Expressed as the sole Hsp90 of yeast, the α and β isoforms of human Hsp90 differ with regard to their capacities for activation of certain client proteins, whereas only Hsp90β generates sensitivity to the Hsp90 inhibitor radicicol

FEBS Journal

Volumn 274, Issue 17, 2007, Pages 4453-4463

  Millson, Stefan H ^a   Truman, Andrew W ^a   Rácz, Attila ^b   Hu, Bin ^c   Panaretou, Barry ^c   Nuttall, James ^a   Mollapour, Mehdi ^a   Söti, Csaba ^b   Piper, Peter W ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b SEMMELWEIS UNIVERSITY   (Hungary)

^c KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Chaperone inhibitor; Human heat shock protein 90 chaperone; Isoforms of heat shock protein 90; Radicicol; Yeast expression

Indexed keywords

GLUCOCORTICOID RECEPTOR; HEAT SHOCK PROTEIN 90; HEAT SHOCK PROTEIN 90 ALPHA; HEAT SHOCK PROTEIN 90 BETA; HEAT SHOCK TRANSCRIPTION FACTOR 1; ISOPROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 7; RADICICOL; UNCLASSIFIED DRUG;

ARTICLE; CELL SPECIFICITY; CONTROLLED STUDY; DRUG SENSITIVITY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MAMMAL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; TISSUE SPECIFICITY; VERTEBRATE; YEAST;

BASE SEQUENCE; BLOTTING, WESTERN; DNA PRIMERS; HSP90 HEAT-SHOCK PROTEINS; HUMANS; MACROLIDES; MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN ISOFORMS; RECOMBINANT PROTEINS; SACCHAROMYCES CEREVISIAE; TWO-HYBRID SYSTEM TECHNIQUES;

EUKARYOTA; MAMMALIA; VERTEBRATA;

EID: 34548131162     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2007.05974.x     Document Type: Article

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