Epicardial adipose tissue: Emerging physiological, pathophysiological and clinical features

Trends in Endocrinology and Metabolism

Volumn 22, Issue 11, 2011, Pages 450-457

  Iacobellis, Gianluca ^a   Bianco, Antonio C ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOSE TISSUE; ATHEROSCLEROSIS; BROWN ADIPOSE TISSUE; CLINICAL FEATURE; CORONARY ARTERY; EPICARDIAL ADIPOSE TISSUE; HEART MUSCLE; HEART MUSCLE METABOLISM; HEART PROTECTION; HUMAN; NONHUMAN; PATHOPHYSIOLOGY; PHYSIOLOGY; PRIORITY JOURNAL; REVIEW;

ADIPOSE TISSUE; ANIMALS; ATHEROSCLEROSIS; HUMANS; PERICARDIUM;

EID: 82455199186     PISSN: 10432760     EISSN: 18793061     Source Type: Journal    
DOI: 10.1016/j.tem.2011.07.003     Document Type: Review

References (88)

1. Iacobellis G., et al. Epicardial adipose tissue: anatomic, biomolecular and clinical relationships with the heart. Nat. Clin. Pract. Cardiovasc. Med. 2005, 2:536-543.
2. Iacobellis G. Epicardial and pericardial fat: close, but very different. Obesity 2009, 17:625.
3. Sacks H.S., Fain J.N. Human epicardial adipose tissue: a review. Am. Heart J. 2007, 153:907-917.
4. Rabkin R.W. Epicardial fat: properties, function and relationship to obesity. Obes. Rev. 2007, 8:253-261.
5. Corradi D., et al. The ventricular epicardial fat is related to the myocardial mass in normal, ischemic and hypertrophic hearts. Cardiovasc. Pathol. 2004, 13:313-316.
6. Iacobellis G., et al. Do cardiac and perivascular adipose tissue play a role in atherosclerosis?. Curr. Diab. Rep. 2008, 8:20-24.
7. Greif M., et al. Pericardial adipose tissue determined by dual score CT is a risk factor for coronary atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 2009, 29:781-786.
8. Gorter P.M., et al. Quantification of epicardial and peri-coronary fat using cardiac computed tomography: reproducibility and relation with obesity and metabolic syndrome in patients suspected of CAD. Atherosclerosis 2008, 197:896-903.
9. Company J.M., et al. Epicardial fat gene expression after aerobic exercise training in pigs with coronary atherosclerosis: relationship to visceral and subcutaneous fat. J. Appl. Physiol. 2010, 109:1904-1912.
10. Mazurek T., et al. Human epicardial adipose tissue is a source of inflammatory mediators. Circulation 2003, 108:2460-2466.
11. Bambace C., et al. Adiponectin gene expression and adipocyte diameter: a comparison between epicardial and subcutaneous adipose tissue in men. Cardiovasc. Pathol. 2010, 10.1016/j.carpath.2010.07.005.
12. Eiras S., et al. Relationship between epicardial adipose tissue adipocyte size and MCP-1 expression. Cytokine 2010, 51:207-212.
13. Caprio M., et al. Antiadipogenic effects of the mineralocorticoid receptor antagonist drospirenone: potential implications for the treatment of metabolic syndrome. Endocrinology 2011, 152:113-125.
14. Fei J., et al. Age and sex mediated changes in epicardial fat adipokines. Atherosclerosis 2010, 212:488-494.
15. Tansey D.K., et al. Fat in the right ventricle of the normal heart. Histopathology 2005, 46:98-104.
16. Iacobellis G., Willens H. Echocardiographic epicardial fat: a review of research and clinical applications. J. Am. Soc. Echocardiogr. 2009, 23:1311-1319.
17. Marchington J.M., et al. Adipose tissue in the mammalian heart and pericardium; structure, foetal development and biochemical properties. Comp. Biochem. Physiol. 1989, 94B:225-232.
18. Vural B., et al. Presence of fatty-acid-binding protein 4 expression in human epicardial adipose tissue in metabolic syndrome. Cardiovasc. Pathol. 2008, 17:392-398.
19. Pezeshkian M., et al. Fatty acid composition of epicardial and subcutaneous human adipose tissue. Metab. Syndr. Relat. Disord. 2009, 7:125-131.
20. Richard D., Picard F. Brown fat biology and thermogenesis. Front. Biosci. 2011, 16:1233-1260.
21. Sacks H.S., et al. Uncoupling Protein-1 and related mRNAs in human epicardial and other adipose tissues: epicardial fat functioning as brown fat. J. Clin. Endocrinol. Metab. 2009, 94:3611-3615.
22. van Marken Lichtenbelt W.D., et al. Cold-activated brown adipose tissue in healthy men. N. Engl. J. Med. 2009, 360:1500-1508.
23. Baker A.R., et al. Human epicardial adipose tissue expresses a pathogenic profile of adipocytokines in patients with cardiovascular disease. Cardiovasc. Diabetol. 2006, 13:1.
24. Chaldakov G.N., et al. Neurotrophin presence in human coronary atherosclerosis and metabolic syndrome: a role for NGF and BDNF in cardiovascular disease?. Prog. Brain Res. 2004, 146:279-289.
25. Fain J.N., et al. Identification of omentin mRNA in human epicardial adipose tissue: comparison to omentin in subcutaneous, internal mammary artery periadventitial and visceral abdominal depots. Int. J. Obes. (Lond.) 2008, 32:810-815.
26. Kremen J., et al. Increased subcutaneous and epicardial adipose tissue production of proinflammatory cytokines in cardiac surgery patients: possible role in postoperative insulin resistance. J. Clin. Endocrinol. Metab. 2006, 91:4620-4627.
27. Cheng K.H., et al. Adipocytokines and proinflammatory mediators from abdominal and epicardial adipose tissue in patients with CAD. Int. J. Obes. (Lond.) 2008, 32:268-274.
28. Fain J.N., et al. Human epicardial adipokine messenger RNAs: comparisons of their expression in substernal, subcutaneous, and omental fat. Metabolism 2010, 59:1379-1386.
29. Salgado-Somoza A., et al. Proteomic analysis of epicardial and subcutaneous adipose tissue reveals differences in proteins involved in oxidative stress. Am. J. Physiol. Heart Circ. Physiol. 2010, 299:H202-H209.
30. Iacobellis G., et al. Epicardial fat thickness and CAD correlate independently of obesity. Int. J. Cardiol. 2011, 146:452-454.
31. Baker A.R. Epicardial adipose tissue as a source of nuclear factor-kappaB and c-Jun N-terminal kinase mediated inflammation in patients with coronary artery disease. J. Clin. Endocrinol. Metab. 2009, 94:261-267.
32. Dutour A., et al. Secretory type II phospholipase A2 is produced and secreted by epicardial adipose tissue and overexpressed in patients with CAD. J. Clin. Endocrinol. Metab. 2010, 95:963-967.
33. Ivandic B., et al. Role of group II secretory phospholipase A2 in atherosclerosis: 1. Increased atherogenesis and altered lipoproteins in transgenic mice expressing group IIa phospholipase A2. Arterioscler. Thromb. Vasc. Biol. 1999, 19:1284-1290.
34. Menschikowski M., et al. Expression of secretory group IIA phospholipase A(2) in relation to the presence of microbial agents, macrophage infiltrates, and transcripts of proinflammatory cytokines in human aortic tissues. Arterioscler. Thromb. Vasc. Biol. 2000, 20:751-762.
35. Kugiyama K., et al. Circulating levels of secretory type II phospholipase A(2) predict coronary events in patients with coronary artery disease. Circulation 1999, 100:1280-1284.
36. Rodríguez A., et al. The inhibitory effect of leptin on angiotensin II-induced vasoconstriction in vascular smooth muscle cells is mediated via a nitric oxide-dependent mechanism. Endocrinology 2007, 148:324-331.
37. Karastergiou K., et al. Epicardial adipokines in obesity and CAD induce atherogenic changes in monocytes and endothelial cells. Arterioscler. Thromb. Vasc. Biol. 2010, 30:1340-1346.
38. Salgado-Somoza A., et al. Coronary artery disease is associated with higher epicardial Renitol binding protein 4 (RBP4) and lower glucose transporter (GLUT) 4 levels in epicardial and subcutaneous adipose tissue. Clin. Endocrinol. (Oxf.) 2011, 10.1111/j.1365-2265.2011.04140.x.
39. Prati F., et al. Eccentric atherosclerotic plaques with positive remodelling have a pericardial distribution: a permissive role of epicardial fat? A three-dimensional intravascular ultrasound study of left anterior descending artery lesions. Eur. Heart J. 2003, 24:329-336.
40. Iacobellis G., et al. Relationship of subepicardial adipose tissue with carotid intima media thickness in HIV-infected patients. Am. J. Cardiol. 2007, 99:1470-1472.
41. Zhou Y.T., et al. Lipotoxic heart disease in obese rats: implications for human obesity. Proc. Natl. Acad. Sci. U.S.A. 2000, 97:1784-1789.
42. Gastaldelli A., Basta G. Ectopic fat and cardiovascular disease: what is the link. Nutr. Metab. Cardiovasc. Dis. 2010, 20:481-490.
43. Malavazos A.E., et al. Relation of echocardiographic epicardial fat thickness and myocardial fat. Am. J. Cardiol. 2010, 105:1831-1835.
44. Kankaanpaa M., et al. Myocardial triglyceride content and epicardial adipose mass in human obesity: relationship to left ventricular function and serum free fatty acid levels. J. Clin. Endocrinol. Metab. 2006, 91:4689-4695.
45. Iacobellis G., et al. Adiponectin expression in human epicardial adipose tissue in vivo is lower in patients with CAD. Cytokine 2005, 29:251-255.
46. Silaghi A., et al. Expression of adrenomedullin in human epicardial adipose tissue: role of coronary status. Am. J. Physiol. Endocrinol. Metab. 2007, 293:E1443-E1450.
47. Iacobellis G., et al. Epicardial adipose tissue adiponectin expression is related to intracoronary adiponectin levels. Horm. Metab. Res. 2009, 41:227-231.
48. Iacobellis G., et al. Epicardial adipose tissue and intracoronary adrenomedullin levels in CAD. Horm. Metab. Res. 2009, 45:855-860.
49. Gomez-Ambrosi J., et al. Plasma osteopontin levels and expression in adipose tissue are increased in obesity. J. Clin. Endocrinol. Metab. 2007, 92:3719-3727.
50. Fernández-Real J.M., et al. The relationship of serum osteocalcin concentration to insulin secretion, sensitivity, and disposal with hypocaloric diet and resistance training. J. Clin. Endocrinol. Metab. 2009, 94:237-245.
51. Iacobellis G., et al. Epicardial fat from echocardiography: a new method for visceral adipose tissue prediction. Obes. Res. 2003, 11:304-310.
52. Nelson A.J., et al. Validation of cardiovascular magnetic resonance assessment of pericardial adipose tissue volume. J. Cardiovasc. Magn. Reson. 2009, 11:15.
53. Greif M., et al. Pericardial adipose tissue determined by dual source CT is a risk factor for coronary atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 2009, 29:781-786.
54. Sarin S., et al. Clinical significance of epicardial fat measured using cardiac multislice computed tomography. Am. J. Cardiol. 2008, 102:767-771.
55. Rosito G.A., et al. Pericardial fat, visceral abdominal fat, cardiovascular disease risk factors, and vascular calcification in a community-based sample: the Framingham Heart Study. Circulation 2008, 117:605-613.
56. Fox C.S., et al. Pericardial fat, intrathoracic fat, and measures of left ventricular structure and function: the Framingham Heart Study. Circulation 2009, 119:1586-1591.
57. Iacobellis G., et al. Threshold values of high-risk echocardiographic epicardial fat thickness. Obesity 2008, 16:887-892.
58. Iacobellis G., et al. Echocardiographic epicardial adipose tissue is related to anthropometric and clinical parameters of metabolic syndrome: a new indicator of cardiovascular risk. J. Clin. Endocrinol. Metab. 2003, 88:5163-5168.
59. Iacobellis G., Leonetti F. Epicardial adipose tissue and insulin resistance in obese subjects. J. Clin. Endocrinol. Metab. 2005, 90:6300-6302.
60. Iacobellis G., et al. Relationship of epicardial fat thickness and fasting glucose. Int. J. Cardiol. 2008, 128:424-426.
61. Malavazos A.E., et al. Epicardial fat thickness: Relationship with plasma visfatin and plasminogen activator inhibitor-1 levels in visceral obesity. Nutr. Metab. Cardiovasc. Dis. 2008, 18:523-530.
62. Yun K.H., et al. Relationship between the echocardiographic epicardial adipose tissue thickness and serum adiponectin in patients with angina. J. Cardiovasc. Ultrasound 2009, 17:121-126.
63. Iacobellis G., et al. Relation of epicardial fat and alanine aminotransferase in subjects with increased visceral fat. Obesity (Silver Spring) 2008, 16:179-183.
64. Ahn S.G., et al. Relationship of epicardial adipose tissue by echocardiography to cad. Heart 2008, 94:e7.
65. Jeong J.W., et al. Echocardiographic epicardial fat thickness and CAD. Circ. J. 2007, 71:536-539.
66. Sade L.E., et al. Relation between epicardial fat thickness and coronary flow reserve in women with chest pain and angiographically normal coronary arteries. Atherosclerosis 2009, 204:580-585.
67. Eroglu S., et al. Epicardial adipose tissue thickness by echocardiography is a marker for the presence and severity of CAD. Nutr. Metab. Cardiovasc. Dis. 2009, 19:211-217.
68. Gorter P.M., et al. Relation of epicardial and pericoronary fat to coronary atherosclerosis and coronary artery calcium in patients undergoing coronary angiography. Am. J. Cardiol. 2008, 102:380-385.
69. De Vos A.M., et al. Peri-coronary epicardial adipose tissue is related to cardiovascular risk factors and coronary artery calcification in post-menopausal women. Eur. Heart J. 2008, 29:777-783.
70. Ahmadi N., et al. Increased epicardial, pericardial, and subcutaneous adipose tissue is associated with the presence and severity of coronary artery calcium. Acad. radiol. 2010, 17:1518-1524.
71. Alexopoulos N., et al. Epicardial adipose tissue and coronary artery plaque characteristics. Atherosclerosis 2010, 210:150-154.
72. Djaberi R., et al. Relation of epicardial adipose tissue to coronary atherosclerosis. Am. J. Cardiol. 2008, 102:1602-1607.
73. Bucci M., et al. Intrapericardial, but not extrapericardial, fat is an independent predictor of impaired hyperemic coronary perfusion in CAD. Arterioscler. Thromb. Vasc. Biol. 2011, 31:211-218.
74. Iacobellis G., et al. Relation between epicardial adipose tissue and left ventricular mass. Am. J. Cardiol. 2004, 94:1084-1087.
75. Iacobellis G. Relation of epicardial fat thickness to right ventricular cavity size in obese subjects. Am. J. Cardiol. 2009, 104:1601-1602.
76. Iacobellis G., et al. Relationship of epicardial adipose tissue with atrial dimensions and diastolic function in morbidly obese subjects. Int. J. Cardiol. 2007, 115:272-273.
77. Shin S.Y., et al. Total, interatrial epicardial adipose tissues are independently associated with left atrial remodeling in patients with atrial fibrillation. J. Cardiovasc. Electrophysiol. 2011, 22:647-655.
78. Thanassoulis G., et al. Pericardial fat is associated with prevalent atrial fibrillation: the Framingham Heart Study. Circ. Arrhythm. Electrophysiol. 2010, 3:345-350.
79. Al Chekakie M.O., et al. Pericardial fat is independently associated with human atrial fibrillation. J. Am. Coll. Cardiol. 2010, 56:784-788.
80. Iacobellis G. Is obesity a risk factor for atrial fibrillation?. Nat. Clin. Pract. Cardiovasc. Med. 2005, 2:134-135.
81. Iacobellis G., et al. Substantial changes in epicardial fat thickness after weight loss in severely obese subjects. Obesity (Silver Spring) 2008, 16:1693-1697.
82. Willens H.J., et al. Effects of weight loss after bariatric surgery on epicardial fat measured using echocardiography. Am. J. Cardiol. 2007, 99:1242-1245.
83. Kim M.K., et al. Aerobic exercise training reduces epicardial fat in obese men. J. Appl. Physiol. 2009, 106:5-11.
84. Lanes R., et al. Endothelial function, carotid artery intima-media thickness, epicardial adipose tissue, and left ventricular mass and function in growth hormone-deficient adolescents: apparent effects of growth hormone treatment on these parameters. J. Clin. Endocrinol. Metab. 2005, 90:3978-3982.
85. Park J.H., et al. Effects of statins on the epicardial fat thickness in patients with coronary artery stenosis underwent percutaneous coronary intervention: comparison of atorvastatin with simvastatin/ezetimibe. J. Cardiovasc. Ultrasound 2010, 18:121-126.
86. Sacks H.S., et al. Inflammatory genes in epicardial fat contiguous with coronary atherosclerosis in the metabolic syndrome and type 2 diabetes: changes associated with pioglitazone. Diabetes Care 2011, 34:730-733.
87. Xiangdong L., et al. Animal models for the atherosclerosis research: a review. Protein Cell 2011, 2:189-201.
88. Frühbeck G., Gómez-Ambrosi J. Rationale for the existence of additional adipostatic hormones. FASEB J. 2001, 15:1996-2006.