Bilirubin-induced apoptosis in cultured rat neural cells is aggravated by chenodeoxycholic acid but prevented by ursodeoxycholic acid

Journal of Hepatology

Volumn 34, Issue 3, 2001, Pages 402-408

  Silva, Rui F M ^a   Rodrigues, Cecília M P ^a   Brites, Dora ^a  

^a RESEARCH INSTITUTE FOR MEDICINES IMED ULISBOA   (Portugal)

Author keywords

Apoptosis; Glial and neuronal cells; Necrosis; Unconjugated bilirubin; Ursodeoxycholic acid

Indexed keywords

ALBUMIN; BILIRUBIN; CHENODEOXYCHOLIC ACID; DEOXYURIDINE TRIPHOSPHATE DERIVATIVE; DNA NUCLEOTIDYLEXOTRANSFERASE; TRYPAN BLUE; URSODEOXYCHOLIC ACID;

ANIMAL CELL; APOPTOSIS; ARTICLE; ASTROCYTE; CELL VIABILITY; CONTROLLED STUDY; CRIGLER NAJJAR SYNDROME; JAUNDICE; NERVE CELL; NEUROTOXICITY; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; APOPTOSIS; ASTROCYTES; BILE ACIDS AND SALTS; BILIRUBIN; CELLS, CULTURED; CHENODEOXYCHOLIC ACID; NEURONS; RATS; RATS, WISTAR; URSODEOXYCHOLIC ACID;

EID: 0035072101     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(01)00015-0     Document Type: Article

References (50)

1. Neonatal jaundice and bilirubin encephalopathy: A clinical and experimental reappraisal
2. The neurotoxicity of bilirubin
3. Inhibition of brain respiration in vitro by bilirubin: Reversal of inhibition by various means
4. Bilirubin encephalopathy: Effect on RIgA polymerase activity and chromatin template activity in the brain of Gunn rat
5. Impairment of DNA synthesis in Gunn rat cerebellum
6. Characteristic changes of cerebellar proteins associated with cerebellar hypoplasia in jaundice Gunn rat and the prevention of these by phototherapy
7. Bilirubin toxicity in neuronal cell lines N-115 and NBR-10A
8. Kernicterus: Effect on choline acetyltransferase, glutamic acid decarboxylase and tyrosine hydroxylase activities in the brain of Gunn rat
9. Bilirubin decreases phosphorylation of synapsin I, a synaptic vesicle-associated neuronal phosphoprotein, in intact synaptosomes from rat cerebral cortex
10. Inhibition of glutumate uptake by unconjugated bilirubin in cultured cortical rat astrocytes: Role of concentration and pH
11. Bilirubin inhibition of protein kinase: Its prevention by cyclic AMP
12. Bilirubin-induced modulation of cerebral protein phosphorylation in neonate rabbits in vivo
13. Mode of inhibitory action of bilirubin on protein kinase C
14. Cell death: The significance of apoptosis
15. The biochemistry of programmed cell death
16. Mitochondria and apoptosis
17. Ursodeoxycholic acid may inhibit deoxycholic acid-induced apoptosis by modulating mitochondrial transmembrane potential and reactive oxygen species production
18. A novel role for ursodeoxycholic acid in inhibiting apoptosis by modulating mitochondrial membrane perturbation
19. Ursodeoxycholic acid prevents cytochrome c release in apoptosis by inhibiting mitochondriai membrane depolarization and channel formation
20. Triiodothyronine is a high-affinity inhibitor of amino acid transport system L1 in cultured astrocytes
21. Optimized survival of hippocampal neurones in B-27 supplemented Neurobasal™. A new serum free medium combination
22. The ready isomerization of bilirubin IX-α in aqueous solution
23. Reperfusion injury to endothelial cells following cold ischemic storage of rat livers
24. Induction of apoptosis in cultured hepatocytes and in regressing liver by transforming growth factor β1
25. Differential sensitivity of neural cells to bilirubin toxicity
26. Alterations of erythrocyte morphology and lipid composition by hyperbilirubinemia
27. Cytotoxicity of bilirubin for human fibroblasts and rat astrocytes in culture. Effect of the ratio of bilirubin to serum albumin
28. Intracellular accumulation of unconjugated bilirubin inhibits phytohemaglutinin-induced proliferation and interleukin-2 production of human lymphocytes
29. Assessment of bilirubin toxicity to erythrocytes. Implication in neonatal jaundice management
30. Bilirubin, an uncoupler of oxidative phosphorylation in isolated mitochondria
31. 31P nuclear magnetic resonance spectroscopy
32. Bilirubin-induced changes in brain energy metabolism after osmotic opening of the blood-brain barrier
33. Effect of bilirubin on the membrane potential of rat brain synaptosomes
34. Inhibition of glutathione efflux in the perfused rat liver and isolated hepatocytes by organic anions and bilirubin. Kinetics, sidedness, and molecular forms
35. Competitive inhibition of thyroid hormone uptake into cultured rat brain astrocytes by bilirubin and bilirubin conjugates
36. Interactions of bilirubin with isolated presynaptic nerve terminals: Functional effects on the uptake and release of neurotransmitters
37. 3H] bilirubin to neurons in rat brain sections
38. Oxidation of bilirubin by rat brain mitochondrial membranes-dependence on cell type and postnatal age
39. Effect of bilirubin on shape and haemolysis, under hypotonic, aggregating or non-aggregating conditions, and correlation with cell age
40. Aging confers different resistance to the rat mitochondrial membrane permeability transition induced by bilirubin
41. Bilirubin metabolism and kernicterus
42. Deposition of bilirubin acid in the central nervous system-hypothesis for the development of kernicterus
43. Kernicteric findings at autopsy in two sick near term infants
44. Glycochenodeoxycholate-induced lethal hepatocellular injury in rat hepatocytes. Role of ATP depletion and cytosolic free calcium
45. Increases of intracellular magnesium promote glycodeoxycholate-induced apoptosis in rat hepatocytes
46. Toxicity of bile acids on the electron transport chain of isolated rat liver mitochondria
47. Mechanism of cholestasis. 4. Structural and biochemical changes in the liver and serum in rats after bile duct ligation
48. Reduced activity of the electron transport chain in liver mitochondria isolated from rats with secondary biliary cirrhosis
49. Ursodeoxycholate (UDCA) inhibits the mitochondrial membrane permeability transition induced by glycochenodeoxycholate: A mechanism of UDCA cytoprotection
50. Unconjugated bilirubin exhibits spontaneous diffusion through model lipid bilayers and native hepatocyte membranes