Association of inflammation of the left anterior descending coronary artery with cardiovascular risk factors, plaque burden and pericardial fat volume: A PET/CT study

European Journal of Nuclear Medicine and Molecular Imaging

Volumn 37, Issue 6, 2010, Pages 1203-1212

  Saam, Tobias ^a   Rominger, Axel ^b   Wolpers, Sarah ^b   Nikolaou, Konstantin ^a   Rist, Carsten ^a   Greif, Martin ^b   Cumming, Paul ^b   Becker, Alexander ^b   Foerster, Stefan ^b   Reiser, Maximilian F ^a   Bartenstein, Peter ^b   Hacker, Marcus ^b  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

Author keywords

Atherosclerosis; Coronary arteries; FDG; Inflammation; PET CT; Plaque imaging

Indexed keywords

GADOLINIUM;

ADULT; AGED; ARTICLE; ATHEROSCLEROTIC PLAQUE; BODY MASS; CARDIOVASCULAR DISEASE; CARDIOVASCULAR PARAMETERS; CARDIOVASCULAR RISK; COMPUTER ASSISTED EMISSION TOMOGRAPHY; CONTRAST ENHANCEMENT; CORRELATION COEFFICIENT; CROSS-SECTIONAL STUDY; DIABETES MELLITUS; DISEASE ASSOCIATION; FEMALE; HUMAN; HYPERCHOLESTEROLEMIA; HYPERTENSION; ISCHEMIC HEART DISEASE; LEFT ANTERIOR DESCENDING CORONARY ARTERY; MAJOR CLINICAL STUDY; MALE; STUDENT T TEST;

ADIPOSE TISSUE; ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ATHEROSCLEROSIS; BIOLOGICAL MARKERS; BIOLOGICAL TRANSPORT; CARDIOVASCULAR DISEASES; CORONARY ANGIOGRAPHY; CORONARY VESSELS; FEMALE; FLUORODEOXYGLUCOSE F18; HUMANS; INFLAMMATION; MALE; MIDDLE AGED; NEOPLASMS; POSITRON-EMISSION TOMOGRAPHY; REPRODUCIBILITY OF RESULTS; RETROSPECTIVE STUDIES; RISK FACTORS; TOMOGRAPHY, X-RAY COMPUTED; YOUNG ADULT;

EID: 77954874237     PISSN: 16197070     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00259-010-1432-2     Document Type: Article

References (29)

1. Lloyd-Jones D, Adams R, Carnethon M, De Simone G, Ferguson TB, Flegal K, et al. Heart disease and stroke statistics-2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 2009;119: e21-181. doi:CIRCULATIONAHA.108.191261 [pii] 10.1161/CIRCULATIONAHA.108.191261.
2. Naghavi M, Libby P, Falk E, Casscells SW, Litovsky S, Rumberger J, et al. From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part II. Circulation 2003;108:1772-8. doi:10.1161/01. CIR.0000087481.55887. C9 108/15/1772 [pii].
3. Naghavi M, Libby P, Falk E, Casscells SW, Litovsky S, Rumberger J, et al. From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part I. Circulation 2003;108:1664-72. doi:10.1161/01. CIR.0000087480.94275.97 108/14/1664 [pii].
4. Hansson GK. Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med 2005;352:1685-95. doi:352/16/1685 [pii] 10.1056/NEJMra043430. (Pubitemid 40530235)
5. Saam T, Hatsukami TS, Takaya N, Chu B, Underhill H, Kerwin WS, et al. The vulnerable, or high-risk, atherosclerotic plaque: noninvasive MR imaging for characterization and assessment. Radiology 2007;244:64-77. doi:244/1/64 [pii] 10.1148/radiol.2441051769. (Pubitemid 46981959)
6. Rudd JH, Myers KS, Bansilal S, Machac J, Rafique A, Farkouh M, et al. (18) Fluorodeoxyglucose positron emission tomography imaging of atherosclerotic plaque inflammation is highly reproducible: implications for atherosclerosis therapy trials. J Am Coll Cardiol 2007;50:892-6. doi:S0735-1097 (07) 01825-6 [pii] 10.1016/j.jacc.2007.05.024. (Pubitemid 47268746)
7. Rudd JH, Warburton EA, Fryer TD, Jones HA, Clark JC, Antoun N, et al. Imaging atherosclerotic plaque inflammation with [18F]-fluorodeoxyglucose positron emission tomography. Circulation 2002;105:2708-11.
8. Tawakol A, Migrino RQ, Bashian GG, Bedri S, Vermylen D, Cury RC, et al. In vivo 18F-fluorodeoxyglucose positron emission tomography imaging provides a noninvasive measure of carotid plaque inflammation in patients. J Am Coll Cardiol 2006;48:1818-24. doi:S0735-1097 (06) 01980-2 [pii] 10.1016/j. jacc.2006.05.076.
9. Ben-Haim S, Kupzov E, Tamir A, Israel O. Evaluation of 18F-FDG uptake and arterial wall calcifications using 18F-FDG PET/CT. J Nucl Med 2004;45:1816-21. doi:45/11/1816 [pii].
10. Bural GG, Torigian DA, Chamroonrat W, Houseni M, Chen W, Basu S, et al. FDG-PET is an effective imaging modality to detect and quantify age-related atherosclerosis in large arteries. Eur J Nucl Med Mol Imaging 2008;35:562-9. doi:10.1007/s00259-007-0528-9. (Pubitemid 351674338)
11. Rominger A, Saam T, Wolpers S, Cyran CC, Schmidt M, Foerster S, et al. 18F-FDG PET/CT identifies patients at risk for future vascular events in an otherwise asymptomatic cohort with neoplastic disease. J Nucl Med 2009;50:1611-20. doi: jnumed.109.065151 [pii] 10.2967/jnumed.109.065151.
12. Virmani R, Burke AP, Farb A, Kolodgie FD. Pathology of the vulnerable plaque. J Am Coll Cardiol 2006;47: C13-8. doi:S0735-1097 (05) 03137-2 [pii] 10.1016/j.jacc.2005.10.065.
13. Ambrose JA, Tannenbaum MA, Alexopoulos D, Hjemdahl-Monsen CE, Leavy J, Weiss M, et al. Angiographic progression of coronary artery disease and the development of myocardial infarction. J Am Coll Cardiol 1988;12:56-62. doi:0735-1097 (88) 90356-7 [pii].
14. Nissen SE. IVUS is redefining atherosclerotic disease. Am J Manag Care 2003; Suppl: 2-3. doi:3356 [pii].
15. Leber AW, Becker A, Knez A, von Ziegler F, Sirol M, Nikolaou K, et al. Accuracy of 64-slice computed tomography to classify and quantify plaque volumes in the proximal coronary system: a comparative study using intravascular ultrasound. J Am Coll Cardiol 2006;47:672-7. doi:S0735-1097 (05) 03035-4 [pii] 10.1016/j.jacc.2005.10.058. (Pubitemid 43170862)
16. Budoff MJ, Shaw LJ, Liu ST, Weinstein SR, Mosler TP, Tseng PH, et al. Long-term prognosis associated with coronary calcification: observations from a registry of 25, 253 patients. J Am Coll Cardiol 2007;49:1860-70. doi:S0735-1097 (07) 00680-8 [pii] 10.1016/j.jacc.2006.10.079. (Pubitemid 46661110)
17. Ding J, Hsu FC, Harris TB, Liu Y, Kritchevsky SB, Szklo M, et al. The association of pericardial fat with incident coronary heart disease: the Multi-Ethnic Study of Atherosclerosis (MESA). Am J Clin Nutr 2009;90:499-504. doi:ajcn. 2008.27358 [pii] 10.3945/ajcn. 2008.27358.
18. Greif M, Becker A, von Ziegler F, Lebherz C, Lehrke M, Broedl UC, et al. Pericardial adipose tissue determined by dual source CT is a risk factor for coronary atherosclerosis. Arterioscler Thromb Vasc Biol 2009;29:781-6. doi:ATVBAHA.108.180653 [pii] 10.1161/ATVBAHA.108.180653.
19. Rominger A, Saam T, Vogl E, übleis C, la Fougère C, Foerster S, et al. In-vivo imaging of macrophage activity in the coronary arteries using 68 Ga-DOTA-TATE PET/CT: correlation with coronary calcium burden and risk factors. J Nucl Med 2010;51:193-7. doi: jnumed.109.070672 [pii] 10.2967/jnumed.109.070672
20. Nichols JH, Samy B, Nasir K, Fox CS, Schulze PC, Bamberg F, et al. Volumetric measurement of pericardial adipose tissue from contrast-enhanced coronary computed tomography angiography: a reproducibility study. J Cardiovasc Comput Tomogr 2008;2:288-95. doi:S1934-5925 (08) 00559-5 [pii] 10.1016/j. jcct.2008.08.008.
21. Bland JM, Altman DG. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1986;1:307-10.
22. Paulmier B, Duet M, Khayat R, Pierquet-Ghazzar N, Laissy JP, Maunoury C, et al. Arterial wall uptake of fluorodeoxyglucose on PET imaging in stable cancer disease patients indicates higher risk for cardiovascular events. J Nucl Cardiol 2008;15:209-17. doi: S1071-3581 (08) 00028-7 [pii] 10.1016/j.nuclcard. 2007.10.009. (Pubitemid 351396317)
23. Yun M, Jang S, Cucchiara A, Newberg AB, Alavi A. 18F FDG uptake in the large arteries: a correlation study with the atherogenic risk factors. Semin Nucl Med 2002;32:70-6. doi: S0001299802500076 [pii].
24. Wykrzykowska J, Lehman S, Williams G, Parker JA, Palmer MR, Varkey S, et al. Imaging of inflamed and vulnerable plaque in coronary arteries with 18F-FDG PET/CT in patients with suppression of myocardial uptake using a low-carbohydrate, high-fat preparation. J Nucl Med 2009;50:563-8. doi: jnumed.108.055616 [pii] 10.2967/jnumed.108.055616.
25. Inglese E, Leva L, Matheoud R, Sacchetti G, Secco C, Gandolfo P, et al. Spatial and temporal heterogeneity of regional myocardial uptake in patients without heart disease under fasting conditions on repeated whole-body 18F-FDG PET/CT. J Nucl Med 2007;48:1662-9. doi:jnumed.107.041574 [pii] 10.2967/jnumed.107.041574. (Pubitemid 47577344)
26. Rudd JH, Myers KS, Bansilal S, Machac J, Pinto CA, Tong C, et al. Atherosclerosis inflammation imaging with 18F-FDG PET: carotid, iliac, and femoral uptake reproducibility, quantification methods, and recommendations. J Nucl Med 2008;49:871-8. doi: jnumed.107.050294 [pii] 10.2967/jnumed.107.050294. (Pubitemid 351793426)
27. Eisen A, Tenenbaum A, Koren-Morag N, Tanne D, Shemesh J, Imazio M, et al. Calcification of the thoracic aorta as detected by spiral computed tomography among stable angina pectoris patients: association with cardiovascular events and death. Circulation 2008;118:1328-34. doi:CIRCULATIONAHA.107.712141 [pii] 10.1161/CIRCULATIONAHA.107.712141.
28. Rosito GA, Massaro JM, Hoffmann U, Ruberg FL, Mahabadi AA, Vasan RS, et al. Pericardial fat, visceral abdominal fat, cardiovascular disease risk factors, and vascular calcification in a community-based sample: the Framingham Heart Study. Circulation 2008;117:605-13. doi:CIRCULATIONAHA.107.743062 [pii] 10.1161/CIRCULATIONAHA.107.743062.
29. Menezes LJ, Kotze CW, Hutton BF, Endozo R, Dickson JC, Cullum I, et al. Vascular inflammation imaging with 18F-FDG PET/CT: when to image? J Nucl Med 2009;50:854-7. doi: jnumed.108.061432 [pii] 10.2967/jnumed.108.061432.