A novel view of paroxysmal nocturnal hemoglobinuria pathogenesis: More motile PNH hematopoietic stem/progenitor cells displace normal HSPCs from their niches in bone marrow due to defective adhesion, enhanced migration and mobilization in response to erythrocyte-released sphingosine-1 phosphate gradient

Leukemia

Volumn 26, Issue 7, 2012, Pages 1722-1725

  Ratajczak, J ^a   Kucia, M ^a   Mierzejewska, K ^a   Liu, R ^a   Kim, C H ^a   Natarajan, N ^a   Sharma, V ^a   Miller, D M ^a   MacIejewski, J ^b   Ratajczak, M Z ^a,c  

^a UNIVERSITY OF LOUISVILLE   (United States)

^b TAUSSIG CANCER INSTITUTE   (United States)

^c POMERANIAN MEDICAL UNIVERSITY   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

SPHINGOSINE 1 PHOSPHATE;

CELL ADHESION; CELL MIGRATION; ERYTHROCYTE; HEMATOPOIETIC STEM CELL; HUMAN; LETTER; PAROXYSMAL NOCTURNAL HEMOGLOBINURIA; PATHOGENESIS; PRIORITY JOURNAL; STEM CELL MOBILIZATION;

ADULT; AGED; BONE MARROW; CELL ADHESION; CELL MOVEMENT; CELLS, CULTURED; ERYTHROCYTES; HEMATOPOIETIC STEM CELL MOBILIZATION; HEMATOPOIETIC STEM CELLS; HEMOGLOBINURIA, PAROXYSMAL; HUMANS; LYSOPHOSPHOLIPIDS; MIDDLE AGED; SPHINGOSINE; YOUNG ADULT;

EID: 84863779040     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2012.46     Document Type: Letter

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