Coma and consciousness: Paradigms (re)framed by neuroimaging

NeuroImage

Volumn 61, Issue 2, 2012, Pages 478-491

  Laureys, Steven ^a   Schiff, Nicholas D ^b  

^a UNIVERSITY OF LIÈGE   (Belgium)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Coma; Consciousness; FMRI; Minimally conscious state; PET; Traumatic brain injury; Vegetative state

Indexed keywords

COGNITION; COMA; CONSCIOUSNESS; ELECTROENCEPHALOGRAM; EVENT RELATED POTENTIAL; FOREBRAIN; FRONTAL CORTEX; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; IMAGERY; INJURY SEVERITY; MEDICAL ETHICS; MINIMALLY CONSCIOUS STATE; NERVE CELL NETWORK; NEUROIMAGING; NEUROMODULATION; PARIETAL CORTEX; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; REST; REVIEW; TASK PERFORMANCE; TRAUMATIC BRAIN INJURY;

BRAIN; BRAIN INJURIES; COMA; CONSCIOUSNESS; CONSCIOUSNESS DISORDERS; HUMANS; IMAGINATION; MAGNETIC RESONANCE IMAGING; NEUROIMAGING; PARIETAL LOBE; PROSENCEPHALON; UNCONSCIOUSNESS;

EID: 84860729047     PISSN: 10538119     EISSN: 10959572     Source Type: Journal    
DOI: 10.1016/j.neuroimage.2011.12.041     Document Type: Review

References (156)

1. Baars B., Ramsoy T., Laureys S. Brain, conscious experience and the observing self. Trends Neurosci. 2003, 26:671-675.
2. Babiloni C., Sara M., Vecchio F., Pistoia F., Sebastiano F., Onorati P., Albertini G., Pasqualetti P., Cibelli G., Buffo P., Rossini P.M. Cortical sources of resting-state alpha rhythms are abnormal in persistent vegetative state patients. Clin. Neurophysiol. 2009, 120:719-729.
3. Bagnato S., Boccagni C., Prestandrea C., Sant'Angelo A., Castiglione A., Galardi G. Prognostic value of standard EEG in traumatic and non-traumatic disorders of consciousness following coma. Clin. Neurophysiol. 2010, 121:274-280.
4. Bardin J.C., Fins J.J., Katz D.I., Hersh J., Heier L.A., Tabelow K., Dyke J.P., Ballon D.J., Schiff N.D., Voss H.U. Dissociations between behavioural and functional magnetic resonance imaging-based evaluations of cognitive function after brain injury. Brain 2011, 134:769-782.
5. Bardin, J.C., Schiff, N.D., Voss, H.U., in press. Pattern classification of volitional fMRI responses in severely brain-injured subjects. Arch Neurol. (to appear in February issue online).
6. Bekinschtein T., Leiguarda R., Armony J., Owen A., Carpintiero S., Niklison J., Olmos L., Sigman L., Manes F. Emotion processing in the minimally conscious state. J. Neurol. Neurosurg. Psychiatry 2004, 75:788.
7. Bekinschtein T., Tiberti C., Niklison J., Tamashiro M., Carpintiero S., Villarreal M., Forcato C., Leiguarda R., Manes F. Assessing level of consciousness and cognitive changes from vegetative state to full recovery. Neuropsycholo. Rehabil. 2005, 15:307-322.
8. Bekinschtein T.A., Coleman M.R., Niklison J., Pickard J.D., Manes F.F. Can electromyography objectively detect voluntary movement in disorders of consciousness?. J. Neurol. Neurosurg. Psychiatry 2008, 79:826-828.
9. Bekinschtein T.A., Dehaene S., Rohaut B., Tadel F., Cohen L., Naccache L. Neural signature of the conscious processing of auditory regularities. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:1672-1677.
10. Bekinschtein T.A., Shalom D.E., Forcato C., Herrera M., Coleman M.R., Manes F.F., Sigman M. Classical conditioning in the vegetative and minimally conscious state. Nat. Neurosci. 2009, 12:1343-1349.
11. Bekinschtein T.A., Manes F.F., Villarreal M., Owen A.M., Della-Maggiore V. Functional imaging reveals movement preparatory activity in the vegetative state. Front. Hum. Neurosci. 2011, 5:5.
12. Beuthien-Baumann B., Handrick W., Schmidt T., Burchert W., Oehme L., Kropp J., Schackert G., Pinkert J., Franke W.G. Persistent vegetative state: evaluation of brain metabolism and brain perfusion with PET and SPECT. Nucl. Med. Commun. 2003, 24:643-649.
13. Boly M., Faymonville M.E., Peigneux P., Lambermont B., Damas P., Del Fiore G., Degueldre C., Franck G., Luxen A., Lamy M., Moonen G., Maquet P., Laureys S. Auditory processing in severely brain injured patients: differences between the minimally conscious state and the persistent vegetative state. Arch. Neurol. 2004, 61:233-238.
14. Boly M., Coleman M.R., Davis M.H., Hampshire A., Bor D., Moonen G., Maquet P.A., Pickard J.D., Laureys S., Owen A.M. When thoughts become action: an fMRI paradigm to study volitional brain activity in non-communicative brain injured patients. NeuroImage 2007, 36:979-992.
15. Boly M., Faymonville M.E., Schnakers C., Peigneux P., Lambermont B., Phillips C., Lancellotti P., Luxen A., Lamy M., Moonen G., Maquet P., Laureys S. Perception of pain in the minimally conscious state with PET activation: an observational study. Lancet Neurol. 2008, 7:1013-1020.
16. Boly M., Phillips C., Balteau E., Schnakers C., Degueldre C., Moonen G., Luxen A., Peigneux P., Faymonville M.E., Maquet P., Laureys S. Consciousness and cerebral baseline activity fluctuations. Hum. Brain Mapp. 2008, 29:868-874.
17. Boly M., Tshibanda L., Vanhaudenhuyse A., Noirhomme Q., Schnakers C., Ledoux D., Boveroux P., Garweg C., Lambermont B., Phillips C., Luxen A., Moonen G., Bassetti C., Maquet P., Laureys S. Functional connectivity in the default network during resting state is preserved in a vegetative but not in a brain dead patient. Hum. Brain Mapp. 2009, 30(8):2393-2400.
18. Boly M., Garrido M.I., Gosseries O., Bruno M.A., Boveroux P., Schnakers C., Massimini M., Litvak V., Laureys S., Friston K. Preserved feedforward but impaired top-down processes in the vegetative state. Science 2011, 332:858-862.
19. Boveroux P., Bonhomme V., Boly M., Vanhaudenhuyse A., Maquet P., Laureys S. Brain function in physiologically, pharmacologically, and pathologically altered states of consciousness. Int. Anesthesiol. Clin. 2008, 46:131-146.
20. Boveroux P., Vanhaudenhuyse A., Bruno M.A., Noirhomme Q., Lauwick S., Luxen A., Degueldre C., Plenevaux A., Schnakers C., Phillips C., Brichant J.F., Bonhomme V., Maquet P., Greicius M.D., Laureys S., Boly M. Breakdown of within- and between-network resting state functional magnetic resonance imaging connectivity during propofol-induced loss of consciousness. Anesthesiology 2010, 113:1038-1053.
21. Brefel-Courbon C., Payoux P., Ory F., Sommet A., Slaoui T., Raboyeau G., Lemesle B., Puel M., Montastruc J.L., Demonet J.F., Cardebat D. Clinical and imaging evidence of zolpidem effect in hypoxic encephalopathy. Ann. Neurol. 2007, 62:102-105.
22. Brown, E.N., Lydic, R., Schiff, N.D., General anesthesia, sleep, and coma. N Engl J Med 363, 2638-2650.
23. Bruno M., Schnakers C., Damas F., Pellas F., Lutte I., Bernheim J., Majerus S., Moonen G., Goldman S., Laureys S. Locked-in syndrome in children: report of five cases and review of the literature. Pediatr. Neurol. 2009, 41:237-246.
24. Bruno M.A., Vanhaudenhuyse A., Schnakers C., Boly M., Gosseries O., Demertzi A., Majerus S., Moonen G., Hustinx R., Laureys S. Visual fixation in the vegetative state: an observational case series PET study. BMC Neurol. 2010, 10:35.
25. Bruno M.A., Fernández-Espejo D., Lehembre R., Tshibanda L., Vanhaudenhuyse A., Gosseries O., Lommers E., Napolitani M., Noirhomme Q., Boly M., Papa M., Owen A., Maquet P., Laureys S., Soddu A. Multimodal neuroimaging in patients with disorders of consciousness showing "functional hemispherectomy". Prog. Brain Res. 2011, 193:323-333.
26. Bruno M.-A., Ledoux D., Lambermont B., Damas F., Schnakers C., Vanhaudenhuyse A., Gosseries O., Laureys S. Comparison of the Full Outline of UnResponsiveness and Glasgow Liege Scale/Glasgow Coma Scale in an intensive care unit population. Neurocrit. Care 2011, 15(3):447-453.
27. Bruno, M.-A., Vanhaudenhuyse, A., Thibaut, A., Moonen, G., Laureys, S., in press. From unresponsive wakefulness to minimally conscious PLUS and functional locked-in syndromes: recent advances in our understanding of disorders of consciousness. Journal of Neurology.
28. Buckwalter J.A., Parvizi J., Morecraft R.J., van Hoesen G.W. Thalamic projections to the posteromedial cortex in the macaque. J. Comp. Neurol. 2008, 507:1709-1733.
29. Cauda F., Micon B., Sacco K., Duca S., D'Agata F., Geminiani G., Canavero S. Disrupted intrinsic functional connectivity in the vegetative state. J. Neurol. Neurosurg. Psychiatry 2009, 80:429-431.
30. Cavinato M., Freo U., Ori C., Zorzi M., Tonin P., Piccione F., Merico A. Post-acute P300 predicts recovery of consciousness from traumatic vegetative state. Brain Inj. 2009, 23:973-980.
31. Clauss R., Nel W. Drug induced arousal from the permanent vegetative state. NeuroRehabilitation 2006, 21:23-28.
32. Coleman M.R., Rodd J.M., Davis M.H., Johnsrude I.S., Menon D.K., Pickard J.D., Owen A.M. Do vegetative patients retain aspects of language comprehension? Evidence from fMRI. Brain 2007, 130:2494-2507.
33. Coleman M., Davis M., Rodd J., Robson T., Ali A., Owen A., Pickard J. Towards the routine use of brain imaging to aid the clinical diagnosis of disorders of consciousness. Brain 2009, 132:2541-2552.
34. Cologan V., Schabus M., Ledoux D., Moonen G., Maquet P., Laureys S. Sleep in disorders of consciousness. Sleep Med. Rev. 2010, 14:97-105.
35. de Jong B., Willemsen A.T., Paans A.M. Regional cerebral blood flow changes related to affective speech presentation in persistent vegetative state. Clin. Neurol. Neurosurg. 1997, 99:213-216.
36. De Volder A.G., Goffinet A.M., Bol A., Michel C., de Barsy T., Laterre C. Brain glucose metabolism in postanoxic syndrome. Positron emission tomographic study. Arch. Neurol. 1990, 47:197-204.
37. Dehaene S. The Cognitive Neuroscience of Consciousness 2000, MIT Press, Cambridge, MA.
38. Di H.B., Yu S.M., Weng X.C., Laureys S., Yu D., Li J.Q., Qin P.M., Zhu Y.H., Zhang S.Z., Chen Y.Z. Cerebral response to patient's own name in the vegetative and minimally conscious states. Neurology 2007, 68:895-899.
39. Di H., Boly M., Weng X., Ledoux D., Laureys S. Neuroimaging activation studies in the vegetative state: predictors of recovery? Clin. Med. 2008, 8(5):502-507.
40. Fellinger R., Klimesch W., Schnakers C., Perrin F., Freunberger R., Gruber W., Laureys S., Schabus M. Cognitive processes in disorders of consciousness as revealed by EEG time-frequency analyses. Clin. Neurophysiol. 2011, 122(11):2177-2184.
41. Fernandez-Espejo D., Junque C., Vendrell P., Bernabeu M., Roig T., Bargallo N., Mercader J.M. Cerebral response to speech in vegetative and minimally conscious states after traumatic brain injury. Brain Inj. 2008, 22:882-890.
42. Fernandez-Espejo D., Bekinschtein T., Monti M.M., Pickard J.D., Junque C., Coleman M.R., Owen A.M. Diffusion weighted imaging distinguishes the vegetative state from the minimally conscious state. NeuroImage 2010, 1:103-112.
43. Fernandez-Espejo D., Junque C., Cruse D., Bernabeu M., Roig-Rovira T., Fábregas N., Rivas E., Mercader J. Combination of diffusion tensor and functional magnetic resonance imaging during recovery from the vegetative state. BMC Neurol. 2010, 10:77.
44. Fins J.J. Being conscious of their burden: severe brain injury and the two cultures challenge. Ann. N. Y. Acad. Sci. 2009, 1157:131-147.
45. Fins J.J. The ethics of measuring and modulating consciousness: the imperative of minding time. Prog. Brain Res. 2009, 177:371-382.
46. Fins J.J., Schiff N.D. In the blink of the mind's eye. Hastings Cent. Rep. 2010, 40(3):21-23.
47. Fins J., Illes J., Bernat J., Hirsch J., Laureys S., Murphy E. Neuroimaging and disorders of consciousness: envisioning an ethical research agenda. Am. J. Bioeth. 2008, 8:3-12.
48. Giacino J.T., Ashwal S., Childs N., Cranford R., Jennett B., Katz D.I., Kelly J.P., Rosenberg J.H., Whyte J., Zafonte R.D., Zasler N.D. The minimally conscious state: definition and diagnostic criteria. Neurology 2002, 58:349-353.
49. Giacino J.T., Kalmar K., Whyte J. The JFK Coma Recovery Scale-Revised: measurement characteristics and diagnostic utility. Arch. Phys. Med. Rehabil. 2004, 85:2020-2029.
50. Giacino J.T., Hirsch J., Schiff N., Laureys S. Functional neuroimaging applications for assessment and rehabilitation planning in patients with disorders of consciousness. Arch. Phys. Med. Rehabil. 2006, 87:67-76.
51. Giacino J.T., Schnakers C., Rodriguez-Moreno D., Kalmar K., Schiff N., Hirsch J. Behavioral assessment in patients with disorders of consciousness: gold standard or fool's gold?. Prog. Brain Res. 2009, 177:33-48.
52. Gold L., Lauritzen M. Neuronal deactivation explains decreased cerebellar blood flow in response to focal cerebral ischemia or suppressed neocortical function. Proc. Natl. Acad. Sci. U. S. A. 2002, 99:7699-7704.
53. Goldfine A.M., Victor J.D., Conte M.M., Bardin J.C., Schiff N.D. Determination of awareness in patients with severe brain injury using EEG power spectral analysis. Clin Neurophysiol 2011.
54. Gosseries O., Bruno M.-A., Vanhaudenhuyse A., Laureys S., Schnakers C. Consciousness in the locked-in syndrome. The Neurology of Consciousness: Cognitive Neuroscience and Neuropathology 2009, 191-203. Elsevier, Oxford. S. Laureys, G. Tononi (Eds.).
55. Heckers S., Geula C., Mesulam M.M. Cholinergic innervation of the human thalamus: dual origin and differential nuclear distribution. J. Comp. Neurol. 1992, 325:68-82.
56. Heelmann V., Lippert-Grüner M., Rommel T., Wedekind C. Abnormal functional MRI BOLD contrast in the vegetative state after severe traumatic brain injury. Int. J. Rehabil. Res. 2010, 33:151-157.
57. Hirsch J., Kamal A., Moreno D., Petrovich N., Giacino J., Plum F., Schiff N. fMRI reveals intact cognitive systems for two minimally conscious patients. Society for Neuroscience, Abstracts 2001, 271:1397.
58. Jennett B. Thirty years of the vegetative state: clinical, ethical and legal problems. Prog. Brain Res. 2005, 150:537-543.
59. Juengling F.D., Kassubek J., Huppertz H.J., Krause T., Els T. Separating functional and structural damage in persistent vegetative state using combined voxel-based analysis of 3-D MRI and FDG-PET. J. Neurol. Sci. 2005, 228:179-184.
60. Kassubek J., Juengling F.D., Els T., Spreer J., Herpers M., Krause T., Moser E., Lucking C.H. Activation of a residual cortical network during painful stimulation in long-term postanoxic vegetative state: a 15O-H2O PET study. J. Neurol. Sci. 2003, 212:85-91.
61. Katz D.I., Alexander M.P., Mandell A.M. Dementia following strokes in the mesencephalon and diencephalon. Arch. Neurol. 1987, 44:1127-1133.
62. Kim Y.W., Shin J.C., An Y.S. Effects of methylphenidate on cerebral glucose metabolism in patients with impaired consciousness after acquired brain injury. Clin. Neuropharmacol. 2009, 32:335-339.
63. Kinney H.C., Korein J., Panigrahy A., Dikkes P., Goode R. Neuropathological findings in the brain of Karen Ann Quinlan - the role of the thalamus in the persistent vegetative state. N. Engl. J. Med. 1994, 330:1469-1475.
64. Kupers R., Faymonville M.E., Laureys S. The cognitive modulation of pain: hypnosis- and placebo-induced analgesia. The Boundaries of Consciousness: Neurobiology and Neuropathology 2005, 251-269. Elsevier, Amsterdam. S. Laureys (Ed.).
65. Landsness E., Bruno M.-A., Noirhomme Q., Riedner B., Gosseries O., Schnakers C., Massimini M., Laureys S. Electrophysiological correlates of behavioural changes in vigilance in vegetative state and minimally conscious state. Brain 2011, 134(8):2222-2232.
66. Laureys S. Functional neuroimaging in the vegetative state. NeuroRehabilitation 2004, 19:335-341.
67. Laureys S. The neural correlate of (un)awareness: lessons from the vegetative state. Trends Cogn. Sci. 2005, 9:556-559.
68. Laureys S. Science and society: death, unconsciousness and the brain. Nat. Rev. Neurosci. 2005, 6:899-909.
69. Laureys S., Boly M. What is it like to be vegetative or minimally conscious?. Curr. Opin. Neurol. 2007, 20:609-613.
70. Laureys S., Boly M. The changing spectrum of coma. Nat. Clin. Pract. Neurol. 2008, 4:544-546.
71. Laureys S., Goldman S., Phillips C., Van Bogaert P., Aerts J., Luxen A., Franck G., Maquet P. Impaired effective cortical connectivity in vegetative state. NeuroImage 1999, 9:377-382.
72. Laureys S., Lemaire C., Maquet P., Phillips C., Franck G. Cerebral metabolism during vegetative state and after recovery to consciousness. J. Neurol. Neurosurg. Psychiatry 1999, 67:121.
73. Laureys S., Faymonville M.E., Degueldre C., Fiore G.D., Damas P., Lambermont B., Janssens N., Aerts J., Franck G., Luxen A., Moonen G., Lamy M., Maquet P. Auditory processing in the vegetative state. Brain 2000, 123:1589-1601.
74. Laureys S., Faymonville M.E., Luxen A., Lamy M., Franck G., Maquet P. Restoration of thalamocortical connectivity after recovery from persistent vegetative state. Lancet 2000, 355:1790-1791.
75. Laureys S., Antoine S., Boly M., Elincx S., Faymonville M.E., Berre J., Sadzot B., Ferring M., De Tiege X., van Bogaert P., Hansen I., Damas P., Mavroudakis N., Lambermont B., Del Fiore G., Aerts J., Degueldre C., Phillips C., Franck G., Vincent J.L., Lamy M., Luxen A., Moonen G., Goldman S., Maquet P. Brain function in the vegetative state. Acta Neurol. Belg. 2002, 102:177-185.
76. Laureys S., Faymonville M.E., Peigneux P., Damas P., Lambermont B., Del Fiore G., Degueldre C., Aerts J., Luxen A., Franck G., Lamy M., Moonen G., Maquet P. Cortical processing of noxious somatosensory stimuli in the persistent vegetative state. NeuroImage 2002, 17:732-741.
77. Laureys S., Owen A.M., Schiff N.D. Brain function in coma, vegetative state, and related disorders. Lancet Neurol. 2004, 3:537-546.
78. Laureys S., Perrin F., Faymonville M.E., Schnakers C., Boly M., Bartsch V., Majerus S., Moonen G., Maquet P. Cerebral processing in the minimally conscious state. Neurology 2004, 63:916-918.
79. Laureys S., Pellas F., Van Eeckhout P., Ghorbel S., Schnakers C., Perrin F., Berre J., Faymonville M.E., Pantke K.H., Damas F., Lamy M., Moonen G., Goldman S. The locked-in syndrome: what is it like to be conscious but paralyzed and voiceless?. Prog. Brain Res. 2005, 150:495-511.
80. Laureys S., Boly M., Maquet P. Tracking the recovery of consciousness from coma. J. Clin. Invest. 2006, 116:1823-1825.
81. Laureys S., Perrin F., Bredart S. Self-consciousness in non-communicative patients. Conscious. Cogn. 2007, 16:722-741. discussion 742-725.
82. Laureys S., Celesia G.G., Cohadon F., Lavrijsen J., Leon-Carrion J., Sannita W.G., Sazbon L., Schmutzhard E., von Wild K.R., Zeman A., Dolce G. Unresponsive wakefulness syndrome: a new name for the vegetative state or apallic syndrome. BMC Med. 2010, 8:68.
83. Levy D.E., Sidtis J.J., Rottenberg D.A., Jarden J.O., Strother S.C., Dhawan V., Ginos J.Z., Tramo M.J., Evans A.C., Plum F. Differences in cerebral blood flow and glucose utilization in vegetative versus locked-in patients. Ann. Neurol. 1987, 22:673-682.
84. Luaute J., Fischer C., Adeleine P., Morlet D., Tell L., Boisson D. Late auditory and event-related potentials can be useful to predict good functional outcome after coma. Arch. Phys. Med. Rehabil. 2005, 86:917-923.
85. Lull N., Noé E., Lull J., García-Panach J., Chirivella J., Ferri J., López-Aznar D., Sopena P., Robles M. Voxel-based statistical analysis of thalamic glucose metabolism in traumatic brain injury: relationship with consciousness and cognition. Brain Inj. 2010, 24:1098-1107.
86. Majerus S., Gill-Thwaites H., Andrews K., Laureys S. Behavioral evaluation of consciousness in severe brain damage. Prog. Brain Res. 2005, 150:397-413.
87. Majerus S., Bruno M.A., Schnakers C., Giacino J.T., Laureys S. The problem of aphasia in the assessment of consciousness in brain-damaged patients. Prog. Brain Res. 2009, 177:49-61.
88. Maquet P. Understanding non rapid eye movement sleep through neuroimaging. World J. Biol. Psychiatry 2010, 11:9-15.
89. Maxwell W.L., MacKinnon M.A., Smith D.H., McIntosh T.K., Graham D.I. Thalamic nuclei after human blunt head injury. J. Neuropathol. Exp. Neurol. 2006, 65:478-488.
90. Menon D., Owen A., Williams E., Minhas P., Allen C., Boniface S., Pickard J. Cortical processing in persistent vegetative state. Wolfson Brain Imaging Centre Team. Lancet 1998, 352:200.
91. Menon D.K., Owen A.M., Pickard J.D. Response from Menon, Owen and Pickard. Trends Cogn. Sci. 1999, 3:44-46.
92. Monti M.M., Laureys S., Owen A.M. The vegetative state. BMJ 2010, 341:292-296.
93. Monti M.M., Vanhaudenhuyse A., Coleman M.R., Boly M., Pickard J.D., Tshibanda L., Owen A.M., Laureys S. Willful modulation of brain activity in disorders of consciousness. N. Engl. J. Med. 2010, 362(7):579-589.
94. Nakase-Richardson R., Yablon S.A., Sherer M., Evans C.C., Nick T.G. Serial yes/no reliability after traumatic brain injury: implications regarding the operational criteria for emergence from the minimally conscious state. J. Neurol. Neurosurg. Psychiatry 2008, 79:216-218.
95. Nakayama N., Okumura A., Shinoda J., Nakashima T., Iwama T. Relationship between regional cerebral metabolism and consciousness disturbance in traumatic diffuse brain injury without large focal lesions: an FDG-PET study with statistical parametric mapping analysis. J. Neurol. Neurosurg. Psychiatry 2006, 77:856-862.
96. Newcombe V.F., Williams G.B., Scoffings D., Cross J., Carpenter T.A., Pickard J.D., Menon D.K. Aetiological differences in neuroanatomy of the vegetative state: insights from diffusion tensor imaging and functional implications. J. Neurol. Neurosurg. Psychiatry 2010, 81:552-561.
97. Noirhomme Q., Soddu A., Lehembre R., Vanhaudenhuyse A., Boveroux P., Boly M., Laureys S. Brain connectivity in pathological and pharmacological coma. Front. Syst. Neurosci. 2010, 4:160.
98. Owen A.M., Menon D.K., Johnsrude I.S., Bor D., Scott S.K., Manly T., Williams E.J., Mummery C., Pickard J.D. Detecting residual cognitive function in persistent vegetative state. Neurocase 2002, 8:394-403.
99. Owen A.M., Coleman M.R., Menon D.K., Johnsrude I.S., Rodd J.M., Davis M.H., Taylor K., Pickard J.D. Residual auditory function in persistent vegetative state: a combined PET and fMRI study. Neuropsychol. Rehabil. 2005, 15:290-306.
100. Owen A.M., Coleman M.R., Boly M., Davis M.H., Laureys S., Pickard J.D. Detecting awareness in the vegetative state. Science 2006, 313:1402.
101. Owen A.M., Schiff N.D., Laureys S. A new era of coma and consciousness science. Prog. Brain Res. 2009, 177:399-411.
102. Phillips C.L., Bruno M.A., Maquet P., Boly M., Noirhomme Q., Schnakers C., Vanhaudenhuyse A., Bonjean M., Hustinx R., Moonen G., Luxen A., Laureys S. "Relevance vector machine" consciousness classifier applied to cerebral metabolism of vegetative and locked-in patients. Neuroimage 2011, 56(2):797-808.
103. Plum F., Schiff N., Ribary U., Llinas R. Coordinated expression in chronically unconscious persons. Philos. Trans. R. Soc. Lond. B Biol. Sci. 1998, 353:1929-1933.
104. Posner J.B., Saper C.B., Schiff N.D., Plum F. Plum and Posner's Diagnosis of Stupor and Coma 2007, Oxford University Press. 4th ed.
105. Qin P., Di H., Liu Y., Yu S., Gong Q., Duncan N., Weng X., Laureys S., Northoff G. Anterior Cingulate Activity and the Self in Disorders of Consciousness 2010, Hum Brain Mapp.
106. Raichle M.E., Snyder A.Z. A Default Mode of Brain Function: A Brief History of an Evolving Idea 2007, Neuroimage.
107. Rees G., Kreiman G., Koch C. Neural correlates of consciousness in humans. Nat. Rev. Neurosci. 2002, 3:261-270.
108. Ribary U., Schiff N., Kronberg E., Plum F., Llinas R. Fractured brain function in unconscious humans: functional brain imaging using MEG. NeuroImage 1998, 7:106. (Suppl), (Abstract).
109. Rodriguez Moreno D., Schiff N.D., Giacino J., Kalmar K., Hirsch J. A network approach to assessing cognition in disorders of consciousness. Neurology 2010, 75:1871-1878.
110. Rousseau M., Confort-Gouny S., Catala A., Graperon J., Blaya J., Soulier E., Viout P., Galanaud D., Le Fur Y., Cozzone P., Ranjeva J. A MRS-MRI-fMRI exploration of the brain. Impact of long-lasting persistent vegetative state. Brain Inj. 2008, 22:123-134.
111. Rudolf J., Ghaemi M., Haupt W.F., Szelies B., Heiss W.D. Cerebral glucose metabolism in acute and persistent vegetative state. J. Neurosurg. Anesthesiol. 1999, 11:17-24.
112. Rudolf J., Sobesky J., Grond M., Heiss W.D. Identification by positron emission tomography of neuronal loss in acute vegetative state. Lancet 2000, 355:155.
113. Schiff, N.D., 1997. Deep brain stimulation method. #5,938,688 US Patent and Trademarks Office.
114. Schiff N.D. Multimodal neuroimaging approaches to disorders of consciousness. J. Head Trauma Rehabil. 2006, 21:388-397.
115. Schiff N.D. Recovery of consciousness after brain injury: a mesocircuit hypothesis. Trends Neurosci. 2010, 33:1-9.
116. Schiff N.D., Plum F. Cortical function in the persistent vegetative state. Trends Cogn. Sci. 1999, 3:43-44.
117. Schiff N.D., Posner J.B. Another "Awakenings". Ann. Neurol. 2007, 62:5-7.
118. Schiff N., Ribary U., Plum F., Llinás R. Words without mind. J. Cogn. Neurosci. 1999, 11:650-656.
119. Schiff N.D., Ribary U., Moreno D.R., Beattie B., Kronberg E., Blasberg R., Giacino J., McCagg C., Fins J.J., Llinas R., Plum F. Residual cerebral activity and behavioural fragments can remain in the persistently vegetative brain. Brain 2002, 125:1210-1234.
120. Schiff N.D., Rodriguez-Moreno D., Kamal A., Kim K.H., Giacino J.T., Plum F., Hirsch J. fMRI reveals large-scale network activation in minimally conscious patients. Neurology 2005, 64:514-523.
121. Schiff N.D., Giacino J.T., Kalmar K., Victor J.D., Baker K., Gerber M., Fritz B., Eisenberg B., O'Connor J., Kobylarz E.J., Farris S., Machado A., McCagg C., Plum F., Fins J.J., Rezai A.R. Behavioural improvements with thalamic stimulation after severe traumatic brain injury. Nature 2007, 448:600-603.
122. Schiff N.D., Giacino J.T., Fins J.J. Deep brain stimulation, neuroethics, and the minimally conscious state: moving beyond proof of principle. Arch. Neurol. 2009, 66:697-702.
123. Schnakers C., Giacino J., Kalmar K., Piret S., Lopez E., Boly M., Malone R., Laureys S. Does the FOUR score correctly diagnose the vegetative and minimally conscious states?. Ann. Neurol. 2006, 60:744-745.
124. Schnakers C., Hustinx R., Vandewalle G., Majerus S., Moonen G., Boly M., Vanhaudenhuyse A., Laureys S. Measuring the effect of amantadine in chronic anoxic minimally conscious state. J. Neurol. Neurosurg. Psychiatry 2008, 79:225-227.
125. Schnakers C., Perrin F., Schabus M., Majerus S., Ledoux D., Damas P., Boly M., Vanhaudenhuyse A., Bruno M.A., Moonen G., Laureys S. Voluntary brain processing in disorders of consciousness. Neurology 2008, 71(20):1614-20.
126. Schnakers C., Vanhaudenhuyse A., Giacino J., Ventura M., Boly M., Majerus S., Moonen G., Laureys S. Diagnostic accuracy of the vegetative and minimally conscious state: clinical consensus versus standardized neurobehavioral assessment. BMC Neurol. 2009, 9:35.
127. Schnakers C., Perrin F., Schabus M., Hustinx R., Majerus S., Moonen G., Boly M., Vanhaudenhuyse A., Bruno M.A., Laureys S. Detecting consciousness in a total locked-in syndrome: an active event-related paradigm. Neurocase 2009, 1-7.
128. Schnakers C., Chatelle C., Majerus S., Gosseries O., De Val M., Laureys S. Assessment and detection of pain in noncommunicative severely brain-injured patients. Expert. Rev. Neurother. 2010, 10:1725-1731.
129. Schrouff J., Perlbarg V., Boly M., Marrelec G., Boveroux P., Vanhaudenhuyse A., Bruno M.A., Laureys S., Phillips C., Pelegrini-Issac M., Maquet P., Benali H. Brain functional integration decreases during propofol-induced loss of consciousness. NeuroImage 2011, 57:198-205.
130. Sherer M., Nakase-Thompson R., Yablon S.A., Gontkovsky S.T. Multidimensional assessment of acute confusion after traumatic brain injury. Arch. Phys. Med. Rehabil. 2005, 86:896-904.
131. Sidaros A., Engberg A.W., Sidaros K., Liptrot M.G., Herning M., Petersen P., Paulson O.B., Jernigan T.L., Rostrup E. Diffusion tensor imaging during recovery from severe traumatic brain injury and relation to clinical outcome: a longitudinal study. Brain 2008, 131:559-572.
132. Silva S., Alacoque X., Fourcade O., Samii K., Marque P., Woods R., Mazziotta J., Chollet F., Loubinoux I. Wakefulness and loss of awareness: brain and brainstem interaction in the vegetative state. Neurology 2010, 74:313-320.
133. Smart C.M., Giacino J.T., Cullen T., Moreno D.R., Hirsch J., Schiff N.D., Gizzi M. A case of locked-in syndrome complicated by central deafness. Nat. Clin. Pract. Neurol. 2008, 4:448-453.
134. Soddu A., Boly M., Nir Y., Noirhomme Q., Vanhaudenhuyse A., Demertzi A., Arzi A., Ovadia S., Stanziano M., Papa M., Laureys S., Malach R. Reaching across the abyss: recent advances in functional magnetic resonance imaging and their potential relevance to disorders of consciousness. Prog. Brain Res. 2009, 177:261-274.
135. Soddu A., Vanhaudenhuyse A., Bahri M.A., Bruno M.-A., Boly M., Demertzi A., Tshibanda L., Phillips C., Stanziano M., Ovadia S., Nir Y., Maquet P., Papa M., Malach R., Laureys S., Noirhomme Q. Identifying the Default Mode Component in Spatial ICA Analyses of Patients with Disorders of Consciousness 2011, Hum Brain Mapp.
136. Sorger B., Dahmen B., Reithler J., Gosseries O., Maudoux A., Laureys S., Goebel R. Another kind of 'BOLD Response': answering multiple-choice questions via online decoded single-trial brain signals. Prog. Brain Res. 2009, 177:275-292.
137. Staffen W., Kronbichler M., Aichhorn M., Mair A., Ladurner G. Selective brain activity in response to one's own name in the persistent vegetative state. J. Neurol. Neurosurg. Psychiatry 2006, 77:1383-1384.
138. Stuss D.T., Guberman A., Nelson R., Larochelle S. The neuropsychology of paramedian thalamic infarction. Brain Cogn. 1988, 8:348-378.
139. Tengvar C., Johansson B., Sorensen J. Frontal lobe and cingulate cortical metabolic dysfunction in acquired akinetic mutism: a PET study of the interval form of carbon monoxide poisoning. Brain Inj. 2004, 18:615-625.
140. The Multi-Society Task Force on PVS Medical aspects of the persistent vegetative state (1). N. Engl. J. Med. 1994, 330:1499-1508.
141. Tollard E., Galanaud D., Perlbarg V., Sanchez-Pena P., Le Fur Y., Abdennour L., Cozzone P., Lehericy S., Chiras J., Puybasset L. Experience of diffusion tensor imaging and 1H spectroscopy for outcome prediction in severe traumatic brain injury: preliminary results. Crit. Care Med. 2009, 37:1448-1455.
142. Tommasino C., Grana C., Lucignani G., Torri G., Fazio F. Regional cerebral metabolism of glucose in comatose and vegetative state patients. J. Neurosurg. Anesthesiol. 1995, 7:109-116.
143. Tshibanda L., Vanhaudenhuyse A., Galanaud D., Boly M., Laureys S., Puybasset L. Magnetic resonance spectroscopy and diffusion tensor imaging in coma survivors: promises and pitfalls. Prog. Brain Res. 2009, 177:215-229.
144. Tshibanda L., Vanhaudenhuyse A., Boly M., Soddu A., Bruno M.A., Moonen G., Laureys S., Noirhomme Q. Neuroimaging after coma. Neuroradiology 2010, 52:15-24.
145. Van Der Werf Y.D., Weerts J.G., Jolles J., Witter M.P., Lindeboom J., Scheltens P. Neuropsychological correlates of a right unilateral lacunar thalamic infarction. J. Neurol. Neurosurg. Psychiatry 1999, 66:36-42.
146. Van der Werf Y.D., Witter M.P., Groenewegen H.J. The intralaminar and midline nuclei of the thalamus. Anatomical and functional evidence for participation in processes of arousal and awareness. Brain Res Brain Res Rev 2002, 39:107-140.
147. van Domburg P.H., ten Donkelaar H.J., Notermans S.L. Akinetic mutism with bithalamic infarction. Neurophysiological correlates. J. Neurol. Sci. 1996, 139:58-65.
148. Vanhaudenhuyse A., Noirhomme Q., Tshibanda L.J., Bruno M.A., Boveroux P., Schnakers C., Soddu A., Perlbarg V., Ledoux D., Brichant J.F., Moonen G., Maquet P., Greicius M.D., Laureys S., Boly M. Default network connectivity reflects the level of consciousness in non-communicative brain-damaged patients. Brain 2010, 133:161-171.
149. Vanhaudenhuyse A., Demertzi A., Schabus M., Noirhomme Q., Bredart S., Boly M., Phillips C., Soddu A., Luxen A., Moonen G., Laureys S. Two distinct neuronal networks mediate the awareness of environment and of self. J. Cogn. Neurosci. 2011, 23:570-578.
150. Victor, J.D., Drover, J.D., Conte, M.M., Schiff, N.D., 2011. Mean-field modeling of thalamocortical dynamics and a model-driven approach to EEG analysis. Proc. Natl. Acad. Sci U S A Sep 13;108 Suppl 3:15631-8.
151. Vogt B.A., Laureys S. Posterior cingulate, precuneal and retrosplenial cortices: cytology and components of the neural network correlates of consciousness. Prog. Brain Res. 2005, 150:205-217.
152. Vogt B., Vogt L., Laureys S. Cytology and functionally correlated circuits of human posterior cingulate areas. NeuroImage 2006, 29:452-466.
153. Voss H.U., Uluc A.M., Dyke J.P., Watts R., Kobylarz E.J., McCandliss B.D., Heier L.A., Beattie B.J., Hamacher K.A., Vallabhajosula S., Goldsmith S.J., Ballon D., Giacino J.T., Schiff N.D. Possible axonal regrowth in late recovery from the minimally conscious state. J. Clin. Invest. 2006, 116:2005-2011.
154. Williams S., Conte M.M., Kobylarz E.J., Hersh J., Victor J.D., Schiff N.D. Quantitative neurophysiologic characterization of a paradoxical response to zolpidem in a severely brain-injured human subject. Society for Neuroscience Meeting Abstract 541.6 2009.
155. Xie G., Deschamps A., Backman S.B., Fiset P., Chartrand D., Dagher A., Plourde G. Critical involvement of the thalamus and precuneus during restoration of consciousness with physostigmine in humans during propofol anaesthesia: a positron emission tomography study. Br. J. Anaesth. 2011, 106:548-557.
156. Zhu J., Wu X., Gao L., Mao Y., Zhong P., Tang W., Zhou L. Cortical activity after emotional visual stimulation in minimally conscious state patients. J. Neurotrauma 2009, 26:677-688.