11β-hydroxysteroid dehydrogenase type 1 of the subcutaneous adipose tissue is dysregulated but not associated with metabolic disorders in adults born small for gestational age

Journal of Clinical Endocrinology and Metabolism

Volumn 95, Issue 8, 2010, Pages 3949-3954

  Meas, Taly ^a,b   Carreira, E ^a   Wang, Y ^a   Rauh, M ^e   Poitou, C ^c,d   Clement K ^c,d   Dotsch J ^e   Levy Marchal C ^a,b  

^a HÔPITAL ROBERT DEBRÉ   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c CENTRE DE RECHERCHE DES CORDELIERS   (France)

^d PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^e UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 1; GLUCOCORTICOID; MESSENGER RNA; GLUCOCORTICOID RECEPTOR;

ABDOMINAL WALL; ADULT; AGE DISTRIBUTION; ARTICLE; BIRTH WEIGHT; BODY FAT; BODY MASS; COHORT ANALYSIS; CONTROLLED STUDY; CORTICOSTEROID METABOLISM; DISEASE ASSOCIATION; FEMALE; GENE EXPRESSION; HUMAN; IN VIVO STUDY; MAJOR CLINICAL STUDY; MALE; METABOLIC DISORDER; MICRODIALYSIS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SEX DIFFERENCE; SMALL FOR DATE INFANT; SUBCUTANEOUS FAT; ANALYSIS OF VARIANCE; ENZYMOLOGY; GENETICS; METABOLIC SYNDROME X; METABOLISM; NEWBORN; OBESITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; ADULT; ANALYSIS OF VARIANCE; GENE EXPRESSION; HUMANS; INFANT, NEWBORN; INFANT, SMALL FOR GESTATIONAL AGE; METABOLIC SYNDROME X; MICRODIALYSIS; OBESITY; RECEPTORS, GLUCOCORTICOID; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SUBCUTANEOUS FAT;

EID: 77955373753     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2010-0254     Document Type: Article

References (20)

1. Jaquet D, Deghmoun S, Chevenne D, Collin D, Czernichow P, Lévy- Marchal C 2005 Dynamic change in adiposity from fetal to postnatal life is involved in the metabolic syndrome associated with reduced fetal growth. Diabetologia 48:849-855
2. Barker DJ, Hales CN, Fall CH, Osmond C, Phipps K, Clark PM 1993 Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): relation to reduced fetal growth. Diabetologia 36:62-67
3. Meas T 2010 Fetal origins of insulin resistance and the metabolic syndrome: a key role for adipose tissue? Diabetes Metab 36:11-20
4. Meas T, Deghmoun S, Armoogum P, Alberti C, Levy-Marchal C 2008 Consequences of being born small for gestational age on body composition: an 8-year follow-up study. J Clin Endocrinol Metab 93:3804-3809
5. Meas T, Deghmoun S, Alberti C, Carreira E, Armoogum P, Chevenne D, Levy-Marchal C 2010 Independent effects of weight gain and fetal programming on metabolic complications in adults born small for gestational age. Diabetologia 53:907-913
6. Ricketts ML, Verhaeg JM, Bujalska I, Howie AJ, Rainey WE, Stewart PM 1998 Immunohistochemical localization of type 1 11β-hydroxysteroid dehydrogenase in human tissues. J Clin Endocrinol Metab 83:1325-1335
7. Rask E, Walker BR, Söderberg S, Livingstone DE, Eliasson M, Johnson O, Andrew R, Olsson T 2002 Tissue-specific changes in peripheral cortisol metabolism in obese women: increased adipose 11β-hydroxysteroid dehydrogenase type 1 activity. J Clin Endocrinol Metab 87:3330-3336
8. Andrews RC, Herlihy O, Livingstone DE, Andrew R, Walker BR 2002 Abnormal cortisol metabolism and tissue sensitivity to cortisol in patients with glucose intolerance. J Clin Endocrinol Metab 87: 5587-5593
9. Kannisto K, Pietiläinen KH, Ehrenborg E, Rissanen A, Kaprio J, Hamsten A, Yki-Järvinen H 2004 Overexpression of 11β-hydroxysteroid dehydrogenase-1 in adipose tissue is associated with acquired obesity and features of insulin resistance: studies in young adult monozygotic twins. J Clin Endocrinol Metab 89:4414-4421
10. Nyirenda MJ, Carter R, Tang JI, de Vries A, Schlumbohm C, Hillier SG, Streit F, Oellerich M, Armstrong VW, Fuchs E, Seckl JR 2009 Prenatal programming of metabolic syndrome in the common marmoset is associated with increased expression of 11β-hydroxysteroid dehydrogenase type 1. Diabetes 58:2873-2879
11. Whorwood CB, Firth KM, Budge H, Symonds ME 2001 Maternal undernutrition during early to midgestation programs tissue-specific alterations in the expression of the glucocorticoid receptor, 11β-hydroxysteroid dehydrogenase isoforms, and type 1 angiotensin II receptor in neonatal sheep. Endocrinology 142:2854-2864
12. DeFronzo RA, Tobin JD, Andres R 1979 Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 237:E214-E223
13. Vogeser M, Briegel J, Jacob K 2001 Determination of serum cortisol by isotope-dilution liquid-chromatography electrospray ionization tandem mass spectrometry with on-line extraction. Clin Chem Lab Med 39:944-947
14. Struwe E, Berzl GM, Schild RL, Beckmann MW,Dörr HG, Rascher W, Dötsch J 2007 Simultaneously reduced gene expression of cortisol-activating and cortisol-inactivating enzymes in placentas of small-for-gestational-age neonates. Am J Obstet Gynecol 197:43 e41-e46
15. Alikhani-Koopaei R, Fouladkou F, Frey FJ, Frey BM 2004 Epigenetic regulation of 11β-hydroxysteroid dehydrogenase type 2 expression. J Clin Invest 114:1146-1157
16. Bertram C, Trowern AR, Copin N, Jackson AA, Whorwood CB 2001 The maternal diet during pregnancy programs altered expression of the glucocorticoid receptor and type 2 11β-hydroxysteroid dehydrogenase: potential molecular mechanisms underlying the programming of hypertension in utero. Endocrinology 142:2841-2853
17. Boiko J, Jaquet D, Chevenne D, Rigal O, Czernichow P, Levy-Marchal C 2005 In situ lipolytic regulation in subjects born small for gestational age. Int J Obes (Lond) 29:565-570
18. Jaquet D, Gaboriau A, Czernichow P, Levy-Marchal C 2001 Relatively low serum leptin levels in adults born with intra-uterine growth retardation. Int J Obes Relat Metab Disord 25:491-495
19. Ozanne SE, Jensen CB, Tingey KJ, Martin-Gronert MS, Grunnet L, Brons C, Storgaard H, Vaag AA 2006 Decreased protein levels of key insulin signalling molecules in adipose tissue from young men with a low birthweight: potential link to increased risk of diabetes? Diabetologia 49:2993-2999
20. Jaquet D, Deghmoun S, Chevenne D, Czernichow P, Levy-Marchal C 2006 Low serum adiponectin levels in subjects born small for gestational age: impact on insulin sensitivity. Int J Obes (Lond) 30:83-87