Association of pericardial fat, intrathoracic fat, and visceral abdominal fat with cardiovascular disease burden: The Framingham Heart Study

European Heart Journal

Volumn 30, Issue 7, 2009, Pages 850-856

  Mahabadi, Amir A ^a   Massaro, Joseph M ^b,d   Rosito, Guido A ^a,e   Levy, Daniel ^d   Murabito, Joanne M ^c,d   Wolf, Philip A ^c,d   O'Donnell, Christopher J ^a,d   Fox, Caroline S ^d,f   Hoffmann, Udo ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b Boston University   (United States)

^c BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d FRAMINGHAM HEART STUDY   (United States)

^e Federal School of Medical Sciences of Porto Alegre   (Brazil)

^f BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Cardiovascular disease; Epidemiology; Framingham Heart Study; Pericardial fat; Visceral abdominal fat

Indexed keywords

ADULT; AGE DISTRIBUTION; ARTICLE; BODY MASS; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; FEMALE; HEART INFARCTION; HUMAN; INTRAABDOMINAL FAT; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; MALE; OBESITY; PERICARDIUM; POPULATION; PREVALENCE; PRIORITY JOURNAL; PROGENY; SEX DIFFERENCE; STROKE; THORACIC AORTA; WAIST CIRCUMFERENCE;

ADIPOSE TISSUE; AGED; BODY MASS INDEX; CARDIOVASCULAR DISEASES; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; INTRA-ABDOMINAL FAT; MALE; MIDDLE AGED; OBESITY; PERICARDIUM; PREVALENCE; RISK FACTORS; SEX FACTORS; TOMOGRAPHY, X-RAY COMPUTED;

EID: 64849115634     PISSN: 0195668X     EISSN: 15229645     Source Type: Journal    
DOI: 10.1093/eurheartj/ehn573     Document Type: Article

References (36)

1. Ogden CL, Carroll MD, Curtin LR, McDowell MA, Tabak CJ, Flegal KM. Prevalence of overweight and obesity in the United States, 1999-2004. JAMA 2006;295:1549-1555.
2. Poirier P, Giles TD, Bray GA, Hong Y, Stern JS, Pi-Sunyer FX, Eckel RH. Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss: an update of the 1997 American Heart Association Scientific Statement on Obesity and Heart Disease from the Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism. Circulation 2006;113:898-918.
3. Despres JP, Lemieux I. Abdominal obesity and metabolic syndrome. Nature 2006;444:881-887.
4. Snijder MB, Dekker JM, Visser M, Bouter LM, Stehouwer CD, Yudkin JS, Heine RJ, Nijpels G, Seidell JC. Trunk fat and leg fat have independent and opposite associations with fasting and postload glucose levels: the Hoorn study. Diabetes Care 2004;27:372-377.
5. Poirier P, Despres JP. Waist circumference, visceral obesity, and cardiovascular risk. J Cordiopulm Rehabil 2003;23:161-169.
6. Despres JP. Is visceral obesity the cause of the metabolic syndrome? Ann Med 2006;38:52-63.
7. Lissner L Bjorkelund C, Heitmann BL, Seidell JC, Bengtsson C. Larger hip circumference independently predicts health and longevity In a Swedish female cohort. Obes Res 2001;9:644-646.
8. Fujimoto WY, Jablonski KA, Bray GA, Kriska A, Barrett-Connor E, Haffner S, Hanson R, Hill JO, Hubbard V, Stamm E. Pi-Sunyer FX. Body size and shape changes and the risk of diabetes in the diabetes prevention program. Diabetes 2007;56:1680-1685.
9. de Vos AM, Prokop M, Roos CJ, Meijs MF, van der Schouw YT, Rutten A, Gorter PM, Cramer MJ, Doevendans PA, Rensing BJ, Bartelink ML, Velthuis BK, Mosterd A, Bots ML. Peri-coronary epicardial adipose tissue is related to cardiovascular risk factors and coronary artery calcification in post-menopausal women. Eur Heart J 2008;29:777-783.
10. Mazurek T, Zhang L, Zalewski A, Mannion JD, Diehl JT, Arafat H, Sarov-Blat L, O'Brien S, Keiper EA, Johnson AG, Martin J, Goldstein BJ, Shi Y. Human epicardial adipose tissue is a source of inflammatory mediators. Circulation 2003;108:2460-2466.
11. Ouchi N, Kihara S, Arita Y, Okamoto Y, Maeda K, Kuriyama H, Hotta K, Nishida M, Takahashi M, Muraguchi M, Ohmoto Y, Nakamura T. Yamashita S, Funahashi T, Matsuzawa Y. Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway. Circulotion 2000;102:1296-1301.
12. Ouchi N, Kihara S, Funahashi T, Nakamura T, Nishida M, Kumada M, Okamoto Y, Ohashi K, Nagaretani H, Kishida K, Nishizawa H, Maeda N, Kobayashi H, Hiraoka H, Matsuzawa Y. Reciprocal association of C-reactive protein with adiponectin in blood stream and adipose tissue. Circulation 2003;107:671-674.
13. Baker AR, Silva NF, Quinn DW, Harte AL, Pagano D, Bonser RS, Kumar S, McTernan PG. Human epicardial adipose tissue expresses a pathogenic profile of adipocytokines in patients with cardiovascular disease. Cardiovasc Diabetol 2006;5:1.
14. Laine P, Kaartinen M, Penttila A, Panula P, Paavonen T, Kovanen PT. Association between myocardial infarction and the mast cells In the adventitia of the infarct-related coronary artery. Circulation 1999;99:361- 369.
15. Yatagai T, Nagasaka S, Taniguchi A, Fukushima M, Nakamura T, Kuroe A, Nakai Y, Ishibashi S. Hypoadiponectinemia is associated with visceral fat accumulation and insulin resistance in Japanese men with type 2 diabetes mellitus. Metabolism 2003;52:1274-1278.
16. Saljo Y, Kiyota N, Kawasaki Y, Miyazaki Y, Kashimura J, Fukuda M, Kishi R. Relationship between C-reactive protein and visceral adipose tissue in healthy Japanese subjects. Diabetes Obes Metab 2004;6:249-258.
17. Kremen J, Dolinkova M, Krajickova J, Blaha J, Anderlova K, Lacinova Z, Haluzikova D. Bosanska L, Vokurka M, Svačina S, Haluzik M. increased subcutaneous and epicardial adipose tissue production of proinflammatory cytokines in cardiac surgery patients: possible role In postoperative insulin resistance. J Clin Endocrinol Metab 2006;91:4620-4627.
18. Rosito GA, Massaro JM, Hoffmann U, Ruberg FL, Mahabadi AA, Vasan RS, O'Donnell CJ, Fox CS. Pericardial fat, visceral abdominal fat, cardiovascular disease risk factors, and vascular calcification in a community-based sample: the Framingham Heart Study. Circulation 2008;117:605-613.
19. Fox CS, Massaro JM, Hoffmann U, Pou KM, Maurovich-Horvat P, Liu CY, Vasan RS, Murabito JM. Meigs JB, Cupples LA, D'Agostlno RB Sr. O'Donnell CJ. Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors In the Framingham Heart Study. Circulation 2007;116:39-48.
20. Vega GL, Adams-Huet B, Peshock R, Willert D. Shah B. Grundy SM. Influence of body fat content and distribution on variation In metabolic risk. J Clin Endocrinol Metab 2006;91:4459-4466.
21. Pou KM, Massaro JM, Hoffmann U, Vasan RS, Maurovich-Horvat P, Larson MG, Keaney JF Jr, Meigs JB, Lipinska I, Kathiresan S, Murabito JM, O'Donnell CJ, Benjamin EJ, Fox CS. Visceral and subcutaneous adipose tissue volumes are cross-sectionally related to markers of inflammation and oxidative stress: the Framingham Heart Study. Circulation 2007;116:1234-1241.
22. Taguchi R, Takasu J, Itani Y, Yamamoto R, Yokoyama K, Watanabe S, Masuda Y. Pericardial fat accumulation in men as a risk factor for coronary artery disease. Atherosclerosis 2001;157:203-209.
23. Jeong JW, Jeong MH, Yun KH, Oh SK, Park EM, Kim YK, Rhee SJ, Lee EM, Lee J, Yoo NJ, Kim NH, Park JC. Echocardiography epicardial fat thickness and coronary artery disease. Circ J 2007;71:536-539.
24. Dawber TR, Kannel WB, Lyell LP. An approach to longitudinal studies in a community: the Framingham Study. Ann N Y Acad Sci 1963;107:539- 556.
25. Shurtleff D. Some characteristics related to the incidence of cardiovascular disease and death: Framingham Study. 18-year follow-up: section 30. In: Kannel W, Fordon T, eds. The Framingham Study: and Epidemiological Investigation of Cardiovascular Disease. Washington, DC: Department of Health. Education, and Welfare; 1973. DHEW publication No. NIH 74-599.
26. Ho KK, Pinsky JL, Kannel WB, Levy D. The epidemiology of heart failure: the Framingham Study. J Am Coll Cardiol 1993;22(Suppl. 4A):6A-13A.
27. Cupples L, D'Agostino R, Kiely D. The Framingham Heart Study, Section 35. An Epidemiological Investigation of Cardiovascular Disease Survival Following Cardiovascular Events: 30 Year Follow-up. Bethesda. MD: National Heart, Lung and Blood Institute; 1988.
28. Sons HU, Hoffmann V. Epicardial fat cell size, fat distribution and fat infiltration of the right and left ventricle of the heart. Anat Anz 1986;161:355-373.
29. Marchington JM, Mattacks CA, Pond CM. Adipose tissue in the mammalian heart and pericardium: structure, foetal development and biochemical properties. Comp Biochem Physiol B 1989;94:225-232.
30. Marchington JM, Pond CM. Site-specific properties of pericardial and epicardial adipose tissue: the effects of insulin and high-fat feeding on lipogenesis and the incorporation of fatty acids in vitro. Int J Obes 1990;14:1013-1022.
31. Wajchenberg BL. Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. Endocr Rev 2000;21:697-738.
32. Arita Y, Kihara S, Ouchi N, Maeda K, Kuriyama H, Okamoto Y, Kumada M, Hotta K, Nishida M, Takahashi M, Nakamura T, Shimomura I, Muraguchi M, Ohmoto Y, Funahashi T, Matsuzawa Y. Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-blnding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell. Circulation 2002;105:2893-2898.
33. Klein S. The case of visceral fat: argument for the defense. J Clin Invest 2004;113:1530-1532.
34. Matsuzawa Y. Therapy insight: adipocytokines in metabolic syndrome and related cardiovascular disease. Nat Clin Pract 2006;3:35-42.
35. Bacha F, Saad R, Gungor N, Arslanian SA. Adiponect in in youth: relationship to visceral adiposity, insulin sensitivity, and beta-cell function. Diabetes Care 2004;27:547-552.
36. Nielsen S, Guo Z, Johnson CM, Hensrud DD, Jensen MD. Splanchnic lipolysls in human obesity. J Clin Invest 2004;113:1582-1588.