Leptin stimulation of COXIV is impaired in obese skeletal muscle myotubes

Obesity Research and Clinical Practice

Volumn 1, Issue 1, 2007, Pages 53-60

  McAinch, A J ^a,e   Steinberg, G R ^b   Mollica, J ^a   O'Brien, P E ^d   Dixon, J B ^d   Kemp, B E ^b,c   Cameron Smith, D ^a  

^a DEAKIN UNIVERSITY   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c CSIRO   (Australia)

^d MONASH UNIVERSITY   (Australia)

^e UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

COXIV; Fat metabolism; mRNA; Obesity; PDK4

Indexed keywords

3 HYDROXYACYL COENZYME A DEHYDROGENASE; CYCLOPHILIN; CYTOCHROME C OXIDASE; CYTOCHROME C OXIDASE III; CYTOCHROME C OXIDASE IV; ISOENZYME; LEPTIN; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PHOSPHOTRANSFERASE; PYRUVATE DEHYDROGENASE KINASE 4; SUPPRESSOR OF CYTOKINE SIGNALING 3; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BIOGENESIS; CELL CULTURE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN TISSUE; LEAN BODY WEIGHT; LIPID OXIDATION; MALE; MITOCHONDRION; MUSCLE BIOPSY; MUSCLE CELL; MYOTUBE; OBESITY; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RECTUS ABDOMINIS MUSCLE; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; SURGICAL PATIENT; UPREGULATION;

EID: 34247868983     PISSN: 1871403X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.orcp.2006.10.003     Document Type: Article

References (43)

1. Ceddia R.B. Direct metabolic regulation in skeletal muscle and fat tissue by leptin: implications for glucose and fatty acids homeostasis. Int J Obes (Lond) 29 10 (2005) 1175-1183
2. Tajima D., Masaki T., Hidaka S., Kakuma T., Sakata T., and Yoshimatsu H. Acute central infusion of leptin modulates fatty acid mobilization by affecting lipolysis and mRNA expression for uncoupling proteins. Exp Biol Med (Maywood) 230 3 (2005) 200-206
3. Steinberg G.R., Bonen A., and Dyck D.J. Fatty acid oxidation and triacylglycerol hydrolysis are enhanced after chronic leptin treatment in rats. Am J Physiol Endocrinol Metab 282 3 (2002) E593-E600
4. Steinberg G.R., Parolin M.L., Heigenhauser G.J., and Dyck D.J. Leptin increases FA oxidation in lean but not obese human skeletal muscle: evidence of peripheral leptin resistance. Am J Physiol Endocrinol Metab 283 1 (2002) E187-E192
5. Zhou Y.T., Shimabukuro M., Koyama K., Lee Y., Wang M.Y., Trieu F., et al. Induction by leptin of uncoupling protein-2 and enzymes of fatty acid oxidation. Proc Natl Acad Sci USA 94 12 (1997) 6386-6390
6. McClelland G.B., Kraft C.S., Michaud D., Russell J.C., Mueller C.R., and Moyes C.D. Leptin and the control of respiratory gene expression in muscle. Biochim Biophys Acta 1688 1 (2004) 86-93
7. Bendinelli P., Piccoletti R., and Maroni P. Leptin rapidly activates PPARs in C2C12 muscle cells. Biochem Biophys Res Commun 332 3 (2005) 719-725
8. Steinberg G.R., Smith A.C., Wormald S., Malenfant P., Collier C., and Dyck D.J. Endurance training partially reverses dietary-induced leptin resistance in rodent skeletal muscle. Am J Physiol Endocrinol Metab 286 1 (2004) E57-E63
9. Rieusset J., Bouzakri K., Chevillotte E., Ricard N., Jacquet D., Bastard J.P., et al. Suppressor of cytokine signaling 3 expression and insulin resistance in skeletal muscle of obese and type 2 diabetic patients. Diabetes 53 9 (2004) 2232-2241
10. Chen M.B., McAinch A.J., Macaulay S.L., et al. Impaired activation of AMPkinase and fatty acid oxidation by globular adiponectin in cultured human skeletal muscle of obese type 2 diabetics. J Clin Endocrinol Metab 90 6 (2005) 3665-3672
11. Henry R.R., Abrams L., Nikoulina S., and Ciaraldi T.P. Insulin action and glucose metabolism in nondiabetic control and NIDDM subjects. Comparison using human skeletal muscle cell cultures. Diabetes 44 8 (1995) 936-946
12. Gaster M., Petersen I., Hojlund K., Poulsen P., and Beck-Nielsen H. The diabetic phenotype is conserved in myotubes established from diabetic subjects: evidence for primary defects in glucose transport and glycogen synthase activity. Diabetes 51 4 (2002) 921-927
13. Gaster M., Rustan A.C., Aas V., and Beck-Nielsen H. Reduced lipid oxidation in skeletal muscle from type 2 diabetic subjects may be of genetic origin: evidence from cultured myotubes. Diabetes 53 3 (2004) 542-548
14. Steinberg G.R., McAinch A.J., Chen M.B., O'Brien P.E., Dixon J.B., Cameron-Smith D., and Kemp B.E. The suppressor of cytokine signaling 3 inhibits leptin activation of AMP-kinase in cultured skeletal muscle of obese humans. J Clin Endocrinol Metab 91 9 (2006) 3592-3597
15. Hickey M.S., Carey J.O., Azevedo J.L., Houmard J.A., Pories W.J., Israel R.G., et al. Skeletal muscle fiber composition is related to adiposity and in vitro glucose transport rate in humans. Am J Physiol 268 3 Part 1 (1995) E453-E457
16. Tanner C.J., Barakat H.A., Dohm G.L., Pories W.J., MacDonald K.G., Cunningham P.R., et al. Muscle fiber type is associated with obesity and weight loss. Am J Physiol Endocrinol Metab 282 6 (2002) E1191-E1196
17. Blau H.M., and Webster C. Isolation and characterization of human muscle cells. Proc Natl Acad Sci USA 78 9 (1981) 5623-5627
18. Gaster M., Beck-Nielsen H., and Schroder H.D. Proliferation conditions for human satellite cells. The fractional content of satellite cells. APMIS 109 11 (2001) 726-734
19. Minokoshi Y., Kim Y.B., Peroni O.D., Fryer L.G., Muller C., Carling D., and Kahn B.B. Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase. Nature 415 6869 (2002) 339-343
20. Schmittgen T.D., Zakrajsek B.A., Mills A.G., Gorn V., Singer M.J., and Reed M.W. Quantitative reverse transcription-polymerase chain reaction to study mRNA decay: comparison of endpoint and real-time methods. Anal Biochem 285 2 (2000) 194-204
21. Muoio D.M., Dohm G.L., Fiedorek Jr. F.T., Tapscott E.B., Coleman R.A., and Dohn G.L. Leptin directly alters lipid partitioning in skeletal muscle. Diabetes 46 8 (1997) 1360-1363
22. Steinberg G.R., and Dyck D.J. Development of leptin resistance in rat soleus muscle in response to high-fat diets. Am J Physiol Endocrinol Metab 279 6 (2000) E1374-E1382
23. Holness M.J., and Sugden M.C. Regulation of pyruvate dehydrogenase complex activity by reversible phosphorylation. Biochem Soc Trans 31 Part 6 (2003) 1143-1151
24. Majer M., Popov K.M., Harris R.A., Bogardus C., and Prochazka M. Insulin downregulates pyruvate dehydrogenase kinase (PDK) mRNA: potential mechanism contributing to increased lipid oxidation in insulin-resistant subjects. Mol Genet Metab 65 2 (1998) 181-186
25. Sugden M.C. PDK4: a factor in fatness?. Obes Res 11 2 (2003) 167-169
26. Holness M.J., Kraus A., Harris R.A., and Sugden M.C. Targeted upregulation of pyruvate dehydrogenase kinase (PDK)-4 in slow-twitch skeletal muscle underlies the stable modification of the regulatory characteristics of PDK induced by high-fat feeding. Diabetes 49 5 (2000) 775-781
27. Peters S.J., Harris R.A., Heigenhauser G.J., and Spriet L.L. Muscle fiber type comparison of PDH kinase activity and isoform expression in fed and fasted rats. Am J Physiol Regul Integr Comp Physiol 280 3 (2001) R661-R668
28. Tunstall R.J., Mehan K.A., Hargreaves M., Spriet L.L., and Cameron-Smith D. Fasting activates the gene expression of UCP3 independent of genes necessary for lipid transport and oxidation in skeletal muscle. Biochem Biophys Res Commun 294 2 (2002) 301-308
29. Ma K., Zhang Y., Elam M.B., Cook G.A., and Park E.A. Cloning of the rat pyruvate dehydrogenase kinase 4 gene promoter: activation of pyruvate dehydrogenase kinase 4 by the peroxisome proliferator-activated receptor gamma coactivator. J Biol Chem 280 33 (2005) 29525-29532
30. Wende A.R., Huss J.M., Schaeffer P.J., Giguere V., and Kelly D.P. PGC-1alpha coactivates PDK4 gene expression via the orphan nuclear receptor ERRalpha: a mechanism for transcriptional control of muscle glucose metabolism. Mol Cell Biol 25 24 (2005) 10684-10694
31. Araki M., and Motojima K. Identification of ERRalpha as a specific partner of PGC-1alpha for the activation of PDK4 gene expression in muscle. FEBS J 273 8 (2006) 1669-1680
32. Hegyi K., Fulop K., Kovacs K., Toth S., and Falus A. Leptin-induced signal transduction pathways. Cell Biol Int 28 3 (2004) 159-169
33. Inoue H., Ogawa W., Ozaki M., Haga S., Matsumoto M., Furukawa K., et al. Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo. Nat Med 10 2 (2004) 168-174
34. Bjorbaek C., Lavery H.J., Bates S.H., Olson R.K., Davis S.M., Flier J.S., et al. SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985. J Biol Chem 275 51 (2000) 40649-40657
35. Mori H., Hanada R., Hanada T., Aki D., Mashima R., Nishinakamura H., et al. Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity. Nat Med 10 7 (2004) 739-743
36. Bjorbaek C., El-Haschimi K., Frantz J.D., and Flier J.S. The role of SOCS-3 in leptin signaling and leptin resistance. J Biol Chem 274 42 (1999) 30059-30065
37. Fruhbeck G. Intracellular signalling pathways activated by leptin. Biochem J 393 Pt 1 (2006) 7-20
38. Stoppani J., Hildebrandt A.L., Sakamoto K., Cameron-Smith D., Goodyear L.J., and Neufer P.D. AMP-activated protein kinase activates transcription of the UCP3 and HKII genes in rat skeletal muscle. Am J Physiol Endocrinol Metab 283 6 (2002) E1239-E1248
39. McGee S.L., Howlett K.F., Starkie R.L., Cameron-Smith D., Kemp B.E., and Hargreaves M. Exercise increases nuclear AMPK alpha2 in human skeletal muscle. Diabetes 52 4 (2003) 926-928
40. Lin J., Handschin C., and Spiegelman B.M. Metabolic control through the PGC-1 family of transcription coactivators. Cell Metab 1 6 (2005) 361-370
41. Zong H., Ren J.M., Young L.H., Pypaert M., Mu J., Birnbaum M.J., et al. AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation. Proc Natl Acad Sci USA 99 25 (2002) 15983-15987
42. Kakuma T., Wang Z.W., Pan W., Unger R.H., and Zhou Y.T. Role of leptin in peroxisome proliferator-activated receptor gamma coactivator-1 expression. Endocrinology 141 12 (2000) 4576-4582
43. Gomez-Ambrosi J., Fruhbeck G., and Martinez J.A. Rapid in vivo PGC-1 mRNA upregulation in brown adipose tissue of Wistar rats by a beta(3)-adrenergic agonist and lack of effect of leptin. Mol Cell Endocrinol 176 1-2 (2001) 85-90