Emerging from an unresponsive wakefulness syndrome: Brain plasticity has to cross a threshold level

Neuroscience and Biobehavioral Reviews

Volumn 37, Issue 10, 2013, Pages 2721-2736

  Bagnato, Sergio ^a   Boccagni, Cristina ^a   Sant'Angelo, Antonino ^a   Fingelkurts, Alexander A ^b   Fingelkurts, Andrew A ^b   Galardi, Giuseppe ^a  

^a Fondazione Istituto San Raffaele G Giglio   (Italy)

^b BM Science   (Finland)

Author keywords

Awareness; Brain hypoxia; Consciousness; Cortex; EEG; Minimally conscious state; Recovery; Rehabilitation; Thalamocortical projections; Thalamus; Traumatic brain injuries (TBI); Vegetative state

Indexed keywords

BRAIN CORTEX; BRAIN DYSFUNCTION; BRAIN HYPOXIA; COGNITIVE REHABILITATION; CONNECTOME; CONSCIOUSNESS; CONVALESCENCE; ELECTROENCEPHALOGRAM; EVENT RELATED POTENTIAL; HUMAN; NERVE CELL PLASTICITY; NEUROIMAGING; NEUROPATHOLOGY; PERSISTENT VEGETATIVE STATE; PRIORITY JOURNAL; REVIEW; SELF CONCEPT; THALAMOCORTICAL TRACT; TRAUMATIC BRAIN INJURY; UNRESPONSIVE WAKEFULNESS SYNDROME;

AWARENESS; BRAIN HYPOXIA; CONSCIOUSNESS; CORTEX; EEG; MINIMALLY CONSCIOUS STATE; RECOVERY; REHABILITATION; THALAMOCORTICAL PROJECTIONS; THALAMUS; TRAUMATIC BRAIN INJURIES (TBI); VEGETATIVE STATE;

BRAIN; HUMANS; NEUROIMAGING; NEURONAL PLASTICITY; UNCONSCIOUSNESS;

EID: 84889659386     PISSN: 01497634     EISSN: 18737528     Source Type: Journal    
DOI: 10.1016/j.neubiorev.2013.09.007     Document Type: Review

References (239)

1. Adams J.H., Doyle D., Ford I., Gennarelli T.A., Graham D.I., McLellan D.R. Diffuse axonal injury in head injury: definition, diagnosis and grading. Histopathology 1989, 15:49-59.
2. Adams J.H., Graham D.I., Jennett B. The neuropathology of the vegetative state after acute brain insults. Brain 2000, 123:1327-1338.
3. Adams J.H., Jennett B., McLellan D.R., Murray L.S., Graham D.I. The neuropathology of the vegetative state after head injury. Journal of Clinical Pathology 1999, 52:804-806.
4. Adams J.H., Jennett B., Murray L.S., Teasdale G.M., Gennarelli T.A., Graham D.I. Neuropathological findings in disabled survivors of a head injury. Journal of Neurotrauma 2011, 28:701-709.
5. Amantini A., Carrai R., Fossi S., Pinto F., Grippo A. The role of early electroclinical assessment in improving the evaluation of patients with disorders of consciousness. Functional Neurology 2011, 26:7-14.
6. Antoniadis E.A., McDonald R.J. Fornix, medial prefrontal cortex, nucleus accumbens, and mediodorsal thalamic nucleus: roles in a fear-based context discrimination task. Neurobiology of Learning and Memory 2006, 85:71-85.
7. Arya K.N., Verma R., Garg R.K., Sharma V.P., Agarwal M., Aggarwal G.G. Meaningful task-specific training (MTST) for stroke rehabilitation: a randomized controlled trial. Topics in Stroke Rehabilitation 2012, 19:193-211.
8. Aston-Jones G., Chen S., Zhu Y., Oshinsky M.L. A neural circuit for circadian regulation of arousal. Nature Neuroscience 2001, 4:732-738.
9. Augustinaite S., Yanagawa Y., Heggelund P. Cortical feedback regulation of input to visual cortex: role of intrageniculate interneurons. Journal of Physiology 2011, 589:2963-2977.
10. Avesani R., Roncari L., Khansefid M., Formisano R., Boldrini P., Zampolini M., Ferro S., De Tanti A., Dambruoso F. The Italian National Registry of severe acquired brain injury: epidemiological, clinical and functional data of 1469 patients. European Journal of Physical and Rehabilitation Medicine 2013, (Epub ahead of print).
11. Bagnato S., Boccagni C., Prestandrea C., Sant'Angelo A., Castiglione A., Galardi G. Prognostic value of standard EEG in traumatic and non-traumatic disorders of consciousness following coma. Clinical Neurophysiology 2010, 121:274-280.
12. Bagnato S., Boccagni C., Sant'Angelo A., Prestandrea C., Romano M.C., Galardi G. Neuromuscular involvement in vegetative and minimally conscious states following acute brain injury. Journal of Peripheral Nervous System 2011, 16:316-321.
13. Bagnato S., Minafra L., Bravatà V., Boccagni C., Sant'angelo A., Castiglione A., Andriolo M., Lucca L.F., De Tanti A., Pistarini C., Formisano R., Dolce G., Gelfi C., Galardi G. Brain-derived neurotrophic factor (Val66Met) polymorphism does not influence recovery from a post-traumatic vegetative state: a blinded retrospective multi-centric study. Journal of Neurotrauma 2012, 29:2050-2059.
14. Bagnato S., Boccagni C., Sant'Angelo A., Prestandrea C., Rizzo S., Galardi G. Patients in a vegetative state following traumatic brain injury display a reduced intracortical modulation. Clinical Neurophysiology 2012, 123:1937-1941.
15. Bagnato S., Boccagni C., Galardi G. Structural epilepsy occurrence in vegetative and minimally conscious states. Epilepsy Research 2013, 103:106-109.
16. Bagnato S., Boccagni C., Sant'angelo A., Galardi G. A range of antiepileptic drugs do not affect the recovery of consciousness in vegetative and minimally conscious states. Epilepsy and Behavior 2013, 27:365-370.
17. Barreca S., Velikonja D., Brown L., Williams L., Davis L., Sigouin C.S. Evaluation of the effectiveness of two clinical training procedures to elicit yes/no responses from patients with a severe acquired brain injury: a randomized single-subject design. Brain Injury 2003, 17:1065-1075.
18. Basar E., Basar-Eroglu C., Karakas S., Schurmann M. Gamma, alpha, delta, and theta oscillations govern cognitive processes. Journal of Psychophysiology 2001, 39:241-248.
19. Bednarek E., Caroni P. β-Adducin is required for stable assembly of new synapses and improved memory upon environmental enrichment. Neuron 2011, 69:1132-1146.
20. Benarroch E.E., Daube J.R., Flemming K.D., Westmoreland B.F. Mayo Clinic Medical Neurosciences: Organized by Neurologic Systems and Levels 2008, Informa Health care, Florence, KY. 5th edition.
21. Biernaskie J., Chernenko G., Corbett D. Efficacy of rehabilitative experience declines with time after focal ischemic brain injury. Journal of Neuroscience 2004, 24:1245-1254.
22. Bigler E.D., Maxwell W.L. Neuroimaging and neuropathology of TBI. NeuroRehabilitation 2011, 28:63-74.
23. Bigler E.D. Anterior and middle cranial fossa in traumatic brain injury: relevant neuroanatomy and neuropathology in the study of neuropsychological outcome. Neuropsychology 2007, 21:515-531.
24. Blumenfeld H. Neuroanatomy Through Clinical Cases 2010, Sinauer Associates Inc., Sunderland, MA. 2nd edition.
25. Boccagni C., Bagnato S., Sant'Angelo A., Prestandrea C., Galardi G. Usefulness of standard EEG in predicting the outcome of patients with disorders of consciousness after anoxic coma. Journal of Clinical Neurophysiology 2011, 28:489-492.
26. Boccagni, C., Bagnato, S., Sant'Angelo, A., Galardi, G. Dystonia after severe brain injuries. Movement Disorders (in press).
27. Boly M., Faymonville M.E., Peigneux P., Lambermont B., Damas P., Del Fiore G., Degueldre C., Franck G., Luxen A., Lamy M., Moonen G., Maquet P., Laureys S. Auditory processing in severely brain injured patients: differences between the minimally conscious state and the persistent vegetative state. Archives of Neurology 2004, 61:233-238.
28. Briggs F., Usrey W.M. Emerging views of corticothalamic function. Current Opinion in Neurobiology 2008, 18:403-407.
29. Bruel-Jungerman E., Laroche S., Rampon C. New neurons in the dentate gyrus are involved in the expression of enhanced long-term memory following environmental enrichment. European Journal of Neuroscience 2005, 21:513-521.
30. Bueno-Junior L.S., Lopes-Aguiar C., Ruggiero R.N., Romcy-Pereira R.N., Leite J.P. Muscarinic and nicotinic modulation of thalamo-prefrontal cortex synaptic plasticity in vivo. PLoS ONE 2012, 7:e47484.
31. Buzsaki G., Draguhn A. Neuronal oscillations in cortical networks. Science 2004, 304:1926-1929.
32. Calabresi P., Centone D., Pisani A., Cupini L., Bernardi G. Synaptic plasticity in the ischaemic brain. Lancet Neurology 2003, 2:622-629.
33. Calabresi P., Picconi B., Tozzi A., Di Filippo M. Dopamine-mediated regulation of corticostriatal synaptic plasticity. Trends in Neurosciences 2007, 30:211-219.
34. Canedo A., Grix M.C., Nicoletti J. An analysis of assessment instruments for the minimally responsive patient (MRP): clinical observations. Brain Injury 2002, 16:453-461.
35. Carmichael S.T., Archibeque I., Luke L., Nolan T., Momiy J., Li S. Growth-associated gene expression after stroke: evidence for a growth-promoting region in peri-infarct cortex. Experimental Neurology 2005, 193:291-311.
36. Castro-Alamancos M.A., Calcagnotto M.E. Presynaptic long-term potentiation in corticothalamic synapses. Journal of Neuroscience 1999, 19:9090-9097.
37. Cauda F., Micon B.M., Sacco K., Duca S., D'Agata F., Geminiani G., Canavero S. Disrupted intrinsic functional connectivity in the vegetative state. Journal of Neurology, Neurosurgery and Psychiatry 2009, 80:429-431.
38. Cavanna A.E., Shah S., Eddy C.M., Williams A., Rickards H. Consciousness: a neurological perspective. Behavioural Neurology 2011, 24:107-116.
39. Chen J.L., Lin W.C., Cha J.W., So P.T., Kubota Y., Nedivi E. Structural basis for the role of inhibition in facilitating adult brain plasticity. Nature Neuroscience 2011, 14:587-594.
40. Chen Z.Y., Patel P.D., Sant G., Meng C.X., Teng K.K., Hempstead B.L., Lee F.S. Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons. Journal of Neuroscience 2004, 24:4401-4411.
41. Cheng S.K., Man D.W. Management of impaired self-awareness in persons with traumatic brain injury. Brain Injury 2006, 20:621-628.
42. Coleman M.R., Rodd J.M., Davis M.H., Johnsrude I.S., Menon D.K., Pickard J.D., Owen A.M. Do vegetative patients retain aspects of language comprehension? Evidence from fMRI. Brain 2007, 130:2494-2507.
43. Clemenzi A., Formisano R., Matteis M., Gallinacci L., Cochi G., Savina P., Cicinelli P. Care management of spasticity with botulinum toxin-A in patients with severe acquired brain injury: a 1-year follow-up prospective study. Brain Injury 2012, 26:979-983.
44. Cologan V., Drouot X., Parapatics S., Delorme A., Gruber G., Moonen G., Laureys S. Sleep in the unresponsive wakefulness syndrome and minimally conscious state. Journal of Neurotrauma 2013, 30:339-346.
45. Cooke S.F., Bear M.F. Visual experience induces long-term potentiation in the primary visual cortex. Journal of Neuroscience 2010, 30:16304-16313.
46. Craft T.K., Glasper E.R., McCullough L., Zhang N., Sugo N., Otsuka T., Hurn P.D., DeVries A.C. Social interaction improves experimental stroke outcome. Stroke 2005, 36:2006-2011.
47. 2+ chelator prevents generation of anoxic LTP. Journal of Neurophysiology 1996, 75:770-779.
48. Crepel V., Hammond C., Chinestra P., Diabira D., Ben-Ari Y. A selective LTP of NMDA receptor-mediated currents induced by anoxia in CA1 hippocampal neurons. Journal of Neurophysiology 1993, 70:2045-2055.
49. Cruccu G., Aminoff M.J., Curio G., Guérit J.M., Kakigi R., Mauguiere F., Rossini P.M., Treede R.D., Garcia-Larrea L. Recommendations for the clinical use of somatosensory-evoked potentials. Clinical Neurophysiology 2008, 119:1705-1719.
50. Cruse D., Chennu S., Chatelle C., Bekinschtein T.A., Fernández-Espejo D., Pickard J.D., Laureys S., Owen A.M. Bedside detection of awareness in the vegetative state: a cohort study. Lancet 2011, 378:2088-2094.
51. Cruse D., Thibaut A., Demertzi A., Nantes J.C., Bruno M.A., Gosseries O., Vanhaudenhuyse A., Bekinschtein T.A., Owen A.M., Laureys S. Actigraphy assessments of circadian sleep-wake cycles in the Vegetative and Minimally Conscious States. BMC Medicine 2013, 11:18.
52. de Lecea L., Carter M.E., Adamantidis A. Shining light on wakefulness and arousal. Biological Psychiatry 2012, 71:1046-1052.
53. de Tommaso M., Navarro J., Ricci K., Lorenzo M., Lanzillotti C., Colonna F., Resta M., Lancioni G., Livrea P. Pain in prolonged disorders of consciousness: laser evoked potentials findings in patients with vegetative and minimally conscious states. Brain Injury 2013, 27:962-972.
54. Deck M., Lokmane L., Chauvet S., Mailhes C., Keita M., Niquille M., Yoshida M., Yoshida Y., Lebrand C., Mann F., Grove E.A., Garel S. Pathfinding of corticothalamic axons relies on a rendezvous with thalamic projections. Neuron 2013, 77:472-484.
55. Dehaene S., Changeux J.P. Experimental and theoretical approaches to conscious processing. Neuron 2011, 70:200-227.
56. Deschenes M., Veinante P., Zhang Z.W. The organization of corticothalamic projections: reciprocity versus parity. Brain Research Reviews 1998, 28:286-308.
57. Destexhe A., Hughes S.W., Rudolph M., Crunelli V. Are corticothalamic 'up' states fragments of wakefulness?. Trends in Neurosciences 2007, 30:334-342.
58. Di H.B., Yu S.M., Weng X.C., Laureys S., Yu D., Li J.Q., Qin P.M., Zhu Y.H., Zhang S.Z., Chen Y.Z. Cerebral response to patient's own name in the vegetative and minimally conscious states. Neurology 2007, 68:895-899.
59. Di Filippo M., Tozzi A., Costa C., Belcastro V., Tantucci M., Picconi B., Calabresi P. Plasticity and repair in the post-ischemic brain. Neuropharmacology 2008, 55:353-362.
60. Ding M.C., Wang Q., Lo E.H., Stanley G.B. Cortical excitation and inhibition following focal traumatic brain injury. Journal of Neuroscience 2011, 31:14085-14094.
61. Doesborgh S.J., van de Sandt-Koenderman M.W., Dippel D.W., van Harskamp F., Koudstaal P.J., Visch-Brink E.G. Effects of semantic treatment on verbal communication and linguistic processing in aphasia after stroke: a randomized controlled trial. Stroke 2004, 35:141-146.
62. Dolce G., Lucca L.F. The vegetative state updated. Journal of Psychophysiology 2010, 24:107-111.
63. Dolce G., Lucca L.F., Quintieri M., Leto E., Rogano S., Riganello F., Pignolo L. Neurorehabilitation for severe disorder of consciousness: the S. Anna - RAN operational model. Journal of Rehabilitation Medicine 2012, 44:512-516.
64. Du B., Shan A., Zhang Y., Zhong X., Chen D., Cai K. Zolpidem arouses patients in vegetative state after brain injury: quantitative evaluation and indications. American Journal of Medical Sciences 2013, (Epub ahead of print). 10.1097/MAJ.0b013e31827bef91.
65. Edlow B.L., Takahashi E., Wu O., Benner T., Dai G., Bu L., Grant P.E., Greer D.M., Greenberg S.M., Kinney H.C., Folkerth R.D. Neuroanatomic connectivity of the human ascending arousal system critical to consciousness and its disorders. Journal of Neuropathology and Experimental Neurology 2012, 71:531-546.
66. Eroglu C., Barres B.A. Regulation of synaptic connectivity by glia. Nature 2010, 468:223-231.
67. Estraneo A., Moretta P., Loreto V., Lanzillo B., Cozzolino A., Saltalamacchia A., Lullo F., Santoro L., Trojano L. Predictors of recovery of responsiveness in prolonged anoxic vegetative state. Neurology 2013, 80:464-470.
68. Feinberg T.E. The nested hierarchy of consciousness: a neurobiological solution to the problem of mental unity. Neurocase 2000, 6:75-81.
69. Feinberg T.E. The nested neural hierarchy and the self. Consciousness and Cognition 2011, 20:4-15.
70. Fingelkurts A.A., Fingelkurts A.A. Operational architectonics of the human brain biopotential field: towards solving the mind-brain problem. Brain and Mind 2001, 2:261-296.
71. Fingelkurts A.A., Fingelkurts A.A. Making complexity simpler: multivariability and metastability in the brain. International Journal of Neuroscience 2004, 114:843-862.
72. Fingelkurts A.A., Fingelkurts A.A. Mapping of the brain operational architectonics. Focus on Brain Mapping Research 2005, 59-98. Nova Science Publishers, Inc., New York. F.J. Chen (Ed.).
73. Fingelkurts A.A., Fingelkurts A.A., Kähkönen S. Functional connectivity in the brain - is it an elusive concept?. Neuroscience and Biobehavioral Reviews 2005, 28:827-836.
74. Fingelkurts A.A., Fingelkurts A.A. Timing in cognition and EEG brain dynamics: discreteness versus continuity. Cognitive Processing 2006, 7:135-162.
75. Fingelkurts A.A., Fingelkurts A.A. Brain-mind operational architectonics imaging: technical and methodological aspects. Open Neuroimaging Journal 2008, 2:73-93.
76. Fingelkurts A.A., Fingelkurts A.A., Neves C.F.H. Natural world physical, brain operational, and mind phenomenal space-time. Physics of Life Reviews 2010, 7:195-249.
77. Fingelkurts A.A., Fingelkurts A.A., Bagnato S., Boccagni C., Galardi G. Life or death: prognostic value of a resting EEG with regards to survival in patients in vegetative and minimally conscious states. PLoS ONE 2011, 6:e25967.
78. Fingelkurts A.A., Fingelkurts A.A., Bagnato S., Boccagni C., Galardi G. EEG oscillatory states as neuro-phenomenology of consciousness as revealed from patients in vegetative and minimally conscious states. Consciousness and Cognition 2012, 21:149-169.
79. Fingelkurts A.A., Fingelkurts A.A., Bagnato S., Boccagni C., Galardi G. Towards operational architectonics of consciousness: basic evidence from patients with severe cerebral injuries. Cognitive Processing 2012, 13:111-131.
80. Fingelkurts A.A., Fingelkurts A.A., Bagnato S., Boccagni C., Galardi G. DMN operational synchrony relates to self-consciousness: evidence from patients in vegetative and minimally conscious states. Open Neuroimaging Journal 2012, 6:55-68.
81. Fingelkurts A.A., Fingelkurts A.A., Neves C.F.H. Consciousness as a phenomenon in the operational architectonics of brain organization: criticality and self-organization considerations. Chaos. Solitons and Fractals 2013, 55:13-31.
82. Fingelkurts A.A., Fingelkurts A.A., Bagnato S., Boccagni C., Galardi G. The value of spontaneous EEG oscillations in distinguishing patients in vegetative and minimally conscious states. Application of Brain Oscillations in Neuropsychiatric Diseases. Supplements to Clinical Neurophysiology 2013, vol. 62:81-99. Elsevier, Amsterdam.
83. Fingelkurts A.A., Fingelkurts A.A., Bagnato S., Boccagni C., Galardi G. Dissociation of vegetative and minimally conscious patients based on brain operational architectonics: factor of etiology. Clinical EEG and Neuroscience 2013, 44:209-220.
84. Fischer C., Luaute J., Morlet D. Event-related potentials (MMN and novelty P3) in permanent vegetative or minimally conscious states. Clinical Neurophysiology 2010, 121:1032-1042.
85. Freeman W.J. Indirect biological measures of consciousness from field studies of brains as dynamical systems. Neural Networks 2007, 20:1021-1031.
86. Ganesh S., Guernon A., Chalcraft L., Harton B., Smith B., Louise-Bender Pape T. Medical comorbidities in disorders of consciousness patients and their association with functional outcomes. Archives of Physical Medicine and Rehabilitation 2013, (Epub ahead of print). 10.1016/j.apmr.2012.12.026.
87. Giacino J., Ashwal T., Childs S., Cranford N., Jennett R., Katz B., Kelly D.I., Rosenberg J.P., Whyte J.H., Zafonte J., Zasler R.D.N.D. The minimally conscious state: definition and diagnostic criteria. Neurology 2002, 58:349-353.
88. Giacino J.T., Kalmar K., Whyte J. The JFK Coma Recovery Scale-Revised: measurement characteristics and diagnostic utility. Archives of Physical Medicine and Rehabilitation 2004, 85:2020-2029.
89. Giacino J., Whyte T., Bagiella J., Kalmar E., Childs K., Khademi N., Eifert A., Long B., Katz D., Cho D.I., Yablon S., Luther S.A., Hammond M., Nordenbo F.M., Novak A., Mercer P., Maurer-Karattup W., Sherer P.M. Placebo-controlled trial of amantadine for severe traumatic brain injury. New England Journal of Medicine 2012, 366:819-826.
90. Giacino J., Fins J.J., Machado A., Schiff N.D. Central thalamic deep brain stimulation to promote recovery from chronic posttraumatic minimally conscious state: challenges and opportunities. Neuromodulation 2012, 15:339-349.
91. Giacino J.T., Katz D.I., Whyte J. Neurorehabilitation in disorders of consciousness. Seminars in Neurology 2013, 33:142-156.
92. Glass T.A., Matchar D.B., Belyea M., Feussner J.R. Impact of social support on outcome in first stroke. Stroke 1993, 24:64-70.
93. Goldberg J.H., Fee M.S. A cortical motor nucleus drives the basal ganglia-recipient thalamus in singing birds. Nature Neuroscience 2012, 15:620-627.
94. Graham D.I., Adams J.H., Murray L.S., Jennett B. Neuropathology of the vegetative state after head injury. Neuropsychological Rehabilitation 2005, 15:198-213.
95. Graham D.I., Maxwell W.L., Adams J.H., Jennett B. Novel aspects of the neuropathology of the vegetative state after blunt head injury. Progress in Brain Research 2005, 150:445-455.
96. Graham D.I., McLellan D., Adams J.H., Doyle D., Kerr A., Murray L.S. The neuropathology of the vegetative state and severe disability after non-missile head injury. Acta Neurochirurgica Supplement (Wien) 1983, 32:65-67.
97. Grant E., Hoerder-Suabedissen A., Molnár Z. Development of the corticothalamic projections. Frontiers in Neuroscience 2012, 6:53.
98. Ha K.S., Youn T., Kong S.W., Park H.J., Ha T.H., Kim M.S., Kwon J.S. Optimized individual mismatch negativity source localization using a realistic head model and the Talairach coordinate system. Brain Topography 2003, 15:233-238.
99. Haider B., McCormick D.A. Rapid neocortical dynamics: cellular and network mechanisms. Neuron 2009, 62:171-189.
100. Harrison A.H., Connolly J.F. Finding a way in: a review and practical evaluation of fMRI and EEG for detection and assessment in disorders of consciousness. Neuroscience and Biobehavioral Reviews 2013, 37:1403-1419.
101. Heelmann V., Lippert-Grüner M., Rommel T., Wedekind C. Abnormal functional MRI BOLD contrast in the vegetative state after severe traumatic brain injury. International Journal of Rehabilitation Research 2010, 33:151-157.
102. Hermann D.M., Siccoli M., Brugger P., Wachter K., Mathis J., Achermann P., Bassetti C.L. Evolution of neurological, neuropsychological and sleep-wake disturbances after paramedian thalamic stroke. Stroke 2008, 39:62-68.
103. Hirata A., Castro-Alamancos M.A. Neocortex network activation and deactivation states controlled by the thalamus. Journal of Neurophysiology 2010, 103:1147-1157.
104. Hopper R.A., Garthwaite J. Tonic and phasic nitric oxide signals in hippocampal long-term potentiation. Journal of Neuroscience 2006, 26:11513-11521.
105. Hsu C.L., Yang H.W., Yen C.T., Min M.Y. Comparison of synaptic transmission and plasticity between sensory and cortical synapses on relay neurons in the ventrobasal nucleus of the rat thalamus. Journal of Physiology 2010, 588:4347-4363.
106. Huang C.C., Hsu K.S. Nitric oxide signalling is required for the generation of anoxia-induced long-term potentiation in the hippocampus. European Journal of Neuroscience 1997, 9:2202-2206.
107. Hudetz A. Cortical disintegration mechanism of anesthetic-induced unconsciousness. Suppressing the Mind: Contemporary Clinical Neuroscience 2010, 99-125. Humana Press, New York. A. Hudetz, R. Pearce (Eds.).
108. Huynh W., Vucic S., Krishnan A.V., Lin C.S., Hornberger M., Kiernan M.C. Longitudinal plasticity across the neural axis in acute stroke. Neurorehabilitation and Neural Repair 2013, 27:219-229.
109. Izquierdo A., Murray E.A. Functional interaction of medial mediodorsal thalamic nucleus but not nucleus accumbens with amygdala and orbital prefrontal cortex is essential for adaptive response selection after reinforce devaluation. Journal of Neuroscience 2010, 30:661-669.
110. Jennett B., Adams J.H., Murray L.S., Graham D.I. Neuropathology in vegetative and severely disabled patients after head injury. Neurology 2001, 56:486-490.
111. John E.R. The neurophysics of consciousness. Brain Research Reviews 2002, 39:1-28.
112. Jones B.E. Activity, modulation and role of basal forebrain cholinergic neurons innervating the cerebral cortex. Progress in Brain Research 2004, 145:157-169.
113. Jones E.G. Some aspects of the organization of the thalamic reticular complex. Journal of Comparative Neurology 1975, 162:285-308.
114. Jones E.G. Thalamic circuitry and thalamocortical synchrony. Philosophical Transactions of the Royal Society B: Biological Sciences 2002, 357:1659-1673.
115. Jones E.G. The Thalamus 2007, Cambridge University Press, Cambridge. 2nd edition.
116. Jones E.G. Synchrony in the interconnected circuitry of the thalamus and cerebral cortex. Annals of the New York Academy of Sciences 2009, 1157:10-23.
117. Kalashnikova L.A., Gulevskaya T.S., Kashina E.M. Disorders of higher mental function due to single infarctions in the thalamus and in the area of the thalamofrontal tracts. Neuroscience and Behavioral Physiology 1999, 29:397-403.
118. Kampfl A., Franz G., Aichner F., Pfausler B., Haring H.P., Felber S., Luz G., Schocke M., Schmutzhard E. The persistent vegetative state after closed head injury: clinical and magnetic resonance imaging findings in 42 patients. Journal of Neurosurgery 1998, 88:809-816.
119. Kampfl A., Schmutzhard E., Franz G., Pfausler B., Haring H.P., Ulmer H., Felber S., Golaszewski S., Aichner F. Prediction of recovery from post-traumatic vegetative state with cerebral magnetic-resonance imaging. Lancet 1998, 351:1763-1767.
120. Kanno T., Morita I., Yamaguchi S., Yokoyama T., Kamei Y., Anil S.M., Karagiozov K.L. Dorsal column stimulation in persistent vegetative state. Neuromodulation 2009, 12:33-38.
121. Kaplan A.Y., Fingelkurts A.A., Fingelkurts A.A., Borisov S.V., Darkhovsky B.S. Nonstationary nature of the brain activity as revealed by EEG/MEG: methodological, practical and conceptual challenges. Signal Processing 2005, 85:2190-2212.
122. Karelina K., Norman G.J., Zhang N., DeVries A.C. Social contact influences histological and behavioral outcomes following cerebral ischemia. Experimental Neurology 2009, 220:276-282.
123. Keiner S., Witte O.W., Redecker C. Immunocytochemical detection of newly generated neurons in the perilesional area of cortical infarcts after intraventricular application of brain-derived neurotrophic factor. Journal of Neuropathology and Experimental Neurology 2009, 68:83-93.
124. Kempermann G., Gast D., Gage F.H. Neuroplasticity in old age: sustained fivefold induction of hippocampal neurogenesis by long-term environmental enrichment. Annals of Neurology 2002, 52:135-143.
125. Kheder A., Nair K.P. Spasticity: pathophysiology, evaluation and management. Practical Neurology 2012, 12:289-298.
126. Kleim J.A., Chan S., Pringle E., Schallert K., Procaccio V., Jimenez R., Cramer S.C. BDNF Val66met polymorphism is associated with modified experience-dependent plasticity in human motor cortex. Nature Neuroscience 2006, 9:735-737.
127. Klimesch W. Alpha-band oscillations, attention, and controlled access to stored information. Trends in Cognitive Sciences 2012, 16:606-617.
128. Kokaia Z., Andsberg G., Yan Q., Lindvall O. Rapid alterations of BDNF protein levels in the rat brain after focal ischemia: evidence for increased synthesis and anterograde axonal transport. Experimental Neurology 1998, 154:289-301.
129. Kotchoubey B., Lang S., Mezger G., Schmalohr D., Schneck M., Semmler A., Bostanov V., Birbaumer N. Information processing in severe disorders of consciousness: vegetative state and minimally conscious state. Clinical Neurophysiology 2005, 116:2441-2453.
130. Krout K.E., Kawano J., Mettenleiter T.C., Loewy A.D. CNS inputs to the suprachiasmatic nucleus of the rat. Neuroscience 2002, 110:73-92.
131. Kuo M.C., Dringenberg H.C. Short-term (2 to 5h) dark exposure lowers long-term potentiation (LTP) induction threshold in rat primary visual cortex. Brain Research 2009, 1276:58-66.
132. Lancioni G., O'Reilly M., Singh N., Buonocunto F., Sacco V., Colonna F., Navarro J., Lanzilotti C., Belardinelli M.O., Bosco A., Megna G., De Tommaso M. Evaluation of technology-assisted learning setups for undertaking assessment and providing intervention to persons with a diagnosis of vegetative state. Developmental Neurorehabilitation 2009, 12:411-420.
133. Lancioni G.E., Singh N.N., O'Reilly M.F., Sigafoos J., Buonocunto F., Sacco V., Colonna F., Navarro J., Lanzilotti C., Bosco A., Megna G., De Tommaso M. A technology-assisted learning setup as assessment supplement for three persons with a diagnosis of post-coma vegetative state and pervasive motor impairment. Research in Developmental Disabilities 2009, 30:1034-1043.
134. Lancioni G.E., Bosco A., Belardinelli M.O., Singh N.N., O'Reilly M.F., Sigafoos J. An overview of intervention options for promoting adaptive behavior of persons with acquired brain injury and minimally conscious state. Research in Developmental Disabilities 2010, 31:1121-1134.
135. Lang C.E., Macdonald J.R., Reisman D.S., Boyd L., Jacobson Kimberley T., Schindler-Ivens S.M., Hornby T.G., Ross S.A., Scheets P.L. Observation of amounts of movement practice provided during stroke rehabilitation. Archives of Physical Medicine and Rehabilitation 2009, 90:1692-1698.
136. Lapitskaya N., Gosseries O., De Pasqua V., Pedersen A.R., Nielsen J.F., de Noordhout A.M., Laureys S. Abnormal corticospinal excitability in patients with disorders of consciousness. Brain Stimulation 2013, 6:590-597.
137. Latronico N., Bertolini G., Guarneri B., Botteri M., Peli E., Andreoletti S., Bera P., Luciani D., Nardella A., Vittorielli E., Simini B., Candiani A. Simplified electrophysiological evaluation of peripheral nerves in critically ill patients: the Italian multi-centre CRIMYNE study. Critical Care 2007, 11:R11.
138. Laureys S. The neural correlate of (un)awareness: lessons from the vegetative state. Trends in Cognitive Sciences 2005, 9:556-559.
139. Laureys S., Giacino J.T., Schiff N.D., Schabus M., Owen A.M. How should functional imaging of patients with disorders of consciousness contribute to their clinical rehabilitation needs?. Current Opinion in Neurology 2006, 19:520-527.
140. Laureys S., Celesia G.G., Cohadon F., Lavrijsen J., León-Carrión J., Sannita W.G., Sazbon L., Schmutzhard E., von Wild K.R., Zeman A., Dolce G. European Task Force on Disorders of Consciousness, Unresponsive wakefulness syndrome: a new name for the vegetative state or apallic syndrome. BMC Medicine 2010, 8:68.
141. Laureys S., Schiff N.D. Coma and consciousness: paradigms (re)framed by neuroimaging. Neuroimage 2012, 61:478-491.
142. Lehembre R., Marie-Aurélie B., Vanhaudenhuyse A., Chatelle C., Cologan V., Leclercq Y., Soddu A., Macq B., Laureys S., Noirhomme Q. Resting-state EEG study of comatose patients: a connectivity and frequency analysis to find differences between vegetative and minimally conscious states. Functional Neurology 2012, 27:41-47.
143. Leonardi M., Sattin D., Raggi A., Frosi G., Pisoni C., Pistarini C., Compostini A., Manera M., Croci M., Guizzetti G.B. Functioning and disability in the vegetative state: results from a pilot study in Italy. Disability and Rehabilitation 2009, 31(Suppl. 1):S128-S133.
144. Leonardi M., Sattin D., Giovannetti A.M., Pagani M., Strazzer S., Villa F., Martinuzzi A., Buffoni M., Castelli E., Lispi M.L., Trabacca A., Gennaro L., Raggi A. Functioning and disability of children and adolescents in a vegetative state and a minimally conscious state: identification of ICF-CY-relevant categories. International Journal of Rehabilitation Research 2012, 35:352-359.
145. Lopez J., Wolff M., Lecourtier L., Cosquer B., Bontempi B., Dalrymple-Alford J., Cassel J.C. The intralaminar thalamic nuclei contribute to remote spatial memory. Journal of Neuroscience 2009, 29:3302-3306.
146. Loureiro M., Cholvin T., Lopez J., Merienne N., Latreche A., Cosquer B., Geiger K., Kelche C., Cassel J.C., Pereira de Vasconcelos A. The ventral midline thalamus (reuniens and rhomboid nuclei) contributes to the persistence of spatial memory in rats. Journal of Neuroscience 2012, 32:9947-9959.
147. Machado C., Korein J., Aubert E., Bosch J., Alvarez M.A., Rodríguez R., Valdés P., Portela L., Garcia M., Pérez N., Chinchilla M., Machado Y., Machado Y. Recognizing a mother's voice in the persistent vegetative state. Clinical EEG and Neuroscience 2007, 38:124-126.
148. Machado C., Estévez M., Carrick F.R., Rodríguez R., Pérez-Nellar J., Chinchilla M., Machado Y., Pérez-Hoz G., Carballo M., Fleitas M., Pando A. Vegetative state is a pejorative term. NeuroRehabilitation 2012, 31:345-347.
149. Maegele M., Lippert-Gruener M., Ester-Bode T., Sauerland S., Schäfer U., Molcanyi M., Lefering R., Bouillon B., Neiss W.F., Angelov D.N., Klug N., McIntosh T.K., Neugebauer E.A. Reversal of neuromotor and cognitive dysfunction in an enriched environment combined with multimodal early onset stimulation after traumatic brain injury in rats. Journal of Neurotrauma 2005, 22:772-782.
150. Mainardi M., Landi S., Gianfranceschi L., Baldini S., De Pasquale R., Berardi N., Maffei L., Caleo M. Environmental enrichment potentiates thalamocortical transmission and plasticity in the adult rat visual cortex. Journal of Neuroscience Research 2010, 88:3048-3059.
151. Maxwell W.L., Pennington K., MacKinnon M.A., Smith D.H., McIntosh T.K., Wilson J.T., Graham D.I. Differential responses in three thalamic nuclei in moderately disabled, severely disabled and vegetative patients after blunt head injury. Brain 2004, 127:2470-2478.
152. Maya Vetencourt J.F., Sale A., Viegi A., Baroncelli L., De Pasquale R., O'Leary O.F., Castrén E., Maffei L. The antidepressant fluoxetine restores plasticity in the adult visual cortex. Science 2008, 320:385-388.
153. McAlonan K., Brown V.J. The thalamic reticular nucleus: more than a sensory nucleus?. Neuroscientist 2002, 8:302-305.
154. McAlonan K., Cavanaugh J., Wurtz R.H. Attentional modulation of thalamic reticular neurons. Journal of Neuroscience 2006, 26:4444-4450.
155. McCormick D.A. Neurotransmitter actions in the thalamus and cerebral cortex and their role in neuromodulation of thalamocortical activity. Progress in Neurobiology 1992, 39:337-388.
156. McFadden J. Synchronous firing and its influence on the brain's electromagnetic field. Evidence for an electromagnetic field theory of consciousness. Journal of Consciousness Studies 2002, 9:23-50.
157. Mesulam M.M. Principles of Behavioral and Cognitive Neurology 2000, Oxford University Press, New York. 2nd edition.
158. Min B.K. A thalamic reticular networking model of consciousness. Theoretical Biology and Medicine Modelling 2010, 7:10.
159. Miyata M., Imoto K. Contrary roles of kainate receptors in transmitter release at corticothalamic synapses onto thalamic relay and reticular neurons. Journal of Physiology 2009, 587:999-1012.
160. Montey K.L., Quinlan E.M. Recovery from chronic monocular deprivation following reactivation of thalamocortical plasticity by dark exposure. Nature Communications 2011, 2:317.
161. Monti M.M., Laureys S., Owen A.M. The vegetative state. British Medical Journal 2010, 341:c3765.
162. Monti M.M., Vanhaudenhuyse A., Coleman M.R., Boly M., Pickard J.D., Tshibanda L., Owen A.M., Laureys S. Willful modulation of brain activity in disorders of consciousness. New England Journal of Medicine 2010, 362:579-589.
163. Morel A., Liu J., Wannier T., Jeanmonod D., Rouiller E.M. Divergence and convergence of thalamocortical projections to premotor and supplementary motor cortex: a multiple tracing study in the macaque monkey. European Journal of Neuroscience 2005, 21:1007-1029.
164. Morin L.P. Neuroanatomy of the extended circadian rhythm system. Experimental Neurology 2013, 243:4-20.
165. Murphy T.H., Corbett D. Plasticity during stroke recovery: from synapse to behaviour. Nature Reviews Neuroscience 2009, 10:861-872.
166. Muscat L., Huberman A.D., Jordan C.L., Morin L.P. Crossed and uncrossed retinal projections to the hamster circadian system. Journal of Comparative Neurology 2003, 466:513-524.
167. Näätänen R., Paavilainen P., Titinen H., Jiang D., Alho K. Attention and mismatch negativity. Psychophysiology 1993, 30:436-450.
168. Newcombe V.F., Williams G.B., Scoffings D., Cross J., Carpenter T.A., Pickard J.D., Menon D.K. Aetiological differences in neuroanatomy of the vegetative state: insights from diffusion tensor imaging and functional implications. Journal of Neurology, Neurosurgery and Psychiatry 2010, 81:552-561.
169. Nudo R.J. Postinfarct cortical plasticity and behavioral recovery. Stroke 2007, 38(Suppl. 2):840-845.
170. Nudo R.J. Neural bases of recovery after brain injury. Journal of Communications Disorders 2011, 44:515-520.
171. Nudo R.J., McNeal D. Plasticity of cerebral functions. Handbook of Clinical Neurology 2013, 110:13-21.
172. Oberlaender M., Ramirez A., Bruno R.M. Sensory experience restructures thalamocortical axons during adulthood. Neuron 2012, 74:648-655.
173. Oh H., Seo W. Sensory stimulation programme to improve recovery in comatose patients. Journal of Clinical Nursing 2003, 12:394-404.
174. Oliveira L., Fregni F. Pharmacological and electrical stimulation in chronic disorders of consciousness: new insights and future directions. Brain Injury 2011, 25:315-327.
175. Overgaard M. How can we know if patients in coma, vegetative state or minimally conscious state are conscious?. Progress in Brain Research 2009, 177:11-19.
176. Overgaard M., Overgaard R. Measurements of consciousness in the vegetative state. Lancet 2011, 378:2052-2054.
177. Owen A.M., Coleman M.R., Boly M., Davis M.H., Laureys S., Pickard J.D. Detecting awareness in the vegetative state. Science 2006, 313:1402.
178. Padberg J., Recanzone G., Engle J., Cooke D., Goldring A., Krubitzer L. Lesions in posterior parietal area 5 in monkeys result in rapid behavioral and cortical plasticity. Journal of Neuroscience 2010, 30:12918-12935.
179. Padilla-Coreano N., Do-Monte F.H., Quirk G.J. A time-dependent role of midline thalamic nuclei in the retrieval of fear memory. Neuropharmacology 2012, 62:457-463.
180. Palva S., Palva J.M. New vistas for alpha-frequency band oscillations. Trends in Neurosciences 2007, 30:150-158.
181. Palva S., Palva J.M. Functional roles of alpha-band phase synchronization in local and large-scale cortical networks. Frontiers in Psychology 2011, 2:204.
182. Parvizi J., Damasio A.R. Consciousness and the brainstem. Cognition 2001, 79:135-160.
183. Parvizi J., Damasio A.R. Neuroanatomical correlates of brainstem coma. Brain 2003, 126:1524-1536.
184. Passineau M.J., Green E.J., Dietrich W.D. Therapeutic effects of environmental enrichment on cognitive function and tissue integrity following severe traumatic brain injury in rats. Experimental Neurology 2001, 168:373-384.
185. Pignolo L., Riganello F., Dolce G., Sannita W.G. Ambient intelligence for monitoring and research in clinical neurophysiology and medicine: the MIMERICA* project and prototype. Clinical EEG and Neuroscience 2013, 44:144-149.
186. Pistoia F., Mura E., Govoni S., Fini M., Sarà M. Awakenings and awareness recovery in disorders of consciousness: is there a role for drugs?. CNS Drugs 2010, 24:625-638.
187. Poulet J.F., Fernandez L.M., Crochet S., Petersen C.C. Thalamic control of cortical states. Nature Neuroscience 2012, 15:370-372.
188. Qin P., Di H., Yan X., Yu S., Yu D., Laureys S., Weng X. Mismatch negativity to the patient's own name in chronic disorders of consciousness. Neuroscience Letters 2008, 448:24-28.
189. Rex C.S., Lin C.Y., Kramar E.A., Chen L.Y., Gall C.M., Lynch G. Brain-derived neurotrophic factor promotes long-term potentiation-related cytoskeletal changes in adult hippocampus. Journal of Neuroscience 2007, 27:3017-3029.
190. Riganello F., Candelieri A., Quintieri M., Conforti D., Dolce G. Heart rate variability: an index of brain processing in vegetative state? An artificial intelligence, data mining study. Clinical Neurophysiology 2010, 121:2024-2034.
191. Rigas P., Castro-Alamancos M.A. Thalamocortical up states: differential effects of intrinsic and extrinsic cortical inputs on persistent activity. Journal of Neuroscience 2007, 27:4261-4272.
192. Robinson L.R., Micklesen P.J., Tirschwell D.L., Lew H.L. Predictive value of somatosensory evoked potentials for awakening from coma. Critical Care Medicine 2003, 31:960-967.
193. Rosanova M., Gosseries O., Casarotto S., Boly M., Casali A.G., Bruno M.A., Mariotti M., Boveroux P., Tononi G., Laureys S., Massimini M. Recovery of cortical effective connectivity and recovery of consciousness in vegetative patients. Brain 2012, 135:1308-1320.
194. Ross D.T., Graham D.I., Adams J.H. Selective loss of neurons from the thalamic reticular nucleus following severe human head injury. Journal of Neurotrauma 1993, 10:151-165.
195. Rouiller E.M., Durif C. The dual pattern of corticothalamic projection of the primary auditory cortex in macaque monkey. Neuroscience Letters 2004, 358:49-52.
196. Royal College of Physicians The permanent vegetative state: guidance on diagnosis and management. Report of a working party 2003, R.C.P., London.
197. Rusalova M.N. Characteristics of interhemisphere interactions at different levels of consciousness. Neuroscience and Behavioral Physiology 2005, 35:821-827.
198. Sale A., Maya Vetencourt J.F., Medini P., Cenni M.C., Baroncelli L., De Pasquale R., Maffei L. Environmental enrichment in adulthood promotes amblyopia recovery through a reduction of intracortical inhibition. Nature Neuroscience 2007, 10:679-681.
199. Sarà M., Pistoia F., Mura E., Onorati P., Govoni S. Intrathecal baclofen in patients with persistent vegetative state: 2 hypotheses. Archives of Physical Medicine and Rehabilitation 2009, 90:1245-1249.
200. Sarà M., Pistoia F., Pasqualetti P., Sebastiano F., Onorati P., Rossini P.M. Functional isolation within the cerebral cortex in the vegetative state: a nonlinear method to predict clinical outcomes. Neurorehabilitation and Neural Repair 2011, 25:35-42.
201. Schabitz W.R., Steigleder T., Cooper-Kuhn C.M., Schwab S., Sommer C., Schneider A., Kuhn H.G. Intravenous brain-derived neurotrophic factor enhances poststroke sensorimotor recovery and stimulates neurogenesis. Stroke 2007, 38:2165-2172.
202. Schiff N.D., Giacino J.T., Kalmar K., Victor J.D., Baker K., Gerber M., Fritz B., Eisenberg B., Biondi T., O'Connor J., Kobylarz E.J., Farris S., Machado A., McCagg C., Plum F., Fins J.J., Rezai A.R. Behavioural improvements with thalamic stimulation after severe traumatic brain injury. Nature 2007, 448:600-603.
203. Schiff N.D. Central thalamic contributions to arousal regulation and neurological disorders of consciousness. Annals of the New York Academy of Sciences 2008, 1129:105-118.
204. Schiff N.D. Recovery of consciousness after brain injury: a mesocircuit hypothesis. Trends in Neurosciences 2010, 33:1-9.
205. Schiff N.D. Moving toward a generalizable application of central thalamic deep brain stimulation for support of forebrain arousal regulation in the severely injured brain. Annals of the New York Academy of Sciences 2012, 1265:56-68.
206. Schnakers C., Vanhaudenhuyse A., Giacino J., Ventura M., Boly M., Majerus S., Moonen G., Laureys S. Diagnostic accuracy of the vegetative and minimally conscious state: clinical consensus versus standardized neurobehavioral assessment. BMC Neurology 2009, 9:35.
207. Seel R.T., Sherer M., Whyte J., Katz D.I., Giacino J.T., Rosenbaum A.M., Hammond F.M., Kalmar K., Pape T.L., Zafonte R., Biester R.C., Kaelin D., Kean J., Zasler N. Assessment scales for disorders of consciousness: evidence-based recommendations for clinical practice and research. Archives of Physical Medicine and Rehabilitation 2010, 91:1795-1813.
208. Seel R.T., Douglas J., Dennison A.C., Heaner S., Farris K., Rogers C. Specialized early treatment for persons with disorders of consciousness: program components and outcomes. Archives of Physical Medicine and Rehabilitation 2013, (Epub ahead of print). 10.1016/j.apmr.2012.11.052.
209. Shen W., Wu B., Zhang Z., Dou Y., Rao Z.R., Chen Y.R., Duan S. Activity-induced rapid synaptic maturation mediated by presynaptic cdc42 signaling. Neuron 2006, 50:401-414.
210. Skandsen T., Kvistad K.A., Solheim O., Strand I.H., Folvik M., Vik A. Prevalence and impact of diffuse axonal injury in patients with moderate and severe head injury: a cohort study of early magnetic resonance imaging findings and 1-year outcome. Journal of Neurosurgery 2010, 113:556-563.
211. Smith D.H., Meaney D.F., Shull W.H. Diffuse axonal injury in head trauma. Journal of Head Trauma Rehabilitation 2003, 18:307-316.
212. Soddu A., Vanhaudenhuyse A., Demertzi A., Bruno M.A., Tshibanda L., Di H., Boly M., Papa M., Laureys S., Noirhomme Q. Resting state activity in patients with disorders of consciousness. Functional Neurology 2011, 26:37-43.
213. Steriade M., Jones E.G., McCormick D.A. Thalamic organization and chemical neuroanatomy. Thalamus 1997, vol. 1:31-174. Elsevier, Amsterdam.
214. Sun Y.G., Beierlein M. Receptor saturation controls short-term synaptic plasticity at corticothalamic synapses. Journal of Neurophysiology 2011, 105:2319-2329.
215. Tang J., Yang W., Suga N. Modulation of thalamic auditory neurons by the primary auditory cortex. Journal of Neurophysiology 2012, 108:935-942.
216. Tatemichi T.K., Desmond D.W., Prohovnik I., Cross D.T., Gropen T.I., Mohr J.P., Stern Y. Confusion and memory loss from capsular genu infarction: a thalamocortical disconnection syndrome?. Neurology 1992, 42:1966-1979.
217. The Multi-Society Task Force on PVS Medical aspects of the persistent vegetative state (1). New England Journal of Medicine 1994, 330:1499-1508.
218. The Multi-Society Task Force on PVS Medical aspects of the persistent vegetative state (2). New England Journal of Medicine 1994, 330:1572-1579.
219. Tononi G. An information integration theory of consciousness. BMC Neuroscience 2004, 5:42.
220. Tononi G. Consciousness as integrated information: a provisional manifesto. Biological Bulletin 2008, 215:216-242.
221. Tononi G., Koch C. The neural correlates of consciousness: an update. Annals of the New York Academy of Sciences 2008, 1124:239-261.
222. Trachtenberg J.T., Chen B.E., Knott G.W., Feng G., Sanes J.R., Welker E., Svoboda K. Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex. Nature 2002, 420:788-794.
223. Tyler W.J., Alonso M., Bramham C.R., Pozzo-Miller L.D. From acquisition to consolidation: on the role of brain-derived neurotrophic factor signaling in hippocampal-dependent learning. Learning and Memory 2002, 9:224-237.
224. Vakalopoulos C. Neural correlates of consciousness: a definition of the dorsal and ventral streams and their relation to phenomenology. Medical Hypotheses 2005, 65:922-931.
225. Vanhaudenhuyse A., Noirhomme Q., Tshibanda L.J., Bruno M.A., Boveroux P., Schnakers C., Soddu A., Perlbarg V., Ledoux D., Brichant J.F., Moonen G., Maquet P., Greicius M.D., Laureys S., Boly M. Default network connectivity reflects the level of consciousness in non-communicative brain-damaged patients. Brain 2010, 133:161-171.
226. Wang H.C., Ma Y.B. Experimental models of traumatic axonal injury. Journal of Clinical Neuroscience 2010, 17:157-162.
227. Ward L.M. The thalamic dynamic core theory of conscious experience. Consciousness and Cognition 2011, 20:464-486.
228. Watanabe Y., Funahashi S. Thalamic mediodorsal nucleus and working memory. Neuroscience and Biobehavioral Reviews 2012, 36:134-142.
229. WHO International Classification of Functioning, Disability and Health, 2001 2006, World Health Organization, Switzerland.
230. Whyte J., Myers R. Incidence of clinically significant responses to zolpidem among patients with disorders of consciousness: a preliminary placebo controlled trial. American Journal of Physical Medicine and Rehabilitation 2009, 88:410-418.
231. Whyte J., Nordenbo A.M., Kalmar K., Merges B., Bagiella E., Chang H., Yablon S., Cho S., Hammond F., Khademi A., Giacino J. Medical complications during inpatient rehabilitation among patients with traumatic disorders of consciousness. Archives of Physical Medicine and Rehabilitation 2013, (Epub ahead of print). 10.1016/j.apmr.2012.12.027.
232. Wijnen V.J., van Boxtel G.J., Eilander H.J., de Gelder B. Mismatch negativity predicts recovery from the vegetative state. Clinical Neurophysiology 2007, 118:597-605.
233. Winer J.A., Diehl J.J., Larue D.T. Projections of auditory cortex to the medial geniculate body of the cat. Journal of Comparative Neurology 2001, 430:27-55.
234. Xu T., Yu X., Perlik A.J., Tobin W.F., Zweig J.A., Tennant K., Jones T., Zuo Y. Rapid formation and selective stabilization of synapses for enduring motor memories. Nature 2009, 462:915-919.
235. Yamamoto T., Katayama Y., Kobayashi K., Oshima H., Fukaya C., Tsubokawa T. Deep brain stimulation for the treatment of vegetative state. European Journal of Neuroscience 2010, 32:1145-1151.
236. Yu T., Lang S., Vogel D., Markl A., Müller F., Kotchoubey B. Patients with unresponsive wakefulness syndrome respond to the pain cries of other people. Neurology 2013, 80:345-352.
237. Zeman A. Consciousness. Brain 2001, 124:1263-1289.
238. Zembrzycki A., Chou S.J., Ashery-Padan R., Stoykova A., O'Leary D.D. Sensory cortex limits cortical maps and drives top-down plasticity in thalamocortical circuits. Nature Neuroscience 2013, 16:1060-1067.
239. Zhu S.W., Yee B.K., Nyffeler M., Winblad B., Feldon J., Mohammed A.H. Influence of differential housing on emotional behaviour and neurotrophin levels in mice. Behavioral Brain Research 2006, 169:10-20.