IC101 induces apoptosis by Akt dephosphorylation via an inhibition of heat shock protein 90-ATP binding activity accompanied by preventing the interaction with Akt in L1210 cells

Journal of Pharmacology and Experimental Therapeutics

Volumn 310, Issue 3, 2004, Pages 1288-1295

  Fujiwara, Hironori ^a   Yamakuni, Tohru ^a   Ueno, Mitsuhiro ^b   Ishizuka, Masaaki ^b   Shinkawa, Takashi ^c   Isobe, Toshiaki ^d   Ohizumi, Yasushi ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b Numazu Bio Medical Research Institute   (Japan)

^c TOKYO METROPOLITAN UNIVERSITY   (Japan)

^d NONE

Author keywords

[No Author keywords available]

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ADENOSINE TRIPHOSPHATE; ANTIBODY; CASPASE 3; CYCLODEPSIPEPTIDE; HEAT SHOCK PROTEIN 90; IC 101; PHOSPHOTYROSINE; PROTEIN BAD; PROTEIN KINASE B; RAF PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CHROMATIN CONDENSATION; COMPLEX FORMATION; CONCENTRATION RESPONSE; DEPHOSPHORYLATION; DNA DETERMINATION; DRUG PROTEIN BINDING; IMMUNOBLOTTING; IMMUNOPRECIPITATION; LIQUID CHROMATOGRAPHY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; STREPTOMYCES; TANDEM MASS SPECTROMETRY;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADENOSINE TRIPHOSPHATE; ANIMALS; APOPTOSIS; BCL-ASSOCIATED DEATH PROTEIN; CARRIER PROTEINS; CASPASE 3; CASPASES; CELL SURVIVAL; DNA FRAGMENTATION; HSP90 HEAT-SHOCK PROTEINS; LEUKEMIA L1210; MICE; PEPTIDES; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-RAF; TUMOR CELLS, CULTURED;

EID: 4243105077     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.104.065979     Document Type: Article

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