An IκBα phosphorylation inhibitor induces heme oxygenase-1(HO-1) expression through the activation of reactive oxygen species (ROS)-Nrf2-ARE signaling and ROS-PI3K/Akt signaling in an NF-κB-independent mechanism

Cellular Signalling

Volumn 23, Issue 9, 2011, Pages 1505-1513

  Min, Kyoung Jin ^a   Lee, Jung Tae ^a   Joe, Eun hye ^b   Kwon, Taeg Kyu ^a  

^a Keimyung University   (South Korea)

^b Ajou University School of Medicine   (South Korea)

Author keywords

Bay 11 7082; Heme oxygenase 1; NF B; Nrf2; PI3K; Reactive oxygen species

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 3 (4 METHYLPHENYLSULFONYL) 2 PROPENENITRILE; ACETYLCYSTEINE; CYCLOOXYGENASE 2; GLUTATHIONE; HEME OXYGENASE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR NRF2;

ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; CANCER CELL; COLON CANCER; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; PROTEIN TRANSPORT; REGULATORY MECHANISM; TRANSCRIPTION REGULATION;

ANALYSIS OF VARIANCE; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; GLUTATHIONE; HEME OXYGENASE-1; HT29 CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; LEUPEPTINS; NF-E2-RELATED FACTOR 2; NF-KAPPA B; NITRILES; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROLINE; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; RESPONSE ELEMENTS; RNA, MESSENGER; SIGNAL TRANSDUCTION; SULFONES; THIOCARBAMATES; TRANSFECTION;

EID: 79958766190     PISSN: 08986568     EISSN: 18733913     Source Type: Journal    
DOI: 10.1016/j.cellsig.2011.05.013     Document Type: Article

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