-
1
-
-
33746191768
-
Inhibitors of the HSP90 molecular chaperone: Current status
-
Sharp S, Workman P. Inhibitors of the HSP90 molecular chaperone: current status. Adv Cancer Res 2006;95:323-48.
-
(2006)
Adv Cancer Res
, vol.95
, pp. 323-348
-
-
Sharp, S.1
Workman, P.2
-
2
-
-
33846861747
-
Targeting of multiple signalling pathways by heat shock protein 90 molecular chaperone inhibitors
-
Powers MV, Workman P. Targeting of multiple signalling pathways by heat shock protein 90 molecular chaperone inhibitors. Endocr Relat Cancer 2006;13 Suppl 1:S125-35.
-
(2006)
Endocr Relat Cancer
, vol.13
, Issue.SUPPL. 1
-
-
Powers, M.V.1
Workman, P.2
-
3
-
-
35348890981
-
Drugging the cancer chaperone HSP90: Combinatorial therapeutic exploitation of oncogene addiction and tumor stress
-
Workman P, Burrows F, Neckers L, Rosen N. Drugging the cancer chaperone HSP90: combinatorial therapeutic exploitation of oncogene addiction and tumor stress. Ann NY Acad Sci 2007;1113:202-16.
-
(2007)
Ann NY Acad Sci
, vol.1113
, pp. 202-216
-
-
Workman, P.1
Burrows, F.2
Neckers, L.3
Rosen, N.4
-
4
-
-
23044441106
-
Phase I pharmacokinetic and pharmacodynamic study of 17-allylamino, 17-demethoxygeldanamycin in patients with advanced malignancies
-
Banerji U, O'Donnell A, Scurr M, et al. Phase I pharmacokinetic and pharmacodynamic study of 17-allylamino, 17-demethoxygeldanamycin in patients with advanced malignancies. J Clin Oncol 2005;23:4152-61.
-
(2005)
J Clin Oncol
, vol.23
, pp. 4152-4161
-
-
Banerji, U.1
O'Donnell, A.2
Scurr, M.3
-
5
-
-
20044384168
-
Phase I trial of 17-allylamino-17- demethoxygeldanamycin in patients with advanced cancer
-
Goetz MP, Toft D, Reid J, et al. Phase I trial of 17-allylamino-17- demethoxygeldanamycin in patients with advanced cancer. J Clin Oncol 2005;23:1078-87.
-
(2005)
J Clin Oncol
, vol.23
, pp. 1078-1087
-
-
Goetz, M.P.1
Toft, D.2
Reid, J.3
-
6
-
-
20944444881
-
Phase I pharmacokinetic- pharmacodynamic study of 17-(allylamino)-17-demethoxygeldanamycin (17AAG, NSC 330507), a novel inhibitor of heat shock protein 90, in patients with refractory advanced cancers
-
Ramanathan RK, Trump DL, Eiseman JL, et al. Phase I pharmacokinetic- pharmacodynamic study of 17-(allylamino)-17-demethoxygeldanamycin (17AAG, NSC 330507), a novel inhibitor of heat shock protein 90, in patients with refractory advanced cancers. Clin Cancer Res 2005;11:3385-91.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 3385-3391
-
-
Ramanathan, R.K.1
Trump, D.L.2
Eiseman, J.L.3
-
7
-
-
20144375312
-
Phase I and pharmacologic study of 17-(allylamino)-17-demethoxygeldanamycin in adult patients with solid tumors
-
Grem JL, Morrison G, Guo XD, et al. Phase I and pharmacologic study of 17-(allylamino)-17-demethoxygeldanamycin in adult patients with solid tumors. J Clin Oncol 2005;23:1885-93.
-
(2005)
J Clin Oncol
, vol.23
, pp. 1885-1893
-
-
Grem, J.L.1
Morrison, G.2
Guo, X.D.3
-
8
-
-
34250197902
-
Phase I trial of 17-allylamino-17- demethoxygeldanamycin in patients with advanced cancer
-
Solit DB, Ivy SP, Kopil C, et al. Phase I trial of 17-allylamino-17- demethoxygeldanamycin in patients with advanced cancer. Clin Cancer Res 2007;13:1775-82.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 1775-1782
-
-
Solit, D.B.1
Ivy, S.P.2
Kopil, C.3
-
9
-
-
0036132096
-
Estimates of the world-wide prevalence of cancer for 25 sites in the adult population
-
Pisani P, Bray F, Parkin DM. Estimates of the world-wide prevalence of cancer for 25 sites in the adult population. Int J Cancer 2002;97:72-81.
-
(2002)
Int J Cancer
, vol.97
, pp. 72-81
-
-
Pisani, P.1
Bray, F.2
Parkin, D.M.3
-
10
-
-
34548543781
-
Durable complete responses with high-dose bolus interleukin-2 in patients with metastatic melanoma who have experienced progression after biochemotherapy
-
Tarhini AA, Kirkwood JM, Gooding WE, Cai C, Agarwala SS. Durable complete responses with high-dose bolus interleukin-2 in patients with metastatic melanoma who have experienced progression after biochemotherapy. J Clin Oncol 2007;25:3802-7.
-
(2007)
J Clin Oncol
, vol.25
, pp. 3802-3807
-
-
Tarhini, A.A.1
Kirkwood, J.M.2
Gooding, W.E.3
Cai, C.4
Agarwala, S.S.5
-
11
-
-
18444374405
-
Mutations of the BRAF gene in human cancer
-
Davies H, Bignell GR, Cox C, et al. Mutations of the BRAF gene in human cancer. Nature 2002;417:949-54.
-
(2002)
Nature
, vol.417
, pp. 949-954
-
-
Davies, H.1
Bignell, G.R.2
Cox, C.3
-
12
-
-
33845592531
-
NRAS and BRAF mutations in melanoma tumours in relation to clinical characteristics: A study based on mutation screening by pyrosequencing
-
Edlundh-Rose E, Egyhazi S, Omholt K, et al. NRAS and BRAF mutations in melanoma tumours in relation to clinical characteristics: a study based on mutation screening by pyrosequencing. Melanoma Res 2006;16:471-8.
-
(2006)
Melanoma Res
, vol.16
, pp. 471-478
-
-
Edlundh-Rose, E.1
Egyhazi, S.2
Omholt, K.3
-
13
-
-
33644774541
-
Examination of mutations in BRAF, NRAS, PTEN in primary cutaneous melanoma
-
Goel VK, Lazar AJ, Warneke CL, Redston MS, Haluska FG. Examination of mutations in BRAF, NRAS, PTEN in primary cutaneous melanoma. J Invest Dermatol 2006;126:154-60.
-
(2006)
J Invest Dermatol
, vol.126
, pp. 154-160
-
-
Goel, V.K.1
Lazar, A.J.2
Warneke, C.L.3
Redston, M.S.4
Haluska, F.G.5
-
14
-
-
1342330881
-
Frequent alterations of Ras signaling pathway genes in sporadic malignant melanomas
-
Reifenberger J, Knobbe CB, Sterzinger AA, et al. Frequent alterations of Ras signaling pathway genes in sporadic malignant melanomas. Int J Cancer 2004;109:377-84.
-
(2004)
Int J Cancer
, vol.109
, pp. 377-384
-
-
Reifenberger, J.1
Knobbe, C.B.2
Sterzinger, A.A.3
-
15
-
-
33846201272
-
New insight into BRAF mutations in cancer
-
Dhomen N, Marais R. New insight into BRAF mutations in cancer. Curr Opin Genet Dev 2007;17:31-9.
-
(2007)
Curr Opin Genet Dev
, vol.17
, pp. 31-39
-
-
Dhomen, N.1
Marais, R.2
-
16
-
-
30444441778
-
V600E B-Raf requires the Hsp90 chaperone for stability and is degraded in response to Hsp90 inhibitors
-
Grbovic OM, Basso AD, Sawai A, et al. V600E B-Raf requires the Hsp90 chaperone for stability and is degraded in response to Hsp90 inhibitors. Proc Natl Acad Sci U S A 2006;103:57-62.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 57-62
-
-
Grbovic, O.M.1
Basso, A.D.2
Sawai, A.3
-
17
-
-
28244444919
-
Activated B-RAF is an Hsp90 client protein that is targeted by the anticancer drug 17-allylamino-17-demethoxygeldanamycin
-
da Rocha Dias S, Friedlos F, Light Y, Springer C, Workman P, Marais R. Activated B-RAF is an Hsp90 client protein that is targeted by the anticancer drug 17-allylamino-17-demethoxygeldanamycin. Cancer Res 2005;65:10686-91.
-
(2005)
Cancer Res
, vol.65
, pp. 10686-10691
-
-
da Rocha Dias, S.1
Friedlos, F.2
Light, Y.3
Springer, C.4
Workman, P.5
Marais, R.6
-
18
-
-
26444482073
-
Pharmacokinetic-pharmacodynamic relationships for the heat shock protein 90 molecular chaperone inhibitor 17-allylamino, 17-demethoxygeldanamycin in human ovarian cancer xenograft models
-
Banerji U, Walton M, Raynaud F, et al. Pharmacokinetic-pharmacodynamic relationships for the heat shock protein 90 molecular chaperone inhibitor 17-allylamino, 17-demethoxygeldanamycin in human ovarian cancer xenograft models. Clin Cancer Res 2005;11:7023-32.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 7023-7032
-
-
Banerji, U.1
Walton, M.2
Raynaud, F.3
-
20
-
-
0035881074
-
Final version of the American Joint Committee on Cancer staging system for cutaneous melanoma
-
Balch CM, Buzaid AC, Soong SJ, et al. Final version of the American Joint Committee on Cancer staging system for cutaneous melanoma. J Clin Oncol 2001;19:3635-48.
-
(2001)
J Clin Oncol
, vol.19
, pp. 3635-3648
-
-
Balch, C.M.1
Buzaid, A.C.2
Soong, S.J.3
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