메뉴 건너뛰기




Volumn 70, Issue 24, 2013, Pages 4759-4770

The therapeutic potential of GPR43: A novel role in modulating metabolic health

Author keywords

Adipogenesis; GPR43; Muscle; Obesity; Short chain fatty acids

Indexed keywords

G PROTEIN COUPLED RECEPTOR 43; REGULATOR PROTEIN; SHORT CHAIN FATTY ACID; UNCLASSIFIED DRUG;

EID: 84889881184     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-013-1419-9     Document Type: Review
Times cited : (7)

References (127)
  • 1
    • 33749521608 scopus 로고    scopus 로고
    • Latest development in drug discovery on G protein-coupled receptors
    • 17073697 1:CAS:528:DC%2BD28XhtVamsLvO
    • Lundstrom K (2006) Latest development in drug discovery on G protein-coupled receptors. Curr Protein Pept Sci 7(5):465-470
    • (2006) Curr Protein Pept Sci , vol.7 , Issue.5 , pp. 465-470
    • Lundstrom, K.1
  • 2
    • 0038491435 scopus 로고    scopus 로고
    • Functional characterization of human receptors for short-chain fatty acids and their role in polymorphonuclear cell activation
    • 12711604
    • Le Poul E et al (2003) Functional characterization of human receptors for short-chain fatty acids and their role in polymorphonuclear cell activation. J Biol Chem 278(28):25481-25489
    • (2003) J Biol Chem , vol.278 , Issue.28 , pp. 25481-25489
    • Le Poul, E.1
  • 3
    • 0038363378 scopus 로고    scopus 로고
    • The orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short-chain carboxylic acids
    • 12496283 1:CAS:528:DC%2BD3sXit1Kgsbc%3D
    • Brown AJ et al (2003) The orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short-chain carboxylic acids. J Biol Chem 278(13):11312-11319
    • (2003) J Biol Chem , vol.278 , Issue.13 , pp. 11312-11319
    • Brown, A.J.1
  • 4
    • 0023276469 scopus 로고
    • Short-chain fatty acids in human large intestine, portal, hepatic and venous blood
    • 3678950 1:STN:280:DyaL1c%2Fls1CrsA%3D%3D
    • Cummings JH et al (1987) Short-chain fatty acids in human large intestine, portal, hepatic and venous blood. Gut 28(10):1221-1227
    • (1987) Gut , vol.28 , Issue.10 , pp. 1221-1227
    • Cummings, J.H.1
  • 5
    • 80054980812 scopus 로고    scopus 로고
    • Regulation of inflammation by short-chain fatty acids
    • 22254083 1:CAS:528:DC%2BC3MXhsVKju7nJ
    • Vinolo MA et al (2011) Regulation of inflammation by short-chain fatty acids. Nutrients 3(10):858-876
    • (2011) Nutrients , vol.3 , Issue.10 , pp. 858-876
    • Vinolo, M.A.1
  • 6
    • 57049182455 scopus 로고    scopus 로고
    • Dietary resistant starch upregulates total GLP-1 and PYY in a sustained day-long manner through fermentation in rodents
    • 18796545 1:CAS:528:DC%2BD1cXhsVWku77P
    • Zhou J et al (2008) Dietary resistant starch upregulates total GLP-1 and PYY in a sustained day-long manner through fermentation in rodents. Am J Physiol Endocrinol Metab 295(5):E1160-E1166
    • (2008) Am J Physiol Endocrinol Metab , vol.295 , Issue.5
    • Zhou, J.1
  • 7
    • 33846827097 scopus 로고    scopus 로고
    • Effects of resistant starch, a non-digestible fermentable fiber, on reducing body fat
    • 1:CAS:528:DC%2BD28Xht1WjsLzN
    • Keenan MJ et al (2006) Effects of resistant starch, a non-digestible fermentable fiber, on reducing body fat. Obesity (Silver Spring) 14(9):1523-1534
    • (2006) Obesity (Silver Spring) , vol.14 , Issue.9 , pp. 1523-1534
    • Keenan, M.J.1
  • 8
    • 84867404198 scopus 로고    scopus 로고
    • Gut microbiota-derived propionate reduces cancer cell proliferation in the liver
    • 22976799 1:CAS:528:DC%2BC38XhsFSgtb7K
    • Bindels LB et al (2012) Gut microbiota-derived propionate reduces cancer cell proliferation in the liver. Br J Cancer 107(8):1337-1344
    • (2012) Br J Cancer , vol.107 , Issue.8 , pp. 1337-1344
    • Bindels, L.B.1
  • 9
    • 34347223232 scopus 로고    scopus 로고
    • Anti-inflammatory properties of the short-chain fatty acids acetate and propionate: A study with relevance to inflammatory bowel disease
    • 17569118 1:CAS:528:DC%2BD2sXot1antrs%3D
    • Tedelind S et al (2007) Anti-inflammatory properties of the short-chain fatty acids acetate and propionate: a study with relevance to inflammatory bowel disease. World J Gastroenterol 13(20):2826-2832
    • (2007) World J Gastroenterol , vol.13 , Issue.20 , pp. 2826-2832
    • Tedelind, S.1
  • 10
    • 84855206779 scopus 로고    scopus 로고
    • Regulation of inflammatory responses by the commensal microbiota
    • 21825084
    • Marsland BJ (2012) Regulation of inflammatory responses by the commensal microbiota. Thorax 67(1):93-94
    • (2012) Thorax , vol.67 , Issue.1 , pp. 93-94
    • Marsland, B.J.1
  • 11
    • 0036252352 scopus 로고    scopus 로고
    • The effects of short-chain fatty acids on human colon cancer cell phenotype are associated with histone hyperacetylation
    • 11983830 1:CAS:528:DC%2BD38XjvFSnsbg%3D
    • Hinnebusch BF et al (2002) The effects of short-chain fatty acids on human colon cancer cell phenotype are associated with histone hyperacetylation. J Nutr 132(5):1012-1017
    • (2002) J Nutr , vol.132 , Issue.5 , pp. 1012-1017
    • Hinnebusch, B.F.1
  • 12
    • 84876018174 scopus 로고    scopus 로고
    • GPR43/FFA2: Physiopathological relevance and therapeutic prospects
    • 23489932 1:CAS:528:DC%2BC3sXjvVOrsrk%3D
    • Bindels LB, Dewulf EM, Delzenne NM (2013) GPR43/FFA2: physiopathological relevance and therapeutic prospects. Trends Pharmacol Sci 34(4):226-232
    • (2013) Trends Pharmacol Sci , vol.34 , Issue.4 , pp. 226-232
    • Bindels, L.B.1    Dewulf, E.M.2    Delzenne, N.M.3
  • 13
    • 0037453280 scopus 로고    scopus 로고
    • Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids
    • 12684041 1:CAS:528:DC%2BD3sXis12gsbc%3D
    • Nilsson NE et al (2003) Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids. Biochem Biophys Res Commun 303(4):1047-1052
    • (2003) Biochem Biophys Res Commun , vol.303 , Issue.4 , pp. 1047-1052
    • Nilsson, N.E.1
  • 14
    • 0742305675 scopus 로고    scopus 로고
    • Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41
    • 14722361 1:CAS:528:DC%2BD2cXhtFSkt74%3D
    • Xiong Y et al (2004) Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41. Proc Natl Acad Sci USA 101(4):1045-1050
    • (2004) Proc Natl Acad Sci USA , vol.101 , Issue.4 , pp. 1045-1050
    • Xiong, Y.1
  • 15
    • 57049170465 scopus 로고    scopus 로고
    • Fatty acid binding receptors and their physiological role in type 2 diabetes
    • 1:CAS:528:DC%2BD1cXhsFCqtL7P
    • Swaminath G (2008) Fatty acid binding receptors and their physiological role in type 2 diabetes. Arch Pharm (Weinheim) 341(12):753-761
    • (2008) Arch Pharm (Weinheim) , vol.341 , Issue.12 , pp. 753-761
    • Swaminath, G.1
  • 16
    • 51449119654 scopus 로고    scopus 로고
    • Roles of short-chain fatty acids receptors, GPR41 and GPR43 on colonic functions
    • 18812643
    • Tazoe H et al (2008) Roles of short-chain fatty acids receptors, GPR41 and GPR43 on colonic functions. J Physiol Pharmacol 59(Suppl 2):251-262
    • (2008) J Physiol Pharmacol , vol.59 , Issue.SUPPL. 2 , pp. 251-262
    • Tazoe, H.1
  • 17
    • 84870361150 scopus 로고    scopus 로고
    • Extracellular ionic locks determine variation in constitutive activity and ligand potency between species orthologs of the free fatty acid receptors FFA2 and FFA3
    • 23066016 1:CAS:528:DC%2BC38XhslGjs7fI
    • Hudson BD et al (2012) Extracellular ionic locks determine variation in constitutive activity and ligand potency between species orthologs of the free fatty acid receptors FFA2 and FFA3. J Biol Chem 287(49):41195-41209
    • (2012) J Biol Chem , vol.287 , Issue.49 , pp. 41195-41209
    • Hudson, B.D.1
  • 18
    • 0037509909 scopus 로고    scopus 로고
    • Regulation of short-chain fatty acid production
    • 12740060 1:CAS:528:DC%2BD3sXjslyhtLc%3D
    • Macfarlane S, Macfarlane GT (2003) Regulation of short-chain fatty acid production. Proc Nutr Soc 62(1):67-72
    • (2003) Proc Nutr Soc , vol.62 , Issue.1 , pp. 67-72
    • Macfarlane, S.1    Macfarlane, G.T.2
  • 19
    • 0021801223 scopus 로고
    • Carbohydrate fermentation in the human colon and its relation to acetate concentrations in venous blood
    • 3998144 1:CAS:528:DyaL2MXktVChs74%3D
    • Pomare EW, Branch WJ, Cummings JH (1985) Carbohydrate fermentation in the human colon and its relation to acetate concentrations in venous blood. J Clin Invest 75(5):1448-1454
    • (1985) J Clin Invest , vol.75 , Issue.5 , pp. 1448-1454
    • Pomare, E.W.1    Branch, W.J.2    Cummings, J.H.3
  • 20
    • 0032716189 scopus 로고    scopus 로고
    • De novo lipogenesis, lipid kinetics, and whole-body lipid balances in humans after acute alcohol consumption
    • 10539756 1:CAS:528:DyaK1MXntFCgu70%3D
    • Siler SQ, Neese RA, Hellerstein MK (1999) De novo lipogenesis, lipid kinetics, and whole-body lipid balances in humans after acute alcohol consumption. Am J Clin Nutr 70(5):928-936
    • (1999) Am J Clin Nutr , vol.70 , Issue.5 , pp. 928-936
    • Siler, S.Q.1    Neese, R.A.2    Hellerstein, M.K.3
  • 21
    • 84867616398 scopus 로고    scopus 로고
    • High fat diet-induced gut microbiota exacerbates inflammation and obesity in mice via the TLR4 signaling pathway
    • 23091640 1:CAS:528:DC%2BC38Xhs1Wht7fO
    • Kim KA et al (2012) High fat diet-induced gut microbiota exacerbates inflammation and obesity in mice via the TLR4 signaling pathway. PLoS One 7(10):e47713
    • (2012) PLoS One , vol.7 , Issue.10 , pp. 47713
    • Kim, K.A.1
  • 22
    • 84865726183 scopus 로고    scopus 로고
    • Saturated fat stimulates obesity and hepatic steatosis and affects gut microbiota composition by an enhanced overflow of dietary fat to the distal intestine
    • 22700822
    • de Wit N et al (2012) Saturated fat stimulates obesity and hepatic steatosis and affects gut microbiota composition by an enhanced overflow of dietary fat to the distal intestine. Am J Physiol Gastrointest Liver Physiol 303(5):G589-G599
    • (2012) Am J Physiol Gastrointest Liver Physiol , vol.303 , Issue.5
    • De Wit, N.1
  • 23
    • 58749112734 scopus 로고    scopus 로고
    • A core gut microbiome in obese and lean twins
    • 19043404 1:CAS:528:DC%2BD1MXotlOlsw%3D%3D
    • Turnbaugh PJ et al (2009) A core gut microbiome in obese and lean twins. Nature 457(7228):480-484
    • (2009) Nature , vol.457 , Issue.7228 , pp. 480-484
    • Turnbaugh, P.J.1
  • 24
    • 84878579044 scopus 로고    scopus 로고
    • The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43
    • 23652017
    • Kimura I et al (2013) The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43. Nat Commun 4:1829
    • (2013) Nat Commun , vol.4 , pp. 1829
    • Kimura, I.1
  • 25
    • 57349142454 scopus 로고    scopus 로고
    • Identification and functional characterization of allosteric agonists for the G protein-coupled receptor FFA2
    • 18818303 1:CAS:528:DC%2BD1cXhsVGkt7fO
    • Lee T et al (2008) Identification and functional characterization of allosteric agonists for the G protein-coupled receptor FFA2. Mol Pharmacol 74(6):1599-1609
    • (2008) Mol Pharmacol , vol.74 , Issue.6 , pp. 1599-1609
    • Lee, T.1
  • 26
    • 72249086955 scopus 로고    scopus 로고
    • The first synthetic agonists of FFA2: Discovery and SAR of phenylacetamides as allosteric modulators
    • 20005104
    • Wang Y et al (2010) The first synthetic agonists of FFA2: discovery and SAR of phenylacetamides as allosteric modulators. Bioorg Med Chem Lett 20(2):493-498
    • (2010) Bioorg Med Chem Lett , vol.20 , Issue.2 , pp. 493-498
    • Wang, Y.1
  • 27
    • 77957114912 scopus 로고    scopus 로고
    • Allosteric rescuing of loss-of-function FFAR2 mutations
    • 20837008 1:CAS:528:DC%2BC3cXht1GjsrjI
    • Swaminath G et al (2010) Allosteric rescuing of loss-of-function FFAR2 mutations. FEBS Lett 584(19):4208-4214
    • (2010) FEBS Lett , vol.584 , Issue.19 , pp. 4208-4214
    • Swaminath, G.1
  • 28
    • 79959309348 scopus 로고    scopus 로고
    • Extracellular loop 2 of the free fatty acid receptor 2 mediates allosterism of a phenylacetamide ago-allosteric modulator
    • 21498659 1:CAS:528:DC%2BC3MXosFajtLk%3D
    • Smith NJ et al (2011) Extracellular loop 2 of the free fatty acid receptor 2 mediates allosterism of a phenylacetamide ago-allosteric modulator. Mol Pharmacol 80(1):163-173
    • (2011) Mol Pharmacol , vol.80 , Issue.1 , pp. 163-173
    • Smith, N.J.1
  • 29
    • 79953216793 scopus 로고    scopus 로고
    • Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: Identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3
    • 21220428 1:CAS:528:DC%2BC3MXjsVyqs7k%3D
    • Schmidt J et al (2011) Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3. J Biol Chem 286(12):10628-10640
    • (2011) J Biol Chem , vol.286 , Issue.12 , pp. 10628-10640
    • Schmidt, J.1
  • 30
    • 84879037150 scopus 로고    scopus 로고
    • Defining the molecular basis for the first potent and selective orthosteric agonists of the FFA2 free fatty acid receptor
    • 23589301 1:CAS:528:DC%2BC3sXpsFansro%3D
    • Hudson BD et al (2013) Defining the molecular basis for the first potent and selective orthosteric agonists of the FFA2 free fatty acid receptor. J Biol Chem 288(24):17296-17312
    • (2013) J Biol Chem , vol.288 , Issue.24 , pp. 17296-17312
    • Hudson, B.D.1
  • 33
    • 74049124329 scopus 로고    scopus 로고
    • Short-chain fatty acids act as antiinflammatory mediators by regulating prostaglandin E(2) and cytokines
    • 19938193 1:CAS:528:DC%2BD1MXhsFSmtbrF
    • Cox MA et al (2009) Short-chain fatty acids act as antiinflammatory mediators by regulating prostaglandin E(2) and cytokines. World J Gastroenterol 15(44):5549-5557
    • (2009) World J Gastroenterol , vol.15 , Issue.44 , pp. 5549-5557
    • Cox, M.A.1
  • 34
    • 83755225879 scopus 로고    scopus 로고
    • Diet-induced obesity up-regulates the abundance of GPR43 and GPR120 in a tissue specific manner
    • 22178946 1:CAS:528:DC%2BC3MXhs1eltbnO
    • Cornall LM et al (2011) Diet-induced obesity up-regulates the abundance of GPR43 and GPR120 in a tissue specific manner. Cell Physiol Biochem 28(5):949-958
    • (2011) Cell Physiol Biochem , vol.28 , Issue.5 , pp. 949-958
    • Cornall, L.M.1
  • 35
    • 41049090425 scopus 로고    scopus 로고
    • Expression of the short-chain fatty acid receptor, GPR43, in the human colon
    • 17899402 1:CAS:528:DC%2BD1cXjsFWrsbc%3D
    • Karaki S et al (2008) Expression of the short-chain fatty acid receptor, GPR43, in the human colon. J Mol Histol 39(2):135-142
    • (2008) J Mol Histol , vol.39 , Issue.2 , pp. 135-142
    • Karaki, S.1
  • 36
    • 27844440904 scopus 로고    scopus 로고
    • Acetate and propionate short-chain fatty acids stimulate adipogenesis via GPCR43
    • 16123168 1:CAS:528:DC%2BD2MXht1Ogur%2FL
    • Hong YH et al (2005) Acetate and propionate short-chain fatty acids stimulate adipogenesis via GPCR43. Endocrinology 146(12):5092-5099
    • (2005) Endocrinology , vol.146 , Issue.12 , pp. 5092-5099
    • Hong, Y.H.1
  • 37
    • 77952957384 scopus 로고    scopus 로고
    • Roles of GPR41 and GPR43 in leptin secretory responses of murine adipocytes to short-chain fatty acids
    • 20399779 1:CAS:528:DC%2BC3cXmsVOiu7k%3D
    • Zaibi MS et al (2010) Roles of GPR41 and GPR43 in leptin secretory responses of murine adipocytes to short-chain fatty acids. FEBS Lett 584(11):2381-2386
    • (2010) FEBS Lett , vol.584 , Issue.11 , pp. 2381-2386
    • Zaibi, M.S.1
  • 38
    • 79960299449 scopus 로고    scopus 로고
    • Inulin-type fructans with prebiotic properties counteract GPR43 overexpression and PPARgamma-related adipogenesis in the white adipose tissue of high-fat diet-fed mice
    • 21115338
    • Dewulf EM et al (2010) Inulin-type fructans with prebiotic properties counteract GPR43 overexpression and PPARgamma-related adipogenesis in the white adipose tissue of high-fat diet-fed mice. J Nutr Biochem 22(8):712-722
    • (2010) J Nutr Biochem , vol.22 , Issue.8 , pp. 712-722
    • Dewulf, E.M.1
  • 39
    • 79954435406 scopus 로고    scopus 로고
    • Density distribution of free fatty acid receptor 2 (FFA2)-expressing and GLP-1-producing enteroendocrine L cells in human and rat lower intestine, and increased cell numbers after ingestion of fructo-oligosaccharide
    • 21113792 1:CAS:528:DC%2BC3MXjvVenurg%3D
    • Kaji I et al (2011) Density distribution of free fatty acid receptor 2 (FFA2)-expressing and GLP-1-producing enteroendocrine L cells in human and rat lower intestine, and increased cell numbers after ingestion of fructo-oligosaccharide. J Mol Histol 42(1):27-38
    • (2011) J Mol Histol , vol.42 , Issue.1 , pp. 27-38
    • Kaji, I.1
  • 40
    • 71849088409 scopus 로고    scopus 로고
    • Identification of transforming activity of free fatty acid receptor 2 by retroviral expression screening
    • 19780758 1:CAS:528:DC%2BC3cXnvVKruw%3D%3D
    • Hatanaka H et al (2010) Identification of transforming activity of free fatty acid receptor 2 by retroviral expression screening. Cancer Sci 101(1):54-59
    • (2010) Cancer Sci , vol.101 , Issue.1 , pp. 54-59
    • Hatanaka, H.1
  • 41
    • 78650618692 scopus 로고    scopus 로고
    • G-protein-coupled receptor for short-chain fatty acids suppresses colon cancer
    • 20979106 1:CAS:528:DC%2BC3cXhsF2rtrjP
    • Tang Y et al (2011) G-protein-coupled receptor for short-chain fatty acids suppresses colon cancer. Int J Cancer 128(4):847-856
    • (2011) Int J Cancer , vol.128 , Issue.4 , pp. 847-856
    • Tang, Y.1
  • 42
    • 57749112018 scopus 로고    scopus 로고
    • Conserved polar residues in transmembrane domains V, VI, and VII of free fatty acid receptor 2 and free fatty acid receptor 3 are required for the binding and function of short-chain fatty acids
    • 18801738 1:CAS:528:DC%2BD1cXhtlOjtLnE
    • Stoddart LA et al (2008) Conserved polar residues in transmembrane domains V, VI, and VII of free fatty acid receptor 2 and free fatty acid receptor 3 are required for the binding and function of short-chain fatty acids. J Biol Chem 283(47):32913-32924
    • (2008) J Biol Chem , vol.283 , Issue.47 , pp. 32913-32924
    • Stoddart, L.A.1
  • 43
    • 84870373974 scopus 로고    scopus 로고
    • Chemically engineering ligand selectivity at the free fatty acid receptor 2 based on pharmacological variation between species orthologs
    • 22919070 1:CAS:528:DC%2BC38XhvVCgtrnO
    • Hudson BD et al (2012) Chemically engineering ligand selectivity at the free fatty acid receptor 2 based on pharmacological variation between species orthologs. FASEB J 26(12):4951-4965
    • (2012) FASEB J , vol.26 , Issue.12 , pp. 4951-4965
    • Hudson, B.D.1
  • 44
    • 33845345276 scopus 로고    scopus 로고
    • Short-chain fatty acids induce acute phosphorylation of the p38 mitogen-activated protein kinase/heat shock protein 27 pathway via GPR43 in the MCF-7 human breast cancer cell line
    • 16887331 1:CAS:528:DC%2BD28Xhtlalt7jJ
    • Yonezawa T, Kobayashi Y, Obara Y (2007) Short-chain fatty acids induce acute phosphorylation of the p38 mitogen-activated protein kinase/heat shock protein 27 pathway via GPR43 in the MCF-7 human breast cancer cell line. Cell Signal 19(1):185-193
    • (2007) Cell Signal , vol.19 , Issue.1 , pp. 185-193
    • Yonezawa, T.1    Kobayashi, Y.2    Obara, Y.3
  • 45
    • 84864053102 scopus 로고    scopus 로고
    • Receptor-specific regulation of ERK1/2 activation by members of the "free fatty acid receptor" family
    • 22712802 1:CAS:528:DC%2BC38XhtVClsrzI
    • Seljeset S, Siehler S (2012) Receptor-specific regulation of ERK1/2 activation by members of the "free fatty acid receptor" family. J Recept Signal Transduct Res 32(4):196-201
    • (2012) J Recept Signal Transduct Res , vol.32 , Issue.4 , pp. 196-201
    • Seljeset, S.1    Siehler, S.2
  • 46
    • 79958812655 scopus 로고    scopus 로고
    • SCFAs induce mouse neutrophil chemotaxis through the GPR43 receptor
    • 21698257 1:CAS:528:DC%2BC3MXotVWjsL4%3D
    • Vinolo MA et al (2011) SCFAs induce mouse neutrophil chemotaxis through the GPR43 receptor. PLoS One 6(6):e21205
    • (2011) PLoS One , vol.6 , Issue.6 , pp. 21205
    • Vinolo, M.A.1
  • 47
    • 84866740088 scopus 로고    scopus 로고
    • Short-chain fatty acids suppress lipopolysaccharide-induced production of nitric oxide and proinflammatory cytokines through inhibition of NF-kappaB pathway in RAW264.7 cells
    • 22669487 1:CAS:528:DC%2BC38XhtlGrurjF
    • Liu T et al (2012) Short-chain fatty acids suppress lipopolysaccharide- induced production of nitric oxide and proinflammatory cytokines through inhibition of NF-kappaB pathway in RAW264.7 cells. Inflammation 35(5):1676-1684
    • (2012) Inflammation , vol.35 , Issue.5 , pp. 1676-1684
    • Liu, T.1
  • 48
    • 73349123182 scopus 로고    scopus 로고
    • G protein-coupled receptor 43 is essential for neutrophil recruitment during intestinal inflammation
    • 19917676 1:CAS:528:DC%2BD1MXhsVehtrrN
    • Sina C et al (2009) G protein-coupled receptor 43 is essential for neutrophil recruitment during intestinal inflammation. J Immunol 183(11):7514-7522
    • (2009) J Immunol , vol.183 , Issue.11 , pp. 7514-7522
    • Sina, C.1
  • 49
    • 19644367000 scopus 로고    scopus 로고
    • Activation and signaling of the p38 MAP kinase pathway
    • 15686620 1:CAS:528:DC%2BD2MXkslGisb4%3D
    • Zarubin T, Han J (2005) Activation and signaling of the p38 MAP kinase pathway. Cell Res 15(1):11-18
    • (2005) Cell Res , vol.15 , Issue.1 , pp. 11-18
    • Zarubin, T.1    Han, J.2
  • 50
    • 70350666634 scopus 로고    scopus 로고
    • Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43
    • 19865172 1:CAS:528:DC%2BD1MXhtlOjt7vI
    • Maslowski KM et al (2009) Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43. Nature 461(7268):1282-1286
    • (2009) Nature , vol.461 , Issue.7268 , pp. 1282-1286
    • Maslowski, K.M.1
  • 51
    • 33646376658 scopus 로고    scopus 로고
    • Short-chain fatty acid receptor, GPR43, is expressed by enteroendocrine cells and mucosal mast cells in rat intestine
    • 16453106 1:CAS:528:DC%2BD28XjvFSgu7k%3D
    • Karaki S et al (2006) Short-chain fatty acid receptor, GPR43, is expressed by enteroendocrine cells and mucosal mast cells in rat intestine. Cell Tissue Res 324(3):353-360
    • (2006) Cell Tissue Res , vol.324 , Issue.3 , pp. 353-360
    • Karaki, S.1
  • 52
    • 78751643126 scopus 로고    scopus 로고
    • - secretion and free fatty acid receptor 2 (FFA2, GPR43) expression in the guinea pig distal colon
    • 20945073 1:CAS:528:DC%2BC3MXjsVGr
    • - secretion and free fatty acid receptor 2 (FFA2, GPR43) expression in the guinea pig distal colon. Pflugers Arch 461(1):141-152
    • (2011) Pflugers Arch , vol.461 , Issue.1 , pp. 141-152
    • Karaki, S.1    Kuwahara, A.2
  • 53
    • 0037405738 scopus 로고    scopus 로고
    • Short-chain fatty acids stimulate colonic transit via intraluminal 5-HT release in rats
    • 12676748 1:CAS:528:DC%2BD3sXjvFGru7Y%3D
    • Fukumoto S et al (2003) Short-chain fatty acids stimulate colonic transit via intraluminal 5-HT release in rats. Am J Physiol Regul Integr Comp Physiol 284(5):R1269-R1276
    • (2003) Am J Physiol Regul Integr Comp Physiol , vol.284 , Issue.5
    • Fukumoto, S.1
  • 54
    • 84856509724 scopus 로고    scopus 로고
    • Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2
    • 22190648 1:CAS:528:DC%2BC38XltVOlt7Y%3D
    • Tolhurst G et al (2012) Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2. Diabetes 61(2):364-371
    • (2012) Diabetes , vol.61 , Issue.2 , pp. 364-371
    • Tolhurst, G.1
  • 55
    • 77951792949 scopus 로고    scopus 로고
    • Immunopathogenesis of inflammatory bowel disease
    • Matricon J (2010) Immunopathogenesis of inflammatory bowel disease. Med Sci (Paris) 26(4):405-410
    • (2010) Med Sci (Paris) , vol.26 , Issue.4 , pp. 405-410
    • Matricon, J.1
  • 56
    • 0034109077 scopus 로고    scopus 로고
    • Obesity, insulin resistance and diabetes - A worldwide epidemic
    • 10889785 1:CAS:528:DC%2BD3cXjs1Ogtbs%3D
    • Seidell JC (2000) Obesity, insulin resistance and diabetes - a worldwide epidemic. Br J Nutr 83(Suppl 1):S5-S8
    • (2000) Br J Nutr , vol.83 , Issue.SUPPL. 1
    • Seidell, J.C.1
  • 57
    • 0037167664 scopus 로고    scopus 로고
    • World Heart Day 2002: The international burden of cardiovascular disease: Responding to the emerging global epidemic
    • 12270848
    • Bonow RO et al (2002) World Heart Day 2002: the international burden of cardiovascular disease: responding to the emerging global epidemic. Circulation 106(13):1602-1605
    • (2002) Circulation , vol.106 , Issue.13 , pp. 1602-1605
    • Bonow, R.O.1
  • 58
    • 80051986265 scopus 로고    scopus 로고
    • Globalization of diabetes: The role of diet, lifestyle, and genes
    • 21617109
    • Hu FB (2011) Globalization of diabetes: the role of diet, lifestyle, and genes. Diabetes Care 34(6):1249-1257
    • (2011) Diabetes Care , vol.34 , Issue.6 , pp. 1249-1257
    • Hu, F.B.1
  • 59
    • 0030819249 scopus 로고    scopus 로고
    • Body mass index and mortality in a general population sample of men and women. The Buffalo health study
    • 9400333 1:STN:280:DyaK1c%2Fmt1ylsw%3D%3D
    • Dorn JM et al (1997) Body mass index and mortality in a general population sample of men and women. The Buffalo health study. Am J Epidemiol 146(11):919-931
    • (1997) Am J Epidemiol , vol.146 , Issue.11 , pp. 919-931
    • Dorn, J.M.1
  • 60
    • 0033001612 scopus 로고    scopus 로고
    • Body weight and weight gain during adult life in men in relation to coronary heart disease and mortality. A prospective population study
    • 10099921 1:STN:280:DyaK1M7pvFKqtg%3D%3D
    • Rosengren A, Wedel H, Wilhelmsen L (1999) Body weight and weight gain during adult life in men in relation to coronary heart disease and mortality. A prospective population study. Eur Heart J 20(4):269-277
    • (1999) Eur Heart J , vol.20 , Issue.4 , pp. 269-277
    • Rosengren, A.1    Wedel, H.2    Wilhelmsen, L.3
  • 61
    • 78650800467 scopus 로고    scopus 로고
    • Improved glucose control and reduced body fat mass in free fatty acid receptor 2-deficient mice fed a high-fat diet
    • 20959533 1:CAS:528:DC%2BC3MXhvVSjsb0%3D
    • Bjursell M et al (2011) Improved glucose control and reduced body fat mass in free fatty acid receptor 2-deficient mice fed a high-fat diet. Am J Physiol Endocrinol Metab 300(1):E211-E220
    • (2011) Am J Physiol Endocrinol Metab , vol.300 , Issue.1
    • Bjursell, M.1
  • 62
    • 50449087891 scopus 로고    scopus 로고
    • Activation of G protein-coupled receptor 43 in adipocytes leads to inhibition of lipolysis and suppression of plasma free fatty acids
    • 18499755 1:CAS:528:DC%2BD1cXhtVKnu7vF
    • Ge H et al (2008) Activation of G protein-coupled receptor 43 in adipocytes leads to inhibition of lipolysis and suppression of plasma free fatty acids. Endocrinology 149(9):4519-4526
    • (2008) Endocrinology , vol.149 , Issue.9 , pp. 4519-4526
    • Ge, H.1
  • 63
    • 33646917184 scopus 로고    scopus 로고
    • Antagonism of peroxisome proliferator-activated receptor gamma prevents high-fat diet-induced obesity in vivo
    • 16696951 1:CAS:528:DC%2BD28Xltl2gt7k%3D
    • Nakano R et al (2006) Antagonism of peroxisome proliferator-activated receptor gamma prevents high-fat diet-induced obesity in vivo. Biochem Pharmacol 72(1):42-52
    • (2006) Biochem Pharmacol , vol.72 , Issue.1 , pp. 42-52
    • Nakano, R.1
  • 64
    • 36048950218 scopus 로고    scopus 로고
    • Adipogenesis and lipotoxicity: Role of peroxisome proliferator-activated receptor gamma (PPARgamma) and PPARgammacoactivator-1 (PGC1)
    • 17903321
    • Medina-Gomez G, Gray S, Vidal-Puig A (2007) Adipogenesis and lipotoxicity: role of peroxisome proliferator-activated receptor gamma (PPARgamma) and PPARgammacoactivator-1 (PGC1). Public Health Nutr 10(10A):1132-1137
    • (2007) Public Health Nutr , vol.10 , Issue.10 A , pp. 1132-1137
    • Medina-Gomez, G.1    Gray, S.2    Vidal-Puig, A.3
  • 65
    • 70350346153 scopus 로고    scopus 로고
    • GPR109A, GPR109B and GPR81, a family of hydroxy-carboxylic acid receptors
    • 19837462 1:CAS:528:DC%2BD1MXhtlCku7zM
    • Ahmed K, Tunaru S, Offermanns S (2009) GPR109A, GPR109B and GPR81, a family of hydroxy-carboxylic acid receptors. Trends Pharmacol Sci 30(11):557-562
    • (2009) Trends Pharmacol Sci , vol.30 , Issue.11 , pp. 557-562
    • Ahmed, K.1    Tunaru, S.2    Offermanns, S.3
  • 66
    • 54349124808 scopus 로고    scopus 로고
    • Leptin regulates peripheral lipid metabolism primarily through central effects on food intake
    • 18635658 1:CAS:528:DC%2BD1cXhtlWnsrrE
    • Prieur X et al (2008) Leptin regulates peripheral lipid metabolism primarily through central effects on food intake. Endocrinology 149(11):5432-5439
    • (2008) Endocrinology , vol.149 , Issue.11 , pp. 5432-5439
    • Prieur, X.1
  • 67
    • 8844255472 scopus 로고    scopus 로고
    • The direct effect of leptin on skeletal muscle thermogenesis is mediated by substrate cycling between de novo lipogenesis and lipid oxidation
    • 15556643 1:CAS:528:DC%2BD2cXhtVSrtLfF
    • Solinas G et al (2004) The direct effect of leptin on skeletal muscle thermogenesis is mediated by substrate cycling between de novo lipogenesis and lipid oxidation. FEBS Lett 577(3):539-544
    • (2004) FEBS Lett , vol.577 , Issue.3 , pp. 539-544
    • Solinas, G.1
  • 68
    • 70350203976 scopus 로고    scopus 로고
    • Central leptin action improves skeletal muscle AKT, AMPK, and PGC1 alpha activation by hypothalamic PI3 K-dependent mechanism
    • 19698760 1:CAS:528:DC%2BD1MXhtlWhtrrL
    • Roman EA et al (2010) Central leptin action improves skeletal muscle AKT, AMPK, and PGC1 alpha activation by hypothalamic PI3 K-dependent mechanism. Mol Cell Endocrinol 314(1):62-69
    • (2010) Mol Cell Endocrinol , vol.314 , Issue.1 , pp. 62-69
    • Roman, E.A.1
  • 69
    • 59049103288 scopus 로고    scopus 로고
    • Chronic leptin treatment stimulates lipid oxidation in immortalized and primary mouse skeletal muscle cells
    • 19103304 1:CAS:528:DC%2BD1MXhsFOlu7k%3D
    • Akasaka Y et al (2009) Chronic leptin treatment stimulates lipid oxidation in immortalized and primary mouse skeletal muscle cells. Biochim Biophys Acta 1791(2):103-109
    • (2009) Biochim Biophys Acta , vol.1791 , Issue.2 , pp. 103-109
    • Akasaka, Y.1
  • 70
    • 79951813012 scopus 로고    scopus 로고
    • Leptin increases skeletal muscle lipoprotein lipase and postprandial lipid metabolism in mice
    • 20494377
    • Donahoo WT et al (2010) Leptin increases skeletal muscle lipoprotein lipase and postprandial lipid metabolism in mice. Metabolism 60(3):438-443
    • (2010) Metabolism , vol.60 , Issue.3 , pp. 438-443
    • Donahoo, W.T.1
  • 71
    • 34247868983 scopus 로고    scopus 로고
    • Leptin stimulation of COXIV is impaired in obese skeletal muscle myotubes
    • McAinch AJ et al (2007) Leptin stimulation of COXIV is impaired in obese skeletal muscle myotubes. Obes Res Clin Pract 1(1):53-60
    • (2007) Obes Res Clin Pract , vol.1 , Issue.1 , pp. 53-60
    • McAinch, A.J.1
  • 72
    • 77956907521 scopus 로고    scopus 로고
    • The adipokine leptin increases skeletal muscle mass and significantly alters skeletal muscle miRNA expression profile in aged mice
    • 20800581 1:CAS:528:DC%2BC3cXht1WltrjE
    • Hamrick MW et al (2010) The adipokine leptin increases skeletal muscle mass and significantly alters skeletal muscle miRNA expression profile in aged mice. Biochem Biophys Res Commun 400(3):379-383
    • (2010) Biochem Biophys Res Commun , vol.400 , Issue.3 , pp. 379-383
    • Hamrick, M.W.1
  • 73
    • 70149104583 scopus 로고    scopus 로고
    • Leptin administration favors muscle mass accretion by decreasing FoxO3a and increasing PGC-1alpha in ob/ob mice
    • 19730740
    • Sainz N et al (2009) Leptin administration favors muscle mass accretion by decreasing FoxO3a and increasing PGC-1alpha in ob/ob mice. PLoS One 4(9):e6808
    • (2009) PLoS One , vol.4 , Issue.9 , pp. 6808
    • Sainz, N.1
  • 74
    • 74949143243 scopus 로고    scopus 로고
    • Narrative review: The role of leptin in human physiology: Emerging clinical applications
    • 20083828
    • Kelesidis T et al (2010) Narrative review: the role of leptin in human physiology: emerging clinical applications. Ann Intern Med 152(2):93-100
    • (2010) Ann Intern Med , vol.152 , Issue.2 , pp. 93-100
    • Kelesidis, T.1
  • 75
    • 78049311283 scopus 로고    scopus 로고
    • Obesity and leptin resistance: Distinguishing cause from effect
    • 20846876 1:CAS:528:DC%2BC3cXhtlKltL7L
    • Myers MG Jr et al (2010) Obesity and leptin resistance: distinguishing cause from effect. Trends Endocrinol Metab 21(11):643-651
    • (2010) Trends Endocrinol Metab , vol.21 , Issue.11 , pp. 643-651
    • Myers Jr., M.G.1
  • 76
    • 77955881869 scopus 로고    scopus 로고
    • Adipokine profile and insulin sensitivity in formerly obese women subjected to bariatric surgery or diet-induced long-term caloric restriction
    • 20576650
    • Mitterberger MC et al (2010) Adipokine profile and insulin sensitivity in formerly obese women subjected to bariatric surgery or diet-induced long-term caloric restriction. J Gerontol A Biol Sci Med Sci 65(9):915-923
    • (2010) J Gerontol A Biol Sci Med Sci , vol.65 , Issue.9 , pp. 915-923
    • Mitterberger, M.C.1
  • 77
    • 33750578279 scopus 로고    scopus 로고
    • Adiponectin increases fatty acid oxidation in skeletal muscle cells by sequential activation of AMP-activated protein kinase, p38 mitogen-activated protein kinase, and peroxisome proliferator-activated receptor alpha
    • 16936205 1:CAS:528:DC%2BD28XpsVOrurs%3D
    • Yoon MJ et al (2006) Adiponectin increases fatty acid oxidation in skeletal muscle cells by sequential activation of AMP-activated protein kinase, p38 mitogen-activated protein kinase, and peroxisome proliferator-activated receptor alpha. Diabetes 55(9):2562-2570
    • (2006) Diabetes , vol.55 , Issue.9 , pp. 2562-2570
    • Yoon, M.J.1
  • 78
    • 33644967119 scopus 로고    scopus 로고
    • The role of adipokines as regulators of skeletal muscle fatty acid metabolism and insulin sensitivity
    • 1:CAS:528:DC%2BD28XisVans7s%3D
    • Dyck DJ, Heigenhauser GJ, Bruce CR (2006) The role of adipokines as regulators of skeletal muscle fatty acid metabolism and insulin sensitivity. Acta Physiol (Oxf) 186(1):5-16
    • (2006) Acta Physiol (Oxf) , vol.186 , Issue.1 , pp. 5-16
    • Dyck, D.J.1    Heigenhauser, G.J.2    Bruce, C.R.3
  • 79
    • 18844432308 scopus 로고    scopus 로고
    • Adiponectin and adiponectin receptors
    • 15897298 1:CAS:528:DC%2BD2MXltVWru7c%3D
    • Kadowaki T, Yamauchi T (2005) Adiponectin and adiponectin receptors. Endocr Rev 26(3):439-451
    • (2005) Endocr Rev , vol.26 , Issue.3 , pp. 439-451
    • Kadowaki, T.1    Yamauchi, T.2
  • 80
    • 0036678916 scopus 로고    scopus 로고
    • Inverse relationship between plasma adiponectin and leptin concentrations in normal-weight and obese women
    • 12153737 1:CAS:528:DC%2BD38XmslSgu7g%3D
    • Matsubara M, Maruoka S, Katayose S (2002) Inverse relationship between plasma adiponectin and leptin concentrations in normal-weight and obese women. Eur J Endocrinol 147(2):173-180
    • (2002) Eur J Endocrinol , vol.147 , Issue.2 , pp. 173-180
    • Matsubara, M.1    Maruoka, S.2    Katayose, S.3
  • 81
    • 44949237971 scopus 로고    scopus 로고
    • Adiponectin and its association with insulin resistance and type 2 diabetes
    • 18571119 1:CAS:528:DC%2BD1cXhtVGjsrvL
    • Sheng T, Yang K (2008) Adiponectin and its association with insulin resistance and type 2 diabetes. J Genet Genomics 35(6):321-326
    • (2008) J Genet Genomics , vol.35 , Issue.6 , pp. 321-326
    • Sheng, T.1    Yang, K.2
  • 82
    • 57049107346 scopus 로고    scopus 로고
    • Endocrine functions of adipose tissue: Focus on adiponectin
    • 19046738 discussion 39-40
    • Sowers JR (2008) Endocrine functions of adipose tissue: focus on adiponectin. Clin Cornerstone 9(1):32-38 discussion 39-40
    • (2008) Clin Cornerstone , vol.9 , Issue.1 , pp. 32-38
    • Sowers, J.R.1
  • 83
    • 0024237258 scopus 로고
    • Rates and tissue sites of non-insulin- and insulin-mediated glucose uptake in humans
    • 3059816 1:CAS:528:DyaL1MXltFKgtg%3D%3D
    • Baron AD et al (1988) Rates and tissue sites of non-insulin- and insulin-mediated glucose uptake in humans. Am J Physiol 255(6 Pt 1):E769-E774
    • (1988) Am J Physiol , vol.255 , Issue.6 PART 1
    • Baron, A.D.1
  • 84
    • 0025047553 scopus 로고
    • Skeletal muscle metabolism is a major determinant of resting energy expenditure
    • 2243122 1:CAS:528:DyaK3cXmt1yguro%3D
    • Zurlo F et al (1990) Skeletal muscle metabolism is a major determinant of resting energy expenditure. J Clin Invest 86(5):1423-1427
    • (1990) J Clin Invest , vol.86 , Issue.5 , pp. 1423-1427
    • Zurlo, F.1
  • 85
    • 0034467428 scopus 로고    scopus 로고
    • PPAR signaling in the control of cardiac energy metabolism
    • 11282301 1:CAS:528:DC%2BD3MXitF2ktr0%3D
    • Barger PM, Kelly DP (2000) PPAR signaling in the control of cardiac energy metabolism. Trends Cardiovasc Med 10(6):238-245
    • (2000) Trends Cardiovasc Med , vol.10 , Issue.6 , pp. 238-245
    • Barger, P.M.1    Kelly, D.P.2
  • 86
    • 0037117651 scopus 로고    scopus 로고
    • Adaptation and maladaptation of the heart in diabetes: Part II: Potential mechanisms
    • 11956132 1:CAS:528:DC%2BD38XjvFakt70%3D
    • Young ME, McNulty P, Taegtmeyer H (2002) Adaptation and maladaptation of the heart in diabetes: Part II: potential mechanisms. Circulation 105(15):1861-1870
    • (2002) Circulation , vol.105 , Issue.15 , pp. 1861-1870
    • Young, M.E.1    McNulty, P.2    Taegtmeyer, H.3
  • 87
    • 34248664707 scopus 로고    scopus 로고
    • Cardiac substrate uptake and metabolism in obesity and type-2 diabetes: Role of sarcolemmal substrate transporters
    • 16988889 1:CAS:528:DC%2BD2sXltFSrt78%3D
    • Coort SL et al (2007) Cardiac substrate uptake and metabolism in obesity and type-2 diabetes: role of sarcolemmal substrate transporters. Mol Cell Biochem 299(1-2):5-18
    • (2007) Mol Cell Biochem , vol.299 , Issue.1-2 , pp. 5-18
    • Coort, S.L.1
  • 88
    • 27844457564 scopus 로고    scopus 로고
    • Reduced cardiac efficiency and altered substrate metabolism precedes the onset of hyperglycemia and contractile dysfunction in two mouse models of insulin resistance and obesity
    • 16141388 1:CAS:528:DC%2BD2MXht1OgurrI
    • Buchanan J et al (2005) Reduced cardiac efficiency and altered substrate metabolism precedes the onset of hyperglycemia and contractile dysfunction in two mouse models of insulin resistance and obesity. Endocrinology 146(12):5341-5349
    • (2005) Endocrinology , vol.146 , Issue.12 , pp. 5341-5349
    • Buchanan, J.1
  • 89
    • 79957969004 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in diabetic cardiomyopathy
    • 21256163 1:CAS:528:DC%2BC3MXntV2lsLc%3D
    • Duncan JG (2011) Mitochondrial dysfunction in diabetic cardiomyopathy. Biochim Biophys Acta 1813(7):1351-1359
    • (2011) Biochim Biophys Acta , vol.1813 , Issue.7 , pp. 1351-1359
    • Duncan, J.G.1
  • 90
    • 0033668021 scopus 로고    scopus 로고
    • Lipid oxidation is reduced in obese human skeletal muscle
    • 11052958 1:CAS:528:DC%2BD3cXotFaqs7w%3D
    • Kim JY et al (2000) Lipid oxidation is reduced in obese human skeletal muscle. Am J Physiol Endocrinol Metab 279(5):E1039-E1044
    • (2000) Am J Physiol Endocrinol Metab , vol.279 , Issue.5
    • Kim, J.Y.1
  • 91
    • 33646394578 scopus 로고    scopus 로고
    • Saturated, but not n-6 polyunsaturated, fatty acids induce insulin resistance: Role of intramuscular accumulation of lipid metabolites
    • 16357064 1:CAS:528:DC%2BD28XltVWlt78%3D
    • Lee JS et al (2006) Saturated, but not n-6 polyunsaturated, fatty acids induce insulin resistance: role of intramuscular accumulation of lipid metabolites. J Appl Physiol 100(5):1467-1474
    • (2006) J Appl Physiol , vol.100 , Issue.5 , pp. 1467-1474
    • Lee, J.S.1
  • 92
    • 77952090390 scopus 로고    scopus 로고
    • Intramyocellular lipid accumulation is associated with permanent relocation ex vivo and in vitro of fatty acid translocase (FAT)/CD36 in obese patients
    • 20333349 1:CAS:528:DC%2BC3cXlt1OmsrY%3D
    • Aguer C et al (2010) Intramyocellular lipid accumulation is associated with permanent relocation ex vivo and in vitro of fatty acid translocase (FAT)/CD36 in obese patients. Diabetologia 53(6):1151-1163
    • (2010) Diabetologia , vol.53 , Issue.6 , pp. 1151-1163
    • Aguer, C.1
  • 93
    • 4544355465 scopus 로고    scopus 로고
    • Triacylglycerol accumulation in human obesity and type 2 diabetes is associated with increased rates of skeletal muscle fatty acid transport and increased sarcolemmal FAT/CD36
    • 15132977 1:CAS:528:DC%2BD2cXlslKktrY%3D
    • Bonen A et al (2004) Triacylglycerol accumulation in human obesity and type 2 diabetes is associated with increased rates of skeletal muscle fatty acid transport and increased sarcolemmal FAT/CD36. FASEB J 18(10):1144-1146
    • (2004) FASEB J , vol.18 , Issue.10 , pp. 1144-1146
    • Bonen, A.1
  • 94
    • 0345305404 scopus 로고    scopus 로고
    • Muscle oxidative capacity is a better predictor of insulin sensitivity than lipid status
    • 14602787 1:CAS:528:DC%2BD3sXptVynt7w%3D
    • Bruce CR et al (2003) Muscle oxidative capacity is a better predictor of insulin sensitivity than lipid status. J Clin Endocrinol Metab 88(11):5444-5451
    • (2003) J Clin Endocrinol Metab , vol.88 , Issue.11 , pp. 5444-5451
    • Bruce, C.R.1
  • 95
    • 0345086474 scopus 로고    scopus 로고
    • Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade
    • 10342815 1:CAS:528:DyaK1MXjsFSgtr8%3D
    • Griffin ME et al (1999) Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade. Diabetes 48(6):1270-1274
    • (1999) Diabetes , vol.48 , Issue.6 , pp. 1270-1274
    • Griffin, M.E.1
  • 96
    • 33745409264 scopus 로고    scopus 로고
    • Reduced insulin suppression of glucose appearance is related to susceptibility to dietary obesity in rats
    • 9140029 1:CAS:528:DyaK2sXjtVSnuro%3D
    • Pagliassotti MJ et al (1997) Reduced insulin suppression of glucose appearance is related to susceptibility to dietary obesity in rats. Am J Physiol 272(4 Pt 2):R1264-R1270
    • (1997) Am J Physiol , vol.272 , Issue.4 PART 2
    • Pagliassotti, M.J.1
  • 97
    • 0035827642 scopus 로고    scopus 로고
    • MKK6/3 and p38 MAPK pathway activation is not necessary for insulin-induced glucose uptake but regulates glucose transporter expression
    • 11279172 1:CAS:528:DC%2BD3MXktlKgtbY%3D
    • Fujishiro M et al (2001) MKK6/3 and p38 MAPK pathway activation is not necessary for insulin-induced glucose uptake but regulates glucose transporter expression. J Biol Chem 276(23):19800-19806
    • (2001) J Biol Chem , vol.276 , Issue.23 , pp. 19800-19806
    • Fujishiro, M.1
  • 98
    • 0035504158 scopus 로고    scopus 로고
    • GLUT4 translocation precedes the stimulation of glucose uptake by insulin in muscle cells: Potential activation of GLUT4 via p38 mitogen-activated protein kinase
    • 11672439 1:CAS:528:DC%2BD3MXovVSisbw%3D
    • Somwar R et al (2001) GLUT4 translocation precedes the stimulation of glucose uptake by insulin in muscle cells: potential activation of GLUT4 via p38 mitogen-activated protein kinase. Biochem J 359(Pt 3):639-649
    • (2001) Biochem J , vol.359 , Issue.PART 3 , pp. 639-649
    • Somwar, R.1
  • 99
    • 0033537853 scopus 로고    scopus 로고
    • An inhibitor of p38 mitogen-activated protein kinase prevents insulin-stimulated glucose transport but not glucose transporter translocation in 3T3-L1 adipocytes and L6 myotubes
    • 10187787 1:CAS:528:DyaK1MXis1Gjtrs%3D
    • Sweeney G et al (1999) An inhibitor of p38 mitogen-activated protein kinase prevents insulin-stimulated glucose transport but not glucose transporter translocation in 3T3-L1 adipocytes and L6 myotubes. J Biol Chem 274(15):10071-10078
    • (1999) J Biol Chem , vol.274 , Issue.15 , pp. 10071-10078
    • Sweeney, G.1
  • 100
    • 66149135126 scopus 로고    scopus 로고
    • Blunting of AICAR-induced human skeletal muscle glucose uptake in type 2 diabetes is dependent on age rather than diabetic status
    • 19190259 1:CAS:528:DC%2BD1MXlvFags7g%3D
    • Babraj JA et al (2009) Blunting of AICAR-induced human skeletal muscle glucose uptake in type 2 diabetes is dependent on age rather than diabetic status. Am J Physiol Endocrinol Metab 296(5):E1042-E1048
    • (2009) Am J Physiol Endocrinol Metab , vol.296 , Issue.5
    • Babraj, J.A.1
  • 101
    • 20144372237 scopus 로고    scopus 로고
    • ERK1/2 inhibition prevents contraction-induced increase in plasma membrane FAT/CD36 content and FA uptake in rodent muscle
    • 15916673 1:CAS:528:DC%2BD2MXkvVajsL4%3D
    • Turcotte LP, Raney MA, Todd MK (2005) ERK1/2 inhibition prevents contraction-induced increase in plasma membrane FAT/CD36 content and FA uptake in rodent muscle. Acta Physiol Scand 184(2):131-139
    • (2005) Acta Physiol Scand , vol.184 , Issue.2 , pp. 131-139
    • Turcotte, L.P.1    Raney, M.A.2    Todd, M.K.3
  • 102
    • 2342428466 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha produces insulin resistance in skeletal muscle by activation of inhibitor kappaB kinase in a p38 MAPK-dependent manner
    • 14764603
    • de Alvaro C et al (2004) Tumor necrosis factor alpha produces insulin resistance in skeletal muscle by activation of inhibitor kappaB kinase in a p38 MAPK-dependent manner. J Biol Chem 279(17):17070-17078
    • (2004) J Biol Chem , vol.279 , Issue.17 , pp. 17070-17078
    • De Alvaro, C.1
  • 103
    • 0037059330 scopus 로고    scopus 로고
    • Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action
    • 11606564 1:CAS:528:DC%2BD38XnvFyjtQ%3D%3D
    • Aguirre V et al (2002) Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action. J Biol Chem 277(2):1531-1537
    • (2002) J Biol Chem , vol.277 , Issue.2 , pp. 1531-1537
    • Aguirre, V.1
  • 104
    • 79953221811 scopus 로고    scopus 로고
    • Counter modulation of fatty acid-induced proinflammatory NFβB signalling in rat skeletal muscle cells by AMPK
    • 21323644 1:CAS:528:DC%2BC3MXlt1Wnur8%3D
    • Green CJ et al (2011) Counter modulation of fatty acid-induced proinflammatory NFβB signalling in rat skeletal muscle cells by AMPK. Biochem J 435(2):463-474
    • (2011) Biochem J , vol.435 , Issue.2 , pp. 463-474
    • Green, C.J.1
  • 105
    • 33750877988 scopus 로고    scopus 로고
    • Palmitate-mediated downregulation of peroxisome proliferator-activated receptor-gamma coactivator 1alpha in skeletal muscle cells involves MEK1/2 and nuclear factor-kappaB activation
    • 17003343 1:CAS:528:DC%2BD28XhtVGlsrbJ
    • Coll T et al (2006) Palmitate-mediated downregulation of peroxisome proliferator-activated receptor-gamma coactivator 1alpha in skeletal muscle cells involves MEK1/2 and nuclear factor-kappaB activation. Diabetes 55(10):2779-2787
    • (2006) Diabetes , vol.55 , Issue.10 , pp. 2779-2787
    • Coll, T.1
  • 106
    • 0034383952 scopus 로고    scopus 로고
    • The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice
    • 11101507 1:CAS:528:DC%2BD3MXjtF2htr4%3D
    • Bueno OF et al (2000) The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice. EMBO J 19(23):6341-6350
    • (2000) EMBO J , vol.19 , Issue.23 , pp. 6341-6350
    • Bueno, O.F.1
  • 107
    • 0033840752 scopus 로고    scopus 로고
    • Requirement of activation of the extracellular signal-regulated kinase cascade in myocardial cell hypertrophy
    • 10888249 1:CAS:528:DC%2BD3cXkvVOrs74%3D
    • Ueyama T et al (2000) Requirement of activation of the extracellular signal-regulated kinase cascade in myocardial cell hypertrophy. J Mol Cell Cardiol 32(6):947-960
    • (2000) J Mol Cell Cardiol , vol.32 , Issue.6 , pp. 947-960
    • Ueyama, T.1
  • 108
    • 34249869321 scopus 로고    scopus 로고
    • Globular and full-length forms of adiponectin mediate specific changes in glucose and fatty acid uptake and metabolism in cardiomyocytes
    • 17499232 1:CAS:528:DC%2BD2sXmt1ynt7Y%3D
    • Palanivel R et al (2007) Globular and full-length forms of adiponectin mediate specific changes in glucose and fatty acid uptake and metabolism in cardiomyocytes. Cardiovasc Res 75(1):148-157
    • (2007) Cardiovasc Res , vol.75 , Issue.1 , pp. 148-157
    • Palanivel, R.1
  • 109
    • 58849116697 scopus 로고    scopus 로고
    • Adiponectin improves cardiomyocyte contractile function in db/db diabetic obese mice
    • 1:CAS:528:DC%2BD1MXhtVWisLc%3D
    • Dong F, Ren J (2009) Adiponectin improves cardiomyocyte contractile function in db/db diabetic obese mice. Obesity (Silver Spring) 17(2):262-268
    • (2009) Obesity (Silver Spring) , vol.17 , Issue.2 , pp. 262-268
    • Dong, F.1    Ren, J.2
  • 110
    • 33744925901 scopus 로고    scopus 로고
    • Role of adiponectin receptors in endothelin-induced cellular hypertrophy in cultured cardiomyocytes and their expression in infarcted heart
    • 16415076 1:CAS:528:DC%2BD28XlvVektrc%3D
    • Fujioka D et al (2006) Role of adiponectin receptors in endothelin-induced cellular hypertrophy in cultured cardiomyocytes and their expression in infarcted heart. Am J Physiol Heart Circ Physiol 290(6):H2409-H2416
    • (2006) Am J Physiol Heart Circ Physiol , vol.290 , Issue.6
    • Fujioka, D.1
  • 111
    • 84859529626 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 recruits microvasculature and increases glucose use in muscle via a nitric oxide-dependent mechanism
    • 22357961 1:CAS:528:DC%2BC38XkslCht7w%3D
    • Chai W et al (2012) Glucagon-like peptide 1 recruits microvasculature and increases glucose use in muscle via a nitric oxide-dependent mechanism. Diabetes 61(4):888-896
    • (2012) Diabetes , vol.61 , Issue.4 , pp. 888-896
    • Chai, W.1
  • 112
    • 33646795007 scopus 로고    scopus 로고
    • Direct effects of glucagon-like peptide-1 on myocardial contractility and glucose uptake in normal and postischemic isolated rat hearts
    • 16489128 1:CAS:528:DC%2BD28Xlt1eqtL8%3D
    • Zhao T et al (2006) Direct effects of glucagon-like peptide-1 on myocardial contractility and glucose uptake in normal and postischemic isolated rat hearts. J Pharmacol Exp Ther 317(3):1106-1113
    • (2006) J Pharmacol Exp Ther , vol.317 , Issue.3 , pp. 1106-1113
    • Zhao, T.1
  • 113
    • 3843089529 scopus 로고    scopus 로고
    • Gut hormones and the control of appetite
    • 15358278 1:CAS:528:DC%2BD2cXmsVGisr8%3D
    • Small CJ, Bloom SR (2004) Gut hormones and the control of appetite. Trends Endocrinol Metab 15(6):259-263
    • (2004) Trends Endocrinol Metab , vol.15 , Issue.6 , pp. 259-263
    • Small, C.J.1    Bloom, S.R.2
  • 114
    • 0032005005 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans
    • 9449682 1:CAS:528:DyaK1cXosVagsg%3D%3D
    • Flint A et al (1998) Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans. J Clin Invest 101(3):515-520
    • (1998) J Clin Invest , vol.101 , Issue.3 , pp. 515-520
    • Flint, A.1
  • 115
    • 39149140997 scopus 로고    scopus 로고
    • Gastrointestinal peptides controlling body weight homeostasis
    • 18164707 1:CAS:528:DC%2BD1cXhslOisLk%3D
    • Mendieta-Zeron H, Lopez M, Dieguez C (2008) Gastrointestinal peptides controlling body weight homeostasis. Gen Comp Endocrinol 155(3):481-495
    • (2008) Gen Comp Endocrinol , vol.155 , Issue.3 , pp. 481-495
    • Mendieta-Zeron, H.1    Lopez, M.2    Dieguez, C.3
  • 116
    • 78149493266 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 and the exenatide analogue AC3174 improve cardiac function, cardiac remodeling, and survival in rats with chronic heart failure
    • 21080957
    • Liu Q et al (2010) Glucagon-like peptide-1 and the exenatide analogue AC3174 improve cardiac function, cardiac remodeling, and survival in rats with chronic heart failure. Cardiovasc Diabetol 9:76
    • (2010) Cardiovasc Diabetol , vol.9 , pp. 76
    • Liu, Q.1
  • 117
    • 0038727630 scopus 로고    scopus 로고
    • The gut hormone peptide YY regulates appetite
    • 12851312 1:CAS:528:DC%2BD3sXmtVCkt7w%3D
    • Batterham RL, Bloom SR (2003) The gut hormone peptide YY regulates appetite. Ann N Y Acad Sci 994:162-168
    • (2003) Ann N y Acad Sci , vol.994 , pp. 162-168
    • Batterham, R.L.1    Bloom, S.R.2
  • 118
    • 33646865736 scopus 로고    scopus 로고
    • Peptide YY(1-36) and peptide YY(3-36): Part I. Distribution, release and actions
    • 16687037
    • Ballantyne GH (2006) Peptide YY(1-36) and peptide YY(3-36): Part I. Distribution, release and actions. Obes Surg 16(5):651-658
    • (2006) Obes Surg , vol.16 , Issue.5 , pp. 651-658
    • Ballantyne, G.H.1
  • 119
    • 3242794268 scopus 로고    scopus 로고
    • PYY3-36 reinforces insulin action on glucose disposal in mice fed a high-fat diet
    • 15277371
    • van den Hoek AM et al (2004) PYY3-36 reinforces insulin action on glucose disposal in mice fed a high-fat diet. Diabetes 53(8):1949-1952
    • (2004) Diabetes , vol.53 , Issue.8 , pp. 1949-1952
    • Van Den Hoek, A.M.1
  • 120
    • 33845970529 scopus 로고    scopus 로고
    • Chronic PYY3-36 treatment promotes fat oxidation and ameliorates insulin resistance in C57BL6 mice
    • 16940471
    • van den Hoek AM et al (2007) Chronic PYY3-36 treatment promotes fat oxidation and ameliorates insulin resistance in C57BL6 mice. Am J Physiol Endocrinol Metab 292(1):E238-E245
    • (2007) Am J Physiol Endocrinol Metab , vol.292 , Issue.1
    • Van Den Hoek, A.M.1
  • 121
    • 77953241787 scopus 로고    scopus 로고
    • Gut hormones: Emerging role in immune activation and inflammation
    • 20408856 1:CAS:528:DC%2BC3cXps1entbs%3D
    • Khan WI, Ghia JE (2010) Gut hormones: emerging role in immune activation and inflammation. Clin Exp Immunol 161(1):19-27
    • (2010) Clin Exp Immunol , vol.161 , Issue.1 , pp. 19-27
    • Khan, W.I.1    Ghia, J.E.2
  • 122
    • 84856337834 scopus 로고    scopus 로고
    • 5-HT(2C) receptor agonists and the control of appetite
    • 22249823 1:CAS:528:DC%2BC38XhslCgu7zK
    • Halford JC, Harrold JA (2012) 5-HT(2C) receptor agonists and the control of appetite. Handb Exp Pharmacol 209:349-356
    • (2012) Handb Exp Pharmacol , vol.209 , pp. 349-356
    • Halford, J.C.1    Harrold, J.A.2
  • 123
    • 0033531943 scopus 로고    scopus 로고
    • Serotonin (5-Hydroxytryptamine), a novel regulator of glucose transport in rat skeletal muscle
    • 10224126 1:CAS:528:DyaK1MXjtFOlurs%3D
    • Hajduch E et al (1999) Serotonin (5-Hydroxytryptamine), a novel regulator of glucose transport in rat skeletal muscle. J Biol Chem 274(19):13563-13568
    • (1999) J Biol Chem , vol.274 , Issue.19 , pp. 13563-13568
    • Hajduch, E.1
  • 124
    • 49349115112 scopus 로고    scopus 로고
    • Effects of olanzapine on glucose transport, proliferation and survival in C2C12 myoblasts
    • 18514390 1:CAS:528:DC%2BD1cXhtVagu7vP
    • Tulipano G, Spano P, Cocchi D (2008) Effects of olanzapine on glucose transport, proliferation and survival in C2C12 myoblasts. Mol Cell Endocrinol 292(1-2):42-49
    • (2008) Mol Cell Endocrinol , vol.292 , Issue.1-2 , pp. 42-49
    • Tulipano, G.1    Spano, P.2    Cocchi, D.3
  • 125
    • 15444368875 scopus 로고    scopus 로고
    • Serotonin (5-HT) drugs: Effects on appetite expression and use for the treatment of obesity
    • 15777190 1:CAS:528:DC%2BD2MXisVSqu74%3D
    • Halford JC et al (2005) Serotonin (5-HT) drugs: effects on appetite expression and use for the treatment of obesity. Curr Drug Targets 6(2):201-213
    • (2005) Curr Drug Targets , vol.6 , Issue.2 , pp. 201-213
    • Halford, J.C.1
  • 126
    • 84872565579 scopus 로고    scopus 로고
    • One-month serotonin infusion results in a prolonged fall in blood pressure in the deoxycorticosterone acetate (DOCA) salt hypertensive rat
    • 23336053 1:CAS:528:DC%2BC38XhtlGjtrrM
    • Davis RP et al (2013) One-month serotonin infusion results in a prolonged fall in blood pressure in the deoxycorticosterone acetate (DOCA) salt hypertensive rat. ACS Chem Neurosci 4(1):141-148
    • (2013) ACS Chem Neurosci , vol.4 , Issue.1 , pp. 141-148
    • Davis, R.P.1
  • 127
    • 84876416957 scopus 로고    scopus 로고
    • Human 5-HT(4) receptor stimulation in atria of transgenic mice
    • 23307014 1:CAS:528:DC%2BC3sXls12rt7k%3D
    • Gergs U et al (2013) Human 5-HT(4) receptor stimulation in atria of transgenic mice. Naunyn Schmiedebergs Arch Pharmacol 386(5):357-367
    • (2013) Naunyn Schmiedebergs Arch Pharmacol , vol.386 , Issue.5 , pp. 357-367
    • Gergs, U.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.