-
1
-
-
36749077060
-
Preclinical studies of celastrol and acetyl isogambogic acid in melanoma
-
Abbas, S., Bhoumik, A., Dahl, R., Vasile, S., Krajewski, S., Cosford, N.D. (2007) Preclinical studies of celastrol and acetyl isogambogic acid in melanoma. Clin Cancer Res, 13, 6769-6778
-
(2007)
Clin Cancer Res
, vol.13
, pp. 6769-6778
-
-
Abbas, S.1
Bhoumik, A.2
Dahl, R.3
Vasile, S.4
Krajewski, S.5
Cosford, N.D.6
-
2
-
-
33646176246
-
Crystal structure of an hsp90-nucleotide-p23/sba1 closed chaperone complex
-
Ali, M.M., Roe, S.M., Vaughan, C.K., Meyer, P., Panaretou, B., Piper, P.W., Prodromou, C., Pearl, L.H. (2006) Crystal structure of an hsp90-nucleotide-p23/sba1 closed chaperone complex. Nature, 440, 1013-1017
-
(2006)
Nature
, vol.440
, pp. 1013-1017
-
-
Ali, M.M.1
Roe, S.M.2
Vaughan, C.K.3
Meyer, P.4
Panaretou, B.5
Piper, P.W.6
Prodromou, C.7
Pearl, L.H.8
-
3
-
-
0033210210
-
GRP94, an ER chaperone with protein and peptide binding properties
-
Argon, Y., Simen, B.B. (1999) GRP94, an ER chaperone with protein and peptide binding properties. Semin Cell Dev Biol, 10, 495-505
-
(1999)
Semin Cell Dev Biol
, vol.10
, pp. 495-505
-
-
Argon, Y.1
Simen, B.B.2
-
4
-
-
22844432021
-
Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90: A novel basis for antileukemia activity of histone deacetylase inhibitors
-
Bali, P., Pranpat, M., Bradner, J., Balasis, M., Fiskus, W., Guo, F., Rocha, K., Kumaraswamy, S., Boyapalle, S., Atadja, P., Seto, E., Bhalla, K. (2005) Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90: A novel basis for antileukemia activity of histone deacetylase inhibitors. J Biol Chem, 280, 26729-26734
-
(2005)
J Biol Chem
, vol.280
, pp. 26729-26734
-
-
Bali, P.1
Pranpat, M.2
Bradner, J.3
Balasis, M.4
Fiskus, W.5
Guo, F.6
Rocha, K.7
Kumaraswamy, S.8
Boyapalle, S.9
Atadja, P.10
Seto, E.11
Bhalla, K.12
-
5
-
-
42249096283
-
BRAF and NRAS mutations in melanoma: Potential relationships to clinical response to HSP90 inhibitors
-
Banerji, U., Affolter, A., Judson, I., Marais, R., Workman, P. (2008a) BRAF and NRAS mutations in melanoma: Potential relationships to clinical response to HSP90 inhibitors. Mol Cancer Ther, 7, 737-739
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 737-739
-
-
Banerji, U.1
Affolter, A.2
Judson, I.3
Marais, R.4
Workman, P.5
-
6
-
-
23044441106
-
Phase i pharmacokinetic and pharmacodynamic study of 17-Allylamino, 17-demethoxygeldanamycin in patients with advanced malignancies
-
Banerji, U., O'Donnell, A., Scurr, M., Pacey, S., Stapleton, S., Asad, Y., Simmons, L., Maloney, A., Raynaud, F., Campbell, M., Walton, M., Lakhani, S., Kaye, S., Workman, P., Judson, I. (2005a) Phase i pharmacokinetic and pharmacodynamic study of 17-Allylamino, 17-demethoxygeldanamycin in patients with advanced malignancies. J Clin Oncol, 23, 4152-4161
-
(2005)
J Clin Oncol
, vol.23
, pp. 4152-4161
-
-
Banerji, U.1
O'Donnell, A.2
Scurr, M.3
Pacey, S.4
Stapleton, S.5
Asad, Y.6
Simmons, L.7
Maloney, A.8
Raynaud, F.9
Campbell, M.10
Walton, M.11
Lakhani, S.12
Kaye, S.13
Workman, P.14
Judson, I.15
-
7
-
-
49849084850
-
An in vitro and in vivo study of the combination of the heat shock protein inhibitor 17-Allylamino-17-demethoxygeldanamycin and carboplatin in human ovarian cancer models
-
Banerji, U., Sain, N., Sharp, S.Y., Valenti, M., Asad, Y., Ruddle, R., Raynaud, F., Walton, M., Eccles, S.A., Judson, I., Jackman, A.L., Workman, P. (2008b) An in vitro and in vivo study of the combination of the heat shock protein inhibitor 17-Allylamino-17-demethoxygeldanamycin and carboplatin in human ovarian cancer models. Cancer Chemother Pharmacol 62(5), 769-78
-
(2008)
Cancer Chemother Pharmacol
, vol.62
, Issue.5
, pp. 769-778
-
-
Banerji, U.1
Sain, N.2
Sharp, S.Y.3
Valenti, M.4
Asad, Y.5
Ruddle, R.6
Raynaud, F.7
Walton, M.8
Eccles, S.A.9
Judson, I.10
Jackman, A.L.11
Workman, P.12
-
8
-
-
26444482073
-
Pharmacokinetic-pharmacodynamic relationships for the heat shock protein 90 molecular chaperone inhibitor 17-Allylamino, 17-demethoxygeldanamycin in human ovarian cancer xenograft models
-
Banerji, U.,Walton, M., Raynaud, F., Grimshaw, R., Kelland, L., Valenti, M., Judson, I.,Workman, P. (2005b) Pharmacokinetic-pharmacodynamic relationships for the heat shock protein 90 molecular chaperone inhibitor 17-Allylamino, 17-demethoxygeldanamycin in human ovarian cancer xenograft models. Clin Cancer Res, 11, 7023-7032
-
(2005)
Clin Cancer Res
, vol.11
, pp. 7023-7032
-
-
Banerji U.Walton, M.1
Raynaud, F.2
Grimshaw, R.3
Kelland, L.4
Valenti, M.5
Judson I.Workman, P.6
-
9
-
-
4143153881
-
Hsp90: An emerging target for breast cancer therapy
-
Beliakoff, J., Whitesell, L. (2004) Hsp90: An emerging target for breast cancer therapy. Anticancer Drugs, 15, 651-662
-
(2004)
Anticancer Drugs
, vol.15
, pp. 651-662
-
-
Beliakoff, J.1
Whitesell, L.2
-
10
-
-
9144261127
-
Geldanamycin and 17-Allylamino-17-demethoxygeldanamycin potentiate the in vitro and in vivo radiation response of cervical tumor cells via the heat shock protein 90-mediated intracellular signaling and cytotoxicity
-
Bisht, K.S., Bradbury, C.M., Mattson, D., Kaushal, A., Sowers, A., Markovina, S., Ortiz, K.L., Sieck, L.K., Isaacs, J.S., Brechbiel, M.W., Mitchell, J.B., Neckers, L.M., Gius, D. (2003) Geldanamycin and 17-Allylamino-17-demethoxygeldanamycin potentiate the in vitro and in vivo radiation response of cervical tumor cells via the heat shock protein 90-mediated intracellular signaling and cytotoxicity. Cancer Res, 63, 8984-8995
-
(2003)
Cancer Res
, vol.63
, pp. 8984-8995
-
-
Bisht, K.S.1
Bradbury, C.M.2
Mattson, D.3
Kaushal, A.4
Sowers, A.5
Markovina, S.6
Ortiz, K.L.7
Sieck, L.K.8
Isaacs, J.S.9
Brechbiel, M.W.10
Mitchell, J.B.11
Neckers, L.M.12
Gius, D.13
-
11
-
-
38349157746
-
5-Diarylisoxazole hsp90 chaperone inhibitors: Potential therapeutic agents for the treatment of cancer
-
Brough, P.A., Aherne, W., Barril, X., Borgognoni, J., Boxall, K., Cansfield, J.E., Cheung, K.M., Collins, I., Davies, N.G., Drysdale, M.J., Dymock, B., Eccles, S.A., Finch, H., Fink, A., Hayes, A., Howes, R., Hubbard, R.E., James, K., Jordan, A.M., Lockie, A., Martins, V., Massey, A., Matthews, T.P., McDonald, E., Northfield, C.J., Pearl, L.H., Prodromou, C., Ray, S., Raynaud, F.I., Roughley, S.D., Sharp, S.Y., Surgenor, A., Walmsley, D.L., Webb, P., Wood, M., Workman, P., Wright, L. (2008) 4, 5-Diarylisoxazole hsp90 chaperone inhibitors: Potential therapeutic agents for the treatment of cancer. J Med Chem, 51, 196-218
-
(2008)
J Med Chem
, vol.4
, Issue.51
, pp. 196-218
-
-
Brough, P.A.1
Aherne, W.2
Barril, X.3
Borgognoni, J.4
Boxall, K.5
Cansfield, J.E.6
Cheung, K.M.7
Collins, I.8
Davies, N.G.9
Drysdale, M.J.10
Dymock, B.11
Eccles, S.A.12
Finch, H.13
Fink, A.14
Hayes, A.15
Howes, R.16
Hubbard, R.E.17
James, K.18
Jordan, A.M.19
Lockie, A.20
Martins, V.21
Massey, A.22
Matthews, T.P.23
McDonald, E.24
Northfield, C.J.25
Pearl, L.H.26
Prodromou, C.27
Ray, S.28
Raynaud, F.I.29
Roughley, S.D.30
Sharp, S.Y.31
Surgenor, A.32
Walmsley, D.L.33
Webb, P.34
Wood, M.35
Workman, P.36
Wright, L.37
more..
-
12
-
-
33644835965
-
Heat shock proteins in cancer: Chaperones of tumorigenesis
-
Calderwood, S.K., Khaleque, M.A., Sawyer, D.B., Ciocca, D.R. (2006) Heat shock proteins in cancer: Chaperones of tumorigenesis. Trends Biochem Sci, 31, 164-172
-
(2006)
Trends Biochem Sci
, vol.31
, pp. 164-172
-
-
Calderwood, S.K.1
Khaleque, M.A.2
Sawyer, D.B.3
Ciocca, D.R.4
-
13
-
-
0029670034
-
P185erbB2 binds to GRP94 in vivo. Dissociation of the p185erbB2/GRP94 heterocomplex by benzoquinone ansamycins precedes depletion of p185erbB2
-
Chavany, C., Mimnaugh, E., Miller, P., Bitton, R., Nguyen, P., Trepel, J., Whitesell, L., Schnur, R., Moyer, J., Neckers, L. (1996) P185erbB2 binds to GRP94 in vivo. Dissociation of the p185erbB2/GRP94 heterocomplex by benzoquinone ansamycins precedes depletion of p185erbB2. J Biol Chem, 271, 4974-4977
-
(1996)
J Biol Chem
, vol.271
, pp. 4974-4977
-
-
Chavany, C.1
Mimnaugh, E.2
Miller, P.3
Bitton, R.4
Nguyen, P.5
Trepel, J.6
Whitesell, L.7
Schnur, R.8
Moyer, J.9
Neckers, L.10
-
14
-
-
28644443855
-
The HSP90 family of genes in the human genome: Insights into their divergence and evolution
-
Chen, B., Piel, W.H., Gui, L., Bruford, E. (2005) The HSP90 family of genes in the human genome: Insights into their divergence and evolution. Genomics, 86, 627-637
-
(2005)
Genomics
, vol.86
, pp. 627-637
-
-
Chen, B.1
Piel, W.H.2
Gui, L.3
Bruford, E.4
-
15
-
-
0032567434
-
Hop as an adaptor in the heat shock protein 70(hsp70) and hsp90 chaperone machinery
-
Chen, S., Smith, D.F. (1998) Hop as an adaptor in the heat shock protein 70(hsp70) and hsp90 chaperone machinery. J Biol Chem, 273, 35194-35200
-
(1998)
J Biol Chem
, vol.273
, pp. 35194-35200
-
-
Chen, S.1
Smith, D.F.2
-
16
-
-
20644448390
-
The identification, syn thesis protein crystal structure and in vitro biochemical evaluation of a new 3, 4-diarylpyrazole class of hsp90 inhibitors
-
Cheung, K.M.,Matthews, T.P., James, K., Rowlands, M.G., Boxall, K.J., Sharp, S.Y., Maloney, A., Roe, S.M., Prodromou, C., Pearl, L.H., Aherne, G.W., McDonald, E., Workman, P. (2005) The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3, 4-diarylpyrazole class of hsp90 inhibitors. Bioorg Med Chem Lett, 15, 3338-3343
-
(2005)
Bioorg Med Chem Lett
, vol.15
, pp. 3338-3343
-
-
Cheung, K.M.1
Matthews, T.P.2
James, K.3
Rowlands, M.G.4
Boxall, K.J.5
Sharp, S.Y.6
Maloney, A.7
Roe, S.M.8
Prodromou, C.9
Pearl, L.H.10
Aherne, G.W.11
McDonald, E.12
Workman, P.13
-
17
-
-
33746365169
-
Discovery and development of purine-scaffold hsp90 inhibitors
-
Chiosis, G. (2006) Discovery and development of purine-scaffold hsp90 inhibitors. Curr Top Med Chem, 6, 1183-1191
-
(2006)
Curr Top Med Chem
, vol.6
, pp. 1183-1191
-
-
Chiosis, G.1
-
18
-
-
0034710542
-
Gene expression profiling of human colon cancer cells following inhibition of signal transduction by 17-Allylamino-17-demethoxygeldanamycin, an inhibitor of the hsp90 molecular chaperone
-
Clarke, P.A., Hostein, I., Banerji, U., Stefano, F.D., Maloney, A., Walton, M., Judson, I., Workman, P. (2000) Gene expression profiling of human colon cancer cells following inhibition of signal transduction by 17-Allylamino-17-demethoxygeldanamycin, an inhibitor of the hsp90 molecular chaperone. Oncogene, 19, 4125-4133
-
(2000)
Oncogene
, vol.19
, pp. 4125-4133
-
-
Clarke, P.A.1
Hostein, I.2
Banerji, U.3
Stefano, F.D.4
Maloney, A.5
Walton, M.6
Judson, I.7
Workman, P.8
-
19
-
-
0035146685
-
The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins
-
Connell, P., Ballinger, C.A., Jiang, J., Wu, Y., Thompson, L.J., Hohfeld, J., Patterson, C. (2001) The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins. Nat Cell Biol, 3, 93-96
-
(2001)
Nat Cell Biol
, vol.3
, pp. 93-96
-
-
Connell, P.1
Ballinger, C.A.2
Jiang, J.3
Wu, Y.4
Thompson, L.J.5
Hohfeld, J.6
Patterson, C.7
-
20
-
-
42449136263
-
Designed TPR modules as novel anticancer agents
-
Cortajarena, A.L., Yi, F., Regan, L. (2008) Designed TPR modules as novel anticancer agents. ACS Chem Biol, 3, 161-166
-
(2008)
ACS Chem Biol
, vol.3
, pp. 161-166
-
-
Cortajarena, A.L.1
Yi, F.2
Regan, L.3
-
21
-
-
28244444919
-
Activated B-RAF is an hsp90 client protein that is targeted by the anticancer drug 17-Allylamino-17-demethoxygeldanamycin
-
da Rocha Dias, S., Friedlos, F., Light, Y., Springer, C., Workman, P., Marais, R. (2005) Activated B-RAF is an hsp90 client protein that is targeted by the anticancer drug 17-Allylamino-17-demethoxygeldanamycin. Cancer Res, 65, 10686-10691
-
(2005)
Cancer Res
, vol.65
, pp. 10686-10691
-
-
Da Rocha Dias, S.1
Friedlos, F.2
Light, Y.3
Springer, C.4
Workman, P.5
Marais, R.6
-
22
-
-
34948890040
-
Heat shock protein inhibition is associated with activation of the unfolded protein response pathway in myeloma plasma cells
-
Davenport, E.L., Moore, H.E., Dunlop, A.S., Sharp, S.Y., Workman, P., Morgan, G.J., Davies, F.E. (2007) Heat shock protein inhibition is associated with activation of the unfolded protein response pathway in myeloma plasma cells. Blood, 110, 2641-2649
-
(2007)
Blood
, vol.110
, pp. 2641-2649
-
-
Davenport, E.L.1
Moore, H.E.2
Dunlop, A.S.3
Sharp, S.Y.4
Workman, P.5
Morgan, G.J.6
Davies, F.E.7
-
23
-
-
18444374405
-
Mutations of the BRAF gene in human cancer
-
Davies, H., Bignell, G.R., Cox, C., Stephens, P., Edkins, S., Clegg, S., Teague, J., Woffendin, H., Garnett, M.J., Bottomley, W., Davis, N., Dicks, E., Ewing, R., Floyd, Y., Gray, K., Hall, S., Hawes, R., Hughes, J., Kosmidou, V., Menzies, A., Mould, C., Parker, A., Stevens, C., Watt, S., Hooper, S., Wilson, R., Jayatilake, H., Gusterson, B.A., Cooper, C., Shipley, J., Hargrave, D., Pritchard-Jones, K., Maitland, N., Chenevix-Trench, G., Riggins, G.J., Bigner, D.D., Palmieri, G., Cossu, A., Flanagan, A., Nicholson, A., Ho, J.W., Leung, S.Y., Yuen, S.T., Weber, B.L., Seigler, H.F., Darrow, T.L., Paterson, H., Marais, R., Marshall, C.J., Wooster, R., Stratton, M.R., and Futreal, P.A. (2002) Mutations of the BRAF gene in human cancer. Nature, 417, 949-954
-
(2002)
Nature
, vol.417
, pp. 949-954
-
-
Davies, H.1
Bignell, G.R.2
Cox, C.3
Stephens, P.4
Edkins, S.5
Clegg, S.6
Teague, J.7
Woffendin, H.8
Garnett, M.J.9
Bottomley, W.10
Davis, N.11
Dicks, E.12
Ewing, R.13
Floyd, Y.14
Gray, K.15
Hall, S.16
Hawes, R.17
Hughes, J.18
Kosmidou, V.19
Menzies, A.20
Mould, C.21
Parker, A.22
Stevens, C.23
Watt, S.24
Hooper, S.25
Wilson, R.26
Jayatilake, H.27
Gusterson, B.A.28
Cooper, C.29
Shipley, J.30
Hargrave, D.31
Pritchard-Jones, K.32
Maitland, N.33
Chenevix-Trench, G.34
Riggins, G.J.35
Bigner, D.D.36
Palmieri, G.37
Cossu, A.38
Flanagan, A.39
Nicholson, A.40
Ho, J.W.41
Leung, S.Y.42
Yuen, S.T.43
Weber, B.L.44
Seigler, H.F.45
Darrow, T.L.46
Paterson, H.47
Marais, R.48
Marshall, C.J.49
Wooster, R.50
Stratton, M.R.51
Futreal, P.A.52
more..
-
24
-
-
0035899897
-
Cooperation of a ubiquitin domain protein and an E3 ubiquitin ligase during chaperone/proteasome coupling
-
Demand, J., Alberti, S., Patterson, C., and Hohfeld, J. (2001) Cooperation of a ubiquitin domain protein and an E3 ubiquitin ligase during chaperone/proteasome coupling. Curr Biol, 11, 1569-1577
-
(2001)
Curr Biol
, vol.11
, pp. 1569-1577
-
-
Demand, J.1
Alberti, S.2
Patterson, C.3
Hohfeld, J.4
-
25
-
-
24044518180
-
Structure of unliganded GRP94, the endoplasmic reticulum hsp90 Basis for nucleotide-induced conformational change
-
Dollins, D.E., Immormino, R.M., and Gewirth, D.T. (2005) Structure of unliganded GRP94, the endoplasmic reticulum hsp90. Basis for nucleotide-induced conformational change. J Biol Chem, 280, 30438-30447
-
(2005)
J Biol Chem
, vol.280
, pp. 30438-30447
-
-
Dollins, D.E.1
Immormino, R.M.2
Gewirth, D.T.3
-
26
-
-
21244505104
-
Novel, potent small-molecule inhibitors of the molecular chaperone hsp90 discovered through structure-based design
-
Dymock, B.W., Barril, X., Brough, P.A., Cansfield, J.E.,Massey, A.,McDonald, E., Hubbard, R.E., Surgenor, A., Roughley, S.D., Webb, P., Workman, P., Wright, L., and Drysdale, M.J. (2005) Novel, potent small-molecule inhibitors of the molecular chaperone hsp90 discovered through structure-based design. J Med Chem, 48, 4212-4215
-
(2005)
J Med Chem
, vol.48
, pp. 4212-4215
-
-
Dymock, B.W.1
Barril, X.2
Brough, P.A.3
Cansfield, J.E.4
Massey, A.5
McDonald, E.6
Hubbard, R.E.7
Surgenor, A.8
Roughley, S.D.9
Webb, P.10
Workman, P.11
Wright, L.12
Drysdale, M.J.13
-
27
-
-
42349084306
-
NVP-AUY922: A novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis
-
Eccles, S.A., Massey, A., Raynaud, F.I., Sharp, S.Y., Box, G., Valenti, M., Patterson, L., de Haven, B.A., Gowan, S., Boxall, F., Aherne, W., Rowlands, M., Hayes, A.,Martins, V., Urban, F., Boxall, K., Prodromou, C., Pearl, L., James, K., Matthews, T.P., Cheung, K.M., Kalusa, A., Jones, K.,McDonald, E., Barril, X., Brough, P.A., Cansfield, J.E., Dymock, B., Drysdale, M.J., Finch, H., Howes, R., Hubbard, R.E., Surgenor, A.,Webb, P.,Wood, M.,Wright, L., andWorkman, P. (2008) NVP-AUY922: A novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis. Cancer Res, 68, 2850-2860
-
(2008)
Cancer Res
, vol.68
, pp. 2850-2860
-
-
Eccles, S.A.1
Massey, A.2
Raynaud, F.I.3
Sharp, S.Y.4
Box, G.5
Valenti, M.6
Patterson, L.7
De Haven, B.A.8
Gowan, S.9
Boxall, F.10
Aherne, W.11
Rowlands, M.12
Hayes A.Martins, V.13
Urban, F.14
Boxall, K.15
Prodromou, C.16
Pearl, L.17
James, K.18
Matthews, T.P.19
Cheung, K.M.20
Kalusa, A.21
Jones K.McDonald, E.22
Barril, X.23
Brough, P.A.24
Cansfield, J.E.25
Dymock, B.26
Drysdale, M.J.27
Finch, H.28
Howes, R.29
Hubbard, R.E.30
Surgenor, A.31
Webb, P.32
Wood, M.33
Wright, L.34
Workman, P.35
more..
-
28
-
-
33845592531
-
NRAS and BRAF mutations in melanoma tumours in relation to clinical characteristics: A study based on mutation screening by pyrosequencing
-
Edlundh-Rose, E., Egyhazi, S., Omholt, K., Mansson-Brahme, E., Platz, A., Hansson, J., and Lundeberg, J. (2006) NRAS and BRAF mutations in melanoma tumours in relation to clinical characteristics: A study based on mutation screening by pyrosequencing. Melanoma Res, 16, 471-478
-
(2006)
Melanoma Res
, vol.16
, pp. 471-478
-
-
Edlundh-Rose, E.1
Egyhazi, S.2
Omholt, K.3
Mansson-Brahme, E.4
Platz, A.5
Hansson, J.6
Lundeberg, J.7
-
29
-
-
0032101569
-
Metabolism of 17-(allylamino)-17-emethoxygeldanamycin(NSC 330507) by murine and human hepatic preparations
-
Egorin, M.J., Rosen, D.M., Wolff, J.H., Callery, P.S., Musser, S.M., and Eiseman, J.L. (1998) Metabolism of 17-(allylamino)-17-demethoxygeldanamycin(NSC 330507) by murine and human hepatic preparations. Cancer Res, 58, 2385-2396
-
(1998)
Cancer Res
, vol.58
, pp. 2385-2396
-
-
Egorin, M.J.1
Rosen, D.M.2
Wolff, J.H.3
Callery, P.S.4
Musser, S.M.5
Eiseman, J.L.6
-
30
-
-
0346995281
-
Combination treatment with 17-N-Allylamino-17-demethoxy geldanamycin and acute irradiation produces supra-Additive growth suppression in human prostate carcinoma spheroids
-
Enmon, R., Yang, W.H., Ballangrud, A.M., Solit, D.B., Heller, G., Rosen, N., Scher, H.I., and Sgouros, G. (2003) Combination treatment with 17-N-Allylamino-17-demethoxy geldanamycin and acute irradiation produces supra-Additive growth suppression in human prostate carcinoma spheroids. Cancer Res, 63, 8393-8399
-
(2003)
Cancer Res
, vol.63
, pp. 8393-8399
-
-
Enmon, R.1
Yang, W.H.2
Ballangrud, A.M.3
Solit, D.B.4
Heller, G.5
Rosen, N.6
Scher, H.I.7
Sgouros, G.8
-
31
-
-
2942716692
-
Functional proteomic screens reveal an essential extracellular role for hsp90 alpha in cancer cell invasiveness
-
Eustace, B.K., Sakurai, T., Stewart, J.K., Yimlamai, D., Unger, C., Zehetmeier, C., Lain, B., Torella, C., Henning, S.W., Beste, G., Scroggins, B.T., Neckers, L., Ilag, L.L., and Jay, D.G. (2004) Functional proteomic screens reveal an essential extracellular role for hsp90 alpha in cancer cell invasiveness. Nat Cell Biol, 6, 507-514
-
(2004)
Nat Cell Biol
, vol.6
, pp. 507-514
-
-
Eustace, B.K.1
Sakurai, T.2
Stewart, J.K.3
Yimlamai, D.4
Unger, C.5
Zehetmeier, C.6
Lain, B.7
Torella, C.8
Henning, S.W.9
Beste, G.10
Scroggins, B.T.11
Neckers, L.12
Ilag, L.L.13
Jay, D.G.14
-
32
-
-
0034603178
-
The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties
-
Felts, S.J., Owen, B.A., Nguyen, P., Trepel, J., Donner, D.B., and Toft, D.O. (2000) The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties. J Biol Chem, 275, 3305-3312
-
(2000)
J Biol Chem
, vol.275
, pp. 3305-3312
-
-
Felts, S.J.1
Owen, B.A.2
Nguyen, P.3
Trepel, J.4
Donner, D.B.5
Toft, D.O.6
-
33
-
-
37249011744
-
The ATPase cycle of the endoplasmic chaperone grp94
-
Frey, S., Leskovar, A., Reinstein, J., and Buchner, J. (2007) The ATPase cycle of the endoplasmic chaperone grp94. J Biol Chem, 282, 35612-35620
-
(2007)
J Biol Chem
, vol.282
, pp. 35612-35620
-
-
Frey, S.1
Leskovar, A.2
Reinstein, J.3
Buchner, J.4
-
34
-
-
4243105077
-
IC101 induces apoptosis by akt dephosphorylation via an inhibition of heat shock protein 90-ATP binding activity accompanied by preventing the interaction with akt in L1210 cells
-
Fujiwara, H., Yamakuni, T., Ueno, M., Ishizuka, M., Shinkawa, T., Isobe, T., and Ohizumi, Y. (2004) IC101 induces apoptosis by akt dephosphorylation via an inhibition of heat shock protein 90-ATP binding activity accompanied by preventing the interaction with akt in L1210 cells. J Pharmacol Exp Ther, 310, 1288-1295
-
(2004)
J Pharmacol Exp Ther
, vol.310
, pp. 1288-1295
-
-
Fujiwara, H.1
Yamakuni, T.2
Ueno, M.3
Ishizuka, M.4
Shinkawa, T.5
Isobe, T.6
Ohizumi, Y.7
-
35
-
-
18844378888
-
Increased expression of the major heat shock protein hsp72 in human prostate carcinoma cells is dispensable for their viability but confers resistance to a variety of anticancer agents
-
Gabai, V.L., Budagova, K.R., and Sherman, M.Y. (2005) Increased expression of the major heat shock protein hsp72 in human prostate carcinoma cells is dispensable for their viability but confers resistance to a variety of anticancer agents. Oncogene, 24, 3328-3338
-
(2005)
Oncogene
, vol.24
, pp. 3328-3338
-
-
Gabai, V.L.1
Budagova, K.R.2
Sherman, M.Y.3
-
36
-
-
45849105629
-
Integration of gene dosage and gene expression in non-small cell lung cancer, identification of HSP90 as potential target
-
Gallegos Ruiz, M.I., Floor, K., Roepman, P., Rodriguez, J.A., Meijer, G.A., Mooi, W.J., Jassem, E., Niklinski, J., Muley, T., van, Z.N., Smit, E.F., Beebe, K., Neckers, L., Ylstra, B., and Giaccone, G. (2008) Integration of gene dosage and gene expression in non-small cell lung cancer, identification of HSP90 as potential target. PLoS ONE, 3, e0001722
-
(2008)
PLoS ONE
, vol.3
-
-
Gallegos Ruiz, M.I.1
Floor, K.2
Roepman, P.3
Rodriguez, J.A.4
Meijer, G.A.5
Mooi, W.J.6
Jassem, E.7
Niklinski, J.8
Muley, T.9
Van, Z.N.10
Smit, E.F.11
Beebe, K.12
Neckers, L.13
Ylstra, B.14
Giaccone, G.15
-
37
-
-
33644774541
-
Examination of mutations in BRAF, NRAS, and PTEN in primary cutaneous melanoma
-
Goel, V.K., Lazar, A.J., Warneke, C.L., Redston, M.S., and Haluska, F.G. (2006) Examination of mutations in BRAF, NRAS, and PTEN in primary cutaneous melanoma. J Invest Dermatol, 126, 154-160
-
(2006)
J Invest Dermatol
, vol.126
, pp. 154-160
-
-
Goel, V.K.1
Lazar, A.J.2
Warneke, C.L.3
Redston, M.S.4
Haluska, F.G.5
-
38
-
-
20044384168
-
Phase i trial of 17-Allylamino-17-demethoxygeldanamycin in patients with advanced cancer
-
Goetz, M.P., Toft, D., Reid, J., Ames, M., Stensgard, B., Safgren, S., Adjei, A.A., Sloan, J., Atherton, P., Vasile, V., Salazaar, S., Adjei, A., Croghan, G., and Erlichman, C. (2005) Phase i trial of 17-Allylamino-17- demethoxygeldanamycin in patients with advanced cancer. J Clin Oncol, 23, 1078-1087
-
(2005)
J Clin Oncol
, vol.23
, pp. 1078-1087
-
-
Goetz, M.P.1
Toft, D.2
Reid, J.3
Ames, M.4
Stensgard, B.5
Safgren, S.6
Adjei, A.A.7
Sloan, J.8
Atherton, P.9
Vasile, V.10
Salazaar, S.11
Adjei, A.12
Croghan, G.13
Erlichman, C.14
-
39
-
-
0037040975
-
The role of hsp90n, a new member of the hsp90 family, in signal transduction and neoplastic transformation
-
Grammatikakis, N., Vultur, A., Ramana, C.V., Siganou, A., Schweinfest, C.W., Watson, D.K., and Raptis, L. (2002) The role of hsp90n, a new member of the hsp90 family, in signal transduction and neoplastic transformation. J Biol Chem, 277, 8312-8320
-
(2002)
J Biol Chem
, vol.277
, pp. 8312-8320
-
-
Grammatikakis, N.1
Vultur, A.2
Ramana, C.V.3
Siganou, A.4
Schweinfest, C.W.5
Watson, D.K.6
Raptis, L.7
-
40
-
-
37549060720
-
Targeting cdc37 inhibits multiple signaling pathways and induces growth arrest in prostate cancer cells
-
Gray, P.J. Jr., Stevenson, M.A., and Calderwood, S.K. (2007) Targeting cdc37 inhibits multiple signaling pathways and induces growth arrest in prostate cancer cells. Cancer Res, 67, 11942-11950
-
(2007)
Cancer Res
, vol.67
, pp. 11942-11950
-
-
Gray Jr., P.J.1
Stevenson, M.A.2
Calderwood, S.K.3
-
41
-
-
30444441778
-
V600E B-raf requires the hsp90 chaperone for stability and is degraded in response to hsp90 inhibitors
-
Grbovic, O.M., Basso, A.D., Sawai, A., Ye, Q., Friedlander, P., Solit, D., and Rosen, N. (2006) V600E B-raf requires the hsp90 chaperone for stability and is degraded in response to hsp90 inhibitors. Proc Natl Acad Sci U S A, 103, 57-62
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 57-62
-
-
Grbovic, O.M.1
Basso, A.D.2
Sawai, A.3
Ye, Q.4
Friedlander, P.5
Solit, D.6
Rosen, N.7
-
42
-
-
20144375312
-
Phase i and pharmacologic study of 17-(allylamino)-17- demethoxygeldanamycin in adult patients with solid tumors
-
Grem, J.L., Morrison, G., Guo, X.D., Agnew, E., Takimoto, C.H., Thomas, R., Szabo, E., Grochow, L., Grollman, F., Hamilton, J.M., Neckers, L., and Wilson, R.H. (2005) Phase i and pharmacologic study of 17-(allylamino)-17- demethoxygeldanamycin in adult patients with solid tumors. J Clin Oncol, 23, 1885-1893
-
(2005)
J Clin Oncol
, vol.23
, pp. 1885-1893
-
-
Grem, J.L.1
Morrison, G.2
Guo, X.D.3
Agnew, E.4
Takimoto, C.H.5
Thomas, R.6
Szabo, E.7
Grochow, L.8
Grollman, F.9
Hamilton, J.M.10
Neckers, L.11
Wilson, R.H.12
-
43
-
-
0028044818
-
Differential expression of heat shock proteins in pancreatic carcinoma
-
Gress, T.M., Muller-Pillasch, F.,Weber, C., Lerch, M.M., Friess, H., Buchler, M., Beger, H.G., and Adler, G. (1994) Differential expression of heat shock proteins in pancreatic carcinoma. Cancer Res, 54, 547-551
-
(1994)
Cancer Res
, vol.54
, pp. 547-551
-
-
Gress, T.M.1
Muller-Pillasch, F.2
Weber, C.3
Lerch, M.M.4
Friess, H.5
Buchler, M.6
Beger, H.G.7
Adler, G.8
-
44
-
-
28544433004
-
Abrogation of heat shock protein 70 induction as a strategy to increase antileukemia activity of heat shock protein 90 inhibitor 17-Allylamino-demethoxy geldanamycin
-
Guo, F., Rocha, K., Bali, P., Pranpat, M., Fiskus, W., Boyapalle, S., Kumaraswamy, S., Balasis, M., Greedy, B., Armitage, E.S., Lawrence, N., and Bhalla, K. (2005) Abrogation of heat shock protein 70 induction as a strategy to increase antileukemia activity of heat shock protein 90 inhibitor 17-Allylamino-demethoxy geldanamycin. Cancer Res, 65, 10536-10544
-
(2005)
Cancer Res
, vol.65
, pp. 10536-10544
-
-
Guo, F.1
Rocha, K.2
Bali, P.3
Pranpat, M.4
Fiskus, W.5
Boyapalle, S.6
Kumaraswamy, S.7
Balasis, M.8
Greedy, B.9
Armitage, E.S.10
Lawrence, N.11
Bhalla, K.12
-
45
-
-
33747140819
-
Antileukemic activity of shepherdin and molecular diversity of hsp90 inhibitors
-
Gyurkocza, B., Plescia, J., Raskett, C.M., Garlick, D.S., Lowry, P.A., Carter, B.Z., Andreeff, M., Meli, M., Colombo, G., and Altieri, D.C. (2006) Antileukemic activity of shepherdin and molecular diversity of hsp90 inhibitors. J Natl Cancer Inst, 98, 1068-1077
-
(2006)
J Natl Cancer Inst
, vol.98
, pp. 1068-1077
-
-
Gyurkocza, B.1
Plescia, J.2
Raskett, C.M.3
Garlick, D.S.4
Lowry, P.A.5
Carter, B.Z.6
Andreeff, M.7
Meli, M.8
Colombo, G.9
Altieri, D.C.10
-
46
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan, D. and Weinberg, R.A. (2000) The hallmarks of cancer. Cell, 100, 57-70
-
(2000)
Cell
, vol.100
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
47
-
-
34147099104
-
A duplexed phenotypic screen for the simultaneous detection of inhibitors of the molecular chaperone heat shock protein 90 and modulators of cellular acetylation
-
Hardcastle, A., Tomlin, P., Norris, C., Richards, J., Cordwell, M., Boxall, K., Rowlands, M., Jones, K., Collins, I., McDonald, E., Workman, P., and Aherne, W. (2007) A duplexed phenotypic screen for the simultaneous detection of inhibitors of the molecular chaperone heat shock protein 90 and modulators of cellular acetylation. Mol Cancer Ther, 6, 1112-1122
-
(2007)
Mol Cancer Ther
, vol.6
, pp. 1112-1122
-
-
Hardcastle, A.1
Tomlin, P.2
Norris, C.3
Richards, J.4
Cordwell, M.5
Boxall, K.6
Rowlands, M.7
Jones, K.8
Collins, I.9
McDonald, E.10
Workman, P.11
Aherne, W.12
-
48
-
-
30444447639
-
Identification of potent water soluble purine-scaffold inhibitors of the heat shock protein 90
-
He, H., Zatorska, D., Kim, J., Aguirre, J., Llauger, L., She, Y.,Wu, N., Immormino, R.M., Gewirth, D.T., and Chiosis, G. (2006) Identification of potent water soluble purine-scaffold inhibitors of the heat shock protein 90. J Med Chem, 49, 381-390
-
(2006)
J Med Chem
, vol.49
, pp. 381-390
-
-
He, H.1
Zatorska, D.2
Kim, J.3
Aguirre, J.4
Llauger, L.5
She Y.Wu, N.6
Immormino, R.M.7
Gewirth, D.T.8
Chiosis, G.9
-
49
-
-
33749433916
-
Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators
-
Hieronymus, H., Lamb, J., Ross, K.N., Peng, X.P., Clement, C., Rodina, A., Nieto, M., Du, J., Stegmaier, K., Raj, S.M., Maloney, K.N., Clardy, J., Hahn, W.C., Chiosis, G., and Golub, T.R. (2006) Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators. Cancer Cell, 10, 321-330
-
(2006)
Cancer Cell
, vol.10
, pp. 321-330
-
-
Hieronymus, H.1
Lamb, J.2
Ross, K.N.3
Peng, X.P.4
Clement, C.5
Rodina, A.6
Nieto, M.7
Du, J.8
Stegmaier, K.9
Raj, S.M.10
Maloney, K.N.11
Clardy, J.12
Hahn, W.C.13
Chiosis, G.14
Golub, T.R.15
-
50
-
-
40449089789
-
Silencing of HSP90 cochaperone AHA1 expression decreases client protein activation and increases cellular sensitivity to the HSP90 inhibitor 17-Allylamino-17-demethoxygeldanamycin
-
Holmes, J.L., Sharp, S.Y., Hobbs, S., and Workman, P. (2008) Silencing of HSP90 cochaperone AHA1 expression decreases client protein activation and increases cellular sensitivity to the HSP90 inhibitor 17-Allylamino-17- demethoxygeldanamycin. Cancer Res, 68, 1188-1197
-
(2008)
Cancer Res
, vol.68
, pp. 1188-1197
-
-
Holmes, J.L.1
Sharp, S.Y.2
Hobbs, S.3
Workman, P.4
-
51
-
-
0035872442
-
Inhibition of signal transduction by the hsp90 inhibitor 17-Allylamino-17-demethoxygeldanamycin results in cytostasis and apoptosis
-
Hostein, I., Robertson, D., DiStefano, F., Workman, P., and Clarke, P.A. (2001) Inhibition of signal transduction by the hsp90 inhibitor 17-Allylamino-17-demethoxygeldanamycin results in cytostasis and apoptosis. Cancer Res, 61, 4003-4009
-
(2001)
Cancer Res
, vol.61
, pp. 4003-4009
-
-
Hostein, I.1
Robertson, D.2
DiStefano, F.3
Workman, P.4
Clarke, P.A.5
-
52
-
-
42649088411
-
Celastrol inhibits the growth of human glioma xenografts in nude mice through suppressing VEGFR expression
-
Huang, Y., Zhou, Y., Fan, Y., and Zhou, D. (2008) Celastrol inhibits the growth of human glioma xenografts in nude mice through suppressing VEGFR expression. Cancer Lett, 264(1), 101-6
-
(2008)
Cancer Lett
, vol.264
, Issue.1
, pp. 101-106
-
-
Huang, Y.1
Zhou, Y.2
Fan, Y.3
Zhou, D.4
-
53
-
-
0026544498
-
Clinical and biological significance of HSP89 alpha in human breast cancer
-
Jameel, A., Skilton, R.A., Campbell, T.A., Chander, S.K., Coombes, R.C., and Luqmani, Y.A. (1992) Clinical and biological significance of HSP89 alpha in human breast cancer. Int J Cancer, 50, 409-415
-
(1992)
Int J Cancer
, vol.50
, pp. 409-415
-
-
Jameel, A.1
Skilton, R.A.2
Campbell, T.A.3
Chander, S.K.4
Coombes, R.C.5
Luqmani, Y.A.6
-
54
-
-
28144440479
-
Heat shock protein 90 inhibitors A text book example of medicinal chemistry
-
Janin, Y.L. (2005) Heat shock protein 90 inhibitors. A text book example of medicinal chemistrý J Med Chem, 48, 7503-7512
-
(2005)
J Med Chem
, vol.48
, pp. 7503-7512
-
-
Janin, Y.L.1
-
55
-
-
48949119477
-
Nvpauy922: A small molecule hsp90 inhibitor with potent antitumor activity in preclinical breast cancer models
-
Jensen, M.R., Schoepfer, J., Radimerski, T., Massey, A., Guy, C.T., Brueggen, J., Quadt, C., Buckler, A., Cozens, R., Drysdale, M.J., Garcia-Echeverria, C., and Chene, P. (2008) NVPAUY922: A small molecule HSP90 inhibitor with potent antitumor activity in preclinical breast cancer models. Breast Cancer Res, 10, R33
-
(2008)
Breast Cancer Res
, vol.10
-
-
Jensen, M.R.1
Schoepfer, J.2
Radimerski, T.3
Massey, A.4
Guy, C.T.5
Brueggen, J.6
Quadt, C.7
Buckler, A.8
Cozens, R.9
Drysdale, M.J.10
Garcia-Echeverria, C.11
Chene, P.12
-
56
-
-
0141484615
-
A high-Affinity conformation of hsp90 confers tumour selectivity on hsp90 inhibitors
-
Kamal, A., Thao, L., Sensintaffar, J., Zhang, L., Boehm, M.F., Fritz, L.C., and Burrows, F.J. (2003) A high-Affinity conformation of hsp90 confers tumour selectivity on hsp90 inhibitors. Nature, 425, 407-410
-
(2003)
Nature
, vol.425
, pp. 407-410
-
-
Kamal, A.1
Thao, L.2
Sensintaffar, J.3
Zhang, L.4
Boehm, M.F.5
Fritz, L.C.6
Burrows, F.J.7
-
57
-
-
35348887850
-
Regulation of tumor cell mitochondrial homeostasis by an organelle-specific hsp90 chaperone network
-
Kang, B.H., Plescia, J., Dohi, T., Rosa, J., Doxsey, S.J., and Altieri, D.C. (2007) Regulation of tumor cell mitochondrial homeostasis by an organelle-specific hsp90 chaperone network. Cell, 131, 257-270
-
(2007)
Cell
, vol.131
, pp. 257-270
-
-
Kang, B.H.1
Plescia, J.2
Dohi, T.3
Rosa, J.4
Doxsey, S.J.5
Altieri, D.C.6
-
58
-
-
34250877881
-
Rationally designed high-Affinity 2-Amino-6-halopurine heat shock protein 90 inhibitors that exhibit potent antitumor activity
-
Kasibhatla, S.R., Hong, K., Biamonte, M.A., Busch, D.J., Karjian, P.L., Sensintaffar, J.L., Kamal, A., Lough, R.E., Brekken, J., Lundgren, K., Grecko, R., Timony, G.A., Ran, Y., Mansfield, R., Fritz, L.C., Ulm, E., Burrows, F.J., and Boehm, M.F. (2007) Rationally designed high-Affinity 2-Amino-6-halopurine heat shock protein 90 inhibitors that exhibit potent antitumor activity. J Med Chem, 50, 2767-2778
-
(2007)
J Med Chem
, vol.50
, pp. 2767-2778
-
-
Kasibhatla, S.R.1
Hong, K.2
Biamonte, M.A.3
Busch, D.J.4
Karjian, P.L.5
Sensintaffar, J.L.6
Kamal, A.7
Lough, R.E.8
Brekken, J.9
Lundgren, K.10
Grecko, R.11
Timony, G.A.12
Ran, Y.13
Mansfield, R.14
Fritz, L.C.15
Ulm, E.16
Burrows, F.J.17
Boehm, M.F.18
-
59
-
-
0033579175
-
DT-diaphorase expression and tumor cell sensitivity to 17-Allylamino, 17-demethoxygeldanamycin, an inhibitor of heat shock protein 90
-
Kelland, L.R., Sharp, S.Y., Rogers, P.M., Myers, T.G., and Workman, P. (1999) DT-diaphorase expression and tumor cell sensitivity to 17-Allylamino, 17-demethoxygeldanamycin, an inhibitor of heat shock protein 90. J Natl Cancer Inst, 91, 1940-1949
-
(1999)
J Natl Cancer Inst
, vol.91
, pp. 1940-1949
-
-
Kelland, L.R.1
Sharp, S.Y.2
Rogers, P.M.3
Myers, T.G.4
Workman, P.5
-
60
-
-
21144444486
-
HDAC6 regulates hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor
-
Kovacs, J.J., Murphy, P.J., Gaillard, S., Zhao, X.,Wu, J.T., Nicchitta, C.V., Yoshida, M., Toft, D.O., Pratt, W.B., and Yao, T.P. (2005) HDAC6 regulates hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor. Mol Cell, 18, 601-607
-
(2005)
Mol Cell
, vol.18
, pp. 601-607
-
-
Kovacs, J.J.1
Murphy, P.J.2
Gaillard, S.3
Zhao X.Wu, J.T.4
Nicchitta, C.V.5
Yoshida, M.6
Toft, D.O.7
Pratt, W.B.8
Yao, T.P.9
-
61
-
-
31644447446
-
Increased expression of GRP94 protein is associated with decreased sensitivity to X-rays in cervical cancer cell lines
-
Kubota, H., Suzuki, T., Lu, J., Takahashi, S., Sugita, K., Sekiya, S., and Suzuki, N. (2005) Increased expression of GRP94 protein is associated with decreased sensitivity to X-rays in cervical cancer cell lines. Int J Radiat Biol, 81, 701-709
-
(2005)
Int J Radiat Biol
, vol.81
, pp. 701-709
-
-
Kubota, H.1
Suzuki, T.2
Lu, J.3
Takahashi, S.4
Sugita, K.5
Sekiya, S.6
Suzuki, N.7
-
62
-
-
0012999148
-
Interaction of hsp90 with the nascent form of the mutant epidermal growth factor receptor EGFRvIII
-
Lavictoire, S.J., Parolin, D.A., Klimowicz, A.C., Kelly, J.F., and Lorimer, I.A. (2003) Interaction of hsp90 with the nascent form of the mutant epidermal growth factor receptor EGFRvIII. J Biol Chem, 278, 5292-5299
-
(2003)
J Biol Chem
, vol.278
, pp. 5292-5299
-
-
Lavictoire, S.J.1
Parolin, D.A.2
Klimowicz, A.C.3
Kelly, J.F.4
Lorimer, I.A.5
-
63
-
-
45549104450
-
The ATPase cycle of the mitochondrial hsp90 analog trap1
-
Leskovar, A., Wegele, H., Werbeck, N.D., Buchner, J., (2008) The ATPase cycle of the mitochondrial hsp90 analog trap1. J Biol Chem, 283, 11677-11688
-
(2008)
J Biol Chem
, vol.283
, pp. 11677-11688
-
-
Leskovar, A.1
Wegele, H.2
Werbeck, N.D.3
Buchner, J.4
-
64
-
-
27844506524
-
Akt-regulated pathways in prostate cancer
-
Majumder, P.K. and Sellers, W.R. (2005) Akt-regulated pathways in prostate cancer. Oncogene, 24, 7465-7474
-
(2005)
Oncogene
, vol.24
, pp. 7465-7474
-
-
Majumder, P.K.1
Sellers, W.R.2
-
65
-
-
34147150867
-
Gene and protein expression profiling of human ovarian cancer cells treated with the heat shock protein 90 inhibitor 17-Allylamino-17- demethoxygeldanamycin
-
Maloney, A., Clarke, P.A., Naaby-Hansen, S., Stein, R., Koopmann, J.O., Akpan, A., Yang, A., Zvelebil, M., Cramer, R., Stimson, L., Aherne, W., Banerji, U., Judson, I., Sharp, S., Powers, M., deBilly, E., Salmons, J., Walton, M., Burlingame, A., Waterfield, M., and Workman, P. (2007) Gene and protein expression profiling of human ovarian cancer cells treated with the heat shock protein 90 inhibitor 17-Allylamino-17-demethoxygeldanamycin. Cancer Res, 67, 3239-3253
-
(2007)
Cancer Res
, vol.67
, pp. 3239-3253
-
-
Maloney, A.1
Clarke, P.A.2
Naaby-Hansen, S.3
Stein, R.4
Koopmann, J.O.5
Akpan, A.6
Yang, A.7
Zvelebil, M.8
Cramer, R.9
Stimson, L.10
Aherne, W.11
Banerji, U.12
Judson, I.13
Sharp, S.14
Powers, M.15
De Billy, E.16
Salmons, J.17
Walton, M.18
Burlingame, A.19
Waterfield, M.20
Workman, P.21
more..
-
66
-
-
0034711270
-
The heat shock protein 90 antagonist novobiocin interacts with a previously unrecognized ATP-binding domain in the carboxyl terminus of the chaperone
-
Marcu, M.G., Chadli, A., Bouhouche, I., Catelli, M., and Neckers, L.M. (2000a) The heat shock protein 90 antagonist novobiocin interacts with a previously unrecognized ATP-binding domain in the carboxyl terminus of the chaperone. J Biol Chem, 275, 37181-37186
-
(2000)
J Biol Chem
, vol.275
, pp. 37181-37186
-
-
Marcu, M.G.1
Chadli, A.2
Bouhouche, I.3
Catelli, M.4
Neckers, L.M.5
-
67
-
-
0034594644
-
Novobiocin and related coumarins and depletion of heat shock protein 90-dependent signaling proteins
-
Marcu, M.G., Schulte, T.W., and Neckers, L. (2000b) Novobiocin and related coumarins and depletion of heat shock protein 90-dependent signaling proteins. J Natl Cancer Inst, 92, 242-248
-
(2000)
J Natl Cancer Inst
, vol.92
, pp. 242-248
-
-
Marcu, M.G.1
Schulte, T.W.2
Neckers, L.3
-
68
-
-
42949088494
-
Molecular characterization of macbecin as an hsp90 inhibitor
-
Martin, C.J., Gaisser, S., Challis, I.R., Carletti, I.,Wilkinson, B., Gregory, M., Prodromou, C., Roe, S.M., Pearl, L.H., Boyd, S.M., and Zhang, M.Q. (2008) Molecular characterization of macbecin as an hsp90 inhibitor. J Med Chem, 51(9), 2853-7
-
(2008)
J Med Chem
, vol.51
, Issue.9
, pp. 2853-2857
-
-
Martin, C.J.1
Gaisser, S.2
Challis, I.R.3
Carletti, I.4
Wilkinson, B.5
Gregory, M.6
Prodromou, C.7
Roe, S.M.8
Pearl, L.H.9
Boyd, S.M.10
Zhang, M.Q.11
-
69
-
-
5644259582
-
Involvement of tumor necrosis factor receptorassociated protein 1(trap1) in apoptosis induced by beta-hydroxyisovalerylshikonin
-
Masuda, Y., Shima, G., Aiuchi, T., Horie, M., Hori, K., Nakajo, S., Kajimoto, S., Shibayama-Imazu, T., and Nakaya, K. (2004) Involvement of tumor necrosis factor receptorassociated protein 1(TRAP1) in apoptosis induced by beta-hydroxyisovalerylshikonin. J Biol Chem, 279, 42503-42515
-
(2004)
J Biol Chem
, vol.279
, pp. 42503-42515
-
-
Masuda, Y.1
Shima, G.2
Aiuchi, T.3
Horie, M.4
Hori, K.5
Nakajo, S.6
Kajimoto, S.7
Shibayama-Imazu, T.8
Nakaya, K.9
-
70
-
-
33845915755
-
Small-molecule targeting of heat shock protein 90 chaperone function: Rational identification of a new anticancer lead
-
Meli, M., Pennati, M., Curto, M., Daidone, M.G., Plescia, J., Toba, S., Altieri, D.C., Zaffaroni, N., and Colombo, G. (2006) Small-molecule targeting of heat shock protein 90 chaperone function: Rational identification of a new anticancer lead. J Med Chem, 49, 7721-7730
-
(2006)
J Med Chem
, vol.49
, pp. 7721-7730
-
-
Meli, M.1
Pennati, M.2
Curto, M.3
Daidone, M.G.4
Plescia, J.5
Toba, S.6
Altieri, D.C.7
Zaffaroni, N.8
Colombo, G.9
-
71
-
-
0026808864
-
The endoplasmic reticulum stress protein GRP94, in addition to BiP, associates with unassembled immunoglobulin chains
-
Melnick, J., Aviel, S., and Argon, Y. (1992) The endoplasmic reticulum stress protein GRP94, in addition to BiP, associates with unassembled immunoglobulin chains. J Biol Chem, 267, 21303-21306
-
(1992)
J Biol Chem
, vol.267
, pp. 21303-21306
-
-
Melnick, J.1
Aviel, S.2
Argon, Y.3
-
72
-
-
0028170231
-
Sequential interaction of the chaperones BiP and GRP94 with immunoglobulin chains in the endoplasmic reticulum
-
Melnick, J., Dul, J.L., and Argon, Y. (1994) Sequential interaction of the chaperones BiP and GRP94 with immunoglobulin chains in the endoplasmic reticulum. Nature, 370, 373-375
-
(1994)
Nature
, vol.370
, pp. 373-375
-
-
Melnick, J.1
Dul, J.L.2
Argon, Y.3
-
73
-
-
34548131162
-
Expressed as the sole hsp90 of yeast, the alpha and β isoforms of human hsp90 differ with regard to their capacities for activation of certain client proteins, whereas only hsp90β generates sensitivity to the hsp90 inhibitor radicicol
-
Millson, S.H., Truman, A.W., Racz, A., Hu, B., Panaretou, B., Nuttall, J., Mollapour, M., Soti, C., and Piper, P.W. (2007) Expressed as the sole hsp90 of yeast, the alpha and β isoforms of human hsp90 differ with regard to their capacities for activation of certain client proteins, whereas only hsp90β generates sensitivity to the hsp90 inhibitor radicicol. Febs J, 274, 4453-4463
-
(2007)
Febs J
, vol.274
, pp. 4453-4463
-
-
Millson, S.H.1
Truman, A.W.2
Racz, A.3
Hu, B.4
Panaretou, B.5
Nuttall, J.6
Mollapour, M.7
Soti, C.8
Piper, P.W.9
-
74
-
-
4444311881
-
Simultaneous inhibition of hsp 90 and the proteasome promotes protein ubiquitination, causes endoplasmic reticulum-derived cytosolic vacuolization, and enhances antitumor activity
-
Mimnaugh, E.G., Xu, W., Vos, M., Yuan, X., Isaacs, J.S., Bisht, K.S., Gius, D., and Neckers, L. (2004) Simultaneous inhibition of hsp 90 and the proteasome promotes protein ubiquitination, causes endoplasmic reticulum-derived cytosolic vacuolization, and enhances antitumor activity. Mol Cancer Ther, 3, 551-566
-
(2004)
Mol Cancer Ther
, vol.3
, pp. 551-566
-
-
Mimnaugh, E.G.1
Xu, W.2
Vos, M.3
Yuan, X.4
Isaacs, J.S.5
Bisht, K.S.6
Gius, D.7
Neckers, L.8
-
75
-
-
22344439139
-
CK2 binds, phosphorylates, and regulates its pivotal substrate cdc37, an hsp90-cochaperone
-
Miyata, Y. and Nishida, E. (2005) CK2 binds, phosphorylates, and regulates its pivotal substrate cdc37, an hsp90-cochaperone. Mol Cell Biochem, 274, 171-179
-
(2005)
Mol Cell Biochem
, vol.274
, pp. 171-179
-
-
Miyata, Y.1
Nishida, E.2
-
76
-
-
36849055007
-
Combination of trastuzumab and tanespimycin(17-AAG, KOS-953) is safe and active in trastuzumab-refractory HER-2 overexpressing breast cancer: A phase i dose-escalation study
-
Modi, S., Stopeck, A.T., Gordon, M.S., Mendelson, D., Solit, D.B., Bagatell, R., Ma, W., Wheler, J., Rosen, N., Norton, L., Cropp, G.F., Johnson, R.G., Hannah, A.L., and Hudis, C.A. (2007) Combination of trastuzumab and tanespimycin(17-AAG, KOS-953) is safe and active in trastuzumab-refractory HER-2 overexpressing breast cancer: A phase i dose-escalation study. J Clin Oncol, 25, 5410-5417
-
(2007)
J Clin Oncol
, vol.25
, pp. 5410-5417
-
-
Modi, S.1
Stopeck, A.T.2
Gordon, M.S.3
Mendelson, D.4
Solit, D.B.5
Bagatell, R.6
Ma, W.7
Wheler, J.8
Rosen, N.9
Norton, L.10
Cropp, G.F.11
Johnson, R.G.12
Hannah, A.L.13
Hudis, C.A.14
-
77
-
-
2342651518
-
Molecular chaperones and the stress of oncogenesis
-
Mosser, D.D. and Morimoto, R.I. (2004) Molecular chaperones and the stress of oncogenesis. Oncogene, 23, 2907-2918
-
(2004)
Oncogene
, vol.23
, pp. 2907-2918
-
-
Mosser, D.D.1
Morimoto, R.I.2
-
78
-
-
0034886833
-
Modulation of hsp90 function by ansamycins sensitizes breast cancer cells to chemotherapy-induced apoptosis in an RB-And schedule-dependent manner See: E A Sausville, combining cytotoxics and 17-Allylamino, 17-demethoxygeldanamycin: Sequence and tumor biology matters
-
2228-2236
-
Munster, P.N., Basso, A., Solit, D., Norton, L., and Rosen, N. (2001) Modulation of hsp90 function by ansamycins sensitizes breast cancer cells to chemotherapy-induced apoptosis in an RB-And schedule-dependent manner. See: E. A. Sausville, combining cytotoxics and 17-Allylamino, 17-demethoxygeldanamycin: Sequence and tumor biology matters. Clin Cancer Res, 7, 2155-2158, 2228-2236
-
(2001)
Clin Cancer Res
, vol.7
, pp. 2155-2158
-
-
Munster, P.N.1
Basso, A.2
Solit, D.3
Norton, L.4
Rosen, N.5
-
79
-
-
36148976786
-
Hsp90 inhibitors disrupt mitochondrial homeostasis in cancer cells
-
Neckers, L., Kern, A., and Tsutsumi, S. (2007) Hsp90 inhibitors disrupt mitochondrial homeostasis in cancer cells. Chem Biol, 14, 1204-1206
-
(2007)
Chem Biol
, vol.14
, pp. 1204-1206
-
-
Neckers, L.1
Kern, A.2
Tsutsumi, S.3
-
80
-
-
33646011550
-
Hsp90 inhibitors in the clinic
-
Pacey, S., Banerji, U., Judson, I., and Workman, P. (2006) Hsp90 inhibitors in the clinic. Handb Exp Pharmacol, 172, 331-358
-
(2006)
Handb Exp Pharmacol
, vol.172
, pp. 331-358
-
-
Pacey, S.1
Banerji, U.2
Judson, I.3
Workman, P.4
-
81
-
-
0036931438
-
Activation of the ATPase activity of hsp90 by the stressregulated cochaperone aha1
-
Panaretou, B., Siligardi, G., Meyer, P., Maloney, A., Sullivan, J.K., Singh, S., Millson, S.H., Clarke, P.A., Naaby-Hansen, S., Stein, R., Cramer, R., Mollapour, M.,Workman, P., Piper, P.W., Pearl, L.H., and Prodromou, C. (2002) Activation of the ATPase activity of hsp90 by the stressregulated cochaperone aha1. Mol Cell, 10, 1307-1318
-
(2002)
Mol Cell
, vol.10
, pp. 1307-1318
-
-
Panaretou, B.1
Siligardi, G.2
Meyer, P.3
Maloney, A.4
Sullivan, J.K.5
Singh, S.6
Millson, S.H.7
Clarke, P.A.8
Naaby-Hansen, S.9
Stein, R.10
Cramer, R.11
Mollapour, M.12
Workman, P.13
Piper, P.W.14
Pearl, L.H.15
Prodromou, C.16
-
82
-
-
12344291243
-
Hsp90 and cdc37-A chaperone cancer conspiracy
-
Pearl, L.H. (2005) Hsp90 and cdc37-A chaperone cancer conspiracy. Curr Opin Genet Dev, 15, 55-61
-
(2005)
Curr Opin Genet Dev
, vol.15
, pp. 55-61
-
-
Pearl, L.H.1
-
83
-
-
41149111451
-
The hsp90 molecular chaperone: An open and shut case for treatment
-
Pearl, L.H., Prodromou, C., and Workman, P. (2008) The hsp90 molecular chaperone: An open and shut case for treatment. Biochem J, 410, 439-453
-
(2008)
Biochem J
, vol.410
, pp. 439-453
-
-
Pearl, L.H.1
Prodromou, C.2
Workman, P.3
-
84
-
-
34248195608
-
High HSP90 expression is associated with decreased survival in breast cancer
-
Pick, E., Kluger, Y., Giltnane, J.M., Moeder, C., Camp, R.L., Rimm, D.L., and Kluger, H.M. (2007) High HSP90 expression is associated with decreased survival in breast cancer. Cancer Res, 67, 2932-2937
-
(2007)
Cancer Res
, vol.67
, pp. 2932-2937
-
-
Pick, E.1
Kluger, Y.2
Giltnane, J.M.3
Moeder, C.4
Camp, R.L.5
Rimm, D.L.6
Kluger, H.M.7
-
85
-
-
21144437911
-
Rational design of shepherdin, a novel anticancer agent
-
Plescia, J., Salz, W., Xia, F., Pennati, M., Zaffaroni, N., Daidone, M.G., Meli, M., Dohi, T., Fortugno, P., Nefedova, Y., Gabrilovich, D.I., Colombo, G., and Altieri, D.C. (2005) Rational design of shepherdin, a novel anticancer agent. Cancer Cell, 7, 457-468
-
(2005)
Cancer Cell
, vol.7
, pp. 457-468
-
-
Plescia, J.1
Salz, W.2
Xia, F.3
Pennati, M.4
Zaffaroni, N.5
Daidone, M.G.6
Meli, M.7
Dohi, T.8
Fortugno, P.9
Nefedova, Y.10
Gabrilovich, D.I.11
Colombo, G.12
Altieri, D.C.13
-
86
-
-
33846861747
-
Targeting of multiple signalling pathways by heat shock protein 90 molecular chaperone inhibitors
-
Powers, M.V. and Workman, P. (2006) Targeting of multiple signalling pathways by heat shock protein 90 molecular chaperone inhibitors. Endocr Relat Cancer, 13(suppl. 1), S125-S135
-
(2006)
Endocr Relat Cancer
, vol.13
, Issue.SUPPL. 1
-
-
Powers, M.V.1
Workman, P.2
-
87
-
-
34447507818
-
Inhibitors of the heat shock response: Biology and pharmacology
-
Powers, M.V. and Workman, P. (2007) Inhibitors of the heat shock response: Biology and pharmacology. FEBS Lett, 581, 3758-3769
-
(2007)
FEBS Lett
, vol.581
, pp. 3758-3769
-
-
Powers, M.V.1
Workman, P.2
-
88
-
-
34547127902
-
PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1
-
Pridgeon, J.W., Olzmann, J.A., Chin, L.S., and Li, L. (2007) PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1. PLoS Biol, 5, e172
-
(2007)
PLoS Biol
, vol.5
-
-
Pridgeon, J.W.1
Olzmann, J.A.2
Chin, L.S.3
Li, L.4
-
89
-
-
0034663806
-
The ATPase cycle of hsp90 drives a molecular 'clamp' via transient dimerization of the N-Terminal domains
-
Prodromou, C., Panaretou, B., Chohan, S., Siligardi, G., O'Brien, R., Ladbury, J.E., Roe, S.M., Piper, P.W., and Pearl, L.H. (2000) The ATPase cycle of hsp90 drives a molecular 'clamp' via transient dimerization of the N-Terminal domains. Embo J, 19, 4383-4392
-
(2000)
Embo J
, vol.19
, pp. 4383-4392
-
-
Prodromou, C.1
Panaretou, B.2
Chohan, S.3
Siligardi, G.4
O'Brien, R.5
Ladbury, J.E.6
Roe, S.M.7
Piper, P.W.8
Pearl, L.H.9
-
90
-
-
0031444238
-
Identification and structural characterization of the ATP/ADP-binding site in the hsp90 molecular chaperone
-
Prodromou, C., Roe, S.M., O'Brien, R., Ladbury, J.E., Piper, P.W., and Pearl, L.H. (1997) Identification and structural characterization of the ATP/ADP-binding site in the hsp90 molecular chaperone. Cell, 90, 65-75
-
(1997)
Cell
, vol.90
, pp. 65-75
-
-
Prodromou, C.1
Roe, S.M.2
O'Brien, R.3
Ladbury, J.E.4
Piper, P.W.5
Pearl, L.H.6
-
91
-
-
21744462772
-
Synergistic activity of imatinib and 17-AAG in imatinib-resistant CML cells overexpressing BCR-ABL-inhibition of P-glycoprotein function by 17-AAG
-
Radujkovic, A., Schad, M., Topaly, J., Veldwijk, M.R., Laufs, S., Schultheis, B.S., Jauch, A., Melo, J.V., Fruehauf, S., and Zeller, W.J. (2005) Synergistic activity of imatinib and 17-AAG in imatinib-resistant CML cells overexpressing BCR-ABL-inhibition of P-glycoprotein function by 17-AAG. Leukemia, 19, 1198-1206
-
(2005)
Leukemia
, vol.19
, pp. 1198-1206
-
-
Radujkovic, A.1
Schad, M.2
Topaly, J.3
Veldwijk, M.R.4
Laufs, S.5
Schultheis, B.S.6
Jauch, A.7
Melo, J.V.8
Fruehauf, S.9
Zeller, W.J.10
-
92
-
-
0347951253
-
Additive interaction of oxaliplatin and 17-Allylamino-17- demethoxygeldanamycin in colon cancer cell lines results from inhibition of nuclear factor kappaB signaling
-
Rakitina, T.V., Vasilevskaya, I.A., and O'Dwyer, P.J. (2003) Additive interaction of oxaliplatin and 17-Allylamino-17-demethoxygeldanamycin in colon cancer cell lines results from inhibition of nuclear factor kappaB signaling. Cancer Res, 63, 8600-8605
-
(2003)
Cancer Res
, vol.63
, pp. 8600-8605
-
-
Rakitina, T.V.1
Vasilevskaya, I.A.2
O'Dwyer, P.J.3
-
93
-
-
0033214088
-
The endoplasmic reticulum chaperone glycoprotein GRP94 with ca (2+)-binding and antiapoptotic properties is a novel proteolytic target of calpain during etoposide-induced apoptosis
-
Reddy, R.K., Lu, J., and Lee, A.S. (1999) The endoplasmic reticulum chaperone glycoprotein GRP94 with ca(2+)-binding and antiapoptotic properties is a novel proteolytic target of calpain during etoposide-induced apoptosis. J Biol Chem, 274, 28476-28483
-
(1999)
J Biol Chem
, vol.274
, pp. 28476-28483
-
-
Reddy, R.K.1
Lu, J.2
Lee, A.S.3
-
94
-
-
1342330881
-
Frequent alterations of ras signaling pathway genes in sporadic malignant melanomas
-
Reifenberger, J., Knobbe, C.B., Sterzinger, A.A., Blaschke, B., Schulte, K.W., Ruzicka, T., and Reifenberger, G. (2004) Frequent alterations of ras signaling pathway genes in sporadic malignant melanomas. Int J Cancer, 109, 377-384
-
(2004)
Int J Cancer
, vol.109
, pp. 377-384
-
-
Reifenberger, J.1
Knobbe, C.B.2
Sterzinger, A.A.3
Blaschke, B.4
Schulte, K.W.5
Ruzicka, T.6
Reifenberger, G.7
-
95
-
-
11844276669
-
Functional specificity of co-chaperone interactions with hsp90 client proteins
-
Riggs, D., Cox, M., Cheung-Flynn, J., Prapapanich, V., Carrigan, P., and Smith, D. (2004) Functional specificity of co-chaperone interactions with hsp90 client proteins. Crit Rev Biochem Mol Biol, 39, 279-295
-
(2004)
Crit Rev Biochem Mol Biol
, vol.39
, pp. 279-295
-
-
Riggs, D.1
Cox, M.2
Cheung-Flynn, J.3
Prapapanich, V.4
Carrigan, P.5
Smith, D.6
-
96
-
-
0742269688
-
The mechanism of hsp90 regulation by the protein kinase-specific cochaperone p50(cdc37)
-
Roe, S.M., Ali, M.M., Meyer, P., Vaughan, C.K., Panaretou, B., Piper, P.W., Prodromou, C., and Pearl, L.H. (2004) The mechanism of hsp90 regulation by the protein kinase-specific cochaperone p50(cdc37). Cell, 116, 87-98
-
(2004)
Cell
, vol.116
, pp. 87-98
-
-
Roe, S.M.1
Ali, M.M.2
Meyer, P.3
Vaughan, C.K.4
Panaretou, B.5
Piper, P.W.6
Prodromou, C.7
Pearl, L.H.8
-
97
-
-
0032959590
-
Structural basis for inhibition of the hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin
-
Roe, S.M., Prodromou, C., O'Brien, R., Ladbury, J.E., Piper, P.W., and Pearl, L.H. (1999) Structural basis for inhibition of the hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin. J Med Chem, 42, 260-266
-
(1999)
J Med Chem
, vol.42
, pp. 260-266
-
-
Roe, S.M.1
Prodromou, C.2
O'Brien, R.3
Ladbury, J.E.4
Piper, P.W.5
Pearl, L.H.6
-
98
-
-
33745071182
-
Potentiation of paclitaxel activity by the HSP90 inhibitor 17-Allylamino-17-demethoxygeldanamycin in human ovarian carcinoma cell lines with high levels of activated AKT
-
Sain, N., Krishnan, B., Ormerod, M.G., De, R.A., Liu, W.M., Kaye, S.B., Workman, P., and Jackman, A.L. (2006) Potentiation of paclitaxel activity by the HSP90 inhibitor 17-Allylamino-17-demethoxygeldanamycin in human ovarian carcinoma cell lines with high levels of activated AKT. Mol Cancer Ther, 5, 1197-1208
-
(2006)
Mol Cancer Ther
, vol.5
, pp. 1197-1208
-
-
Sain, N.1
Krishnan, B.2
Ormerod, M.G.3
De, R.A.4
Liu, W.M.5
Kaye, S.B.6
Workman, P.7
Jackman, A.L.8
-
99
-
-
39049150922
-
Inhibition of hsp90 down-regulates mutant epidermal growth factor receptor(EGFR) expression and sensitizes EGFR mutant tumors to paclitaxel
-
Sawai, A., Chandarlapaty, S., Greulich, H., Gonen, M., Ye, Q., Arteaga, C.L., Sellers, W., Rosen, N., and Solit, D.B. (2008) Inhibition of hsp90 down-regulates mutant epidermal growth factor receptor(EGFR) expression and sensitizes EGFR mutant tumors to paclitaxel. Cancer Res, 68, 589-596
-
(2008)
Cancer Res
, vol.68
, pp. 589-596
-
-
Sawai, A.1
Chandarlapaty, S.2
Greulich, H.3
Gonen, M.4
Ye, Q.5
Arteaga, C.L.6
Sellers, W.7
Rosen, N.8
Solit, D.B.9
-
100
-
-
0031844350
-
Antibiotic radicicol binds to the N-Terminal domain of hsp90 and shares important biologic activities with geldanamycin
-
Schulte, T.W., Akinaga, S., Soga, S., Sullivan, W., Stensgard, B., Toft, D., and Neckers, L.M. (1998) Antibiotic radicicol binds to the N-Terminal domain of hsp90 and shares important biologic activities with geldanamycin. Cell Stress Chaperones, 3, 100-108
-
(1998)
Cell Stress Chaperones
, vol.3
, pp. 100-108
-
-
Schulte, T.W.1
Akinaga, S.2
Soga, S.3
Sullivan, W.4
Stensgard, B.5
Toft, D.6
Neckers, L.M.7
-
101
-
-
33846014703
-
An acetylation site in the middle domain of hsp90 regulates chaperone function
-
Scroggins, B.T., Robzyk, K., Wang, D., Marcu, M.G., Tsutsumi, S., Beebe, K., Cotter, R.J., Felts, S., Toft, D., Karnitz, L., Rosen, N., and Neckers, L. (2007) An acetylation site in the middle domain of hsp90 regulates chaperone function. Mol Cell, 25, 151-159
-
(2007)
Mol Cell
, vol.25
, pp. 151-159
-
-
Scroggins, B.T.1
Robzyk, K.2
Wang, D.3
Marcu, M.G.4
Tsutsumi, S.5
Beebe, K.6
Cotter, R.J.7
Felts, S.8
Toft, D.9
Karnitz, L.10
Rosen, N.11
Neckers, L.12
-
102
-
-
33947210121
-
In vitro biological characterization of a novel, synthetic diaryl pyrazole resorcinol class of heat shock protein 90 inhibitors
-
Sharp, S.Y., Boxall, K., Rowlands, M., Prodromou, C., Roe, S.M., Maloney, A., Powers, M., Clarke, P.A., Box, G., Sanderson, S., Patterson, L., Matthews, T.P., Cheung, K.M., Ball, K., Hayes, A., Raynaud, F., Marais, R., Pearl, L., Eccles, S., Aherne, W., McDonald, E., and Workman, P. (2007a) In vitro biological characterization of a novel, synthetic diaryl pyrazole resorcinol class of heat shock protein 90 inhibitors. Cancer Res, 67, 2206-2216
-
(2007)
Cancer Res
, vol.67
, pp. 2206-2216
-
-
Sharp, S.Y.1
Boxall, K.2
Rowlands, M.3
Prodromou, C.4
Roe, S.M.5
Maloney, A.6
Powers, M.7
Clarke, P.A.8
Box, G.9
Sanderson, S.10
Patterson, L.11
Matthews, T.P.12
Cheung, K.M.13
Ball, K.14
Hayes, A.15
Raynaud, F.16
Marais, R.17
Pearl, L.18
Eccles, S.19
Aherne, W.20
McDonald, E.21
Workman, P.22
more..
-
103
-
-
34248166042
-
Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues
-
Sharp, S.Y., Prodromou, C., Boxall, K., Powers, M.V., Holmes, J.L., Box, G., Matthews, T.P., Cheung, K.M., Kalusa, A., James, K., Hayes, A., Hardcastle, A., Dymock, B., Brough, P.A., Barril, X., Cansfield, J.E., Wright, L., Surgenor, A., Foloppe, N., Hubbard, R.E., Aherne, W., Pearl, L., Jones, K., McDonald, E., Raynaud, F., Eccles, S., Drysdale, M., and Workman, P. (2007b) Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues. Mol Cancer Ther, 6, 1198-1211
-
(2007)
Mol Cancer Ther
, vol.6
, pp. 1198-1211
-
-
Sharp, S.Y.1
Prodromou, C.2
Boxall, K.3
Powers, M.V.4
Holmes, J.L.5
Box, G.6
Matthews, T.P.7
Cheung, K.M.8
Kalusa, A.9
James, K.10
Hayes, A.11
Hardcastle, A.12
Dymock, B.13
Brough, P.A.14
Barril, X.15
Cansfield, J.E.16
Wright, L.17
Surgenor, A.18
Foloppe, N.19
Hubbard, R.E.20
Aherne, W.21
Pearl, L.22
Jones, K.23
McDonald, E.24
Raynaud, F.25
Eccles, S.26
Drysdale, M.27
Workman, P.28
more..
-
104
-
-
0032031725
-
Molecular chaperones as HSF1-specific transcriptional repressors
-
Shi, Y., Mosser, D.D., and Morimoto, R.I. (1998) Molecular chaperones as HSF1-specific transcriptional repressors. Genes Dev, 12, 654-666
-
(1998)
Genes Dev
, vol.12
, pp. 654-666
-
-
Shi, Y.1
Mosser, D.D.2
Morimoto, R.I.3
-
105
-
-
33750008686
-
Structural analysis of E Coli hsp90 reveals dramatic nucleotide-dependent conformational rearrangements
-
Shiau, A.K., Harris, S.F., Southworth, D.R., and Agard, D.A. (2006) Structural analysis of E. Coli hsp90 reveals dramatic nucleotide-dependent conformational rearrangements. Cell, 127, 329-340
-
(2006)
Cell
, vol.127
, pp. 329-340
-
-
Shiau, A.K.1
Harris, S.F.2
Southworth, D.R.3
Agard, D.A.4
-
106
-
-
0028828273
-
Progesterone receptor structure and function altered by geldanamycin, an hsp90-binding agent
-
Smith, D.F., Whitesell, L., Nair, S.C., Chen, S., Prapapanich, V., and Rimerman, R.A. (1995) Progesterone receptor structure and function altered by geldanamycin, an hsp90-binding agent. Mol Cell Biol, 15, 6804-6812
-
(1995)
Mol Cell Biol
, vol.15
, pp. 6804-6812
-
-
Smith, D.F.1
Whitesell, L.2
Nair, S.C.3
Chen, S.4
Prapapanich, V.5
Rimerman, R.A.6
-
107
-
-
33746040516
-
Preclinical pharmacokinetics and metabolism of a novel diaryl pyrazole resorcinol series of heat shock protein 90 inhibitors
-
Smith, N.F., Hayes, A., James, K., Nutley, B.P., McDonald, E., Henley, A., Dymock, B., Drysdale, M.J., Raynaud, F.I., and Workman, P. (2006) Preclinical pharmacokinetics and metabolism of a novel diaryl pyrazole resorcinol series of heat shock protein 90 inhibitors. Mol Cancer Ther, 5, 1628-1637
-
(2006)
Mol Cancer Ther
, vol.5
, pp. 1628-1637
-
-
Smith, N.F.1
Hayes, A.2
James, K.3
Nutley, B.P.4
McDonald, E.5
Henley, A.6
Dymock, B.7
Drysdale, M.J.8
Raynaud, F.I.9
Workman, P.10
-
108
-
-
0033564430
-
KF25706, a novel oxime derivative of radicicol, exhibits in vivo antitumor activity via selective depletion of hsp90 binding signaling molecules
-
Soga, S., Neckers, L.M., Schulte, T.W., Shiotsu, Y., Akasaka, K., Narumi, H., Agatsuma, T., Ikuina, Y., Murakata, C., Tamaoki, T., and Akinaga, S. (1999) KF25706, a novel oxime derivative of radicicol, exhibits in vivo antitumor activity via selective depletion of hsp90 binding signaling molecules. Cancer Res, 59, 2931-2938
-
(1999)
Cancer Res
, vol.59
, pp. 2931-2938
-
-
Soga, S.1
Neckers, L.M.2
Schulte, T.W.3
Shiotsu, Y.4
Akasaka, K.5
Narumi, H.6
Agatsuma, T.7
Ikuina, Y.8
Murakata, C.9
Tamaoki, T.10
Akinaga, S.11
-
109
-
-
0035206178
-
Stereospecific antitumor activity of radicicol oxime derivatives
-
Soga, S., Sharma, S.V., Shiotsu, Y., Shimizu, M., Tahara, H., Yamaguchi, K., Ikuina, Y., Murakata, C., Tamaoki, T., Kurebayashi, J., Schulte, T.W., Neckers, L.M., and Akinaga, S. (2001) Stereospecific antitumor activity of radicicol oxime derivatives. Cancer Chemother Pharmacol, 48, 435-445
-
(2001)
Cancer Chemother Pharmacol
, vol.48
, pp. 435-445
-
-
Soga, S.1
Sharma, S.V.2
Shiotsu, Y.3
Shimizu, M.4
Tahara, H.5
Yamaguchi, K.6
Ikuina, Y.7
Murakata, C.8
Tamaoki, T.9
Kurebayashi, J.10
Schulte, T.W.11
Neckers, L.M.12
Akinaga, S.13
-
110
-
-
18244378478
-
Phase 1 pharmacokinetic and pharmacodynamic trial of docetaxel and 17-AAG(17-Allylamino-17-demethoxygeldanamcyin [abstract 3032
-
Solit, D.B., Egorin, M., Valentin, G., Delacruz, A., Ye, Q., Schwartz, L., Larson, S., Rosen, N., and Scher, H.I (2004) Phase 1 pharmacokinetic and pharmacodynamic trial of docetaxel and 17-AAG(17-Allylamino-17- demethoxygeldanamcyin) [abstract 3032]. Proc Am Soc Clin Oncol, 23, 203
-
(2004)
Proc Am Soc Clin Oncol
, vol.23
, pp. 203
-
-
Solit, D.B.1
Egorin, M.2
Valentin, G.3
Delacruz, A.4
Ye, Q.5
Schwartz, L.6
Larson, S.7
Rosen, N.8
Scher, H.I.9
-
111
-
-
33746417580
-
Hsp90: A novel target for cancer therapy
-
Solit, D.B. and Rosen, N. (2006) Hsp90: A novel target for cancer therapy. Curr Top Med Chem, 6, 1205-1214
-
(2006)
Curr Top Med Chem
, vol.6
, pp. 1205-1214
-
-
Solit, D.B.1
Rosen, N.2
-
112
-
-
0036091221
-
17-Allylamino-17-demethoxygeldanamycin induces the degradation of androgen receptor and HER-2/neu and inhibits the growth of prostate cancer xenografts
-
Solit, D.B., Zheng, F.F., Drobnjak, M., Munster, P.N., Higgins, B., Verbel, D., Heller, G., Tong, W., Cordon-Cardo, C., Agus, D.B., Scher, H.I., and Rosen, N. (2002) 17-Allylamino-17-demethoxygeldanamycin induces the degradation of androgen receptor and HER-2/neu and inhibits the growth of prostate cancer xenografts. Clin. Cancer Res, 8, 986-993
-
(2002)
Clin. Cancer Res
, vol.8
, pp. 986-993
-
-
Solit, D.B.1
Zheng, F.F.2
Drobnjak, M.3
Munster, P.N.4
Higgins, B.5
Verbel, D.6
Heller, G.7
Tong, W.8
Cordon-Cardo, C.9
Agus, D.B.10
Scher, H.I.11
Rosen, N.12
-
113
-
-
1642268986
-
Hsp90 isoforms: Functions, expression and clinical importance
-
Sreedhar, A.S., Kalmar, E., Csermely, P., and Shen, Y.F. (2004a) Hsp90 isoforms: Functions, expression and clinical importance. FEBS Lett, 562, 11-15
-
(2004)
FEBS Lett
, vol.562
, pp. 11-15
-
-
Sreedhar, A.S.1
Kalmar, E.2
Csermely, P.3
Shen, Y.F.4
-
114
-
-
1542328907
-
Inhibition of hsp90: A new strategy for inhibiting protein kinases
-
Sreedhar, A.S., Soti, C., and Csermely, P. (2004b) Inhibition of hsp90: A new strategy for inhibiting protein kinases. Biochim Biophys Acta, 1697, 233-242
-
(2004)
Biochim Biophys Acta
, vol.1697
, pp. 233-242
-
-
Sreedhar, A.S.1
Soti, C.2
Csermely, P.3
-
115
-
-
0031005361
-
Crystal structure of an hsp90-geldanamycin complex: Targeting of a protein chaperone by an antitumor agent
-
Stebbins, C.E., Russo, A.A., Schneider, C., Rosen, N., Hartl, F.U., and Pavletich, N.P. (1997) Crystal structure of an hsp90-geldanamycin complex: Targeting of a protein chaperone by an antitumor agent. Cell, 89, 239-250
-
(1997)
Cell
, vol.89
, pp. 239-250
-
-
Stebbins, C.E.1
Russo, A.A.2
Schneider, C.3
Rosen, N.4
Hartl, F.U.5
Pavletich, N.P.6
-
116
-
-
0029056501
-
Preclinical pharmacologic evaluation of geldanamycin as an antitumor agent
-
Supko, J.G., Hickman, R.L., Grever, M.R., and Malspeis, L. (1995) Preclinical pharmacologic evaluation of geldanamycin as an antitumor agent. Cancer Chemother Pharmacol, 36, 305-315
-
(1995)
Cancer Chemother Pharmacol
, vol.36
, pp. 305-315
-
-
Supko, J.G.1
Hickman, R.L.2
Grever, M.R.3
Malspeis, L.4
-
117
-
-
0028979675
-
A mechanism for the specific immunogenicity of heat shock protein-chaperoned peptides
-
Suto, R. and Srivastava, P.K. (1995) A mechanism for the specific immunogenicity of heat shock protein-chaperoned peptides. Science, 269, 1585-1588
-
(1995)
Science
, vol.269
, pp. 1585-1588
-
-
Suto, R.1
Srivastava, P.K.2
-
118
-
-
33751258297
-
Development of 17-Allylamino-17-demethoxygeldanamycin hydroquinone hydrochloride(IPI-504), an anti-cancer agent directed against hsp90
-
Sydor, J.R., Normant, E., Pien, C.S., Porter, J.R., Ge, J., Grenier, L., Pak, R.H., Ali, J.A., Dembski, M.S., Hudak, J., Patterson, J., Penders, C., Pink, M., Read, M.A., Sang, J., Woodward, C., Zhang, Y., Grayzel, D.S., Wright, J., Barrett, J.A., Palombella, V.J., Adams, J., and Tong, J.K. (2006) Development of 17-Allylamino-17-demethoxygeldanamycin hydroquinone hydrochloride(IPI-504), an anti-cancer agent directed against hsp90. Proc Natl Acad Sci U S A, 103, 17408-17413
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 17408-17413
-
-
Sydor, J.R.1
Normant, E.2
Pien, C.S.3
Porter, J.R.4
Ge, J.5
Grenier, L.6
Pak, R.H.7
Ali, J.A.8
Dembski, M.S.9
Hudak, J.10
Patterson, J.11
Penders, C.12
Pink, M.13
Read, M.A.14
Sang, J.15
Woodward, C.16
Zhang, Y.17
Grayzel, D.S.18
Wright, J.19
Barrett, J.A.20
Palombella, V.J.21
Adams, J.22
Tong, J.K.23
more..
-
119
-
-
0038069088
-
Geldanamycin and its 17-Allylamino-17-demethoxy analogue antagonize the action of cisplatin in human colon adenocarcinoma cells: Differential caspase activation as a basis for interaction
-
Vasilevskaya, I.A., Rakitina, T.V., and O'Dwyer, P.J. (2003) Geldanamycin and its 17-Allylamino-17-demethoxy analogue antagonize the action of cisplatin in human colon adenocarcinoma cells: Differential caspase activation as a basis for interaction. Cancer Res, 63, 3241-3246
-
(2003)
Cancer Res
, vol.63
, pp. 3241-3246
-
-
Vasilevskaya, I.A.1
Rakitina, T.V.2
O'Dwyer, P.J.3
-
120
-
-
1642576969
-
Quantitative effects on c-Jun N-Terminal protein kinase signaling determine synergistic interaction of cisplatin and 17-Allylamino-17- demethoxygeldanamycin in colon cancer cell lines
-
Vasilevskaya, I.A., Rakitina, T.V., and O'Dwyer, P.J. (2004) Quantitative effects on c-Jun N-Terminal protein kinase signaling determine synergistic interaction of cisplatin and 17-Allylamino-17-demethoxygeldanamycin in colon cancer cell lines. Mol Pharmacol, 65, 235-243
-
(2004)
Mol Pharmacol
, vol.65
, pp. 235-243
-
-
Vasilevskaya, I.A.1
Rakitina, T.V.2
O'Dwyer, P.J.3
-
121
-
-
34948853214
-
GRP94 is essential for mesoderm induction and muscle development because it regulates insulin-like growth factor secretion
-
Wanderling, S., Simen, B.B., Ostrovsky, O., Ahmed, N.T., Vogen, S.M., Gidalevitz, T., and Argon, Y. (2007) GRP94 is essential for mesoderm induction and muscle development because it regulates insulin-like growth factor secretion. Mol Biol Cell, 18, 3764-3775
-
(2007)
Mol Biol Cell
, vol.18
, pp. 3764-3775
-
-
Wanderling, S.1
Simen, B.B.2
Ostrovsky, O.3
Ahmed, N.T.4
Vogen, S.M.5
Gidalevitz, T.6
Argon, Y.7
-
122
-
-
31444454302
-
The phosphatase ppt1 is a dedicated regulator of the molecular chaperone hsp90
-
Wandinger, S.K., Suhre, M.H., Wegele, H., and Buchner, J. (2006) The phosphatase ppt1 is a dedicated regulator of the molecular chaperone hsp90. Embo J, 25, 367-376
-
(2006)
Embo J
, vol.25
, pp. 367-376
-
-
Wandinger, S.K.1
Suhre, M.H.2
Wegele, H.3
Buchner, J.4
-
123
-
-
4644278673
-
Hsp70 and hsp90-A relay team for protein folding
-
Wegele, H., Muller, L., and Buchner, J. (2004) Hsp70 and hsp90-A relay team for protein folding. Rev Physiol Biochem Pharmacol, 151, 1-44
-
(2004)
Rev Physiol Biochem Pharmacol
, vol.151
, pp. 1-44
-
-
Wegele, H.1
Muller, L.2
Buchner, J.3
-
124
-
-
3042637928
-
Structure-Activity relationships in purine-based inhibitor binding to HSP90 isoforms
-
Wright, L., Barril, X., Dymock, B., Sheridan, L., Surgenor, A., Beswick, M., Drysdale, M., Collier, A., Massey, A., Davies, N., Fink, A., Fromont, C., Aherne, W., Boxall, K., Sharp, S., Workman, P., and Hubbard, R.E. (2004) Structure-Activity relationships in purine-based inhibitor binding to HSP90 isoforms. Chem Biol, 11, 775-785
-
(2004)
Chem Biol
, vol.11
, pp. 775-785
-
-
Wright, L.1
Barril, X.2
Dymock, B.3
Sheridan, L.4
Surgenor, A.5
Beswick, M.6
Drysdale, M.7
Collier, A.8
Massey, A.9
Davies, N.10
Fink, A.11
Fromont, C.12
Aherne, W.13
Boxall, K.14
Sharp, S.15
Workman, P.16
Hubbard, R.E.17
-
125
-
-
34548588385
-
Sensitivity of epidermal growth factor receptor and ErbB2 exon 20 insertion mutants to hsp90 inhibition
-
Xu, W., Soga, S., Beebe, K., Lee, M.J., Kim, Y.S., Trepel, J., and Neckers, L. (2007) Sensitivity of epidermal growth factor receptor and ErbB2 exon 20 insertion mutants to hsp90 inhibition. Br J Cancer, 97, 741-744
-
(2007)
Br J Cancer
, vol.97
, pp. 741-744
-
-
Xu, W.1
Soga, S.2
Beebe, K.3
Lee, M.J.4
Kim, Y.S.5
Trepel, J.6
Neckers, L.7
-
126
-
-
33646406554
-
Celastrol, a triterpene extracted from the chinese thunder of god vine, is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice
-
Yang, H., Chen, D., Cui, Q.C., Yuan, X., and Dou, Q.P. (2006) Celastrol, a triterpene extracted from the chinese thunder of god vine, is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice. Cancer Res, 66, 4758-4765
-
(2006)
Cancer Res
, vol.66
, pp. 4758-4765
-
-
Yang, H.1
Chen, D.2
Cui, Q.C.3
Yuan, X.4
Dou, Q.P.5
-
127
-
-
5044239107
-
Pathways of chaperone-mediated protein folding in the cytosol
-
Young, J.C., Agashe, V.R., Siegers, K., and Hartl, F.U. (2004) Pathways of chaperone-mediated protein folding in the cytosol. Nat Rev Mol Cell Biol, 5, 781-791
-
(2004)
Nat Rev Mol Cell Biol
, vol.5
, pp. 781-791
-
-
Young, J.C.1
Agashe, V.R.2
Siegers, K.3
Hartl, F.U.4
-
128
-
-
38349153572
-
A novel hsp90 inhibitor to disrupt hsp90/cdc37 complex against pancreatic cancer cells
-
Zhang, T., Hamza, A., Cao, X., Wang, B., Yu, S., Zhan, C.G., and Sun, D. (2008) A novel hsp90 inhibitor to disrupt hsp90/cdc37 complex against pancreatic cancer cells. Mol Cancer Ther, 7, 162-170
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 162-170
-
-
Zhang, T.1
Hamza, A.2
Cao, X.3
Wang, B.4
Yu, S.5
Zhan, C.G.6
Sun, D.7
-
129
-
-
0035980061
-
Hsp90 phosphorylation is linked to its chaperoning function assembly of the reovirus cell attachment protein
-
Zhao, Y.G., Gilmore, R., Leone, G., Coffey, M.C., Weber, B., and Lee, P.W. (2001) Hsp90 phosphorylation is linked to its chaperoning function.
-
(2001)
J Biol Chem
, vol.276
, pp. 32822-32827
-
-
Zhao, Y.G.1
Gilmore, R.2
Leone, G.3
Coffey, M.C.4
Weber, B.5
Lee, P.W.6
|