Secretory products from epicardial adipose tissue of patients with type 2 diabetes mellitus induce cardiomyocyte dysfunction

Circulation

Volumn 126, Issue 19, 2012, Pages 2324-2334

  Greulich, Sabrina ^a   Maxhera, Bujar ^c,d   Vandenplas, Guy ^e   De Wiza, Daniella Herzfeld ^a   Smiris, Konstantinos ^c,d   Mueller, Heidi ^a   Heinrichs, Jessica ^a   Blumensatt, Marcel ^a   Cuvelier, Claude ^e   Akhyari, Payam ^c,d   Ruige, Johannes B ^e   Ouwens, D Margriet ^e   Eckel, Juergen ^b  

^a Institute of Clinical Biochemistry and Pathobiochemistry   (Germany)

^b Paul Langerhans Group Integrative Physiology   (Germany)

^c LEIBNIZ CENTER FOR DIABETES RESEARCH AT HEINRICH HEINE UNIVERSITY DÜSSELDORF   (Germany)

^d Department of Orthopedic Surgery   (Germany)

^e GHENT UNIVERSITY HOSPITAL   (Belgium)

Author keywords

adipose tissue; angiopoietin 2; insulin resistance; type 2 diabetes mellitus; Words: activins

Indexed keywords

ACTIVIN A; ANGIOPOIETIN 2; CALCIUM ION; CD14 ANTIGEN; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; INSULIN; NEUTRALIZING ANTIBODY; PROTEIN KINASE B; RECOMBINANT PROTEIN; SARCOPLASMIC ENDOPLASMIC RETICULUM ATPASE 2A; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; SERINE; SMAD2 PROTEIN; UNCLASSIFIED DRUG;

ADIPOSE TISSUE; AGED; ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; CYTOSOL; ENZYME PHOSPHORYLATION; EPICARDIAL ADIPOSE TISSUE; EPICARDIUM; HEART DISEASE; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HUMAN; HUMAN TISSUE; MONOCYTE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; RAT; SARCOMERE; SIGNAL TRANSDUCTION;

ACTIVINS; ADIPOSE TISSUE; AGED; ANGIOPOIETIN-2; ANIMALS; BIOPSY; CALCIUM; CELLS, CULTURED; CULTURE MEDIA, CONDITIONED; DIABETES MELLITUS, TYPE 2; HUMANS; INSULIN; MALE; MODELS, ANIMAL; MYOCYTES, CARDIAC; PERICARDIUM; RATS; RATS, INBRED LEW; SARCOMERES; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; SIGNAL TRANSDUCTION;

EID: 84868573391     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.111.039586     Document Type: Article

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