Expression of stress-response ATF3 is mediated by Nrf2 in astrocytes

Nucleic Acids Research

Volumn 38, Issue 1, 2009, Pages 48-59

  Kim, Kyu Han ^a   Jeong, Jae Yeon ^a   Surh, Young Joon ^a   Kim, Kyu Won ^a  

^a Seoul National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 3; ARSENITE SODIUM; BUTYLATED HYDROXYANISOLE; PHENAZINE METHOSULFATE; TERT BUTYLHYDROQUINONE; TRANSCRIPTION FACTOR NRF2;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; ASTROCYTE; BINDING SITE; CELL FUNCTION; CELL PROTECTION; CELLULAR STRESS RESPONSE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN VERSUS ANIMAL COMPARISON; MOUSE; NONHUMAN; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; TRANSCRIPTION REGULATION; UPREGULATION;

ACTIVATING TRANSCRIPTION FACTOR 3; ANIMALS; ASTROCYTES; BINDING SITES; CELLS, CULTURED; CYTOPROTECTION; HUMANS; MICE; NF-E2-RELATED FACTOR 2; OXIDANTS; OXIDATIVE STRESS; RESPONSE ELEMENTS;

EID: 75649138332     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkp865     Document Type: Article

References (23)

1. Ahlgren-Beckendorf, J.A., Reising, A.M., Schander, M.A., Herdler, J.W. and Johnson, J.A. (1999) Coordinate regulation of NAD(P)H: quinone oxidoreductase and glutathione-S-transferases in primary cultures of rat neurons and glia: role of the antioxidant/electrophile responsive element. Glia, 25, 131-142.
2. Shih, A.Y., Johnson, D.A., Wong, G., Kraft, A.D., Jiang, L., Erb, H., Johnson, J.A. and Murphy, T.H. (2003) Coordinate regulation of glutathione biosynthesis and release by Nrf2-expressing glia potently protects neurons from oxidative stress. J. Neurosci., 23, 3394-3406.
3. Kraft, A.D., Johnson, D.A. and Johnson, J.A. (2004) Nuclear factor E2-related factor 2-dependent antioxidant response element activation by tert-butylhydroquinone and sulforaphane occurring preferentially in astrocytes conditions neurons against oxidative insult. J. Neurosci., 24, 1101-1112.
4. Vargas, M.R., Johnson, D.A., Sirkis, D.W., Messing, A. and Johnson, J.A. (2008) Nrf2 activation in astrocytes protects against neurodegeneration in mouse models of familial amyotrophic lateral sclerosis. J. Neurosci., 28, 13574-13581.
5. Chen, P.C., Vargas, M.R., Pani, A.K., Smeyne, R.J., Johnson, D.A., Kan, Y.W. and Johnson, J.A. (2009) Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease: critical role for the astrocyte. Proc. Natl Acad. Sci. USA, 106, 2933-2938.
6. Hai, T., Wolfgang, C.D., Marsee, D.K., Allen, A.E. and Sivaprasad, U. (1999) ATF3 and stress responses. Gene Expr., 7, 321-335.
7. Inoue, K., Zama, T., Kamimoto, T., Aoki, R., Ikeda, Y., Kimura, H. and Hagiwara, M. (2004) TNFalpha-induced ATF3 expression is bidirectionally regulated by the JNK and ERK pathways in vascular endothelial cells. Genes Cells, 9, 59-70.
8. Lu, D., Chen, J. and Hai, T. (2007) The regulation of ATF3 gene expression by mitogen-activated protein kinases. Biochem. J., 401, 559-567.
9. Shih, A.Y., Li, P. and Murphy, T.H. (2005) A small-molecule-inducible Nrf2-mediated antioxidant response provides effective prophylaxis against cerebral ischemia in vivo. J. Neurosci., 25, 10321-10335.
10. Leonard, M.O., Kieran, N.E., Howell, K., Burne, M.J., Varadarajan, R., Dhakshinamoorthy, S., Porter, A.G., O'Farrelly, C., Rabb, H. and Taylor, C.T. (2006) Reoxygenation-specific activation of the antioxidant transcription factor Nrf2 mediates cytoprotective gene expression in ischemia-reperfusion injury. FASEB J., 20, 2624-2626.
11. Padmanabhan, B., Tong, K.I., Ohta, T., Nakamura, Y., Scharlock, M., Ohtsuji, M., Kang, M.I., Kobayashi, A., Yokoyama, S. and Yamamoto, M. (2006) Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer. Mol. Cell, 21, 689-700.
12. Dhakshinamoorthy, S., Jain, A.K., Bloom, D.A. and Jaiswal, A.K. (2005) Bach1 competes with Nrf2 leading to negative regulation of the antioxidant response element (ARE)-mediated NAD(P)H: quinone oxidoreductase 1 gene expression and induction in response to antioxidants. J. Biol. Chem., 280, 16891-16900.
13. Frohlich, D.A., McCabe, M.T., Arnold, R.S. and Day, M.L. (2008) The role of Nrf2 in increased reactive oxygen species and DNA damage in prostate tumorigenesis. Oncogene, 27, 4353-4362.
14. Yih, L.H., Hsueh, S.W., Luu, W.S., Chiu, T.H. and Lee, T.C. (2005) Arsenite induces prominent mitotic arrest via inhibition of G2 checkpoint activation in CGL-2 cells. Carcinogenesis, 26, 53-63.
15. Brown, S.L., Sekhar, K.R., Rachakonda, G., Sasi, S. and Freeman, M.L. (2008) Activating transcription factor 3 is a novel repressor of the nuclear factor erythroid-derived 2-related factor 2 (Nrf2)-regulated stress pathway. Cancer Res., 68, 364-368.
16. Turchi, L., Aberdam, E., Mazure, N., Pouyssegur, J., Deckert, M., Kitajima, S., Aberdam, D. and Virolle, T. (2008) Hif-2alpha mediates UV-induced apoptosis through a novel ATF3-dependent death pathway. Cell Death Differ., 15, 1472-1480.
17. Yoshida, T., Sugiura, H., Mitobe, M., Tsuchiya, K., Shirota, S., Nishimura, S., Shiohira, S., Ito, H., Nobori, K., Gullans, S.R. et al. (2008) ATF3 protects against renal ischemia-reperfusion injury. J. Am. Soc. Nephrol., 19, 217-224.
18. Lu, D., Wolfgang, C.D. and Hai, T. (2006) Activating transcription factor 3, a stress-inducible gene, suppresses Ras-stimulated tumorigenesis. J. Biol. Chem., 281, 10473-10481.
19. Nakagomi, S., Suzuki, Y., Namikawa, K., Kiryu-Seo, S. and Kiyama, H. (2003) Expression of the activating transcription factor 3 prevents c-Jun N-terminal kinase-induced neuronal death by promoting heat shock protein 27 expression and Akt activation. J. Neurosci., 23, 5187-5196.
20. Seijffers, R., Mills, C.D. and Woolf, C.J. (2007) ATF3 increases the intrinsic growth state of DRG neurons to enhance peripheral nerve regeneration. J. Neurosci., 27, 7911-7920.
21. Yin, X., Dewille, J.W. and Hai, T. (2008) A potential dichotomous role of ATF3, an adaptive-response gene, in cancer development. Oncogene, 27, 2118-2127.
22. Ohba, N., Maeda, M., Nakagomi, S., Muraoka, M. and Kiyama, H. (2003) Biphasic expression of activating transcription factor-3 in neurons after cerebral infarction. Brain Res. Mol. Brain Res., 115, 147-156.
23. Hunt, D., Hossain-Ibrahim, K., Mason, M.R., Coffin, R.S., Lieberman, A.R., Winterbottom, J. and Anderson, P.N. (2004) ATF3 upregulation in glia during Wallerian degeneration: differential expression in peripheral nerves and CNS white matter. BMC Neurosci., 5, 9.