Thalamic mediodorsal nucleus and working memory

Neuroscience and Biobehavioral Reviews

Volumn 36, Issue 1, 2012, Pages 134-142

  Watanabe, Yumiko ^a,b   Funahashi, Shintaro ^b,c  

^a NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c KYOTO UNIVERSITY   (Japan)

Author keywords

Delayed response; Prefrontal cortex; Prospective information; Retrospective information; Spatial working memory; Thalamic mediodorsal nucleus

Indexed keywords

HAPLORHINI; HUMAN; INFORMATION PROCESSING; NEUROPHYSIOLOGY; NEUROPSYCHOLOGICAL TEST; NONHUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; REVIEW; TASK PERFORMANCE; THALAMUS MEDIALIS CENTRALIS NUCLEUS; WORKING MEMORY;

ACTION POTENTIALS; BRAIN MAPPING; HUMANS; MEDIODORSAL THALAMIC NUCLEUS; MEMORY, SHORT-TERM; MODELS, NEUROLOGICAL; NEURAL PATHWAYS; NEURONS; PREFRONTAL CORTEX;

EID: 82855161460     PISSN: 01497634     EISSN: 18737528     Source Type: Journal    
DOI: 10.1016/j.neubiorev.2011.05.003     Document Type: Review

References (103)

1. Aggleton J.P., Mishkin M. Memory impairments following restricted medial thalamic lesions in monkeys. Exp. Brain Res. 1983, 52:199-209.
2. Aggleton J.P., Mishkin M. Visual recognition impairment following medial thalamic lesions in monkeys. Neuropsychologia 1983, 21:189-197.
3. Alelú-Paz R., Giménez-Amaya J.M. The mediodorsal thalamic nucleus and schizophrenia. J. Psychiatry Neurosci. 2008, 33:489-498.
4. Alexander G.E., Fuster J.M. Effects of cooling prefrontal cortex on cell firing in the nucleus medialis dorsalis. Brain Res. 1973, 61:93-105.
5. Asaad W.F., Rainer G., Miller E.K. Neural activity in the primate prefrontal cortex during associative learning. Neuron 1998, 21:1399-1407.
6. Baddeley A. The episodic buffer: a new component of working memory?. Trends Cogn. Sci. 2000, 4:417-423.
7. Baddeley A.D., Hitch G.J.L. Working memory. The Psychology of Learning and Motivation: Advances in Research and Theory 1974, vol. 8:47-89. Academic Press, New York.
8. Baddeley A., Logie R.H. Working memory: the multiple-component model. Models of Working Memory: Mechanisms of Active Maintenance and Executive Control 1999, 28-61. Cambridge University Press, Cambridge. A. Miyake, P. Shah (Eds.).
9. Barbas H. Architecture and cortical connections of the prefrontal cortex in the rhesus monkey. Advances in Neurology 1992, vol. 57:91-115. Raven Press, New York.
10. Barbas H., Henion T.H.H., Dermon C.R. Diverse thalamic projections to the prefrontal cortex in the rhesus monkey. J. Comp. Neurol. 1991, 313:65-94.
11. Bentivoglio M., Aggleton J.P., Mishkin M. The thalamus and memory formation. Thalamus 1997, vol. 2:689-720. Elsevier, Amsterdam.
12. Byne W., Buchsbaum M.S., Kemether E., Hazlett E.A., Shinwari A., Mitropoulou V., Siever L.J. Magnetic resonance imaging of the thalamic mediodorsal nucleus and pulvinar in schizophrenia and schizotypal personality disorder. Arch. Gen. Psychiatry 2001, 58:133-140.
13. Byne W., Hazlett E.A., Buchsbaum M.S., Kemether E. The thalamus and schizophrenia: current status of research. Acta Neuropathol. 2009, 117:347-368.
14. Chafee M.V., Goldman-Rakic P.S. Matching patterns of activity in primate prefrontal area 8a and parietal area 7ip neurons during a spatial working memory task. J. Neurophysiol. 1998, 79:2919-2940.
15. Constantinidis C., Franowicz M.N., Goldman-Rakic P.S. Coding specificity in cortical microcircuits: a multiple-electrode analysis of primate prefrontal cortex. J. Neurosci. 2001, 21:3646-3655.
16. Cullen T.J., Walker M.A., Parkinson N., Craven R., Crow T.J., Esiri M.M., Harrion P.J. A postmortem study of the mediodorsal nucleus of the thalamus in schizophrenia. Schizophr. Res. 2003, 60:157-166.
17. Daum I., Ackermann H. Frontal-type memory impairment associated with thalamic damage. Int. J. Neurosci. 1994, 77:187-198.
18. Elliott R., Dolan R.J. Differential neural responses during performance of matching and nonmatching to sample tasks at two delay intervals. J. Neurosci. 1999, 19:5066-5073.
19. Funahashi S. Neuronal mechanisms of executive control by the prefrontal cortex. Neurosci. Res. 2001, 39:147-165.
20. Funahashi S. Prefrontal cortex and working memory processes. Neuroscience 2006, 139:251-261.
21. Funahashi S., Inoue M. Neuronal interactions related to working memory processes in the primate prefrontal cortex revealed by cross-correlation analysis. Cereb. Cortex 2000, 10:535-551.
22. Funahashi S., Bruce C.J., Goldman-Rakic P.S. Mnemonic coding of visual space in the monkey's dorsolateral prefrontal cortex. J. Neurophysiol. 1989, 61:331-349.
23. Funahashi S., Bruce C.J., Goldman-Rakic P.S. Visuospatial coding in primate prefrontal neurons revealed by oculomotor paradigms. J. Neurophysiol. 1990, 63:814-831.
24. Funahashi S., Bruce C.J., Goldman-Rakic P.S. Neuronal activity related to saccadic eye movements in the monkey's dorsolateral prefrontal cortex. J. Neurophysiol. 1991, 65:1464-1483.
25. Funahashi S., Chafee M.V., Goldman-Rakic P.S. Prefrontal neuronal activity in rhesus monkeys performing a delayed anti-saccade task. Nature 1993, 365:753-756.
26. Funahashi S., Kubota K. Working memory and prefrontal cortex. Neurosci. Res. 1994, 21:1-11.
27. Funahashi S., Takeda K. Information processes in the primate prefrontal cortex in relation to working memory processes. Rev. Neurosci. 2002, 13:313-345.
28. Fuster J.M. Unit activity in prefrontal cortex during delayed-response performance: neuronal correlates of transient memory. J. Neurophysiol. 1973, 36:61-78.
29. Fuster J.M. The Prefrontal Cortex 2008, Academic Press, New York. fourth edition.
30. Fuster J.M., Alexander G.E. Neuron activity related to short-term memory. Science 1971, 173:652-654.
31. Fuster J.M., Alexander G.E. Firing changes in cells of the nucleus medialis dorsalis associated with delayed response behavior. Brain Res. 1973, 61:79-91.
32. Fuster J.M., Bauer R.H., Jervey J.P. Functional interactions between inferotemporal and prefrontal cortex in a cognitive task. Brain Res. 1985, 330:299-307.
33. Fuster J.M., Jervey J.P. Neuronal firing in the inferotemporal cortex of the monkey in a visual memory task. J. Neurosci. 1982, 2:361-375.
34. Gaffan D., Parker A. Mediodorsal thalamic function in scene memory in rhesus monkeys. Brain 2000, 123:816-827.
35. Georgopoulos A.P. Neural integration of movement: role of motor cortex in reaching. FASEB J. 1988, 2:2849-2857.
36. Georgopoulos A.P., Caminiti R., Kalaska J.F., Massey J.T. Spatial coding of movement: a hypothesis concerning the coding of movement direction by motor cortical populations. Exp. Brain Res. 1983, 7:327-336.
37. Georgopoulos A.P., Kettner R.E., Schwartz A.B. Primate motor cortex and free arm movements to visual targets in three-dimensional space. II. Coding of the direction of movement by a neuronal population. J. Neurosci. 1988, 8:2928-2937.
38. Georgopoulos A.P., Lurito J.T., Petrides M., Schwartz A.B., Massey J.T. Mental rotation of the neuronal population vector. Science 1989, 243:234-237.
39. Georgopoulos A.P., Schwartz A.B., Kettner R.E. Neuronal population coding of movement direction. Science 1986, 233:1416-1419.
40. Georgopoulos A.P., Taira M., Lukashin A. Cognitive neurophysiology of the motor cortex. Science 1993, 260:47-52.
41. Giguere M., Goldman-Rakic P.S. Mediodorsal nucleus: areal, laminar, and tangential distribution of afferents and efferents in the frontal lobe of rhesus monkeys. J. Comp. Neurol. 1988, 277:195-213.
42. Gnadt J.W., Andersen R.A. Memory related motor planning activity in posterior parietal cortex of macaque. Exp. Brain Res. 1988, 70:216-220.
43. Goldman-Rakic P.S. Circuitry of primate prefrontal cortex and regulation of behavior by representational memory. Handbook of Physiology: The Nervous System: Higher Functions of the Brain 1987, vol. 5, Sect. 1:373-417. American Physiological Society, Bethesda, MD.
44. Goldman-Rakic P.S. Working memory dysfunction in schizophrenia. J. Neuropsychiatr. Clin. Neurosci. 1994, 6:348-357.
45. Goldman-Rakic P.S., Porrino L.J. The primate mediodorsal (MD) nucleus and its projection to the frontal lobe. J. Comp. Neurol. 1985, 242:535-560.
46. Hikosaka O., Sakamoto M. Cell activity in monkey caudate nucleus preceding saccadic eye movements. Exp. Brain Res. 1986, 63:659-662.
47. Hikosaka O., Sakamoto M., Usui S. Functional properties of monkey caudate neurons. I. Activities related to saccadic eye movements. J. Neurophysiol. 1989, 61:780-798.
48. Ichihara-Takeda S., Funahashi S. Activity of primate orbitofrontal and dorsolateral prefrontal neurons: task-related activity during an oculomotor delayed-response task. Exp. Brain Res. 2007, 181:409-425.
49. Ilinsky I.A., Jouandet M.L., Goldman-Rakic P.S. Organization of the nigrothalamocortical system in the rhesus monkey. J. Comp. Neurol. 1985, 236:315-330.
50. Isseroff A., Rosvold H.E., Galkin T.W., Goldman-Rakic P.S. Spatial memory impairments following damage to the mediodorsal nucleus of the thalamus in rhesus monkeys. Brain Res. 1982, 232:97-113.
51. Kemether E.M., Buchsbaum M.S., Byne W., Hazlett E.A., Haznedar M., Brickman A.M., Platholi J., Bloom R. Magnetic resonance imaging of mediodorsal, pulvinar, and centromedian nuclei of the thalamus in patients with schizophrenia. Arch. Gen. Psychiatry 2003, 60:983-991.
52. Kettner R.E., Schwartz A.B., Georgopoulos A.P. Primate motor cortex and free arm movements to visual targets in three-dimensional space. III. Positional gradients and population coding of movement direction from various movement origins. J. Neurosci. 1988, 8:2938-2947.
53. Kievit J., Kuypers H.G.J.M. Organization of the thalamo-cortical connexions to the frontal lobe in the rhesus monkey. Exp. Brain Res. 1977, 29:299-322.
54. Kubota K., Niki H., Goto A. Thalamic unit activity and delayed alternation performance in the monkey. Acta Neurobiol. Exp. 1972, 32:177-192.
55. Lurito J.T., Georgakopoulos T., Georgopoulos A.P. Cognitive spatial-motor processes. 7. The making of movements at an angle from a stimulus direction: studies of motor cortical activity at the single cell and population levels. Exp. Brain Res. 1991, 87:562-580.
56. Lynch J.C., Hoover J.E., Strick P.L. Input to the frontal eye field from the substantia nigra, superior colliculus, and dentate nucleus demonstrated by transneuronal transport. Exp. Brain Res. 1994, 100:181-186.
57. Miller E.K., Erickson C.A., Desimone R. Neural mechanisms of visual working memory in prefrontal cortex of the macaque. J. Neurosci. 1996, 16:5154-5167.
58. Miller E.K., Li L., Desimone R. A neural mechanism for working and recognition memory in inferior temporal cortex. Science 1991, 254:1377-1379.
59. Miller E.K., Li L., Desimone R. Activity of neurons in anterior inferior temporal cortex during a short-term memory task. J. Neurosci. 1993, 13:1460-1478.
60. Mitchell A.S., Baxter M.G., Gaffan D. Dissociable performance on scene learning and strategy implementation after lesions to magnocellular mediodorsal thalamic nucleus. J. Neursci. 2007, 27:11888-11895.
61. Mitchell A.S., Browning P.G.F., Wilson C.R.E., Baxter M.G., Gaffan D. Dissociable roles for cortical and subcortical structures in memory retrieval and acquisition. J. Neurosci. 2008, 28:8387-8396.
62. Mitchell A.S., Gaffan D. The magnocellular mediodorsal thalamus is necessary for memory acquisition, but not retrieval. J. Neurosci. 2008, 28:258-263.
63. Miyake A., Shah P. Toward unified theories of working memory: emerging general consensus, unresolved theoretical issues, and future research directions. Models of Working Memory: Mechanisms of Active Maintenance and Executive Control 1999, 442-481. Cambridge University Press, UK. A. Miyake, P. Shah (Eds.).
64. Monchi O., Petrides M., Petre V., Worsley K., Dagher A. Wisconsin card sorting revisited: distinct neural circuits participating in different stages of the task identified by event-related functional magnetic resonance imaging. J. Neurosci. 2001, 21:7733-7741.
65. Niki H., Watanabe M. Prefrontal unit activity and delayed response: relation to cue location versus direction of response. Brain Res. 1976, 105:79-88.
66. Owen A.M., McMillan K.M., Laird A.R., Bullmore E. N-back working memory paradigm: a meta-analysis of normative functional neuroimaging studies. Hum. Brain Mapp. 2005, 25:46-59.
67. Pakkenberg B. Pronounced reduction of total neuron number in mediodorsal thalamic nucleus and nucleus accumbens in schizophrenics. Arch. Gen. Psychiatry 1990, 47:1023-1028.
68. Pakkenberg B. The volume of the mediodorsal thalamic nucleus in treated and untreated schizophrenics. Schizophr. Res. 1992, 7:95-100.
69. Parker A., Eacott M.J., Gaffan D. The recognition memory deficit caused by mediodorsal thalamic lesion in non-human primates: a comparison with rhinal cortex lesion. Eur. J. Neurosci. 1997, 9:2423-2431.
70. Petrides M. Frontal lobes and working memory: evidence from investigations of the effects of cortical excisions in nonhuman primates. Handbook of Neuropsychology 1994, vol. 9:59-82. Elsevier, Amsterdam.
71. Popken G.J., Bunney W.E., Potkin S.G., Jones E.G. Subnucleus-specific loss of neurons in medial thalamus of schizophrenics. Proc. Natl. Acad. Sci. U.S.A. 2000, 97:9276-9280.
72. Porrino L.J., Crane A.M., Goldman-Rakic P.S. Direct and indirect pathways from the amygdala to the frontal lobe in rhesus monkeys. J. Comp. Neurol. 1981, 198:121-136.
73. Rainer G., Asaad W.F., Miller E.K. Memory fields of neurons in the primate prefrontal cortex. Proc. Natl. Acad. Sci. U.S.A. 1998, 95:15008-15013.
74. Rainer G., Asaad W.F., Miller E.K. Selective representation of relevant information by neurons in the primate prefrontal cortex. Nature 1998, 393:577-579.
75. Rainer G., Rao S.C., Miller E.K. Prospective coding for objects in primate prefrontal cortex. J. Neurosci. 1999, 19:5493-5505.
76. Ray J.P., Price J.L. The organization of projections from the mediodorsal nucleus of the thalamus to orbital and medial prefrontal cortex in macaque monkeys. J. Comp. Neurol. 1993, 337:1-31.
77. Schlag J., Schlag-Rey M. Visuomotor functions of central thalamus in monkey. II. Unit activity related to visual events, targeting, and fixation. J. Neurophysiol. 1984, 51:1175-1195.
78. Schlag-Rey M., Schlag J. Visuomotor functions of central thalamus in monkey. I. Unit activity related to spontaneous eye movements. J. Neurophysiol. 1984, 51:1149-1174.
79. Schwartz A.B., Kettner R.E., Georgopoulos A.P. Primate motor cortex and free arm movements to visual targets in three-dimensional space. I. Relations between single cell discharge and direction of movement. J. Neurosci. 1988, 8:2913-2927.
80. Sherman S.M., Guillery R.W. The role of the thalamus in the flow of information to the cortex. Philos. Trans. R. Soc. Lond. B: Biol. Sci. 2002, 357:1695-1708.
81. Shimizu M., Fujiwara H., Hirao K., Namiki C., Fukuyama H., Hayashi T., Murai T. Structural abnormalities of the adhesio interthalamica and mediodorsal nuclei of the thalamus in schizophrenia. Schizophr. Res. 2008, 101:331-338.
82. Smyrnis N., Taira M., Ashe J., Georgopoulos A.P. Motor cortical activity in a memorized delay task. Exp. Brain Res. 1992, 92:139-151.
83. Sommer M.A., Wurtz R.H. A pathway in primate brain for internal monitoring of movements. Science 2002, 296:1480-1482.
84. Sommer M.A., Wurtz R.H. What the brain stem tells the frontal cortex. I. Oculomotor signals sent from superior colliculus to frontal eye field via mediodorsal thalamus. J. Neurophysiol. 2004, 91:1381-1402.
85. Stuss D.T., Levine B. Adult clinical neuropsychology: lessons from studies of the frontal lobes. Annu. Rev. Psychol. 2002, 53:401-433.
86. Stuss R.T., Alexander M.P., Floden D., Binns M.A., Levine B., McIntosh A.R., Rajah N., Hevenor S.J. Fractionation and localization of distinct frontal lobe processes: evidence from focal lesions in humans. Principles of Frontal Lobe Function 2002, 392-407. Oxford University Press, New York. D.T. Stuss, R.T. Knight (Eds.).
87. Takeda K., Funahashi S. Prefrontal task-related activity representing visual cue location or saccade direction in spatial working memory tasks. J. Neurophysiol. 2002, 87:567-588.
88. Takeda K., Funahashi S. Population vector analysis of primate prefrontal activity during spatial working memory. Cereb. Cortex 2004, 14:1328-1339.
89. Takeda K., Funahashi S. Relationship between prefrontal task-related activity and information flow during spatial working memory performance. Cortex 2007, 43:38-52.
90. Tanaka M. Spatiotemporal properties of eye position signals in the primate central thalamus. Cereb. Cortex 2007, 17:1504-1515.
91. Tanibuchi I., Goldman-Rakic P.S. Dissociation of spatial-, object-, and sound-coding neurons in the mediodorsal nucleus of the primate thalamus. J. Neurophysiol. 2003, 89:1067-1077.
92. Tanibuchi I., Kitano H., Jinnai K. Substantia nigra output to prefrontal cortex via thalamus in monkeys. I. Electrophysiological identification of thalamic relay neurons. J. Neurophysiol. 2009, 102:2933-2945.
93. Vaadia E., Haalman I., Abeles M., Bergman H., Prut Y., Slovin H., Aertsen A. Dynamics of neuronal interactions in monkey cortex in relation to behavioural events. Nature 1995, 373:515-518.
94. Van der Werf Y.D., Scheltens P., Lindeboom J., Witter M.P., Uylings H.B.M., Jolles J. Deficits of memory, executive functioning and attention following infarction in the thalamus; a study of 22 cases with localised lesions. Neuropsychologia 2003, 41:1330-1344.
95. Van der Werf Y.D., Witter M.P., Uylings H.B.M., Jolles J. Neuropsychology of infarctions in the thalamus: a review. Neuropsychologia 2000, 38:613-627.
96. Velayos J.L., Reinoso-Suarez F. Prosencephalic afferents to the mediodorsal thalamic nucleus. J. Comp. Neurol. 1985, 242:161-181.
97. Watanabe Y., Funahashi S. Neuronal activity throughout the primate mediodorsal nucleus of the thalamus during oculomotor delayed-responses. I. Cue-, delay-, and response-period activity. J. Neurophysiol. 2004, 92:1738-1755.
98. Watanabe Y., Funahashi S. Neuronal activity throughout the primate mediodorsal nucleus of the thalamus during oculomotor delayed-responses. II. Activity encoding visual versus motor signal. J. Neurophysiol. 2004, 92:1756-1769.
99. Watanabe Y., Takeda K., Funahashi S. Population vector analysis of primate mediodorsal thalamic activity during oculomotor delayed-response performance. Cereb. Cortex 2009, 19:1313-1321.
100. Young K.A., Manaye K.F., Liang C.-L., Hicks P.B., German D.C. Reduced number of mediodorsal and anterior thalamic neurons in schizophrenia. Biol. Psychiatry 2000, 47:944-953.
101. Zola-Morgan S., Squire L.R. Amnesia in monkeys after lesions of the mediodorsal nucleus of the thalamus. Ann. Neurol. 1985, 17:558-564.
102. Zoppelt D., Koch B., Schwarz M., Daum I. Involvement of the mediodorsal thalamic nucleus in mediating recollection and familiarity. Neuropsychologia 2003, 41:1160-1170.
103. de Zubicaray G.I., McMahon K., Wilson S.J., Muthiah S. Brain activity during the encoding, retention, and retrieval of stimulus representations. Learn. Mem. 2001, 8:243-251.