretion and bronze baby syndrome. Acta Paediatr. Scand. 71, 415-420.
    • (1982) Acta Paediatr. Scand. , vol.71 , pp. 415-420
    • Ebbesen, F.1
  • 23
    • 0033744224 scopus 로고    scopus 로고
    • Recurrence of kernicterus in term and near-term infants in Denmark
    • Ebbesen F. (2000) Recurrence of kernicterus in term and near-term infants in Denmark. Acta Paediatr. 89, 1213-1217.
    • (2000) Acta Paediatr. , vol.89 , pp. 1213-1217
    • Ebbesen, F.1
  • 24
    • 33749589489 scopus 로고
    • The mode of action of bilirubin on mitochondria
    • Sass-Kortsak A., ed., University of Toronto Press, Toronto
    • Ernster L. (1961) The mode of action of bilirubin on mitochondria, in Kernicterus, Sass-Kortsak A., ed., University of Toronto Press, Toronto, pp. 174-192.
    • (1961) Kernicterus , pp. 174-192
    • Ernster, L.1
  • 25
    • 0347321488 scopus 로고
    • The neurologic sequelae of Rh sensitization
    • Evans P. R. and Polani N. (1950) The neurologic sequelae of Rh sensitization. Quart. J. Med. 19, 129-149.
    • (1950) Quart. J. Med. , vol.19 , pp. 129-149
    • Evans, P.R.1    Polani, N.2
  • 26
    • 85077347809 scopus 로고    scopus 로고
    • Role of TNFα and biological modifiers on cytokine production after astrocyte exposure to bilirubin: Relationship to NF-kB
    • Fernandes A., Falcao A. S., Silva R. F. M., Brito M. A., and Brites D. (2004a) Role of TNFα and biological modifiers on cytokine production after astrocyte exposure to bilirubin: relationship to NF-kB. Pediatr. Res. 55, 473A.
    • (2004) Pediatr. Res. , vol.55
    • Fernandes, A.1    Falcao, A.S.2    Silva, R.F.M.3    Brito, M.A.4    Brites, D.5
  • 27
    • 3242679583 scopus 로고    scopus 로고
    • Cytokine production, glutamate release and cell death in rat cultured astrocytes treated with unconjugated bilirubin and LPS
    • Fernandes A., Silva R. F. M., Falcao A. S., Brito M. A., and Brites D. (2004b) Cytokine production, glutamate release and cell death in rat cultured astrocytes treated with unconjugated bilirubin and LPS. J. Neuroimmunol. 153, 64-75.
    • (2004) J. Neuroimmunol. , vol.153 , pp. 64-75
    • Fernandes, A.1    Silva, R.F.M.2    Falcao, A.S.3    Brito, M.A.4    Brites, D.5
  • 28
    • 33749626012 scopus 로고    scopus 로고
    • Dissecting astrocyte reactivity by unconjugated bilirubin: Evidence for a biphasic response
    • Fernandes A., Falcao S., Gordo C., et al. (2005) Dissecting astrocyte reactivity by unconjugated bilirubin: evidence for a biphasic response. PAS 57, 2255.
    • (2005) PAS , vol.57 , pp. 2255
    • Fernandes, A.1    Falcao, S.2    Gordo, C.3
  • 29
    • 0014799977 scopus 로고
    • Kernicterus: High incidence in premature infants with low serum bilirubin concentrations
    • Gartner L. M., Snyder R. N., Chabon R. S., and Bernstein J. (1970) Kernicterus: high incidence in premature infants with low serum bilirubin concentrations. Pediatrics 45, 906-917.
    • (1970) Pediatrics , vol.45 , pp. 906-917
    • Gartner, L.M.1    Snyder, R.N.2    Chabon, R.S.3    Bernstein, J.4
  • 30
    • 10744221309 scopus 로고    scopus 로고
    • Bilirubin protects astrocytes from its own toxicity by inducing up-regulation and translocation of multidrug reisistance-associated protein 1 (Mrp1)
    • Gennuso F., Fernetti C., Tirolo C., et al. (2004) Bilirubin protects astrocytes from its own toxicity by inducing up-regulation and translocation of multidrug reisistance-associated protein 1 (Mrp1). Proc. Natl. Acad. Sci. USA 101, 2470-2475.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 2470-2475
    • Gennuso, F.1    Fernetti, C.2    Tirolo, C.3
  • 32
    • 0030663134 scopus 로고    scopus 로고
    • Kernicterus associated with elevated predominantly direct-reacting bilirubin
    • Grobler J. M. and Mercer M. J. (1997) Kernicterus associated with elevated predominantly direct-reacting bilirubin. South Amer. Med. J. 87, 1146.
    • (1997) South Amer. Med. J. , vol.87 , pp. 1146
    • Grobler, J.M.1    Mercer, M.J.2
  • 33
    • 3042795855 scopus 로고    scopus 로고
    • Cerebral metabolism in severe neonatal hyperbilirubinemia
    • Groenendaal F., van der Grond J., and de Vries L. S. (2004) Cerebral metabolism in severe neonatal hyperbilirubinemia. Pediatrics 114, 291-294.
    • (2004) Pediatrics , vol.114 , pp. 291-294
    • Groenendaal, F.1    Van Der Grond, J.2    De Vries, L.S.3
  • 34
    • 0033669937 scopus 로고    scopus 로고
    • Bilirubin induces apoptosis via activation of NMDA receptors in developing rat brain neurons
    • Grojean S., Koziel V., Vert P., and Daval J. L. (2000) Bilirubin induces apoptosis via activation of NMDA receptors in developing rat brain neurons. Exp. Neurol. 166, 334-341.
    • (2000) Exp. Neurol. , vol.166 , pp. 334-341
    • Grojean, S.1    Koziel, V.2    Vert, P.3    Daval, J.L.4
  • 35
    • 0019326940 scopus 로고
    • Photodynamic action of bilirubin on the inner mitochondrial membrane: Implications for the organization of the mitochondrial ATPase
    • Hackney D. D. (1980) Photodynamic action of bilirubin on the inner mitochondrial membrane: implications for the organization of the mitochondrial ATPase. Biochem. Biophys. Res. Commum. 94, 875-880.
    • (1980) Biochem. Biophys. Res. Commum. , vol.94 , pp. 875-880
    • Hackney, D.D.1
  • 37
    • 33644819005 scopus 로고    scopus 로고
    • Synergistic protection of a general caspase inhibitor and MK-801 in bilirubin-induced cell death in human NT2-N neurons
    • Hanko E., Hansen T. W. R., Almaas R., Paulsen R., and Rootwelt T. (2006) Synergistic protection of a general caspase inhibitor and MK-801 in bilirubin-induced cell death in human NT2-N neurons. Pediatr. Res. 59, 72-77.
    • (2006) Pediatr. Res. , vol.59 , pp. 72-77
    • Hanko, E.1    Hansen, T.W.R.2    Almaas, R.3    Paulsen, R.4    Rootwelt, T.5
  • 38
    • 0002691618 scopus 로고    scopus 로고
    • The pathophysiology of bilirubin toxicity
    • Maisels M. J. and Watchko, J. F., eds., Harwood Academic Publishers, Amsterdam, The Netherlands
    • Hansen T. W. R. (2000) The pathophysiology of bilirubin toxicity, in Neonatal Jaundice, Maisels M. J. and Watchko, J. F., eds., Harwood Academic Publishers, Amsterdam, The Netherlands, pp. 89-104.
    • (2000) Neonatal Jaundice , pp. 89-104
    • Hansen, T.W.R.1
  • 39
    • 0036551616 scopus 로고    scopus 로고
    • Kernicterus: An international perspective
    • Hansen T. W. R. (2002) Kernicterus: an international perspective. Semin Neonatol 7, 103-109.
    • (2002) Semin. Neonatol. , vol.7 , pp. 103-109
    • Hansen, T.W.R.1
  • 42
    • 0023921335 scopus 로고
    • Short-term exposure to bilirubin reduces synaptic activation in rat transverse hippocamal slices
    • Hansen T. W. R., Oaulsen O., Gjerstad L., and Bratlid D. (1988) Short-term exposure to bilirubin reduces synaptic activation in rat transverse hippocamal slices. Pediatr. Res. 23, 453-456.
    • (1988) Pediatr. Res. , vol.23 , pp. 453-456
    • Hansen, T.W.R.1    Oaulsen, O.2    Gjerstad, L.3    Bratlid, D.4
  • 43
    • 0029828966 scopus 로고    scopus 로고
    • The in vivo effect of bilirubin on the N-methyl-D-aspartate receptor/ion channel complex in the brains of newborn piglets
    • Hoffman D. J., Zaneli S. A., Kubin J., Mishra O. P., and Delivoria-Papadopoulis M. (1996) The in vivo effect of bilirubin on the N-methyl-D-aspartate receptor/ion channel complex in the brains of newborn piglets. Pediatr Res 40, 804-808.
    • (1996) Pediatr. Res. , vol.40 , pp. 804-808
    • Hoffman, D.J.1    Zaneli, S.A.2    Kubin, J.3    Mishra, O.P.4    Delivoria-Papadopoulis, M.5
  • 44
    • 0030694873 scopus 로고    scopus 로고
    • Brain magnetic resonance imaging in suspected extrapyramidal cerebral palsy: Observations in distinguishing genetic-metabolic from acquired causes
    • Hoon A. H., Reinhardt E. M., Keley R. I., et al. (1997) Brain magnetic resonance imaging in suspected extrapyramidal cerebral palsy: observations in distinguishing genetic-metabolic from acquired causes. J. Pediatr. 131, 240-245.
    • (1997) J. Pediatr. , vol.131 , pp. 240-245
    • Hoon, A.H.1    Reinhardt, E.M.2    Keley, R.I.3
  • 45
    • 23844536093 scopus 로고    scopus 로고
    • Excitotoxicity in perinatal brain injury
    • Johnston M. V. (2005) Excitotoxicity in perinatal brain injury. Brain Pathol. 15, 234-240.
    • (2005) Brain Pathol. , vol.15 , pp. 234-240
    • Johnston, M.V.1
  • 46
    • 0000560724 scopus 로고
    • Bilirubin-dependent brain damage: Incidence and indications for treatment
    • Odell G. B., Schaffer R. and Simopoulos A. P., eds, National Academy of Sciences, Washington, D.C.
    • Johnson L. and Boggs T. R. (1974) Bilirubin-dependent brain damage: incidence and indications for treatment, in Phototherapy in the Newborn: An Overview, Odell G. B., Schaffer R. and Simopoulos A. P., eds, National Academy of Sciences, Washington, D.C., pp. 122-149.
    • (1974) Phototherapy in the Newborn: An Overview , pp. 122-149
    • Johnson, L.1    Boggs, T.R.2
  • 47
    • 0033804314 scopus 로고    scopus 로고
    • Possible mechanisms in infants for selective basal ganglia damage from asphyxia, kernciterus, or mitochondrial encephalopathies
    • Johnston M. V. and Hoon A. H. (2000) Possible mechanisms in infants for selective basal ganglia damage from asphyxia, kernciterus, or mitochondrial encephalopathies. J. Child. Neurol. 15, 588-591.
    • (2000) J. Child. Neurol. , vol.15 , pp. 588-591
    • Johnston, M.V.1    Hoon, A.H.2
  • 49
    • 4344689360 scopus 로고    scopus 로고
    • Understanding and preventing severe hyperbilirubinemia: Is bilirubin neurotoxicity really a problem in the developed world?
    • Kaplan M. and Hammerman C. (2004) Understanding and preventing severe hyperbilirubinemia: is bilirubin neurotoxicity really a problem in the developed world? Clin. Perinatol. 31, 555-575.
    • (2004) Clin. Perinatol. , vol.31 , pp. 555-575
    • Kaplan, M.1    Hammerman, C.2
  • 50
    • 14844350452 scopus 로고    scopus 로고
    • Bilirubin and the genome: The hereditary basis of unconjugated neonatal hyperbilirubinemia
    • Kaplan M. and Hammerman C. (2005) Bilirubin and the genome: The hereditary basis of unconjugated neonatal hyperbilirubinemia. Curr. Pharmacogen. 3, 21-42.
    • (2005) Curr. Pharmacogen. , vol.3 , pp. 21-42
    • Kaplan, M.1    Hammerman, C.2
  • 51
    • 0037385144 scopus 로고    scopus 로고
    • Bilirubin genetics for the nongeneticist: Hereditary defects of neonatal bilirubin conjugation
    • Kaplan M., Hammerman C., and Maisels M. J. (2003) Bilirubin genetics for the nongeneticist: hereditary defects of neonatal bilirubin conjugation. Pediatrics 111, 886-893.
    • (2003) Pediatrics , vol.111 , pp. 886-893
    • Kaplan, M.1    Hammerman, C.2    Maisels, M.J.3
  • 52
    • 0018393722 scopus 로고
    • Biochemical alterations in neonatal hyperbilirubinemia and bilirubin encephalopathy: A review
    • Karp W. B. (1979) Biochemical alterations in neonatal hyperbilirubinemia and bilirubin encephalopathy: a review. Pediatrics 64, 361-368.
    • (1979) Pediatrics , vol.64 , pp. 361-368
    • Karp, W.B.1
  • 54
    • 4644344388 scopus 로고    scopus 로고
    • Unconjugated bilirubin induces apoptosis in colon cancer cells by triggering mitochondrial depolarization
    • Keshavan P., Schwemberger S. J., Smith D. L. H., Babcock G. F., and Zucker S. D. (2004) Unconjugated bilirubin induces apoptosis in colon cancer cells by triggering mitochondrial depolarization. Int. J. Cancer 112, 433-445.
    • (2004) Int. J. Cancer , vol.112 , pp. 433-445
    • Keshavan, P.1    Schwemberger, S.J.2    Smith, D.L.H.3    Babcock, G.F.4    Zucker, S.D.5
  • 55
    • 0031816414 scopus 로고    scopus 로고
    • Apoptosis, excitotoxicity, and neuropathology
    • Leist M. and Nicotera P. (1998) Apoptosis, excitotoxicity, and neuropathology. Exp. Cell Res. 239, 183-201.
    • (1998) Exp. Cell Res. , vol.239 , pp. 183-201
    • Leist, M.1    Nicotera, P.2
  • 56
    • 0344234422 scopus 로고    scopus 로고
    • p38 MAP kinase mediates bilirubin-induced death of cultured rat cerebellar granule neurons
    • Lin S., Yan C., Wei X., Paul S. M., and Du Y. (2003) p38 MAP kinase mediates bilirubin-induced death of cultured rat cerebellar granule neurons. Neurosci. Lett. 353, 209-212.
    • (2003) Neurosci. Lett. , vol.353 , pp. 209-212
    • Lin, S.1    Yan, C.2    Wei, X.3    Paul, S.M.4    Du, Y.5
  • 57
    • 23044460297 scopus 로고    scopus 로고
    • Minocycline blocks bilirubin neurotoxicity and prevents hyperbilirubinemia-induced cerebellar hypoplasia in the Gunn rat
    • Lin S., Wei X., Bales K. R., et al. (2005) Minocycline blocks bilirubin neurotoxicity and prevents hyperbilirubinemia-induced cerebellar hypoplasia in the Gunn rat. Eur. J. Neurosci. 22, 21-27.
    • (2005) Eur. J. Neurosci. , vol.22 , pp. 21-27
    • Lin, S.1    Wei, X.2    Bales, K.R.3
  • 58
    • 0029156843 scopus 로고
    • Hidden risks: Early discharge and bilirubin toxicity due to glucose-6-phosphate dehydrogenase deficiency
    • MacDonald M. G. (1995) Hidden risks: early discharge and bilirubin toxicity due to glucose-6-phosphate dehydrogenase deficiency. Pediatrics 96, 734-738.
    • (1995) Pediatrics , vol.96 , pp. 734-738
    • MacDonald, M.G.1
  • 59
    • 33749639931 scopus 로고
    • Cerebral changes in kernicterus
    • Jacob H., ed., Georg Thieme Verlag, Stuttgart
    • th International Congress of Neuropathology, vol. 3, Jacob H., ed., Georg Thieme Verlag, Stuttgart, pp.83-89.
    • (1961) th International Congress of Neuropathology , vol.3 , pp. 83-89
    • Mair, W.G.P.1
  • 60
    • 0029121161 scopus 로고
    • Kernicterus in otherwise healthy, breast-fed term newborns
    • Maisels M. J. and Newman T. B. (1995) Kernicterus in otherwise healthy, breast-fed term newborns. Pediatrics 96, 730-733.
    • (1995) Pediatrics , vol.96 , pp. 730-733
    • Maisels, M.J.1    Newman, T.B.2
  • 61
    • 0036097810 scopus 로고    scopus 로고
    • Mitochondrial encephalopathy: Comparison of conventional MR imaging with diffusion-weighted and diffusion tensor imaging: Case report
    • Majoie C. B., Akkerman E. M., Blank C., Barth P. G., Poll-The B. T., and den Heeten G. J. (2002) Mitochondrial encephalopathy: comparison of conventional MR imaging with diffusion-weighted and diffusion tensor imaging: case report. A.J.N.R. Am. J. Neuroradiol. 23, 813-816.
    • (2002) A.J.N.R. Am. J. Neuroradiol. , vol.23 , pp. 813-816
    • Majoie, C.B.1    Akkerman, E.M.2    Blank, C.3    Barth, P.G.4    Poll-The, B.T.5    Den Heeten, G.J.6
  • 63
    • 0025257513 scopus 로고
    • Physiological and pathological roles of excitatory amino acids during central nervous system development
    • McDonald J. W. and Johnston M. V. (1990) Physiological and pathological roles of excitatory amino acids during central nervous system development. Brain Res. Rev. 15, 41-70.
    • (1990) Brain Res. Rev. , vol.15 , pp. 41-70
    • McDonald, J.W.1    Johnston, M.V.2
  • 64
    • 0032032683 scopus 로고    scopus 로고
    • Role of glutamate recpetor-mediated excitotoxicity in bilirubin-induced brain injury in the Gunn rat model
    • McDonald J. W., Shapiro S. M., Silverstein F. S., and Johnston M. V. (1998) Role of glutamate recpetor-mediated excitotoxicity in bilirubin-induced brain injury in the Gunn rat model. Exp. Neurol. 150, 21-29.
    • (1998) Exp. Neurol. , vol.150 , pp. 21-29
    • McDonald, J.W.1    Shapiro, S.M.2    Silverstein, F.S.3    Johnston, M.V.4
  • 65
    • 33644678198 scopus 로고    scopus 로고
    • Clinical (video) findings and cerebrospinal fluid neurotransmitters in 2 children with severe chronic bilirubin encephalopathy, including a former preterm infant without marked hyperbilirubinemia
    • Merhar S. L. and Gilbert D. L. (2005) Clinical (video) findings and cerebrospinal fluid neurotransmitters in 2 children with severe chronic bilirubin encephalopathy, including a former preterm infant without marked hyperbilirubinemia. Pediatrics 116, 1226-1230.
    • (2005) Pediatrics , vol.116 , pp. 1226-1230
    • Merhar, S.L.1    Gilbert, D.L.2
  • 66
    • 0021347541 scopus 로고
    • Males with neonatal hyperbilirubinemia examined at 18 years of age
    • Nilsen S. T., Finne P. H., Bergsjo P., and Stamnes O. (1984) Males with neonatal hyperbilirubinemia examined at 18 years of age. Acta Paediatr. Scand. 73, 176-180.
    • (1984) Acta Paediatr. Scand. , vol.73 , pp. 176-180
    • Nilsen, S.T.1    Finne, P.H.2    Bergsjo, P.3    Stamnes, O.4
  • 67
    • 0022887764 scopus 로고
    • Differential sensitivity of neural cells to bilirubin toxicity
    • Notter M. F. D. and Kendig J. W. (1986) Differential sensitivity of neural cells to bilirubin toxicity. Exp. Neurol. 94, 670-682.
    • (1986) Exp. Neurol. , vol.94 , pp. 670-682
    • Notter, M.F.D.1    Kendig, J.W.2
  • 68
    • 0023895734 scopus 로고
    • Glutamate becomes neurotoxic via NMDA receptors when intracellular energy levels are reduced
    • Novelli A., Reily J. A., Lysko P. G., and Henneberry R. C. (1988) Glutamate becomes neurotoxic via NMDA receptors when intracellular energy levels are reduced. Brain Res. 451, 205-212.
    • (1988) Brain Res. , vol.451 , pp. 205-212
    • Novelli, A.1    Reily, J.A.2    Lysko, P.G.3    Henneberry, R.C.4
  • 69
    • 32944472762 scopus 로고    scopus 로고
    • 1H MR spectroscopic characteristic of kernicterus: A possible metabolic signature
    • Oakden W. K., Moore A. M., Blaser S., and Noseworthy M. D. (2005) 1H MR spectroscopic characteristic of kernicterus: a possible metabolic signature. AJNR Am. J. Neuroradiol. 26, 1571-1574.
    • (2005) AJNR Am. J. Neuroradiol. , vol.26 , pp. 1571-1574
    • Oakden, W.K.1    Moore, A.M.2    Blaser, S.3    Noseworthy, M.D.4
  • 70
    • 24944549081 scopus 로고    scopus 로고
    • Early steps in bilirubin-mediated apoptosis in murine hepatoma (Hepa 1c1c7) cells are characterized by aryl hydrocarbon receptor-independent oxidative stress and activation of the mitiochondrial pathway
    • Oakes G. H. and Bend J. R. (2005) Early steps in bilirubin-mediated apoptosis in murine hepatoma (Hepa 1c1c7) cells are characterized by aryl hydrocarbon receptor-independent oxidative stress and activation of the mitiochondrial pathway. J. Biochem. Mol. Toxicol. 19, 244-255.
    • (2005) J. Biochem. Mol. Toxicol. , vol.19 , pp. 244-255
    • Oakes, G.H.1    Bend, J.R.2
  • 71
    • 0006296117 scopus 로고
    • Possible biochemical basis for bilirubin neurotoxicity
    • O'Callaghan A. and Duggan P. F. (1984) Possible biochemical basis for bilirubin neurotoxicity. Biochem. Soc. Trans. 12, 483-483.
    • (1984) Biochem. Soc. Trans. , vol.12 , pp. 483-483
    • O'Callaghan, A.1    Duggan, P.F.2
  • 72
    • 0027512207 scopus 로고
    • Interactions of bilirubin with isolated presynaptic nerve terminals: Functional effects on the uptake and release of neurotransmitters
    • Ochoa E. L., Wennberg R. P., An Y., et al. (1993) Interactions of bilirubin with isolated presynaptic nerve terminals: functional effects on the uptake and release of neurotransmitters. Cell Molec. Neurobiol. 13, 69-86.
    • (1993) Cell Molec. Neurobiol. , vol.13 , pp. 69-86
    • Ochoa, E.L.1    Wennberg, R.P.2    An, Y.3
  • 73
    • 3042814901 scopus 로고    scopus 로고
    • Reassessment of the unbound concentration of unconjugated bilirubin in relation to neurotoxicity in vitro
    • Ostrow J. D., Pascolo L., and Tiribelli C. (2003) Reassessment of the unbound concentration of unconjugated bilirubin in relation to neurotoxicity in vitro. Pediatr. Res. 54, 98-104.
    • (2003) Pediatr. Res. , vol.54 , pp. 98-104
    • Ostrow, J.D.1    Pascolo, L.2    Tiribelli, C.3
  • 74
    • 0029822354 scopus 로고    scopus 로고
    • Long-term follow-up of indirect hyperbilirubinemia in full-term Turkish infants
    • Ozmert E., Erdem G., Topcu M., et al. (1996) Long-term follow-up of indirect hyperbilirubinemia in full-term Turkish infants. Acta Paeditr. 85, 1440-1444.
    • (1996) Acta Paeditr. , vol.85 , pp. 1440-1444
    • Ozmert, E.1    Erdem, G.2    Topcu, M.3
  • 75
    • 0043037253 scopus 로고    scopus 로고
    • Endoplasmic reticulum: A primary target in various acute disorders and degenerative diseases of the brain
    • Paschen W. (2003) Endoplasmic reticulum: a primary target in various acute disorders and degenerative diseases of the brain. Cell Calcium 34, 365-383.
    • (2003) Cell Calcium , vol.34 , pp. 365-383
    • Paschen, W.1
  • 77
    • 0001065901 scopus 로고
    • The late clinical syndrome of posticteric encephalopathy
    • Perlstein M. A. (1960) The late clinical syndrome of posticteric encephalopathy. Pediatr. Clin. North. Am. 7, 665-687.
    • (1960) Pediatr. Clin. North. Am. , vol.7 , pp. 665-687
    • Perlstein, M.A.1
  • 78
    • 33749604369 scopus 로고    scopus 로고
    • Apoptosis in the Gunn rat model of kernicterus
    • Rice A. C. and Shapiro S. M. (2005) Apoptosis in the Gunn rat model of kernicterus. PAS 57, 1269.
    • (2005) PAS , vol.57 , pp. 1269
    • Rice, A.C.1    Shapiro, S.M.2
  • 79
    • 7444248391 scopus 로고    scopus 로고
    • The human multidrug-resistance associated protein MRP1 mediates ATP-dependent transport of unconjugated bilirubin
    • Rigato I., Pascolo L., Fernetti C., Ostrow J. D., and Tiribelli C. (2004) The human multidrug-resistance associated protein MRP1 mediates ATP-dependent transport of unconjugated bilirubin. Biochem. J. 383, 335-341.
    • (2004) Biochem. J. , vol.383 , pp. 335-341
    • Rigato, I.1    Pascolo, L.2    Fernetti, C.3    Ostrow, J.D.4    Tiribelli, C.5
  • 80
    • 0036238782 scopus 로고    scopus 로고
    • Bilirubin induces apoptosis via the mitochondrial pathway in developing rat brain neurons
    • Rodrigues C. M. P., Sola S., and Brites D. (2002a) Bilirubin induces apoptosis via the mitochondrial pathway in developing rat brain neurons. Hepatology 35, 1186-1195.
    • (2002) Hepatology , vol.35 , pp. 1186-1195
    • Rodrigues, C.M.P.1    Sola, S.2    Brites, D.3
  • 81
    • 0035988343 scopus 로고    scopus 로고
    • Perturbation of membrane dynamics in nerve cells as an early event during bilirubin-induced apoptosis
    • Rodrigues C. M. P., Sola S., Castro R. E., Laires P. A., Brites D., and Moura J. J. G. (2002b) Perturbation of membrane dynamics in nerve cells as an early event during bilirubin-induced apoptosis. J. Lipid Res. 43, 885-894.
    • (2002) J. Lipid Res. , vol.43 , pp. 885-894
    • Rodrigues, C.M.P.1    Sola, S.2    Castro, R.E.3    Laires, P.A.4    Brites, D.5    Moura, J.J.G.6
  • 82
    • 0034327232 scopus 로고    scopus 로고
    • Bilirubin and amyloid-beta peptide induce cytochrome c release through mitochondrial membrane permeabilization
    • Rodrigues C. M., Sola A., Silva R., and Brites D. (2000) Bilirubin and amyloid-beta peptide induce cytochrome c release through mitochondrial membrane permeabilization. Mol. Med. 6, 936-946.
    • (2000) Mol. Med. , vol.6 , pp. 936-946
    • Rodrigues, C.M.1    Sola, A.2    Silva, R.3    Brites, D.4
  • 83
    • 0026077459 scopus 로고
    • Molecular basis for the lack of bilirubin-specific and 3-methylcholanthrene inducible UDP-glucuronosyltransferase activities in Gunn rats
    • Roy-Chowdhury J., Huang T., Kesari K., Lederstein M., Arias I. M., and Roy-Chowdhury N. (1991) Molecular basis for the lack of bilirubin-specific and 3-methylcholanthrene inducible UDP-glucuronosyltransferase activities in Gunn rats. J. Biol. Chem. 266, 18,294-18,298.
    • (1991) J. Biol. Chem. , vol.266
    • Roy-Chowdhury, J.1    Huang, T.2    Kesari, K.3    Lederstein, M.4    Arias, I.M.5    Roy-Chowdhury, N.6
  • 84
    • 0032200186 scopus 로고    scopus 로고
    • How do tetraclyclines work?
    • Ryan M. E. and Ashley R. A. (1998) How do tetraclyclines work? Adv. Dent. Res. 12, 149-151.
    • (1998) Adv. Dent. Res. , vol.12 , pp. 149-151
    • Ryan, M.E.1    Ashley, R.A.2
  • 85
    • 0036897613 scopus 로고    scopus 로고
    • Breast-feeding continues to increase into the new millennium
    • Ryan A. S., Wenjun Z., and Acosta A. (2002) Breast-feeding continues to increase into the new millennium. Pediatrics 110, 1103-1109.
    • (2002) Pediatrics , vol.110 , pp. 1103-1109
    • Ryan, A.S.1    Wenjun, Z.2    Acosta, A.3
  • 86
    • 0021920319 scopus 로고
    • Mode of inhibition of bilirubin on protein kinase C
    • Sano K., Nakamura H., and Matsuo T. (1985) Mode of inhibition of bilirubin on protein kinase C. Pediatr. Res. 19, 587-590.
    • (1985) Pediatr. Res. , vol.19 , pp. 587-590
    • Sano, K.1    Nakamura, H.2    Matsuo, T.3
  • 87
    • 0141887509 scopus 로고    scopus 로고
    • Patterned Purkinje cell death in the cerebellum
    • Sarna J. R. and Hawkes R. (2003) Patterned Purkinje cell death in the cerebellum. Prog. Neurobiol. 70,473-507.
    • (2003) Prog. Neurobiol. , vol.70 , pp. 473-507
    • Sarna, J.R.1    Hawkes, R.2
  • 88
    • 0013923491 scopus 로고
    • Studies on cellular toxicity of unconjugated bilirubin in kernicteric brain
    • Schenker S., McCandless D. W., and Zollman P. E. (1966) Studies on cellular toxicity of unconjugated bilirubin in kernicteric brain. J. Clin. Invest. 45, 1213-1220.
    • (1966) J. Clin. Invest. , vol.45 , pp. 1213-1220
    • Schenker, S.1    McCandless, D.W.2    Zollman, P.E.3
  • 89
    • 0014982082 scopus 로고
    • Electron microscopic observations on acute bilirubin encephalopathy in Gunn rats induced by sulfadimethoxine
    • Schutta H. S. and Johnson L. (1971) Electron microscopic observations on acute bilirubin encephalopathy in Gunn rats induced by sulfadimethoxine. Lab. Invest. 24, 82-89.
    • (1971) Lab. Invest. , vol.24 , pp. 82-89
    • Schutta, H.S.1    Johnson, L.2
  • 91
    • 0036073635 scopus 로고    scopus 로고
    • Apoptosis in murine hepatoma Hepa 1c1c7 wild type, C12, and C4 cells mediated by bilirubin
    • Seubert J. M., Darmon A. J., El-Kadi A. O. S., D'Souza J. A., and Bend J. R. (2002) Apoptosis in murine hepatoma Hepa 1c1c7 wild type, C12, and C4 cells mediated by bilirubin. Mol. Pharmacol. 62, 257-264.
    • (2002) Mol. Pharmacol. , vol.62 , pp. 257-264
    • Seubert, J.M.1    Darmon, A.J.2    El-Kadi, A.O.S.3    D'Souza, J.A.4    Bend, J.R.5
  • 92
    • 0036836931 scopus 로고    scopus 로고
    • Immunohistochemical localization of calcium-binding proteins in the brainstem vestibular nuclei of the jaundiced Gunn rat
    • Shaia W. T., Shapiro S. M., Heller A. J., Galiani D. L., Sismanis A., and Spencer R. F. (2002) Immunohistochemical localization of calcium-binding proteins in the brainstem vestibular nuclei of the jaundiced Gunn rat. Hear. Res. 173, 82-90.
    • (2002) Hear. Res. , vol.173 , pp. 82-90
    • Shaia, W.T.1    Shapiro, S.M.2    Heller, A.J.3    Galiani, D.L.4    Sismanis, A.5    Spencer, R.F.6
  • 93
    • 0346995454 scopus 로고    scopus 로고
    • Bilirubin toxicity in the developing nervous system
    • Shapiro S. M. (2003) Bilirubin toxicity in the developing nervous system. Pediatr. Neurol. 29, 410-421.
    • (2003) Pediatr. Neurol. , vol.29 , pp. 410-421
    • Shapiro, S.M.1
  • 94
    • 33749604021 scopus 로고    scopus 로고
    • Abnormalities on magnetic resonance imaging (MRI) in children with kernciterus
    • Shapiro S. M., Geiger A. S., O'Tuama L. A., and Baron M. S. (2005) Abnormalities on magnetic resonance imaging (MRI) in children with kernciterus. PAS 57, 1262.
    • (2005) PAS , vol.57 , pp. 1262
    • Shapiro, S.M.1    Geiger, A.S.2    O'Tuama, L.A.3    Baron, M.S.4
  • 95
    • 0035072101 scopus 로고    scopus 로고
    • Bilirubin-induced apoptosis in cultured rat neural cells is aggravated by cheonodeoxycholic acid but prevented by urodeoxycholic acid
    • Silva R. F. M., Rodrigues C. M. P., and Brites D. (2001a) Bilirubin-induced apoptosis in cultured rat neural cells is aggravated by cheonodeoxycholic acid but prevented by urodeoxycholic acid. J. Hepatol. 34, 402-408.
    • (2001) J. Hepatol. , vol.34 , pp. 402-408
    • Silva, R.F.M.1    Rodrigues, C.M.P.2    Brites, D.3
  • 96
    • 0034857845 scopus 로고    scopus 로고
    • Endocytosis in rat cultured astrocytes is inhibitied by unconjugated bilirubin
    • Silva R. F. M., Mata L. M., Gulbenkian S., and Brites D. (2001b) Endocytosis in rat cultured astrocytes is inhibitied by unconjugated bilirubin. Neurochem. Res. 26, 793-800.
    • (2001) Neurochem. Res. , vol.26 , pp. 793-800
    • Silva, R.F.M.1    Mata, L.M.2    Gulbenkian, S.3    Brites, D.4
  • 97
    • 0033547349 scopus 로고    scopus 로고
    • Inhibition of glutamate uptake by unconjugated bilirubin in cultured cortical rat astrocytes: Role of concentration and pH
    • Silva R. F. M., Mata L. M., Gulbenkian S., Brito M. A., Tiribelli C., and Brites D. (1999) Inhibition of glutamate uptake by unconjugated bilirubin in cultured cortical rat astrocytes: role of concentration and pH. Biochem. Biophys. Res. Commun. 265, 67-72.
    • (1999) Biochem. Biophys. Res. Commun. , vol.265 , pp. 67-72
    • Silva, R.F.M.1    Mata, L.M.2    Gulbenkian, S.3    Brito, M.A.4    Tiribelli, C.5    Brites, D.6
  • 98
    • 0000022275 scopus 로고
    • A difference in mortality rate and incidence of kernicterus among premature infants allotted to two prophylactic antibacterial regimens
    • Silverman W. A., Andersen D. H., Blanc W. A., and Crozier D. N. (1956) A difference in mortality rate and incidence of kernicterus among premature infants allotted to two prophylactic antibacterial regimens. Pediatrics 18, 614-625.
    • (1956) Pediatrics , vol.18 , pp. 614-625
    • Silverman, W.A.1    Andersen, D.H.2    Blanc, W.A.3    Crozier, D.N.4
  • 99
    • 12344284585 scopus 로고    scopus 로고
    • Don't get too excited: Mechanisms of glutamate-mediated Purkinje cell death
    • Slemmer J. E., De Zeeuw C. I., and Weber J. T. (2005) Don't get too excited: mechanisms of glutamate-mediated Purkinje cell death. Prog. Brain Res. 148, 367-390.
    • (2005) Prog. Brain Res. , vol.148 , pp. 367-390
    • Slemmer, J.E.1    De Zeeuw, C.I.2    Weber, J.T.3
  • 100
    • 0036768228 scopus 로고    scopus 로고
    • Changes in calcium-binding protein expression in the auditory brain-stem nuclei of the jaundiced Gunn rat
    • Spencer R. F., Shaia W. T., Gleason A. T., Sismanis A., and Shapiro S. M. (2002) Changes in calcium-binding protein expression in the auditory brain-stem nuclei of the jaundiced Gunn rat. Hear. Res. 171, 129-141.
    • (2002) Hear. Res. , vol.171 , pp. 129-141
    • Spencer, R.F.1    Shaia, W.T.2    Gleason, A.T.3    Sismanis, A.4    Shapiro, S.M.5
  • 101
    • 0015228608 scopus 로고
    • Bile pigment phospholipid interactions
    • Talafant E. (1971) Bile pigment phospholipid interactions. Biochim. Biophys. Acta 231, 394-398.
    • (1971) Biochim. Biophys. Acta , vol.231 , pp. 394-398
    • Talafant, E.1
  • 102
    • 20444379574 scopus 로고    scopus 로고
    • The molecular basis of bilirubin encephalopathy and toxicity: Report of an EASL single topic conference, Trieste, Italy, 1-2 October, 2004
    • Tiribelli C. and Ostrow J. D. (2005) The molecular basis of bilirubin encephalopathy and toxicity: report of an EASL single topic conference, Trieste, Italy, 1-2 October, 2004. J. Hepatol. 43, 156-166.
    • (2005) J. Hepatol. , vol.43 , pp. 156-166
    • Tiribelli, C.1    Ostrow, J.D.2
  • 103
    • 0028362766 scopus 로고
    • Severe neonatal jaundice associated with glucose-6-phosphate dehydrogenase deficiency: Pathogenesis and global epidemiology
    • Valaes T. (1994) Severe neonatal jaundice associated with glucose-6-phosphate dehydrogenase deficiency: pathogenesis and global epidemiology. Acta Paediatr. 83(suppl 394), 58-76.
    • (1994) Acta Paediatr. , vol.83 , Issue.SUPPL. 394 , pp. 58-76
    • Valaes, T.1
  • 104
    • 0002019579 scopus 로고    scopus 로고
    • Neonatal jaundice in glucose-6-phosphate dehydrogenase deficiency
    • Maisels M. J. and Watchko, J. F., eds., Harwood Academic Publishers, Amsterdam
    • Valaes T. (2000) Neonatal jaundice in glucose-6-phosphate dehydrogenase deficiency, in Neonatal Jaundice, Maisels M. J. and Watchko, J. F., eds., Harwood Academic Publishers, Amsterdam, pp. 67-72.
    • (2000) Neonatal Jaundice , pp. 67-72
    • Valaes, T.1
  • 105
    • 33749624650 scopus 로고
    • Erythroblastosis fetalis. IV. Further observations on kernicterus
    • Vaughan III V. C., Allen F. H., and Diamond L. K. (1950) Erythroblastosis fetalis. IV. Further observations on kernicterus. Pediatrics 6, 706-716.
    • (1950) Pediatrics , vol.6 , pp. 706-716
    • Vaughan III, V.C.1    Allen, F.H.2    Diamond, L.K.3
  • 107
    • 0014354355 scopus 로고
    • The effect of bilirubin on energy metabolism of brain mitochondria
    • Vogt M. T. and Basford R. E. (1968) The effect of bilirubin on energy metabolism of brain mitochondria. J. Neurochem. 15, 1313-1320.
    • (1968) J. Neurochem. , vol.15 , pp. 1313-1320
    • Vogt, M.T.1    Basford, R.E.2
  • 108
    • 0034613310 scopus 로고    scopus 로고
    • Bilirubin does not modulate ionotropic glutamate receptors or glutamate transporters
    • Warr O., Mort D., and Attwell D. (2000) Bilirubin does not modulate ionotropic glutamate receptors or glutamate transporters. Brain. Res. 879, 13-16.
    • (2000) Brain. Res. , vol.879 , pp. 13-16
    • Warr, O.1    Mort, D.2    Attwell, D.3
  • 109
    • 0002934025 scopus 로고    scopus 로고
    • The clinical sequelae of hyperbilirubinemia
    • Maisels M. J. and Watchko J. F., eds, Harwood Academic Publishers, Amsterdam
    • Watchko J. F. (2000a) The clinical sequelae of hyperbilirubinemia, in Neonatal Jaundice, Maisels M. J. and Watchko J. F., eds, Harwood Academic Publishers, Amsterdam, pp. 115-135.
    • (2000) Neonatal Jaundice , pp. 115-135
    • Watchko, J.F.1
  • 110
    • 0003145034 scopus 로고    scopus 로고
    • Indirect hyperbilirubinemia in the neonate
    • Maisels M. J. and Watchko J. F., eds, Harwood Academic Publishers, Amsterdam
    • Watchko J. F. (2000b) Indirect hyperbilirubinemia in the neonate, in Neonatal Jaundice, Maisels M. J. and Watchko J. F., eds, Harwood Academic Publishers, Amsterdam, pp. 51-72.
    • (2000) Neonatal Jaundice , pp. 51-72
    • Watchko, J.F.1
  • 111
    • 12844259417 scopus 로고    scopus 로고
    • Bilirubin induced apoptosis in vitro: Insights for kernciterus
    • Watchko J. F. (2005a) Bilirubin induced apoptosis in vitro: insights for kernciterus. Pediatr. Res. 177-178.
    • (2005) Pediatr. Res. , pp. 177-178
    • Watchko, J.F.1
  • 112
    • 6344265401 scopus 로고    scopus 로고
    • Genetics and the risk of neonatal hyperbilirubinemia
    • Watchko J. F. (2005b) Genetics and the risk of neonatal hyperbilirubinemia. Pediatr. Res. 56, 677-678.
    • (2005) Pediatr. Res. , vol.56 , pp. 677-678
    • Watchko, J.F.1
  • 113
    • 27744446527 scopus 로고    scopus 로고
    • Vigintiphobia revisited
    • Watchko J. F. (2005c) Vigintiphobia revisited. Pediatrics 115, 1747-1753.
    • (2005) Pediatrics , vol.115 , pp. 1747-1753
    • Watchko, J.F.1
  • 114
    • 0026943667 scopus 로고
    • Kernicterus in preterm newborns: Past, present, and future
    • Watchko J. F. and Oski F. A. (1992) Kernicterus in preterm newborns: past, present, and future. Pediatrics 90, 707-715.
    • (1992) Pediatrics , vol.90 , pp. 707-715
    • Watchko, J.F.1    Oski, F.A.2
  • 115
    • 0036551617 scopus 로고    scopus 로고
    • Understanding neonatal hyperbilirubinemia in the era of genomics
    • Watchko J. F., Daood M. J., and Biniwale M. (2002) Understanding neonatal hyperbilirubinemia in the era of genomics. Semin. Neonatol. 7, 143-152.
    • (2002) Semin. Neonatol. , vol.7 , pp. 143-152
    • Watchko, J.F.1    Daood, M.J.2    Biniwale, M.3
  • 116
    • 0031742968 scopus 로고    scopus 로고
    • Brain bilirubin content is increased in P-glyco-protein deficient transgenic null mutant mice
    • Watchko J. F., Daood M. J., and Hansen T. W. R. (1998) Brain bilirubin content is increased in P-glyco-protein deficient transgenic null mutant mice. Pediatr. Res. 44, 763-766.
    • (1998) Pediatr. Res. , vol.44 , pp. 763-766
    • Watchko, J.F.1    Daood, M.J.2    Hansen, T.W.R.3
  • 117
    • 0242517562 scopus 로고    scopus 로고
    • Inhibition of human MDR1 P-glycoprotein increases bilirubin-induced cell apoptosis in vitro
    • Watchko J. F., Ziegler J., Daood M. J., and Balkundi D. (2003) Inhibition of human MDR1 P-glycoprotein increases bilirubin-induced cell apoptosis in vitro. Pediatr. Res. 53, 400A.
    • (2003) Pediatr. Res. , vol.53
    • Watchko, J.F.1    Ziegler, J.2    Daood, M.J.3    Balkundi, D.4
  • 119
    • 0025952769 scopus 로고
    • Bilirubin-induced changes in brain energy metabolism after osmotic opening of the blood-brain barrier
    • Wennberg R. P., Johansson B. B., Folbergrova J., and Siesjo B. K. (1991) Bilirubin-induced changes in brain energy metabolism after osmotic opening of the blood-brain barrier. Pediatr. Res. 30, 473-478.
    • (1991) Pediatr. Res. , vol.30 , pp. 473-478
    • Wennberg, R.P.1    Johansson, B.B.2    Folbergrova, J.3    Siesjo, B.K.4
  • 120
    • 0029127393 scopus 로고
    • Magnetic resonance imaging in children with kernciterus
    • Yokochi K. (1995) Magnetic resonance imaging in children with kernciterus. Acta Paediatr. 84, 937-939.
    • (1995) Acta Paediatr. , vol.84 , pp. 937-939
    • Yokochi, K.1
  • 121
    • 0001721278 scopus 로고
    • Bilirubin, an uncoupler of oxidative phosphorylation in isolated mitochondria
    • Zetterstrom R. and Ernster L. (1956) Bilirubin, an uncoupler of oxidative phosphorylation in isolated mitochondria. Nature 178, 1335-1337.
    • (1956) Nature , vol.178 , pp. 1335-1337
    • Zetterstrom, R.1    Ernster, L.2
  • 122
    • 3042801604 scopus 로고    scopus 로고
    • Morphological features of cell death
    • Ziegler U. and Groscurth P. (2004) Morphological features of cell death. News Physiol. 19, 124-128.
    • (2004) News Physiol. , vol.19 , pp. 124-128
    • Ziegler, U.1    Groscurth, P.2
  • 123
    • 0035655285 scopus 로고    scopus 로고
    • Localization of bilirubin in phospholipid bilayers by parallax analysis of fluorescence quenching
    • Zucker S. D., Goessling W., Bootle E. J., and Sterritt. (2001) Localization of bilirubin in phospholipid bilayers by parallax analysis of fluorescence quenching. J. Lipid Res. 42, 1377-1388.
    • (2001) J. Lipid Res. , vol.42 , pp. 1377-1388
    • Zucker, S.D.1    Goessling, W.2    Bootle, E.J.3    Sterritt4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.