The role of sphingosine-1 phosphate and ceramide-1 phosphate in trafficking of normal stem cells and cancer cells

Expert Opinion on Therapeutic Targets

Volumn 18, Issue 1, 2014, Pages 95-107

  Ratajczak, Mariusz Z ^a   Suszynska, Malwina ^a   Borkowska, Sylwia ^a   Ratajczak, Janina ^a   Schneider, Gabriela ^a  

^a UNIVERSITY OF LOUISVILLE   (United States)

Author keywords

Cancer metastasis; Ceramide 1 phosphate; Sphingosine 1 phosphate; Stem cell homing; Stem cell mobilization

Indexed keywords

CERAMIDE 1 PHOSPHATE; CHEMOATTRACTANT; CHEMOKINE RECEPTOR CXCR4; COMPLEMENT COMPONENT C5A; GRANULOCYTE COLONY STIMULATING FACTOR; SPHINGOSINE 1 PHOSPHATE; STAT1 PROTEIN; STAT3 PROTEIN; STAT5 PROTEIN; STROMAL CELL DERIVED FACTOR 1;

BLOOD; BONE MARROW; BREAST CANCER; CALCIUM TRANSPORT; CANCER CELL; CELL MIGRATION; ENDOTHELIAL PROGENITOR CELL; ERYTHROID CELL; GENOTYPE; HEMATOPOIETIC CELL; HEMATOPOIETIC STEM CELL; HUMAN; IMMUNOCOMPETENT CELL; PANCREAS CARCINOMA; PAROXYSMAL NOCTURNAL HEMOGLOBINURIA; PHENOTYPE; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RECEPTOR DOWN REGULATION; REGENERATIVE MEDICINE; REVIEW; RHABDOMYOSARCOMA; SICKLE CELL ANEMIA; STEADY STATE; STEM CELL; STEM CELL MOBILIZATION; THYROID FOLLICULAR CARCINOMA; TUMOR INVASION; UPREGULATION;

BIOLOGICAL TRANSPORT; CERAMIDES; HUMANS; LYSOPHOSPHOLIPIDS; NEOPLASMS; SPHINGOSINE; STEM CELLS;

EID: 84890339518     PISSN: 14728222     EISSN: 17447631     Source Type: Journal    
DOI: 10.1517/14728222.2014.851671     Document Type: Review

References (103)

1. Obinata H, Hla T. Sphingosine 1-phosphate in coagulation and inflammation. Semin Immunopathol 2012;34(1):73-91
2. Fyrst H, Saba JD. An update on sphingosine-1-phosphate and other sphingolipid mediators. Nat Chem Biol 2010;6(7):489-97
3. Chalfant CE, Spiegel S. Sphingosine 1-phosphate and ceramide 1-phosphate: Expanding roles in cell signaling. J Cell Sci 2005;118(Pt 20):4605-12
4. Gomez-Munoz A, Gangoiti P, Arana L, et al. New insights on the role of ceramide 1-phosphate in inflammation. Biochim Biophys Acta 2013;1831(6):1060-6
5. Lamour NF, Chalfant CE. Ceramide- 1-phosphate: The "missing" link in eicosanoid biosynthesis and inflammation. Mol Interv 2005;5(6):358-67
6. Rosen H, Stevens RC, Hanson M, et al. Sphingosine-1-phosphate and its receptors: Structure, signaling, and influence. Annu Rev Biochem 2013;82:637-62
7. Kim CH, Wu W, Wysoczynski M, et al. Conditioning for hematopoietic transplantation activates the complement cascade and induces a proteolytic environment in bone marrow: A novel role for bioactive lipids and soluble C5b-C9 as homing factors. Leukemia 2012;26(1):106-16
8. Hammad SM, Pierce JS, Soodavar F, et al. Blood sphingolipidomics in healthy humans: Impact of sample collection methodology. J Lipid Res 2010;51(10):3074-87
9. Pappu R, Schwab SR, Cornelissen I, et al. Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate. Science 2007;316(5822):295-8
10. Schwab SR, Pereira JP, Matloubian M, et al. Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients. Science 2005;309(5741):1735-9
11. Hla T. Immunology. Dietary factors and immunological consequences. Science 2005;309(5741):1682-3
12. Schneider G, Bryndza E, Abdel-Latif A, et al. Bioactive lipids S1P and C1P are prometastatic factors in human rhabdomyosarcoma, and their tissue levels increase in response to radio/ chemotherapy. Mol Cancer Res 2013;11(7):793-807
13. Kim C, Schneider G, Abdel-Latif A, et al. Ceramide-1-phosphate regulates migration of multipotent stromal cells and endothelial progenitor cells-implications for tissue regeneration. Stem Cells 2013;31(3):500-10
14. Mizugishi K, Yamashita T, Olivera A, et al. Essential role for sphingosine kinases in neural and vascular development. Mol Cell Biol 2005;25(24):11113-21
15. Rivera J, Proia RL, Olivera A. The alliance of sphingosine-1-phosphate and its receptors in immunity. Nat Rev Immunol 2008;8(10):753-63
16. Liu Y, Wada R, Yamashita T, et al. Edg- 1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation. J Clin Invest 2000;106(8):951-61
17. Ishii I, Friedman B, Ye X, et al. Selective loss of sphingosine 1-phosphate signaling with no obvious phenotypic abnormality in mice lacking its G protein-coupled receptor, LP(B3)/EDG-3. J Biol Chem 2001;276(36):33697-704
18. Ishii I, Ye X, Friedman B, et al. Marked perinatal lethality and cellular signaling deficits in mice null for the two sphingosine 1-phosphate (S1P) receptors, S1P(2)/LP(B2)/EDG-5 and S1P(3)/LP (B3)/EDG-3. J Biol Chem 2002;277(28):25152-9
19. Kono M, Mi Y, Liu Y, et al. The sphingosine-1-phosphate receptors S1P1, S1P2, and S1P3 function coordinately during embryonic angiogenesis. J Biol Chem 2004;279(28):29367-73
20. Ishii M, Kikuta J, Shimazu Y, et al. Chemorepulsion by blood S1P regulates osteoclast precursor mobilization and bone remodeling in vivo. J Exp Med 2010;207(13):2793-8
21. Sciorra VA, Morris AJ. Roles for lipid phosphate phosphatases in regulation of cellular signaling. Biochim Biophys Acta 2002;1582(1-3):45-51
22. Long J, Darroch P, Wan KF, et al. Regulation of cell survival by lipid phosphate phosphatases involves the modulation of intracellular phosphatidic acid and sphingosine 1-phosphate pools. Biochem J 2005;391(Pt 1):25-32
23. Hannun YA, Obeid LM. Principles of bioactive lipid signalling: Lessons from sphingolipids. Nat Rev Mol Cell Biol 2008;9(2):139-50
24. Graf C, Zemann B, Rovina P, et al. Neutropenia with impaired immune response to Streptococcus pneumoniae in ceramide kinase-deficient mice. J Immunol 2008;180(5):3457-66
25. Graf C, Niwa S, Muller M, et al. Wild-Type levels of ceramide and ceramide-1-phosphate in the retina of ceramide kinase-like-deficient mice. Biochem Biophys Res Commun 2008;373(1):159-63
26. Brindley DN, Waggoner DW. Mammalian lipid phosphate phosphohydrolases. J Biol Chem 1998;273(38):24281-4
27. Brindley DN, Pilquil C. Lipid phosphate phosphatases and signaling. J Lipid Res 2009;50(Suppl):S225-30
28. Granado MH, Gangoiti P, Ouro A, et al. Ceramide 1-phosphate (C1P) promotes cell migration Involvement of a specific C1P receptor. Cell Signal 2009;21(3):405-12
29. Ratajczak MZ, Lee H, Wysoczynski M, et al. Novel insight into stem cell mobilization-plasma sphingosine-1-phosphate is a major chemoattractant that directs the egress of hematopoietic stem progenitor cells from the bone marrow and its level in peripheral blood increases during mobilization due to activation of complement cascade/membrane attack complex. Leukemia 2010;24(5):976-85
30. Kim ES, Kim JS, Kim SG, et al. Sphingosine 1-phosphate regulates matrix metalloproteinase-9 expression and breast cell invasion through S1P3-Galphaq coupling. J Cell Sci 2011;124(Pt 13):2220-30
31. Bao M, Chen Z, Xu Y, et al. Sphingosine kinase 1 promotes tumour cell migration and invasion via the S1P/ EDG1 axis in hepatocellular carcinoma. Liver Int 2012;32(2):331-8
32. Hla T, Venkataraman K, Michaud J. The vascular S1P gradient-cellular sources and biological significance. Biochim Biophys Acta 2008;1781(9):477-82
33. Bode C, Sensken SC, Peest U, et al. Erythrocytes serve as a reservoir for cellular and extracellular sphingosine 1-phosphate. J Cell Biochem 2010;109(6):1232-43
34. Ratajczak J, Kucia M, Mierzejewska K, et al. A novel view of paroxysmal nocturnal hemoglobinuria pathogenesis: More motile PNH hematopoietic stem/ progenitor cells displace normal HSPCs from their niches in bone marrow due to defective adhesion, enhanced migration and mobilization in response to erythrocyte-released sphingosine- 1 phosphate gradient. Leukemia 2012;26(7):1722-5
35. Taylor JGT, Nolan VG, Mendelsohn L, et al. Chronic hyper-hemolysis in sickle cell anemia: Association of vascular complications and mortality with less frequent vasoocclusive pain. PLoS ONE 2008;3(5):e2095
36. Selim S, Sunkara M, Salous AK, et al. Plasma levels of sphingosine 1-phosphate are strongly correlated with haematocrit, but variably restored by red blood cell transfusions. Clin Sci (Lond) 2011;121(12):565-72
37. Yatomi Y, Igarashi Y, Yang L, et al. Sphingosine 1-phosphate, a bioactive sphingolipid abundantly stored in platelets, is a normal constituent of human plasma and serum. J Biochem 1997;121(5):969-73
38. Venkataraman K, Lee YM, Michaud J, et al. Vascular endothelium as a contributor of plasma sphingosine 1-phosphate. Circ Res 2008;102(6):669-76
39. Gomez-Munoz A, Duffy PA, Martin A, et al. Short-chain ceramide-1-phosphates are novel stimulators of DNA synthesis and cell division: Antagonism by cell-permeable ceramides. Mol Pharmacol 1995;47(5):833-9
40. Gangoiti P, Bernacchioni C, Donati C, et al. Ceramide 1-phosphate stimulates proliferation of C2C12 myoblasts. Biochimie 2012;94(3):597-607
41. Bertolucci C, Pinotti M, Colognesi I, et al. Circadian rhythms in mouse blood coagulation. J Biol Rhythms 2005;20(3):219-24
42. Hoopes PC, McCall CE. The effect or cobra venom factor (CVJ) activation of the complement cascade on leukocyte circadian variation in the rat. Experientia 1977;33(2):224-6
43. Kim Y, Pallansch M, Carandente F, et al. Circadian and circannual aspects of the complement cascade - new and old results, differing in specificity. Chronobiologia 1980;7(2):189-204
44. Ratajczak J, Wysoczynski M, Hayek F, et al. Membrane-derived microvesicles: Important and underappreciated mediators of cell-To-cell communication. Leukemia 2006;20(9):1487-95
45. Ratajczak MZ. The emerging role of microvesicles in cellular therapies for organ/tissue regeneration. Nephrol Dial Transplant 2011;26(5):1453-6
46. Brinkmann V, Billich A, Baumruker T, et al. Fingolimod (FTY720): Discovery and development of an oral drug to treat multiple sclerosis. Nat Rev Drug Discov 2010;9(11):883-97
47. Jo E, Sanna MG, Gonzalez-Cabrera PJ, et al. S1P1-selective in vivo-Active agonists from high-Throughput screening: Off-The-shelf chemical probes of receptor interactions, signaling, and fate. Chem Biol 2005;12(6):703-15
48. Obinata H, Hla T. Fine-Tuning S1P therapeutics. Chem Biol 2012;19(9):1080-2
49. Gonzalez-Cabrera PJ, Cahalan SM, Nguyen N, et al. S1P(1) receptor modulation with cyclical recovery from lymphopenia ameliorates mouse model of multiple sclerosis. Mol Pharmacol 2012;81(2):166-74
50. Cohen JA, Barkhof F, Comi G, et al. Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis. N Engl J Med 2010;362(5):402-15
51. Bandhuvula P, Honbo N, Wang GY, et al. S1P lyase: A novel therapeutic target for ischemia-reperfusion injury of the heart. Am J Physiol Heart Circ Physiol 2011;300(5):H1753-61
52. Liu J, Hsu A, Lee JF, et al. To stay or to leave: Stem cells and progenitor cells navigating the S1P gradient. World J Biol Chem 2011;2:1 1-13
53. Bendall LJ, Basnett J. Role of sphingosine 1-phosphate in trafficking and mobilization of hematopoietic stem cells. Curr Opin Hematol 2013;20(4):281-8
54. Pyne NJ, Pyne S. Sphingosine 1-phosphate and cancer. Nat Rev Cancer 2010;10(7):489-503
55. Yanagawa Y, Masubuchi Y, Chiba K. FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats, III. Increase in frequency of CD62L-positive T cells in Peyer's patches by FTY720-induced lymphocyte homing. Immunology 1998;95(4):591-4
56. Chiba K. FTY720, a new class of immunomodulator, inhibits lymphocyte egress from secondary lymphoid tissues and thymus by agonistic activity at sphingosine 1-phosphate receptors. Pharmacol Ther 2005;108(3):308-19
57. Brinkmann V, Cyster JG, Hla T. FTY720: Sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function. Am J Transplant 2004;4(7):1019-25
58. Thangada S, Khanna KM, Blaho VA, et al. Cell-surface residence of sphingosine 1-phosphate receptor 1 on lymphocytes determines lymphocyte egress kinetics. J Exp Med 2010;207(7):1475-83
59. Walzer T, Chiossone L, Chaix J, et al. Natural killer cell trafficking in vivo requires a dedicated sphingosine 1-phosphate receptor. Nat Immunol 2007;8(12):1337-44
60. Czeloth N, Bernhardt G, Hofmann F, et al. Sphingosine-1-phosphate mediates migration of mature dendritic cells. J Immunol 2005;175(5):2960-7
61. Vora KA, Nichols E, Porter G, et al. Sphingosine 1-phosphate receptor agonist FTY720-phosphate causes marginal zone B cell displacement. J Leukoc Biol 2005;78(2):471-80
62. Chiba K, Yanagawa Y, Masubuchi Y, et al. FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. I. FTY720 selectively decreases the number of circulating mature lymphocytes by acceleration of lymphocyte homing. J Immunol 1998;160(10):5037-44
63. Kimura T, Boehmler AM, Seitz G, et al. The sphingosine 1-phosphate receptor agonist FTY720 supports CXCR4-dependent migration and bone marrow homing of human CD34+ progenitor cells. Blood 2004;103(12):4478-86
64. Seitz G, Boehmler AM, Kanz L, Mohle R. The role of sphingosine 1-phosphate receptors in the trafficking of hematopoietic progenitor cells. Ann N Y Acad Sci 2005;1044:84-9
65. Juarez JG, Harun N, Thien M, et al. Sphingosine-1-phosphate facilitates trafficking of hematopoietic stem cells and their mobilization by CXCR4 antagonists in mice. Blood 2012;119(3):707-16
66. Massberg S, Schaerli P, Knezevic-Maramica I, et al. Immunosurveillance by hematopoietic progenitor cells trafficking through blood, lymph, and peripheral tissues. Cell 2007;131(5):994-1008
67. Weichand B, Weis N, Weigert A, et al. Apoptotic cells enhance sphingosine-1-phosphate receptor 1 dependent macrophage migration. Eur J Immunol 2013;doi: 10.1002/eji.201343441
68. Petit I, Szyper-Kravitz M, Nagler A, et al. G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4. Nat Immunol 2002;3(7):687-94
69. Greenbaum AM, Link DC. Mechanisms of G-CSF-mediated hematopoietic stem and progenitor mobilization. Leukemia 2011;25(2):211-17
70. Aiuti A, Webb IJ, Bleul C, et al. The chemokine SDF-1 is a chemoattractant for human CD34+ hematopoietic progenitor cells and provides a new mechanism to explain the mobilization of CD34+ progenitors to peripheral blood. J Exp Med 1997;185(1):111-20
71. Ratajczak MZ, Serwin K, Schneider G. Innate immunity derived factors as external modulators of the CXCL12-CXCR4 axis and their role in stem cell homing and mobilization. Theranostics 2013;3(1):3-10
72. Kozuka T, Ishimaru F, Fujii K, et al. Plasma stromal cell-derived factor- 1 during granulocyte colony-stimulating factor-induced peripheral blood stem cell mobilization. Bone Marrow Transplant 2003;31(8):651-4
73. Golan K, Vagima Y, Ludin A, et al. S1P promotes murine progenitor cell egress and mobilization via S1P1-mediated ROS signaling and SDF-1 release. Blood 2012;119(11):2478-88
74. Ratajczak MZ, Borkowska S, Ratajczak J. An emerging link in stem cell mobilization between activation of the complement cascade and the chemotactic gradient of sphingosine-1-phosphate. Prostaglandins Other Lipid Mediat 2013;104-105:122-9
75. Schraufstatter IU, Trieu K, Sikora L, et al. Complement c3a and c5a induce different signal transduction cascades in endothelial cells. J Immunol 2002;169(4):2102-10
76. Mierzejewska K, Kucia M, Ratajczak J, Ratajczak MZ. Novel Evidence That Hematopoietic Stem/Progenitor Cells (HSPCs) Are Mobilized During Hemolysis in an Erythrocyte Lysis-Derived, Sphingosine-1-Phosphate (S1P)-Dependent manner The Crucial Involvement of Complement Cascade (CC) Activation and Attenuation of CXCR4 Retention Signaling Blood. ASH Annual Meeting Abstracts. 2012
77. Ratajczak MZ, Kim CH, Abdel-Latif A, et al. A novel perspective on stem cell homing and mobilization: Review on bioactive lipids as potent chemoattractants and cationic peptides as underappreciated modulators of responsiveness to SDF-1 gradients. Leukemia 2012;26(1):63-72
78. Arana L, Ordonez M, Ouro A, et al. Ceramide 1-phosphate induces macrophage chemoattractant protein-1 release: Involvement in ceramide 1-phosphate-stimulated cell migration. Am J Physiol Endocrinol Metab 2013;304(11):E1213-26
79. Ortiz LA, Gambelli F, McBride C et al. Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects. Proc Natl Acad Sci USA 2003;100(14):8407-11
80. Minguell JJ, Erices A. Mesenchymal stem cells and the treatment of cardiac disease. Exp Biol Med (Maywood) 2006;231(1):39-49
81. Ratajczak MZ, Liu R, Ratajczak J, et al. The role of pluripotent embryonic-like stem cells residing in adult tissues in regeneration and longevity. Differentiation 2011;81(3):153-61
82. Wojakowski W, Kucia M, Liu R, et al. Circulating very small embryonic-like stem cells in cardiovascular disease. J Cardiovasc Transl Res 2011;4(2):138-44
83. Herrera MB, Fonsato V, Gatti S, et al. Human liver stem cell-derived microvesicles accelerate hepatic regeneration in hepatectomized rats. J Cell Mol Med 2010;14(6B):1605-18
84. Baglio SR, Pegtel DM, Baldini N. Mesenchymal stem cell secreted vesicles provide novel opportunities in (stem) cell-free therapy. Front Physiol 2012;3:359
85. Kimura A, Ohmori T, Kashiwakura Y, et al. Antagonism of sphingosine 1-phosphate receptor-2 enhances migration of neural progenitor cells toward an area of brain. Stroke 2008;39(12):3411-17
86. Karapetyan AV, Klyachkin YM, Selim S, et al. Bioactive lipids and cationic antimicrobial peptides as new potential regulators for trafficking of bone marrow-derived stem cells in patients with acute myocardial infarction. Stem Cells Dev 2013;22(11):1645-56
87. Quint P, Ruan M, Pederson L, et al. Sphingosine 1-phosphate (S1P) receptors 1 and 2 coordinately induce mesenchymal cell migration through S1P activation of complementary kinase pathways. J Biol Chem 2013;288(8):5398-406
88. Niwa S, Graf C, Bornancin F. Ceramide kinase deficiency impairs microendothelial cell angiogenesis in vitro. Microvasc Res 2009;77(3):389-93
89. Peranteau WH, Endo M, Adibe OO, et al. CD26 inhibition enhances allogeneic donor-cell homing and engraftment after in utero hematopoietic-cell transplantation. Blood 2006;108(13):4268-74
90. Moon H, Chon J, Joo J, et al. FTY720 preserved islet beta-cell mass by inhibiting apoptosis and increasing survival of beta-cells in db/db mice. Diabetes Metab Res Rev 2013;29(1):19-24
91. Ieronimakis N, Pantoja M, Hays AL, et al. Increased sphingosine-1- phosphate improves muscle regeneration in acutely injured mdx mice. Skelet Muscle 2013;3(1):20
92. Leong WI, Saba JD. S1P metabolism in cancer and other pathological conditions. Biochimie 2010;92(6):716-23
93. Van Brocklyn J, Letterle C, Snyder P, Prior T. Sphingosine-1-phosphate stimulates human glioma cell proliferation through Gi-coupled receptors: Role of ERK MAP kinase and phosphatidylinositol 3-kinase beta. Cancer Lett 2002;181(2):195-204
94. Bergelin N, Blom T, Heikkila J, et al. Sphingosine kinase as an oncogene: Autocrine sphingosine 1-phosphate modulates ML-1 thyroid carcinoma cell migration by a mechanism dependent on protein kinase C-Alpha and ERK1/2. Endocrinology 2009;150(5):2055-63
95. Visentin B, Vekich JA, Sibbald BJ, et al. Validation of an anti-sphingosine-1- phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages. Cancer Cell 2006;9(3):225-38
96. Yoon CM, Hong BS, Moon HG, et al. Sphingosine-1-phosphate promotes lymphangiogenesis by stimulating S1P1/ Gi/PLC/Ca2+ signaling pathways. Blood 2008;112(4):1129-38
97. Li MH, Sanchez T, Yamase H, et al. S1P/S1P1 signaling stimulates cell migration and invasion in Wilms tumor. Cancer Lett 2009;276(2):171-9
98. Yamashita H, Kitayama J, Shida D, et al. Sphingosine 1-phosphate receptor expression profile in human gastric cancer cells: Differential regulation on the migration and proliferation. J Surg Res 2006;130(1):80-7
99. Jankowski K, Kucia M, Wysoczynski M, et al. Both hepatocyte growth factor (HGF) and stromal-derived factor- 1 regulate the metastatic behavior of human rhabdomyosarcoma cells, but only HGF enhances their resistance to radiochemotherapy. Cancer Res 2003;63(22):7926-35
100. O'Brien N, Jones ST, Williams DG, et al. Production and characterization of monoclonal anti-sphingosine-1-phosphate antibodies. J Lipid Res 2009;50(11):2245-57
101. Davis MD, Clemens JJ, Macdonald TL, Lynch KR. Sphingosine 1-phosphate analogs as receptor antagonists. J Biol Chem 2005;280(11):9833-41
102. Brinkmann V. Sphingosine 1-phosphate receptors in health and disease: Mechanistic insights from gene deletion studies and reverse pharmacology. Pharmacol Ther 2007;115(1):84-105
103. Simanshu DK, Kamlekar RK, Wijesinghe DS, et al. Non-vesicular trafficking by a ceramide-1-phosphate transfer protein regulates eicosanoids. Nature 2013;7463):463-7