Epicardial fat: More than just an epi phenomenon?

Hormone and Metabolic Research

Volumn 45, Issue 13, 2013, Pages 991-1001

  Gaborit, B ^a,b,c   Abdesselam, I ^b,c,d   Dutour, A ^a,b,c  

^a HÔPITAL NORD   (France)

^b INSERM   (France)

^c AIX MARSEILLE UNIVERSITY   (France)

^d University of Aix Marseille   (France)

Author keywords

cardiac adiposity; coronary artery disease; ectopic fat; ectopy; epicardial adipose tissue; myocardium; obesity

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ADIPONECTIN; ADRENOMEDULLIN; ATORVASTATIN; C REACTIVE PROTEIN; CATALASE; CHEMERIN; EZETIMIBE PLUS SIMVASTATIN; FATTY ACID BINDING PROTEIN 4; HAPTOGLOBIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1BETA; INTERLEUKIN 6; LEPTIN; MONOCYTE CHEMOTACTIC PROTEIN 1; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; PLASMINOGEN ACTIVATOR INHIBITOR 1; PRAVASTATIN; RANTES; RESISTIN; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; SECRETORY PHOSPHOLIPASE A2; TETRAHYDROLIPSTATIN; TRYPTOPHAN HYDROXYLASE; TUMOR NECROSIS FACTOR ALPHA; UNCOUPLING PROTEIN 1;

ABDOMINAL FAT; ADIPOSE TISSUE; COMPUTER ASSISTED TOMOGRAPHY; CORONARY ARTERY; CORONARY ARTERY ATHEROSCLEROSIS; CORONARY ARTERY DISEASE; EPICARDIAL FAT; GENE LOCUS; GENETIC PREDISPOSITION; HEART ATRIUM FIBRILLATION; HEART MUSCLE; HUMAN; HYPERLIPIDEMIA; MOLECULAR INTERACTION; NUCLEAR MAGNETIC RESONANCE IMAGING; OPTICAL COHERENCE TOMOGRAPHY; PATHOPHYSIOLOGY; PHYSICAL ACTIVITY; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; REVIEW; WEIGHT REDUCTION;

ADIPOSE TISSUE; ANIMALS; CARDIOVASCULAR DISEASES; CORONARY VESSELS; HUMANS; MYOCARDIUM; PERICARDIUM;

EID: 84890554079     PISSN: 00185043     EISSN: 14394286     Source Type: Journal    
DOI: 10.1055/s-0033-1358669     Document Type: Review

References (148)

1. Vague J. The degree of masculine differentiation of obesities: a factor determining predisposition to diabetes, atherosclerosis, gout, and uric calculous disease. Am J Clin Nutr: 1956; 4 20 34
2. Despres J. P., Lemieux I. Abdominal obesity and metabolic syndrome. Nature: 2006; 444 881 887 (Pubitemid 46024995)
3. Despres J. P. Body fat distribution and risk of cardiovascular disease: an update. Circulation: 2012; 126 1301 1313
4. Ouwens D. M., Sell H., Greulich S., Eckel J. The role of epicardial and perivascular adipose tissue in the pathophysiology of cardiovascular disease. J Cell Mol Med: 2010; 14 2223 2234
5. Iacobellis G. Epicardial and pericardial fat: close, but very different. Obesity (Silver Spring): 2009; 17 625 author's reply 626-627
6. Sacks H. S., Fain J. N. Human epicardial adipose tissue: a review. Am Heart J: 2007; 153 907 917 (Pubitemid 46809849)
7. Rabkin S. W. Epicardial fat: properties, function and relationship to obesity. Obes Rev: 2007; 8 253 261 (Pubitemid 46632691)
8. Iacobellis G., Corradi D., Sharma A. M. Epicardial adipose tissue: anatomic, biomolecular and clinical relationships with the heart. Nat Clin Pract Cardiovasc Med: 2005; 2 536 543 (Pubitemid 41670345)
9. Mazurek T., Zhang L., Zalewski A., Mannion J. D., Diehl J. T., Arafat H., Sarov-Blat L., O'Brien S., Keiper E. A., Johnson A. G., Martin J., Goldstein B. J., Shi Y. Human epicardial adipose tissue is a source of inflammatory mediators. Circulation: 2003; 108 2460 2466 (Pubitemid 37444406)
10. Katsiki N., Mikhailidis D. P., Wierzbicki A. S. Epicardial fat and vascular risk: a narrative review. Curr Opin Cardiol: 2013; 28 458 463
11. Raggi P., Alakija P. Epicardial adipose tissue: A long-overlooked marker of risk of cardiovascular disease. Atherosclerosis: 2013; 229 32 33
12. Clement K., Basdevant A., Dutour A. Weight of pericardial fat on coronaropathy. Arterioscler Thromb Vasc Biol: 2009; 29 615 616
13. Marchington J. M., Mattacks C. A., Pond C. M. Adipose tissue in the mammalian heart and pericardium: structure, foetal development and biochemical properties. Comp Biochem Physiol B: 1989; 94 225 232
14. Venteclef N., Guglielmi V., Balse E., Gaborit B., Cotillard A., Atassi F., Amour J., Leprince P., Dutour A., Clément K., Hatem S. N. Human epicardial adipose tissue induces fibrosis of the atrial myocardium through the secretion of adipo-fibrokines. Eur Heart J: 2013; [Epub ahead of print]
15. Hassan M., Latif N., Yacoub M. Adipose tissue: friend or foe? Nat Rev Cardiol: 2012; 9 689 702
16. Sacks H. S., Fain J. N., Holman B., Cheema P., Chary A., Parks F., Karas J., Optican R., Bahouth S. W., Garrett E., Wolf R. Y., Carter R. A., Robbins T., Wolford D., Samaha J. Uncoupling protein-1 and related messenger ribonucleic acids in human epicardial and other adipose tissues: epicardial fat functioning as brown fat. J Clin Endocrinol Metab: 2009; 94 3611 3615
17. Cheng K. H., Chu C. S., Lee K. T., Lin T. H., Hsieh C. C., Chiu C. C., Voon W. C., Sheu S. H., Lai W. T. Adipocytokines and proinflammatory mediators from abdominal and epicardial adipose tissue in patients with coronary artery disease. Int J Obes (Lond): 2008; 32 268 274
18. Iacobellis G., Barbaro G. The double role of epicardial adipose tissue as pro- and anti-inflammatory organ. Horm Metab Res: 2008; 40 442 445
19. Spiroglou S. G., Kostopoulos C. G., Varakis J. N., Papadaki H. H. Adipokines in periaortic and epicardial adipose tissue: differential expression and relation to atherosclerosis. J Atheroscler Thromb: 2010; 17 115 130
20. Iglesias M. J., Eiras S., Pineiro R., López-Otero D., Gallego R., Fernández A. L., Lago F., González-Juanatey J. R. Gender differences in adiponectin and leptin expression in epicardial and subcutaneous adipose tissue. Findings in patients undergoing cardiac surgery. Rev Esp Cardiol: 2006; 59 1252 1260 (Pubitemid 46188824)
21. Bambace C., Telesca M., Zoico E., Sepe A., Olioso D., Rossi A., Corzato F., Di Francesco V., Mazzucco A., Santini F., Zamboni M. Adiponectin gene expression and adipocyte diameter: a comparison between epicardial and subcutaneous adipose tissue in men. Cardiovasc Pathol: 2011; 20 e153 e156
22. Cherian S., Lopaschuk G. D., Carvalho E. Cellular cross-talk between epicardial adipose tissue and myocardium in relation to the pathogenesis of cardiovascular disease. Am J Physiol Endocrinol Metab: 2012; 303 E937 E949
23. Iacobellis G., Bianco A. C. Epicardial adipose tissue: emerging physiological, pathophysiological and clinical features. Trends Endocrinol Metab: 2011; 22 450 457
24. Sacks H. S., Fain J. N., Cheema P., Bahouth S. W., Garrett E., Wolf R. Y., Wolford D., Samaha J. Inflammatory genes in epicardial fat contiguous with coronary atherosclerosis in the metabolic syndrome and type 2 diabetes: changes associated with pioglitazone. Diabetes Care: 2011; 34 730 733
25. Iacobellis G., Leonetti F. Epicardial adipose tissue and insulin resistance in obese subjects. J Clin Endocrinol Metab: 2005; 90 6300 6302 (Pubitemid 41606560)
26. Marchington J. M., Pond C. M. Site-specific properties of pericardial and epicardial adipose tissue: the effects of insulin and high-fat feeding on lipogenesis and the incorporation of fatty acids in vitro. Int J Obes: 1990; 14 1013 1022
27. Arora R. C., Waldmann M., Hopkins D. A., Armour J. A. Porcine intrinsic cardiac ganglia. Anat Rec A Discov Mol Cell Evol Biol: 2003; 271 249 258 (Pubitemid 37238363)
28. Huang M. H., Ardell J. L., Hanna B. D., Wolf S. G., Armour J. A. Effects of transient coronary artery occlusion on canine intrinsic cardiac neuronal activity. Integr Physiol Behav Sci: 1993; 28 5 21
29. Cannon B., Nedergaard J. Brown adipose tissue: function and physiological significance. Physiol Rev: 2004; 84 277 359 (Pubitemid 38054374)
30. Lowell B. B., Spiegelman B. M. Towards a molecular understanding of adaptive thermogenesis. Nature: 2000; 404 652 660 (Pubitemid 30205070)
31. Nedergaard J., Bengtsson T., Cannon B. Unexpected evidence for active brown adipose tissue in adult humans. Am J Physiol Endocrinol Metab: 2007; 293 E444 E452 (Pubitemid 47205086)
32. Cypess A. M., Lehman S., Williams G., Tal I., Rodman D., Goldfine A. B., Kuo F. C., Palmer E. L., Tseng Y. H., Doria A., Kolodny G. M., Kahn C. R. Identification and importance of brown adipose tissue in adult humans. N Engl J Med: 2009; 360 1509 1517
33. Chechi K., Blanchard P. G., Mathieu P., Deshaies Y., Richard D. Brown fat like gene expression in the epicardial fat depot correlates with circulating HDL-cholesterol and triglycerides in patients with coronary artery disease. Int J Cardiol: 2012; 167 2264 2270
34. Ahmadi N., Nabavi V., Hajsadeghi F., Zeb I., Flores F., Ebrahimi R., Budoff M. Aged garlic extract with supplement is associated with increase in brown adipose, decrease in white adipose tissue and predict lack of progression in coronary atherosclerosis. Int J Cardiol: 2013; [Epub ahead of print]
35. Whittle A., Vidal-Puig A. When BAT is lacking, WAT steps up. Cell Res: 2013; 23 868 869
36. Wu J., Bostrom P., Sparks L. M., Ye L., Choi J. H., Giang A. H., Khandekar M., Virtanen K. A., Nuutila P., Schaart G., Huang K., Tu H., van Marken Lichtenbelt W. D., Hoeks J., Enerbäck S., Schrauwen P., Spiegelman B. M. Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell: 2012; 150 366 376
37. Petrovic N., Walden T. B., Shabalina I. G., Timmons J. A., Cannon B., Nedergaard J. Chronic peroxisome proliferator-activated receptor gamma (PPARgamma) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic brown adipocytes. J Biol Chem: 2010; 285 7153 7164
38. Villarroya F., Vidal-Puig A. Beyond the Sympathetic Tone: The New Brown Fat Activators. Cell Metab: 2013; 17 638 643
39. Bordicchia M., Liu D., Amri E. Z., Ailhaud G., Dessì-Fulgheri P., Zhang C., Takahashi N., Sarzani R., Collins S. Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes. J Clin Invest: 2012; 122 1022 1036
40. Moreno-Aliaga M. J., Perez-Echarri N., Marcos-Gomez B., Larequi E., Gil-Bea F. J., Viollet B., Gimenez I., Martínez J. A., Prieto J., Bustos M. Cardiotrophin-1 is a key regulator of glucose and lipid metabolism. Cell Metab: 2011; 14 242 253
41. Bostrom P., Wu J., Jedrychowski M. P., Korde A., Ye L., Lo J. C., Rasbach K. A., Boström E. A., Choi J. H., Long J. Z., Kajimura S., Zingaretti M. C., Vind B. F., Tu H., Cinti S., Hojlund K., Gygi S. P., Spiegelman B. M. A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature: 2012; 481 463 468
42. Vigouroux C., Caron-Debarle M., Le Dour C., Magré J., Capeau J. Molecular mechanisms of human lipodystrophies: from adipocyte lipid droplet to oxidative stress and lipotoxicity. Int J Biochem Cell Biol: 2011; 43 862 876
43. Dutour A., Roll P., Gaborit B., Courrier S., Alessi M. C., Tregouet D. A., Angelis F., Robaglia-Schlupp A., Lesavre N., Cau P., Lévy N., Badens C., Morange P. E. High prevalence of laminopathies among patients with metabolic syndrome. Hum Mol Genet: 2011; 20 3779 3786
44. Britton K. A., Fox C. S. Ectopic fat depots and cardiovascular disease. Circulation: 2011; 124 e837 e841
45. Arner E., Westermark P. O., Spalding K. L., Britton T., Rydén M., Frisén J., Bernard S., Arner P. Adipocyte turnover: relevance to human adipose tissue morphology. Diabetes: 2010; 59 105 109
46. Tchoukalova Y. D., Koutsari C., Karpyak M. V., Votruba S. B., Wendland E., Jensen M. D. Subcutaneous adipocyte size and body fat distribution. Am J Clin Nutr: 2008; 87 56 63
47. Cancello R., Clement K. Is obesity an inflammatory illness? Role of low-grade inflammation and macrophage infiltration in human white adipose tissue. BJOG: 2006; 113 1141 1147 (Pubitemid 44401207)
48. Divoux A., Clement K. Architecture and the extracellular matrix: the still unappreciated components of the adipose tissue. Obes Rev: 2011; 12 e494 e503
49. Villaret A., Galitzky J., Decaunes P., Estève D., Marques M. A., Sengenès C., Chiotasso P., Tchkonia T., Lafontan M., Kirkland J. L., Bouloumié A. Adipose tissue endothelial cells from obese human subjects: differences among depots in angiogenic, metabolic, and inflammatory gene expression and cellular senescence. Diabetes: 2010; 59 2755 2763
50. Lacasa D., Taleb S., Keophiphath M., Miranville A., Clement K. Macrophage-secreted factors impair human adipogenesis: involvement of proinflammatory state in preadipocytes. Endocrinology: 2007; 148 868 877 (Pubitemid 46143186)
51. Paulmyer-Lacroix O., Boullu S., Oliver C., Alessi M. C., Grino M. Expression of the mRNA coding for 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue from obese patients: an in situ hybridization study. J Clin Endocrinol Metab: 2002; 87 2701 2705 (Pubitemid 34655333)
52. Desbriere R., Vuaroqueaux V., Achard V., Boullu-Ciocca S., Labuhn M., Dutour A., Grino M. 11beta-hydroxysteroid dehydrogenase type 1 mRNA is increased in both visceral and subcutaneous adipose tissue of obese patients. Obesity (Silver Spring): 2006; 14 794 798 (Pubitemid 46219720)
53. Paulmyer-Lacroix O., Boullu-Ciocca S., Oliver C., Dutour A., Grino M. Glucocorticoids, 11 beta-hydroxysteroid dehydrogenase type 1, and visceral obesity. Med Sci (Paris): 2003; 19 473 476 (Pubitemid 36433544)
54. Boullu-Ciocca S., Dutour A., Guillaume V., Achard V., Oliver C., Grino M. Postnatal diet-induced obesity in rats upregulates systemic and adipose tissue glucocorticoid metabolism during development and in adulthood: its relationship with the metabolic syndrome. Diabetes: 2005; 54 197 203 (Pubitemid 40105113)
55. Meas T., Carreira E., Wang Y., Rauh M., Poitou C., Clément K., Dötsch J., Lévy-Marchal C. 11beta-hydroxysteroid dehydrogenase type 1 of the subcutaneous adipose tissue is dysregulated but not associated with metabolic disorders in adults born small for gestational age. J Clin Endocrinol Metab: 2010; 95 3949 3954
56. Gaborit B. A., Kober I., Jacquier F., Boullu-Ciocca A., Emungania S., Bernard O., Dutour M. A. Diminution de la stéatose pancréatique après chirurgie bariatrique: évaluation du contenu en triglycérides intrapancréatique par spectroscopie proton en IRM à 3T (Abstract). Diabet Metab: 2013; 39 A101
57. Snel M., Jonker J. T., Schoones J., Lamb H., de Roos A., Pijl H., Smit J. W., Meinders A. E., Jazet I. M. Ectopic fat and insulin resistance: pathophysiology and effect of diet and lifestyle interventions. Int J Endocrinol: 2012; 2012 983814
58. Visiedo F., Bugatto F., Sanchez V., Cózar-Castellano I., Bartha J. L., Perdomo G. High-glucose levels reduce fatty acid oxidation and increase triglyceride accumulation in human placenta. Am J Physiol Endocrinol Metab: 2013; 305 E205 E212
59. Silaghi A., Piercecchi-Marti M. D., Grino M., Leonetti G., Alessi M. C., Clement K., Dadoun F., Dutour A. Epicardial adipose tissue extent: relationship with age, body fat distribution, and coronaropathy. Obesity (Silver Spring): 2008; 16 2424 2430
60. Gaborit B., Kober F., Jacquier A., Moro P. J., Cuisset T., Boullu S., Dadoun F., Alessi M. C., Morange P., Clément K., Bernard M., Dutour A. Assessment of epicardial fat volume and myocardial triglyceride content in severely obese subjects: relationship to metabolic profile, cardiac function and visceral fat. Int J Obes (Lond): 2012; 36 422 430
61. Nakazato R., Rajani R., Cheng V. Y., Shmilovich H., Nakanishi R., Otaki Y., Gransar H., Slomka P. J., Hayes S. W., Thomson L. E., Friedman J. D., Wong N. D., Shaw L. J., Budoff M., Rozanski A., Berman D. S., Dey D. Weight change modulates epicardial fat burden: a 4-year serial study with non-contrast computed tomography. Atherosclerosis: 2012; 220 139 144
62. Mahabadi A. A., Massaro J. M., Rosito G. A., Levy D., Murabito J. M., Wolf P. A., O'Donnell C. J., Fox C. S., Hoffmann U. Association of pericardial fat, intrathoracic fat, and visceral abdominal fat with cardiovascular disease burden: the Framingham Heart Study. Eur Heart J: 2009; 30 850 856
63. Graner M., Siren R., Nyman K., Lundbom J., Hakkarainen A., Pentikäinen M. O., Lauerma K., Lundbom N., Adiels M., Nieminen M. S., Taskinen M. R. Cardiac steatosis associates with visceral obesity in nondiabetic obese men. J Clin Endocrinol Metab: 2013; 98 1189 1197
64. Iozzo P., Lautamaki R., Borra R., Lehto H. R., Bucci M., Viljanen A., Parkka J., Lepomaki V., Maggio R., Parkkola R., Knuuti J., Nuutila P. Contribution of glucose tolerance and gender to cardiac adiposity. J Clin Endocrinol Metab: 2009; 94 4472 4482
65. Wang C. P., Hsu H. L., Hung W. C., Yu T. H., Chen Y. H., Chiu C. A., Lu L. F., Chung F. M., Shin S. J., Lee Y. J. Increased epicardial adipose tissue (EAT) volume in type 2 diabetes mellitus and association with metabolic syndrome and severity of coronary atherosclerosis. Clin Endocrinol (Oxf): 2009; 70 876 882
66. Wang T. D., Lee W. J., Shih F. Y., Huang C. H., Chang Y. C., Chen W. J., Lee Y. T., Chen M. F. Relations of epicardial adipose tissue measured by multidetector computed tomography to components of the metabolic syndrome are region-specific and independent of anthropometric indexes and intraabdominal visceral fat. J Clin Endocrinol Metab: 2009; 94 662 669
67. Greulich S., Chen W. J., Maxhera B., Rijzewijk L. J., van der Meer R. W., Jonker J. T., Mueller H., de Wiza D. H., Floerke R. R., Smiris K., Lamb H. J., de Roos A., Bax J. J., Romijn J. A., Smit J. W., Akhyari P., Lichtenberg A., Eckel J., Diamant M., Ouwens D. M. Cardioprotective properties of omentin-1 in type 2 diabetes: evidence from clinical and in vitro studies. PLoS One: 2013; 8 e59697
68. Greulich S., Maxhera B., Vandenplas G., de Wiza D. H., Smiris K., Mueller H., Heinrichs J., Blumensatt M., Cuvelier C., Akhyari P., Ruige J. B., Ouwens D. M., Eckel J. Secretory products from epicardial adipose tissue of patients with type 2 diabetes mellitus induce cardiomyocyte dysfunction. Circulation: 2012; 126 2324 2334
69. Momesso D. P., Bussade I., Epifanio M. A., Schettino C. D., Russo L. A., Kupfer R. Increased epicardial adipose tissue in type 1 diabetes is associated with central obesity and metabolic syndrome. Diabetes Res Clin Pract: 2011; 91 47 53
70. Alp H., Karaarslan S., Selver Eklioǧlu B., Atabek M. E., AltIn H., Baysal T. Association Between Nonalcoholic Fatty Liver Disease and Cardiovascular Risk in Obese Children and Adolescents. Can J Cardiol: 2012; 29 1118 1125
71. Colak Y., Karabay C. Y., Tuncer I., Kocabay G., Kalayci A., Senates E., Ozturk O., Doganay H. L., Enc F. Y., Ulasoglu C., Kiziltas S. Relation of epicardial adipose tissue and carotid intima-media thickness in patients with nonalcoholic fatty liver disease. Eur J Gastroenterol Hepatol: 2012; 24 613 618
72. Sengul C., Cevik C., Ozveren O., Duman D., Eroglu E., Oduncu V., Tanboga H. I., Can M. M., Akgun T., Dindar I. Epicardial fat thickness is associated with non-dipper blood pressure pattern in patients with essential hypertension. Clin Exp Hypertens: 2012; 34 165 170
73. Wang T. D., Chen M. F. Thicker epicardial adipose tissue in nonobese hypertensive patients: an innocent bystander or overlooked villain? Am J Hypertens: 2011; 24 1191 1192
74. Mariani S., Fiore D., Barbaro G., Basciani S., Saponara M., D'Arcangelo E., Ulisse S., Moretti C., Fabbri A., Gnessi L. Association of epicardial fat thickness with the severity of obstructive sleep apnea in obese patients. Int J Cardiol: 2013; 167 2244 2249
75. Lubrano C., Saponara M., Barbaro G., Specchia P., Addessi E., Costantini D., Tenuta M., Di Lorenzo G., Genovesi G., Donini L. M., Lenzi A., Gnessi L. Relationships between body fat distribution, epicardial fat and obstructive sleep apnea in obese patients with and without metabolic syndrome. PLoS One: 2012; 7 e47059
76. Iozzo P. Viewpoints on the way to the consensus session: where does insulin resistance start? The adipose tissue. Diabetes Care: 2009; 32 02 S168 S173
77. Iozzo P. Myocardial, perivascular, and epicardial fat. Diabetes Care: 2011; 34 02 S371 S379
78. Fox C. S., White C. C., Lohman K., Heard-Costa N., Cohen P., Zhang Y., Johnson A. D., Emilsson V., Liu C. T., Chen Y. D., Taylor K. D., Allison M., Budoff M. CARDIoGRAM Consortium Rotter J. I., Carr J. J., Hoffmann U., Ding J., Cupples L. A., Liu Y. Genome-wide association of pericardial fat identifies a unique locus for ectopic fat. PLoS Genet: 2012; 8 e1002705
79. Lipson A., Alexopoulos N., Hartlage G. R., Arepalli C., Oeser A., Bian A., Gebretsadik T., Shintani A., Stillman A. E., Stein C. M., Raggi P. Epicardial adipose tissue is increased in patients with systemic lupus erythematosus. Atherosclerosis: 2012; 223 389 393
80. Lo J., Abbara S., Rocha-Filho J. A., Shturman L., Wei J., Grinspoon S. K. Increased epicardial adipose tissue volume in HIV-infected men and relationships to body composition and metabolic parameters. AIDS: 2010; 24 2127 2130
81. Guaraldi G., Scaglioni R., Zona S., Orlando G., Carli F., Ligabue G., Besutti G., Bagni P., Rossi R., Modena M. G., Raggi P. Epicardial adipose tissue is an independent marker of cardiovascular risk in HIV-infected patients. AIDS: 2011; 25 1199 1205
82. Raggi P. Epicardial adipose tissue as a marker of coronary artery disease risk. J Am Coll Cardiol: 2013; 61 1396 1397
83. Ishikawa Y., Akasaka Y., Suzuki K., Fujiwara M., Ogawa T., Yamazaki K., Niino H., Tanaka M., Ogata K., Morinaga S., Ebihara Y., Kawahara Y., Sugiura H., Takimoto T., Komatsu A., Shinagawa T., Taki K., Satoh H., Yamada K., Yanagida-Iida M., Shimokawa R., Shimada K., Nishimura C., Ito K., Ishii T. Anatomic properties of myocardial bridge predisposing to myocardial infarction. Circulation: 2009; 120 376 383
84. Mohlenkamp S., Hort W., Ge J., Erbel R. Update on myocardial bridging. Circulation: 2002; 106 2616 2622 (Pubitemid 35340699)
85. Greif M., Becker A., von Ziegler F., Lebherz C., Lehrke M., Broedl U. C., Tittus J., Parhofer K., Becker C., Reiser M., Knez A., Leber A. W. Pericardial adipose tissue determined by dual source CT is a risk factor for coronary atherosclerosis. Arterioscler Thromb Vasc Biol: 2009; 29 781 786
86. Xu Y., Cheng X., Hong K., Huang C., Wan L. How to interpret epicardial adipose tissue as a cause of coronary artery disease: a meta-analysis. Coron Artery Dis: 2012; 23 227 233
87. Alexopoulos N., McLean D. S., Janik M., Arepalli C. D., Stillman A. E., Raggi P. Epicardial adipose tissue and coronary artery plaque characteristics. Atherosclerosis: 2010; 210 150 154
88. Ito T., Nasu K., Terashima M., Ehara M., Kinoshita Y., Ito T., Kimura M., Tanaka N., Habara M., Tsuchikane E., Suzuki T. The impact of epicardial fat volume on coronary plaque vulnerability: insight from optical coherence tomography analysis. Eur Heart J Cardiovasc Imaging: 2012; 13 408 415
89. Saam T., Rominger A., Wolpers S., Nikolaou K., Rist C., Greif M., Cumming P., Becker A., Foerster S., Reiser M. F., Bartenstein P., Hacker M. Association of inflammation of the left anterior descending coronary artery with cardiovascular risk factors, plaque burden and pericardial fat volume: a PET/CT study. Eur J Nucl Med Mol Imaging: 2010; 37 1203 1212
90. Ding J., Hsu F. C., Harris T. B., Liu Y., Kritchevsky S. B., Szklo M., Ouyang P., Espeland M. A., Lohman K. K., Criqui M. H., Allison M., Bluemke D. A., Carr J. J. The association of pericardial fat with incident coronary heart disease: the Multi-Ethnic Study of Atherosclerosis (MESA). Am J Clin Nutr: 2009; 90 499 504
91. Mahabadi A. A., Berg M. H., Lehmann N., Kälsch H., Bauer M., Kara K., Dragano N., Moebus S., Jöckel K. H., Erbel R., Möhlenkamp S. Association of epicardial fat with cardiovascular risk factors and incident myocardial infarction in the general population: the Heinz Nixdorf Recall Study. J Am Coll Cardiol: 2013; 61 1388 1395
92. Gaborit B., Kober F., Jacquier A., Moro P. J., Flavian A., Quilici J., Cuisset T., Simeoni U., Cozzone P., Alessi M. C., Clément K., Bernard M., Dutour A. Epicardial fat volume is associated with coronary microvascular response in healthy subjects: a pilot study. Obesity (Silver Spring): 2012; 20 1200 1205
93. Sade L. E., Eroglu S., Bozbas H., Ozbiçer S., Hayran M., Haberal A., Müderrisoǧlu H. Relation between epicardial fat thickness and coronary flow reserve in women with chest pain and angiographically normal coronary arteries. Atherosclerosis: 2009; 204 580 585
94. Choi T. Y., Ahmadi N., Sourayanezhad S., Zeb I., Budoff M. J. Relation of vascular stiffness with epicardial and pericardial adipose tissues, and coronary atherosclerosis. Atherosclerosis: 2013; 229 118 123
95. Guauque-Olarte S., Gaudreault N., Piché MÈ, Fournier D., Mauriège P., Mathieu P., Bossé Y. The transcriptome of human epicardial, mediastinal and subcutaneous adipose tissues in men with coronary artery disease. PLoS One: 2011; 6 e19908
96. Karastergiou K., Evans I., Ogston N., Miheisi N., Nair D., Kaski J. C., Jahangiri M., Mohamed-Ali V. Epicardial adipokines in obesity and coronary artery disease induce atherogenic changes in monocytes and endothelial cells. Arterioscler Thromb Vasc Biol: 2010; 30 1340 1346
97. Iacobellis G., di Gioia C. R., Cotesta D., Petramala L., Travaglini C., De Santis V., Vitale D., Tritapepe L., Letizia C. Epicardial adipose tissue adiponectin expression is related to intracoronary adiponectin levels. Horm Metab Res: 2009; 41 227 231
98. Iacobellis G., Pistilli D., Gucciardo M., Leonetti F., Miraldi F., Brancaccio G., Gallo P., di Gioia C. R. Adiponectin expression in human epicardial adipose tissue in vivo is lower in patients with coronary artery disease. Cytokine: 2005; 29 251 255 (Pubitemid 40320925)
99. Langheim S., Dreas L., Veschini L., Maisano F., Foglieni C., Ferrarello S., Sinagra G., Zingone B., Alfieri O., Ferrero E., Maseri A., Ruotolo G. Increased expression and secretion of resistin in epicardial adipose tissue of patients with acute coronary syndrome. Am J Physiol Heart Circ Physiol: 2010; 298 H746 H753
100. Baker A. R., Harte A. L., Howell N., Pritlove D. C., Ranasinghe A. M., da Silva N. F., Youssef E. M., Khunti K., Davies M. J., Bonser R. S., Kumar S., Pagano D., McTernan P. G. Epicardial adipose tissue as a source of nuclear factor-kappaB and c-Jun N-terminal kinase mediated inflammation in patients with coronary artery disease. J Clin Endocrinol Metab: 2009; 94 261 267
101. Payne G. A., Borbouse L., Kumar S., Neeb Z., Alloosh M., Sturek M., Tune J. D. Epicardial perivascular adipose-derived leptin exacerbates coronary endothelial dysfunction in metabolic syndrome via a protein kinase C-beta pathway. Arterioscler Thromb Vasc Biol: 2010; 30 1711 1717
102. Hirata Y., Tabata M., Kurobe H., Motoki T., Akaike M., Nishio C., Higashida M., Mikasa H., Nakaya Y., Takanashi S., Igarashi T., Kitagawa T., Sata M. Coronary atherosclerosis is associated with macrophage polarization in epicardial adipose tissue. J Am Coll Cardiol: 2011; 58 248 255
103. Dutour A., Achard V., Sell H., Naour N., Collart F., Gaborit B., Silaghi A., Eckel J., Alessi M. C., Henegar C., Clément K. Secretory type II phospholipase A2 is produced and secreted by epicardial adipose tissue and overexpressed in patients with coronary artery disease. J Clin Endocrinol Metab: 2010; 95 963 967
104. Salgado-Somoza A., Teijeira-Fernandez E., Fernandez A. L., Gonzalez-Juanatey J. R., Eiras S. Proteomic analysis of epicardial and subcutaneous adipose tissue reveals differences in proteins involved in oxidative stress. Am J Physiol Heart Circ Physiol: 2010; 299 H202 H209
105. Salgado-Somoza A., Teijeira-Fernandez E., Fernandez A. L., Gonzalez-Juanatey J. R., Eiras S. Changes in lipid transport-involved proteins of epicardial adipose tissue associated with coronary artery disease. Atherosclerosis: 2012; 224 492 499
106. Tsang T. S., Gersh B. J. Atrial fibrillation: an old disease, a new epidemic. Am J Med: 2002; 113 432 435 (Pubitemid 35223616)
107. Kannel W. B., Abbott R. D., Savage D. D., McNamara P. M. Epidemiologic features of chronic atrial fibrillation: the Framingham study. N Engl J Med: 1982; 306 1018 1022 (Pubitemid 12155370)
108. Wolf P. A., Abbott R. D., Kannel W. B. Atrial fibrillation as an independent risk factor for stroke: the Framingham Study. Stroke: 1991; 22 983 988
109. Krahn A. D., Manfreda J., Tate R. B., Mathewson F. A., Cuddy T. E. The natural history of atrial fibrillation: incidence, risk factors, and prognosis in the Manitoba Follow-Up Study. Am J Med: 1995; 98 476 484
110. Wanahita N., Messerli F. H., Bangalore S., Gami A. S., Somers V. K., Steinberg J. S. Atrial fibrillation and obesity - results of a meta-analysis. Am Heart J: 2008; 155 310 315
111. Dublin S., French B., Glazer N. L., Wiggins K. L., Lumley T., Psaty B. M., Smith N. L., Heckbert S. R. Risk of new-onset atrial fibrillation in relation to body mass index. Arch Intern Med: 2006; 166 2322 2328 (Pubitemid 44833356)
112. Wang T. J., Parise H., Levy D., D'Agostino R. B. Sr, Wolf P. A., Vasan R. S., Benjamin E. J. Obesity and the risk of new-onset atrial fibrillation. JAMA: 2004; 292 2471 2477 (Pubitemid 39552671)
113. Nagashima K., Okumura Y., Watanabe I., Nakai T., Ohkubo K., Kofune T., Kofune M., Mano H., Sonoda K., Hirayama A. Association between epicardial adipose tissue volumes on 3-dimensional reconstructed CT images and recurrence of atrial fibrillation after catheter ablation. Circ J: 2011; 75 2559 2565
114. Thanassoulis G., Massaro J. M., O'Donnell C. J., Hoffmann U., Levy D., Ellinor P. T., Wang T. J., Schnabel R. B., Vasan R. S., Fox C. S., Benjamin E. J. Pericardial fat is associated with prevalent atrial fibrillation: the Framingham Heart Study. Circ Arrhythm Electrophysiol: 2010; 3 345 350
115. Wong C. X., Abed H. S., Molaee P., Nelson A. J., Brooks A. G., Sharma G., Leong D. P., Lau D. H., Middeldorp M. E., Roberts-Thomson K. C., Wittert G. A., Abhayaratna W. P., Worthley S. G., Sanders P. Pericardial fat is associated with atrial fibrillation severity and ablation outcome. J Am Coll Cardiol: 2011; 57 1745 1751
116. Al Chekakie M. O., Welles C. C., Metoyer R., Ibrahim A., Shapira A. R., Cytron J., Santucci P., Wilber D. J., Akar J. G. Pericardial fat is independently associated with human atrial fibrillation. J Am Coll Cardiol: 2010; 56 784 788
117. Lin Y. K., Chen Y. J., Chen S. A. Potential atrial arrhythmogenicity of adipocytes: implications for the genesis of atrial fibrillation. Med Hypotheses: 2010; 74 1026 1029
118. Soeki T., Sata M. Role of epicardial adipose tissue in atrial fibrillation. Circ J: 2012; 76 2738 2739
119. Lin Y. K., Chen Y. C., Chang S. L., Lin Y. J., Chen J. H., Yeh Y. H., Chen S. A., Chen Y. J. Heart failure epicardial fat increases atrial arrhythmogenesis. Int J Cardiol: 2013; 167 1979 1983
120. Corradi D., Maestri R., Callegari S., Pastori P., Goldoni M., Luong T. V., Bordi C. The ventricular epicardial fat is related to the myocardial mass in normal, ischemic and hypertrophic hearts. Cardiovasc Pathol: 2004; 13 313 316 (Pubitemid 39531917)
121. Kankaanpaa M., Lehto H. R., Parkka J. P., Komu M., Viljanen A., Ferrannini E., Knuuti J., Nuutila P., Parkkola R., Iozzo P. Myocardial triglyceride content and epicardial fat mass in human obesity: relationship to left ventricular function and serum free fatty acid levels. J Clin Endocrinol Metab: 2006; 91 4689 4695 (Pubitemid 44833458)
122. Iacobellis G., Leonetti F., Singh N., Sharma M. A. Relationship of epicardial adipose tissue with atrial dimensions and diastolic function in morbidly obese subjects. Int J Cardiol: 2007; 115 272 273 (Pubitemid 46136512)
123. Doesch C., Haghi D., Fluchter S., Suselbeck T., Schoenberg S. O., Michaely H., Borggrefe M., Papavassiliu T. Epicardial adipose tissue in patients with heart failure. J Cardiovasc Magn Reson: 2010; 12 40
124. Doesch C., Streitner F., Bellm S., Suselbeck T., Haghi D., Heggemann F., Schoenberg S. O., Michaely H., Borggrefe M., Papavassiliu T. Epicardial adipose tissue assessed by cardiac magnetic resonance imaging in patients with heart failure due to dilated cardiomyopathy. Obesity (Silver Spring): 2013; 21 E253 E261
125. Jaffer I., Riederer M., Shah P., Peters P., Quehenberger F., Wood A., Scharnagl H., März W., Kostner K. M., Kostner G. M. Expression of fat mobilizing genes in human epicardial adipose tissue. Atherosclerosis: 2012; 220 122 127
126. Greulich S., de Wiza D. H., Preilowski S., Ding Z., Mueller H., Langin D., Jaquet K., Ouwens D. M., Eckel J. Secretory products of guinea pig epicardial fat induce insulin resistance and impair primary adult rat cardiomyocyte function. J Cell Mol Med: 2011; 15 2399 2410
127. Silaghi A., Achard V., Paulmyer-Lacroix O., Scridon T., Tassistro V., Duncea I., Clément K., Dutour A., Grino M. Expression of adrenomedullin in human epicardial adipose tissue: role of coronary status. Am J Physiol Endocrinol Metab: 2007; 293 E1443 E1450 (Pubitemid 350106615)
128. Gaborit B., Jacquier A., Kober F., Abdesselam I., Cuisset T., Boullu-Ciocca S., Emungania O., Alessi M. C., Clément K., Bernard M., Dutour A. Effects of bariatric surgery on cardiac ectopic fat: lesser decrease in epicardial fat compared to visceral fat loss and no change in myocardial triglyceride content. J Am Coll Cardiol: 2012; 60 1381 1389
129. Guzzardi M. A., Iozzo P. Fatty heart, cardiac damage, and inflammation. Rev Diabet Stud: 2011; 8 403 417
130. McGavock J. M., Victor R. G., Unger R. H., Szczepaniak L. S. American College of Physicians and the American Physiological Society Adiposity of the heart, revisited. Ann Intern Med: 2006; 144 517 524 (Pubitemid 46780675)
131. Szendroedi J., Roden M. Ectopic lipids and organ function. Curr Opin Lipidol: 2009; 20 50 56
132. Hammer S., van der Meer R. W., Lamb H. J., de Boer H. H., Bax J. J., de Roos A., Romijn J. A., Smit J. W. Short-term flexibility of myocardial triglycerides and diastolic function in patients with type 2 diabetes mellitus. Am J Physiol Endocrinol Metab: 2008; 295 E714 E718
133. Lamb H. J., Smit J. W., van der Meer R. W., Hammer S., Doornbos J., de Roos A., Romijn J. A. Metabolic MRI of myocardial and hepatic triglyceride content in response to nutritional interventions. Curr Opin Clin Nutr Metab Care: 2008; 11 573 579
134. Iacobellis G., Singh N., Wharton S., Sharma A. M. Substantial changes in epicardial fat thickness after weight loss in severely obese subjects. Obesity (Silver Spring): 2008; 16 1693 1697 (Pubitemid 351915121)
135. Willens H. J., Byers P., Chirinos J. A., Labrador E., Hare J. M., de Marchena E. Effects of weight loss after bariatric surgery on epicardial fat measured using echocardiography. Am J Cardiol: 2007; 99 1242 1245 (Pubitemid 46659864)
136. Bosy-Westphal A., Kossel E., Goele K., Blöcker T., Lagerpusch M., Later W., Heller M., Glüer C. C., Müller M. J. Association of pericardial fat with liver fat and insulin sensitivity after diet-induced weight loss in overweight women. Obesity (Silver Spring): 2010; 18 2111 2117
137. Kim M. K., Tanaka K., Kim M. J., Matuso T., Endo T., Tomita T., Maeda S., Ajisaka R. Comparison of epicardial, abdominal and regional fat compartments in response to weight loss. Nutr Metab Cardiovasc Dis: 2009; 19 760 766
138. Snel M., Jonker J. T., Hammer S., Kerpershoek G., Lamb H. J., Meinders A. E., Pijl H., de Roos A., Romijn J. A., Smit J. W., Jazet I. M. Long-term beneficial effect of a 16-week very low calorie diet on pericardial fat in obese type 2 diabetes mellitus patients. Obesity (Silver Spring): 2012; 20 1572 1576
139. Kim M. K., Tomita T., Kim M. J., Sasai H., Maeda S., Tanaka K. Aerobic exercise training reduces epicardial fat in obese men. J Appl Physiol: 2009; 106 5 11
140. Wilund K. R., Tomayko E. J., Wu P. T., Ryong Chung H., Vallurupalli S., Lakshminarayanan B., Fernhall B. Intradialytic exercise training reduces oxidative stress and epicardial fat: a pilot study. Nephrol Dial Transplant: 2010; 25 2695 2701
141. Brinkley T. E., Ding J., Carr J. J., Nicklas B. J. Pericardial fat loss in postmenopausal women under conditions of equal energy deficit. Med Sci Sports Exerc: 2011; 43 808 814
142. Jonker J. T., Lamb H. J., van der Meer R. W., Rijzewijk L. J., Menting L. J., Diamant M., Bax J. J., de Roos A., Romijn J. A., Smit J. W. Pioglitazone compared with metformin increases pericardial fat volume in patients with type 2 diabetes mellitus. J Clin Endocrinol Metab: 2010; 95 456 460
143. Zhou Q., Liao J. K. Pleiotropic effects of statins - Basic research and clinical perspectives. Circ J: 2010; 74 818 826
144. Park J. H., Park Y. S., Kim Y. J., Lee I. S., Kim J. H., Lee J. H., Choi S. W., Jeong J. O., Seong I. W. Effects of statins on the epicardial fat thickness in patients with coronary artery stenosis underwent percutaneous coronary intervention: comparison of atorvastatin with simvastatin/ezetimibe. J Cardiovasc Ultrasound: 2010; 18 121 126
145. Alexopoulos N., Melek B. H., Arepalli C. D., Hartlage G. R., Chen Z., Kim S., Stillman A. E., Raggi P. Effect of Intensive Versus Moderate Lipid-Lowering Therapy on Epicardial Adipose Tissue in Hyperlipidemic Post-Menopausal Women: A Substudy of the BELLES Trial (Beyond Endorsed Lipid Lowering with EBT Scanning). J Am Coll Cardiol: 2013; 61 1956 1961
146. Gaborit B., Bernard M., Clement K., Dutour A. Reply. J Am Coll Cardiol: 2013; 61 991
147. Khalaf K. I., Taegtmeyer H. Slimming the heart with bariatric surgery. J Am Coll Cardiol: 2013; 61 990 991
148. de Roos A. Reversibility of intrathoracic lipotoxicity in obesity after bariatric surgery: use of magnetic resonance imaging. J Am Coll Cardiol: 2012; 60 1390 1392