De novo lipogenesis, lipid kinetics, and whole-body lipid balances in humans after acute alcohol consumption

American Journal of Clinical Nutrition

Volumn 70, Issue 5, 1999, Pages 928-936

  Siler, Scott Q ^b   Neese, Richard A ^b   Hellerstein, Marc K ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NONE

Author keywords

Acetate; Ethanol; Fatty acid synthesis; Hypertriglyceridemia; Lipogenesis; Lipolysis; Mass isotopomer distribution analysis; Men; Stable isotopes

Indexed keywords

ADULT; ALCOHOL CONSUMPTION; ARTICLE; CALORIMETRY; HUMAN; HUMAN EXPERIMENT; LIPID ANALYSIS; LIPID TRANSPORT; LIPOGENESIS; MALE; MASS SPECTROMETRY; NORMAL HUMAN; TRANSPORT KINETICS;

EID: 0032716189     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/70.5.928     Document Type: Article

References (64)

1. Shelmet JJ, Reichard GA, Skutches CL, Hoeldtke RD, Owen OE, Boden G. Ethanol causes acute inhibition of carbohydrate, fat, and protein oxidation and insulin resistance. J Clin Invest 1988; 81:1137-45.
2. Suter PM, Schutz Y, Jequier E. The effect of ethanol on fat storage in healthy subjects. N Engl J Med 1992;326:983-7.
3. Feinman L, Lieber CS. Effect of ethanol on plasma glycerol in man. Am J Clin Nutr 1967;20:400-3.
4. Jones DP, Perman ES, Lieber CS. Free fatty acid turnover and triglyceride metabolism after ethanol ingestion in man. J Lab Clin Med 1965; 6:804-13.
5. Nestel PJ, Hirsch EZ. Mechanism of alcohol-induced hypertriglyceridemia. J Lab Clin Med 1965;66:357-65.
6. Wolfe BM, Havel JR, Marliss EB, Kane JP, Seymour J, Ahuja SP. Effects of a 3-day fast and of ethanol on splanchnic metabolism of FFA, amino acids, and carbohydrates in healthy young men. J Clin Invest 1976;57:329-40.
7. Avogaro P, Cazzolato G. Changes in the composition and physiochemical characteristics of serum lipoproteins during ethanol-induced lipaemia in alcoholic subjects. Metabolism 1975;24: 1231-42.
8. Kaffarnik H, Schneider J, Schubotz R. Plasma lipids, triglyceride/fatty acid pattern, and plasma insulin in fasted healthy volunteers during continuous ingestion of ethanol. Atherosclerosis 1978;29:1-7.
9. Taskinen MR, Nikkila EA. Nocturnal hypertriglyceridemia and hyperinsulinemia following moderate evening intake of alcohol. Acta Med Scand 1977;202:173-7.
10. 1]glycerol. J Lipid Res 1998;39:2319-28.
11. Taskinen MR, Valimaki M, Nikkila EA, Kuusi T, Ylihahri R. Sequence of alcohol-induced initial changes in plasma lipoproteins (VLDL and HDL) and lipolytic enzymes in humans. Metabolism 1985;34:112-9.
12. Rubin E, Lieber CS. Alcohol-induced hepatic injury in nonalcoholic volunteers. N Engl J Med 1968;278:869-76.
13. Wiebe T, Lundquist A, Belfrage P. Time-course of liver fat accumulation in man after a single load of ethanol. Scand J Clin Lab Invest 1971;27:33-6.
14. Belfrage P, Berg B, Cronholm T. Prolonged administration of ethanol to young, healthy volunteers: effects on biochemical, morphological and neuro-physiological parameters. Acta Med Scand Suppl 1973; 552:1-44.
15. Lieber CS, Schmid R. The effect of ethanol on fatty acid metabolism; stimulation of hepatic fatty acid synthesis in vitro. J Clin Invest 1961; 40:394-9.
16. Scheig R. Lipid synthesis from ethanol in liver. Gastroenterology 1971;60:751 (abstr).
17. Reboucas G, Isselbacher KJ. Studies on the pathogenesis of the ethanol-induced fatty liver. I. Synthesis and oxidation of fatty acids by the liver. J Clin Invest 1961;40:1355-62.
18. Guynn RW, Veloso D, Harris RL, Lawson JWR, Veech RL. Ethanol administration and the relationship of malonyl-coenzyme A concentrations to the rate of fatty acid synthesis in rat liver. Biochem J 1973; 136:639-47.
19. Lipkin EW, Cooper C. Triglyceride formation from fatty acid synthesized de novo in ethanol treated rats. Exp Mol Pathol 1978;29: 316-25.
20. Brunengraber H, Boutry M, Lowenstein L, Lowenstein JM. The effect of ethanol on lipogenesis by the perfused liver. In: Thurman RG, Yonetani T, Willimason JR, Chance B, eds. Alcohol and aldehyde metabolizing systems. New York: Academic Press, 1974:329-37.
21. 14C labeled ethanol in man. Arkiv Kemi 1969;30:333-45.
22. Venkatesan S, Leung NWY, Peters TJ. Fatty acid synthesis in vitro by liver tissue from control subjects and patients with alcoholic liver disease. Clin Sci 1986;71:723-8.
23. 13C) ethanol incorporation into very-low-density lipoprotein triglycerides using gas chromatography/isotope ratio mass spectrometry coupling. Biol Mass Spectrom 1991;20:777-82.
24. Rumpler WV, Rhodes DG, Baer DJ, Conway JM, Scale JL. Energy value of moderate alcohol consumption by humans. Am J Clin Nutr 1996;64:108-14.
25. Pirola RC, Lieber C. The energy cost of the metabolism of drugs, including ethanol. Pharmacology 1972;7:185-96.
26. Pirola RC, Lieber CS. Hypothesis: energy wastage in alcoholism and drug abuse: possible role of hepatic microsomal enzymes. Am J Clin Nutr 1976;29:90-3.
27. Rubin E, Beattie DS, Toth A, Lieber CS. Structural and functional effects of ethanol on hepatic mitochondria. Fed Proc 1972;31:131-40.
28. Cederbaum AI, Lieber CS, Rubin E. Effects of chronic ethanol treatment on mitochondrial functions damage to coupling site. Arch Biochem Biophys 1974;165:560-9.
29. Lands WEM, Zakhari S. The case of the missing calories. Am J Clin Nutr 1991;54:47-8.
30. Flatt JP. The biochemistry of energy expenditure. In: Bray GA, ed. Recent advances in obesity research. Vol 2. London: Newman Press, 1978:211-7.
31. Siler SQ, Neese RA, Hellerstein MK. Effects of ethanol on lipolysis and de novo lipogenesis in humans. FASEB J 1996;10:A799 (abstr).
32. Siler SQ, Neese RA, Hellerstein MK. Effects of ethanol consumption on lipolysis, de novo lipogenesis, and acetate in humans. FASEB J 1997;11:A140 (abstr).
33. Frezza M, Di Padova C, Pozzato G, Terpin M, Baraona E, Lieber C. High blood alcohol levels in women: the role of decreased gastric alcohol dehydrogenase activity and first pass metabolism. N Engl J Med 1990;322:95-9.
34. Hellerstein MK, Grunfeld C, Wu K. Increased de novo hepatic lipogenesis in human immunodeficiency virus infection. J Clin Endocrinol Metab 1993;76:559-65.
35. Neese RA, Benowitz NL, Hoh R. Metabolic interactions between surplus dietary energy intake and cigarette smoking or its cessation. Am J Physiol 1994;267:E1023-34.
36. Powers L, Osborn MK, Yang D. Assay of the concentration and stable isotope enrichment of short-chain fatty acids by gas chromatography/mass spectrometry. J Mass Spectrom 1996;30:747-54.
37. 13C]acetate. Am J Physiol 1996; 271:E58-64.
38. Jones AW, Jonsson KA. Food-induced lowering of blood ethanol profiles and increased rate of elimination immediately after a meal. J Forensic Sci 1994;39:1084-93.
39. Schwarz JM, Neese RA, Turner S, Dare D, Hellerstein MK. Short-term alterations in carbohydrate energy intake in humans. Striking effects on hepatic glucose production, de novo lipogenesis, lipolysis, and whole-body fuel selection. J Clin Invest 1995;96:2735-43.
40. Hellerstein MK, Christiansen M, Kaempfer S, et al. Measurement of de novo hepatic lipogenesis in humans using stable isotopes. J Clin Invest 1991;87:1841-52.
41. Hellerstein MK, Neese RA. Mass isotopomer distribution analysis: a technique for measuring biosynthesis and turnover of polymers. Am J Physiol 1992;263:E988-1001.
42. Hellerstein MK. Methods for the measurement of fatty acid and cholesterol metabolism. Curr Opin Lipidol 1995;6:172-81.
43. Hellerstein M, Neese RA. Mass isotopomer distribution analysis at eight years: theoretical, analytic, and experimental considerations. Am J Physiol 1999;276:E1146-70.
44. Hudgins LC, Hellerstein M, Seldman C, Neese R, Diakun J, Hirsch J. Human fatty acid synthesis is stimulated by a eucaloric low fat, high carbohydrate diet. J Clin Invest 1996;97:2081-91.
45. Aarsland A, Chinkes D, Wolfe RR. Contributions of de novo synthesis of fatty acids to total VLDL-triglyceride secretion during prolonged hyperglycemia/hyperinsulinemia in normal men. J Clin Invest 1996; 98:2008-17.
46. Grundy SM, Mok HYI, Zech L, Steinberg D, Berman M. Transport of very low density lipoprotein triglycerides in varying degrees of obesity and hypertriglyceridemia. J Clin Invest 1979;63:1274-83.
47. Olefsky J, Farquhar JW, Reaven GM. Sex differences in the kinetics of triglyceride metabolism in normal and hypertriglyceridaemic human subjects. Eur J Clin Invest 1974;4:121-7.
48. Jequier E, Acheson K, Schutz Y. Assessment of energy expenditure and fuel utilization in man. Annu Rev Nutr 1987;7:187-208.
49. Tijburg LBM, Maquedano A, Bijleveld C, Guzman M, Geelen MJH. Effects of ethanol feeding on hepatic lipid synthesis. Arch Biochem Biophys 1988;267:568-79.
50. Suter PM, Jequier E, Schutz Y. Effect of ethanol on energy expenditure. Am J Physiol 1994;266:R1204-12.
51. Deurden JM, Gibbons GF. Secretion and storage of newly synthesized hepatic triacylglycerol fatty acids in vivo in different nutritional states and in diabetes. Biochem J 1992;287:749-53.
52. Lieber CS, Spritz N, DeCarli LM. Role of dietary, adipose, and endogenously synthesized fatty acids in the pathogenesis of the alcoholic fatty liver. J Clin Invest 1966;45:51-62.
53. Lieber CS, Lefevre A, Spritz N, Feinman L, DeCarli LM. Difference in hepatic metabolism of long- and medium-chain fatty acids: the role of fatty acid chain length in the production of the alcoholic fatty liver. J Clin Invest 1967;46:1451-60.
54. Lundquist F, Tygstrup N, Winkler K, Mellemgaard K, Munck-Petersen S. Ethanol metabolism and production of free acetate in the human liver. J Clin Invest 1962;41:955-61.
55. Lundquist F. Production and utilization of free acetate in man. Nature 1962;193:579-80.
56. Hannak D, Bartelt U, Kattermann R. Acetate formation after short-term ethanol administration in man. Biol Chem Hoppe Seyler 1985; 366:749-53.
57. Nilsson NO, Belfrage P. Effects of acetate, acetaldehyde, and ethanol on lipolysis in isolated rat adipocytes. J Lipid Res 1978;19:737-41.
58. Crouse JR, Gerson CD, DeCarli LM, Lieber CS. Role of acetate in the reduction of plasma free fatty acids produced by ethanol in man. J Lipid Res 1968;9:509-12.
59. Yki-Jarvinen H, Koivisto VA, Ylikahri R, Taskinen MR. Acute effects of ethanol and acetate on glucose kinetics in normal subjects. Am J Physiol 1988;254:E175-80.
60. Abramson EA, Arky RA. Acute antilipolytic effects of ethyl alcohol and acetate in man. J Lab Clin Med 1968;72:105-17.
61. Bouchier IA, Dawson AM. The effect of infusions of ethanol on the plasma free fatty acids in man. Clin Sci 1964;26:47-54.
62. Kerbey AL, Randle PJ, Cooper RH, Whitehouse S, Pask HT, Denton RM. Regulation of pyruvate dehydrogenase in rat heart. Mechanism of regulation of proportions of dephosphorylated and phosphorylated enzymes, oxidation of fatty acids and ketone bodies and of effects of diabetes: role of nicotinamide-adenine nucleotide. Biochem J 1976;154:327-48.
63. Knowles SE, Jarret IG, Filsell OH. Ballard FJ. Production and utilization of acetate in mammals. Biochem J 1974;142:401-11.
64. Clore J, Helm S, Blackard W. Loss of hepatic autoregulation after carbohydrate overfeeding in normal men. J Clin Invest 1995;96: 1967-72.