-
1
-
-
0037223174
-
Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001
-
DOI 10.1001/jama.289.1.76
-
Mokdad AH, Ford ES, Bowman BA et al. Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001. JAMA 289, 76-79 (2003 (Pubitemid 36026281)
-
(2003)
Journal of the American Medical Association
, vol.289
, Issue.1
, pp. 76-79
-
-
Mokdad, A.H.1
Ford, E.S.2
Bowman, B.A.3
Dietz, W.H.4
Vinicor, F.5
Bales, V.S.6
Marks, J.S.7
-
2
-
-
22844449583
-
The insulin resistance syndrome: Definition and dietary approaches to treatment
-
DOI 10.1146/annurev.nutr.24.012003.132155
-
Reaven G. The insulin resistance syndrome: Definition and dietary approaches to treatment. Annu. Rev. Nutr. 25, 391-406 (2005 (Pubitemid 41209007)
-
(2005)
Annual Review of Nutrition
, vol.25
, pp. 391-406
-
-
Reaven, G.M.1
-
3
-
-
62549162196
-
The metabolic syndrome: Insulin resistance
-
Mikhail N. The metabolic syndrome: Insulin resistance. Curr. Hypertens. Rep. 11, 156-158 (2009
-
(2009)
Curr. Hypertens. Rep
, vol.11
, pp. 156-158
-
-
Mikhail, N.1
-
4
-
-
39749147110
-
Mechanisms of disease: Molecular and metabolic mechanisms of insulin resistance and β-cell failure in type 2 diabetes
-
DOI 10.1038/nrm2327, PII NRM2327
-
Muoio DM, Newgard C. Mechanisms of disease: Molecular and metabolic mechanisms of insulin resistance and beta-cell failure in Type 2 diabetes. Nat. Rev. Mol. Cell Biol. 9, 193-205 (2008 (Pubitemid 351301824)
-
(2008)
Nature Reviews Molecular Cell Biology
, vol.9
, Issue.3
, pp. 193-205
-
-
Muoio, D.M.1
Newgard, C.B.2
-
6
-
-
76049118432
-
Intramuscular triacylglycerol and insulin resistance: Guilty as charged or wrongly accused?
-
Muoio DM. Intramuscular triacylglycerol and insulin resistance: Guilty as charged or wrongly accused? Biochim. Biophys. Acta 1801(3), 281-288 (2010
-
(2010)
Biochim Biophys. Acta
, vol.3
, pp. 281-288
-
-
Muoio, D.M.1
-
7
-
-
84872051718
-
Acylcarnitines: Reflecting or inflicting insulin resistance?
-
Schooneman MG, Vaz FM, Houten SM, Soeters M Acylcarnitines: Reflecting or inflicting insulin resistance? Diabetes 62, 1-8 (2013
-
(2013)
Diabetes
, vol.62
, pp. 1-8
-
-
Schooneman, M.G.1
Vaz, F.M.2
Houten, S.M.3
Soeters, M.4
-
8
-
-
56749164791
-
Nutrient sensing and inflammation in metabolic diseases
-
Hotamisligil GS, Erbay E. Nutrient sensing and inflammation in metabolic diseases. Nat. Rev. Immunol. 8, 923-934 (2008
-
(2008)
Nat. Rev. Immunol
, vol.8
, pp. 923-934
-
-
Hotamisligil, G.S.1
Erbay, E.2
-
9
-
-
84864293537
-
Role of intramyocelluar lipids in human health
-
Coen PM, Goodpaster B. Role of intramyocelluar lipids in human health. Trends Endocrinol. Metab. 23, 391-398 (2012
-
(2012)
Trends Endocrinol. Metab
, vol.23
, pp. 391-398
-
-
Coen, P.M.1
Goodpaster, B.2
-
10
-
-
84860497397
-
Diacylglycerol activation of protein kinase Cepsilon and hepatic insulin resistance
-
Jornayvaz FR, Shulman G. Diacylglycerol activation of protein kinase Cepsilon and hepatic insulin resistance. Cell Metab. 15, 574-584 (2012
-
(2012)
Cell Metab
, vol.15
, pp. 574-584
-
-
Jornayvaz, F.R.1
Shulman, G.2
-
11
-
-
34248581989
-
Disordered lipid metabolism and the pathogenesis of insulin resistance
-
DOI 10.1152/physrev.00024.2006
-
Savage DB, Petersen KF, Shulman G. Disordered lipid metabolism and the pathogenesis of insulin resistance. Physiol. Rev. 87, 507-520 (2007 (Pubitemid 47084679)
-
(2007)
Physiological Reviews
, vol.87
, Issue.2
, pp. 507-520
-
-
Savage, D.B.1
Petersen, K.F.2
Shulman, G.I.3
-
12
-
-
80054057662
-
Mammalian triacylglycerol metabolism: Synthesis, lipolysis and signaling
-
Coleman RA, Mashek D. Mammalian triacylglycerol metabolism: Synthesis, lipolysis, and signaling. Chem. Rev. 111, 6359-6386 (2011
-
(2011)
Chem. Rev
, vol.111
, pp. 6359-6386
-
-
Coleman, R.A.1
Mashek, D.2
-
13
-
-
34347238724
-
Hepatic overexpression of glycerol-sn-3-phosphate acyltransferase 1 in rats causes insulin resistance
-
DOI 10.1074/jbc.M611550200
-
Nagle CA, An J, Shiota M et al. Hepatic overexpression of glycerol-sn-3-phosphate acyltransferase 1 in rats causes insulin resistance. J. Biol. Chem. 282, 14807-14815 (2007 (Pubitemid 47093356)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.20
, pp. 14807-14815
-
-
Nagle, C.A.1
An, J.2
Shiota, M.3
Torres, T.P.4
Cline, G.W.5
Liu, Z.-X.6
Wang, S.7
Catlin, R.L.8
Shulman, G.I.9
Newgard, C.B.10
Coleman, R.A.11
-
14
-
-
27244440736
-
Prevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 knockout mice
-
DOI 10.1016/j.cmet.2005.06.006, PII S1550413105001713
-
Neschen S, Morino K, Hammond LE et al. Prevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl- CoA:glycerol-sn-3- phosphate acyltransferase 1 knockout mice. Cell Metab. 2, 55-65 (2005 (Pubitemid 43239825)
-
(2005)
Cell Metabolism
, vol.2
, Issue.1
, pp. 55-65
-
-
Neschen, S.1
Morino, K.2
Hammond, L.E.3
Zhang, D.4
Liu, Z.-X.5
Romanelli, A.J.6
Cline, G.W.7
Pongratz, R.L.8
Zhang, X.-M.9
Choi, C.S.10
Coleman, R.A.11
Shulman, G.I.12
-
15
-
-
77954391618
-
Autotaxin - An LPA producing enzyme with diverse functions
-
Nakanaga K, Hama K, Aoki J. Autotaxin - An LPA producing enzyme with diverse functions. J. Biochem. 148, 13-24 (2010
-
(2010)
J. Biochem
, vol.148
, pp. 13-24
-
-
Nakanaga, K.1
Hama, K.2
Aoki, J.3
-
16
-
-
0037422595
-
Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARγ agonist
-
DOI 10.1073/pnas.0135855100
-
McIntyre TM, Pontsler AV, Silva AR et al. Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARgamma agonist. Proc. Natl Acad. Sci. USA 100, 131-136 (2003 (Pubitemid 36078041)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.1
, pp. 131-136
-
-
McIntyre, T.M.1
Pontsler, A.V.2
Silva, A.R.3
St. Hilaire, A.4
Xu, Y.5
Hinshaw, J.C.6
Zimmerman, G.A.7
Hama, K.8
Aoki, J.9
Arai, H.10
Prestwich, G.D.11
-
17
-
-
79955434677
-
Lysophosphatidic acid activates peroxisome proliferator activated receptor-gamma in CHO cells that over-express glycerol 3-phosphate acyltransferase-1
-
Stapleton CM, Mashek DG, Wang S et al. Lysophosphatidic acid activates peroxisome proliferator activated receptor-gamma in CHO cells that over-express glycerol 3-phosphate acyltransferase-1. PLoS ONE 6, e18932 (2011
-
(2011)
PLoS ONE
, vol.6
-
-
Stapleton, C.M.1
Mashek, D.G.2
Wang, S.3
-
18
-
-
0027983920
-
Improvement in glucose tolerance and insulin resistance in obese subjects treated with troglitazone
-
DOI 10.1056/NEJM199411033311803
-
Nolan JJ, Ludvik B, Beerdsen P, Joyce M, Olefsky J. Improvement in glucose tolerance and insulin resistance in obese subjects treated with troglitazone. N. Engl. J. Med. 331, 1188-1193 (1994 (Pubitemid 24331336)
-
(1994)
New England Journal of Medicine
, vol.331
, Issue.18
, pp. 1188-1193
-
-
Nolan, J.J.1
Ludvik, B.2
Beerdsen, P.3
Joyce, M.4
Olefsky, J.5
-
19
-
-
0035976615
-
Phosphatidic acid-mediated mitogenic activation of mTOR signaling
-
DOI 10.1126/science.1066015
-
Fang Y, Vilella-Bach M, Bachmann R, Flanigan A, Chen J. Phosphatidic acid-mediated mitogenic activation of mTOR signaling. Science 294, 1942-1945 (2001 (Pubitemid 33101594)
-
(2001)
Science
, vol.294
, Issue.5548
, pp. 1942-1945
-
-
Fang, Y.1
Vilella-Bach, M.2
Bachmann, R.3
Flanigan, A.4
Chen, J.5
-
20
-
-
33744505375
-
Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1
-
DOI 10.1016/j.cmet.2006.05.003, PII S1550413106001586
-
Um SH, D'Alessio D, Thomas G. Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1. Cell Metab. 3, 393-402 (2006 (Pubitemid 43811780)
-
(2006)
Cell Metabolism
, vol.3
, Issue.6
, pp. 393-402
-
-
Um, S.H.1
D'Alessio, D.2
Thomas, G.3
-
21
-
-
34247120977
-
Nutrient sensing in the mTOR/S6K1 signalling pathway
-
DOI 10.1042/BST0350236
-
Gulati P, Thomas G. Nutrient sensing in the mTOR/S6K1 signalling pathway. BioChem. Soc. Trans. 35, 236-238 (2007 (Pubitemid 46596477)
-
(2007)
Biochemical Society Transactions
, vol.35
, Issue.2
, pp. 236-238
-
-
Gulati, P.1
Thomas, G.2
-
22
-
-
0036753494
-
Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control
-
DOI 10.1016/S1097-2765(02)00636-6
-
Loewith R, Jacinto E, Wullschleger S et al. Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Mol. Cell 10, 457-468 (2002 (Pubitemid 35284167)
-
(2002)
Molecular Cell
, vol.10
, Issue.3
, pp. 457-468
-
-
Loewith, R.1
Jacinto, E.2
Wullschleger, S.3
Lorberg, A.4
Crespo, J.L.5
Bonenfant, D.6
Oppliger, W.7
Jenoe, P.8
Hall, M.N.9
-
23
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
-
DOI 10.1126/science.1106148
-
Sarbassov DD, Guertin DA, Ali SM, Sabatini D. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307, 1098-1101 (2005 (Pubitemid 40262113)
-
(2005)
Science
, vol.307
, Issue.5712
, pp. 1098-1101
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
Sabatini, D.M.4
-
24
-
-
62849111751
-
Regulation of mTORC1 and mTORC2 complex assembly by phosphatidic acid: Competition with rapamycin
-
Toschi A, Lee E, Xu L, Garcia A, Gadir N, Foster D. Regulation of mTORC1 and mTORC2 complex assembly by phosphatidic acid: Competition with rapamycin. Mol. Cell Biol. 29, 1411-1420 (2009
-
(2009)
Mol. Cell Biol
, vol.29
, pp. 1411-1420
-
-
Toschi, A.1
Lee, E.2
Xu, L.3
Garcia, A.4
Gadir, N.5
Foster, D.6
-
25
-
-
80054080494
-
Regulation and functions of diacylglycerol kinases
-
Shulga YV, Topham MK, Epand R. Regulation and functions of diacylglycerol kinases. Chem. Rev. 111, 6186-6208 (2011
-
(2011)
Chem. Rev
, vol.111
, pp. 6186-6208
-
-
Shulga, Y.V.1
Topham, M.K.2
Epand, R.3
-
26
-
-
38149018650
-
Diacylglycerol kinases: At the hub of cell signalling
-
Merida I, Avila-Flores A, Merino E. Diacylglycerol kinases: At the hub of cell signalling. Biochem. J. 409, 1-18 (2008
-
(2008)
Biochem. J.
, vol.409
, pp. 1-18
-
-
Merida, I.1
Avila-Flores, A.2
Merino, E.3
-
27
-
-
38849090672
-
Downregulation of Diacylglycerol Kinase Delta Contributes to Hyperglycemia-Induced Insulin Resistance
-
DOI 10.1016/j.cell.2007.12.035, PII S0092867408000561
-
Chibalin AV, Leng Y, Vieira E et al. Downregulation of diacylglycerol kinase delta contributes to hyperglycemia-induced insulin resistance. Cell 132, 375-386 (2008 (Pubitemid 351191998)
-
(2008)
Cell
, vol.132
, Issue.3
, pp. 375-386
-
-
Chibalin, A.V.1
Leng, Y.2
Vieira, E.3
Krook, A.4
Bjornholm, M.5
Long, Y.C.6
Kotova, O.7
Zhong, Z.8
Sakane, F.9
Steiler, T.10
Nylen, C.11
Wang, J.12
Laakso, M.13
Topham, M.K.14
Gilbert, M.15
Wallberg-Henriksson, H.16
Zierath, J.R.17
-
28
-
-
84863115883
-
Glycerolipid signals alter mTOR complex 2 (mTORC2) to diminish insulin signaling
-
Zhang C, Wendel AA, Keogh MR, Harris TE, Chen J, Coleman R. Glycerolipid signals alter mTOR complex 2 (mTORC2) to diminish insulin signaling. Proc. Natl Acad. Sci. USA 109, 1667-1672 (2012
-
(2012)
Proc. Natl Acad. Sci. USA
, vol.109
, pp. 1667-1672
-
-
Zhang, C.1
Wendel, A.A.2
Keogh, M.R.3
Harris, T.E.4
Chen, J.5
Coleman, R.6
-
29
-
-
0025761733
-
Molecular species analysis of 1,2-diacylglycerols and phosphatidic acid formed during bombesin stimulation of Swiss 3T3 cells
-
Divecha N, Lander DJ, Scott TW, Irvine R. Molecular species analysis of 1,2-diacylglycerols and phosphatidic acid formed during bombesin stimulation of Swiss 3T3 cells. Biochim. Biophys. Acta 1093, 184-188 (1991
-
(1991)
Biochim. Biophys. Acta
, vol.1093
, pp. 184-188
-
-
Divecha, N.1
Lander, D.J.2
Scott, T.W.3
Irvine, R.4
-
30
-
-
0026317973
-
Quantitative analysis of molecular species of diacylglycerol and phosphatidate formed upon muscarinic receptor activation of human SK-N-SH neuroblastoma cells
-
Lee C, Fisher SK, Agranoff BW, Hajra A. Quantitative analysis of molecular species of diacylglycerol and phosphatidate formed upon muscarinic receptor activation of human SK-N-SH neuroblastoma cells. J. Biol. Chem. 266, 22837-22846 (1991 (Pubitemid 21908727)
-
(1991)
Journal of Biological Chemistry
, vol.266
, Issue.34
, pp. 22837-22846
-
-
Lee, C.1
Fisher, S.K.2
Agranoff, B.W.3
Hajra, A.K.4
-
31
-
-
0029984699
-
Molecular species of phospholipids in a murine stem-cell line responsive to erythropoietin
-
Beckman BS, Mallia C, Clejan S. Molecular species of phospholipids in a murine stem-cell line responsive to erythropoietin. Biochem. J. 314(Pt 3), 861-867 (1996 (Pubitemid 26097748)
-
(1996)
Biochemical Journal
, vol.314
, Issue.3
, pp. 861-867
-
-
Beckman, B.S.1
Mallia, C.2
Clejan, S.3
-
32
-
-
0030760711
-
Diacylglycerol and phosphatidate generated by phospholipases C and D, respectively, have distinct fatty acid compositions and functions: Phospholipase D-derived diacylglycerol does not activate protein kinase C in porcine aortic endothelial cells
-
DOI 10.1074/jbc.272.28.17354
-
Pettitt TR, Martin A, Horton T, Liossis C, Lord JM, Wakelam M. Diacylglycerol and phosphatidate generated by phospholipases C and D, respectively, have distinct fatty acid compositions and functions. Phospholipase D-derived diacylglycerol does not activate protein kinase C in porcine aortic endothelial cells. J. Biol. Chem. 272, 17354-17359 (1997 (Pubitemid 27311161)
-
(1997)
Journal of Biological Chemistry
, vol.272
, Issue.28
, pp. 17354-17359
-
-
Pettitt, T.R.1
Martin, A.2
Horton, T.3
Liossis, C.4
Lord, J.M.5
Wakelam, M.J.O.6
-
33
-
-
33847404482
-
Inhibition of protein kinase Cε prevents hepatic insulin resistance in nonalcoholic fatty liver disease
-
DOI 10.1172/JCI30400
-
Samuel VT, Liu ZX, Wang A et al. Inhibition of protein kinase Cepsilon prevents hepatic insulin resistance in nonalcoholic fatty liver disease. J. Clin Invest. 117, 739-745 (2007 (Pubitemid 46348532)
-
(2007)
Journal of Clinical Investigation
, vol.117
, Issue.3
, pp. 739-745
-
-
Samuel, V.T.1
Liu, Z.-X.2
Wang, A.3
Beddow, S.A.4
Geisler, J.G.5
Kahn, M.6
Zhang, X.-M.7
Monia, B.P.8
Bhanot, S.9
Shulman, G.I.10
-
34
-
-
0037184925
-
Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle
-
DOI 10.1074/jbc.M200958200
-
Yu C, Chen Y, Cline GW et al. Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle. J. Biol. Chem. 277, 50230-50236 (2002 (Pubitemid 36042170)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.52
, pp. 50230-50236
-
-
Yu, C.1
Chen, Y.2
Cline, G.W.3
Zhang, D.4
Zong, H.5
Wang, Y.6
Bergeron, R.7
Kim, J.K.8
Cushman, S.W.9
Cooney, G.J.10
Atcheson, B.11
White, M.F.12
Kraegen, E.W.13
Shulman, G.I.14
-
35
-
-
77953868236
-
Lipid-induced insulin resistance: Unravelling the mechanism
-
Samuel VT, Petersen KF, Shulman G. Lipid-induced insulin resistance: Unravelling the mechanism. Lancet 375, 2267-2277 (2010
-
(2010)
Lancet
, vol.375
, pp. 2267-2277
-
-
Samuel, V.T.1
Petersen, K.F.2
Shulman, G.3
-
36
-
-
4143050204
-
Insulin resistance due to phosphorylation of insulin receptor substrate-1 at serine 302
-
DOI 10.1074/jbc.M405203200
-
Werner ED, Lee J, Hansen L, Yuan M, Shoelson S. Insulin resistance due to phosphorylation of insulin receptor substrate-1 at serine 302. J. Biol. Chem. 279, 35298-35305 (2004 (Pubitemid 39100527)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.34
, pp. 35298-35305
-
-
Werner, E.D.1
Lee, J.2
Hansen, L.3
Yuan, M.4
Shoelson, S.E.5
-
37
-
-
0036300538
-
Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IκB-α
-
Itani SI, Ruderman NB, Schmieder F, Boden G. Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha. Diabetes 51, 2005-2011 (2002 (Pubitemid 34729001)
-
(2002)
Diabetes
, vol.51
, Issue.7
, pp. 2005-2011
-
-
Itani, S.I.1
Ruderman, N.B.2
Schmieder, F.3
Boden, G.4
-
38
-
-
0026040907
-
Development of muscle insulin resistance after liver insulin resistance in high-fat-fed rats
-
Kraegen EW, Clark PW, Jenkins AB, Daley EA, Chisholm DJ, Storlien L. Development of muscle insulin resistance after liver insulin resistance in high-fat-fed rats. Diabetes 40, 1397-1403 (1991
-
(1991)
Diabetes
, vol.40
, pp. 1397-1403
-
-
Kraegen, E.W.1
Clark, P.W.2
Jenkins, A.B.3
Daley, E.A.4
Chisholm, D.J.5
Storlien, L.6
-
39
-
-
78751477559
-
Lipid-induced insulin resistance affects women less than men and is not accompanied by inflammation or impaired proximal insulin signaling
-
Hoeg LD, Sjoberg KA, Jeppesen J et al. Lipid-induced insulin resistance affects women less than men and is not accompanied by inflammation or impaired proximal insulin signaling. Diabetes 60, 64-73 (2010
-
(2010)
Diabetes
, vol.60
, pp. 64-73
-
-
Hoeg, L.D.1
Sjoberg, K.A.2
Jeppesen, J.3
-
40
-
-
38949210754
-
Effect of gender on lipid-induced insulin resistance in obese subjects
-
DOI 10.1530/EJE-07-0493
-
Vistisen B, Hellgren LI, Vadset T et al. Effect of gender on lipid-induced insulin resistance in obese subjects. Eur. J. Endocrinol. 158, 61-68 (2008 (Pubitemid 351211041)
-
(2008)
European Journal of Endocrinology
, vol.158
, Issue.1
, pp. 61-68
-
-
Vistisen, B.1
Hellgren, L.I.2
Vadset, T.3
Scheede-Bergdahl, C.4
Helge, J.W.5
Dela, F.6
Stallknecht, B.7
-
41
-
-
70449715632
-
Diabetes mellitus is associated with increased intramyocellular triglyceride, but not diglyceride, content in obese humans
-
Anastasiou CA, Kavouras SA, Lentzas Y, Gova A, Sidossis LS, Melidonis A. Diabetes mellitus is associated with increased intramyocellular triglyceride, but not diglyceride, content in obese humans. Metabolism 58, 1636-1642 (2009
-
(2009)
Metabolism
, vol.58
, pp. 1636-1642
-
-
Anastasiou, C.A.1
Kavouras, S.A.2
Lentzas, Y.3
Gova, A.4
Sidossis, L.S.5
Melidonis, A.6
-
42
-
-
78049296939
-
Altered intramuscular lipid metabolism relates to diminished insulin action in men, but not women, in progression to diabetes
-
Perreault L, Bergman BC, Hunerdosse DM, Eckel R. Altered intramuscular lipid metabolism relates to diminished insulin action in men, but not women, in progression to diabetes. Obesity (Silver Spring) 18, 2093-2100 (2010
-
(2010)
Obesity (Silver Spring
, vol.18
, pp. 2093-2100
-
-
Perreault, L.1
Bergman, B.C.2
Hunerdosse, D.M.3
Eckel, R.4
-
43
-
-
80053403320
-
Skeletal muscle triglycerides diacylglycerols, and ceramides in insulin resistance: Another paradox in endurance-trained athletes?
-
Amati F, Dube JJ, Alvarez-Carnero E et al. Skeletal muscle triglycerides, diacylglycerols, and ceramides in insulin resistance: Another paradox in endurance-trained athletes? Diabetes 60, 2588-2597 (2011
-
(2011)
Diabetes
, vol.60
, pp. 2588-2597
-
-
Amati, F.1
Dube, J.J.2
Alvarez-Carnero, E.3
-
44
-
-
84887165238
-
Reduced skeletal muscle oxidative capacity and elevated ceramide but not diacylglycerol content in severe obesity
-
doi:10.1002/oby.20381 Epub ahead of print
-
Coen PM, Hames KC, Leachman EM et al. Reduced skeletal muscle oxidative capacity and elevated ceramide but not diacylglycerol content in severe obesity. Obesity (Silver Spring) doi:10.1002/oby.20381 (2013) (Epub ahead of print
-
Obesity (Silver Spring
, vol.2013
-
-
Coen, P.M.1
Hames, K.C.2
Leachman, E.M.3
-
45
-
-
84863944529
-
Augmenting muscle diacylglycerol and triacylglycerol content by blocking fatty acid oxidation does not impede insulin sensitivity
-
Timmers S, Nabben M, Bosma M et al. Augmenting muscle diacylglycerol and triacylglycerol content by blocking fatty acid oxidation does not impede insulin sensitivity. Proc. Natl Acad. Sci. USA 109, 11711-11716 (2012
-
(2012)
Proc. Natl Acad. Sci. USA
, vol.109
, pp. 11711-11716
-
-
Timmers, S.1
Nabben, M.2
Bosma, M.3
-
46
-
-
53149101726
-
Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in mice
-
Minehira K, Young SG, Villanueva CJ et al. Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in mice. J. Lipid Res. 49, 2038-2044 (2008
-
(2008)
J. Lipid Res
, vol.49
, pp. 2038-2044
-
-
Minehira, K.1
Young, S.G.2
Villanueva, C.J.3
-
47
-
-
34347235098
-
Dissociation of Hepatic Steatosis and Insulin Resistance in Mice Overexpressing DGAT in the Liver
-
DOI 10.1016/j.cmet.2007.05.005, PII S1550413107001325
-
Monetti M, Levin MC, Watt MJ et al. Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver. Cell Metab. 6, 69-78 (2007 (Pubitemid 46995777)
-
(2007)
Cell Metabolism
, vol.6
, Issue.1
, pp. 69-78
-
-
Monetti, M.1
Levin, M.C.2
Watt, M.J.3
Sajan, M.P.4
Marmor, S.5
Hubbard, B.K.6
Stevens, RobertD.7
Bain, J.R.8
Newgard, C.B.9
Farese Sr., R.V.10
Hevener, A.L.11
Farese Jr., R.V.12
-
48
-
-
80052174716
-
Hepatic acyl-CoA:diacylglcyerol acyltransferase (DGAT) overexpression
-
author reply: E524
-
Monetti M, Levin MC, Watt MJ et al. Hepatic acyl-CoA:diacylglcyerol acyltransferase (DGAT) overexpression, diacylglycerol, and insulin sensitivity. Proc. Natl Acad. Sci. USA 108, e523; author reply: E524 (2011
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
-
-
Monetti, M.1
Levin, M.C.2
Watt, M.J.3
-
49
-
-
84860455885
-
The problem of establishing relationships between hepatic steatosis and hepatic insulin resistance
-
Farese RV Jr, Zechner R, Newgard CB, Walther T. The problem of establishing relationships between hepatic steatosis and hepatic insulin resistance. Cell Metab. 15, 570-573 (2012
-
(2012)
Cell Metab
, vol.15
, pp. 570-573
-
-
Farese Jr., R.V.1
Zechner, R.2
Newgard, C.B.3
Walther, T.4
-
50
-
-
76049092146
-
Acyl-CoA synthesis, lipid metabolism and lipotoxicity
-
Li LO, Klett EL, Coleman R. Acyl-CoA synthesis, lipid metabolism and lipotoxicity. Biochim. Biophys. Acta 1801(3), 246-251 (2009
-
(2009)
Biochim. Biophys. Acta
, vol.1801
, Issue.3
, pp. 246-251
-
-
Li, L.O.1
Klett, E.L.2
Coleman, R.3
-
51
-
-
43249086785
-
Mammalian long-chain acyl-CoA synthetases
-
DOI 10.3181/0710-MR-287
-
Soupene E, Kuypers F. Mammalian long-chain acyl-CoA synthetases. Exp. Biol. Med. (Maywood) 233, 507-521 (2008 (Pubitemid 351657352)
-
(2008)
Experimental Biology and Medicine
, vol.233
, Issue.5
, pp. 507-521
-
-
Soupene, E.1
Kuypers, F.A.2
-
52
-
-
0026690888
-
Effects of high fat-feeding to rats on the interrelationship of body weight, plasma insulin, and fatty acyl-coenzyme A esters in liver and skeletal muscle
-
Chen MT, Kaufman LN, Spennetta T, Shrago E. Effects of high fat-feeding to rats on the interrelationship of body weight, plasma insulin, and fatty acyl-coenzyme A esters in liver and skeletal muscle. Metabolism 41, 564-569 (1992
-
(1992)
Metabolism
, vol.41
, pp. 564-569
-
-
Chen, M.T.1
Kaufman, L.N.2
Spennetta, T.3
Shrago, E.4
-
53
-
-
0030689043
-
Mechanisms of liver and muscle insulin resistance induced by chronic high-fat feeding
-
Oakes ND, Cooney GJ, Camilleri S, Chisholm DJ, Kraegen E. Mechanisms of liver and muscle insulin resistance induced by chronic high-fat feeding. Diabetes 46, 1768-1774 (1997 (Pubitemid 27456409)
-
(1997)
Diabetes
, vol.46
, Issue.11
, pp. 1768-1774
-
-
Oakes, N.D.1
Cooney, G.J.2
Camilleri, S.3
Chisholm, D.J.4
Kraegen, E.W.5
-
54
-
-
0033834079
-
Long-chain acyl-CoA esters as indicators of lipid metabolism and insulin sensitivity in rat and human muscle
-
Ellis BA, Poynten A, Lowy AJ et al. Long-chain acyl-CoA esters as indicators of lipid metabolism and insulin sensitivity in rat and human muscle. Am. J. Physiol. Endocrinol. Metab. 279, e554-e560 (2000
-
(2000)
Am. J. Physiol. Endocrinol. Metab
, vol.279
-
-
Ellis, B.A.1
Poynten, A.2
Lowy, A.J.3
-
55
-
-
80052530278
-
Amelioration of lipid-induced insulin resistance in rat skeletal muscle by overexpression of Pgc-1beta involves reductions in long-chain acyl-CoA levels and oxidative stress
-
Wright LE, Brandon AE, Hoy AJ et al. Amelioration of lipid-induced insulin resistance in rat skeletal muscle by overexpression of Pgc-1beta involves reductions in long-chain acyl-CoA levels and oxidative stress. Diabetologia 54, 1417-1426 (2011
-
(2011)
Diabetologia
, vol.54
, pp. 1417-1426
-
-
Wright, L.E.1
Brandon, A.E.2
Hoy, A.J.3
-
56
-
-
0036092239
-
Dysregulation of fatty acid metabolism in the etiology of type 2 diabetes
-
McGarry J. Banting lecture 2001: Dysregulation of fatty acid metabolism in the etiology of Type 2 diabetes. Diabetes 51, 7-18 (2002 (Pubitemid 34517974)
-
(2002)
Diabetes
, vol.51
, Issue.1
, pp. 7-18
-
-
Denis McGarry, J.1
-
57
-
-
37449020075
-
Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance
-
Koves TR, Ussher JR, Noland RC et al. Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. Cell Metab. 7, 45-56 (2008
-
(2008)
Cell Metab
, vol.7
, pp. 45-56
-
-
Koves, T.R.1
Ussher, J.R.2
Noland, R.C.3
-
58
-
-
84859463290
-
Targeted deletion of thioesterase superfamily member 1 promotes energy expenditure and protects against obesity and insulin resistance
-
Zhang Y, Li Y, Niepel MW et al. Targeted deletion of thioesterase superfamily member 1 promotes energy expenditure and protects against obesity and insulin resistance. Proc. Natl Acad. Sci. USA 109, 5417-5422 (2012
-
(2012)
Proc. Natl Acad. Sci. USA
, vol.109
, pp. 5417-5422
-
-
Zhang, Y.1
Li, Y.2
Niepel, M.W.3
-
59
-
-
84860482342
-
A ceramide-centric view of insulin resistance
-
Chavez JA, Summers S. A ceramide-centric view of insulin resistance. Cell Metab. 15, 585-594 (2012
-
(2012)
Cell Metab
, vol.15
, pp. 585-594
-
-
Chavez, J.A.1
Summers, S.2
-
60
-
-
0035487315
-
A Role for Protein Phosphatase 2A-Like Activity, but Not Atypical Protein Kinase Cζ, in the Inhibition of Protein Kinase B/Akt and Glycogen Synthesis by Palmitate
-
Cazzolli R, Carpenter L, Biden TJ, Schmitz- Peiffer C. A role for protein phosphatase 2A-like activity, but not atypical protein kinase Czeta, in the inhibition of protein kinase B/Akt and glycogen synthesis by palmitate. Diabetes 50, 2210-2218 (2001 (Pubitemid 33641903)
-
(2001)
Diabetes
, vol.50
, Issue.10
, pp. 2210-2218
-
-
Cazzolli, R.1
Carpenter, L.2
Biden, T.J.3
Schmitz-Peiffer, C.4
-
61
-
-
0142091454
-
Ceramide Disables 3-Phosphoinositide Binding to the Pleckstrin Homology Domain of Protein Kinase B (PKB)/Akt by a PKCζ-Dependent Mechanism
-
DOI 10.1128/MCB.23.21.7794-7808.2003
-
Powell DJ, Hajduch E, Kular G, Hundal H. Ceramide disables 3-phosphoinositide binding to the pleckstrin homology domain of protein kinase B (PKB)/Akt by a PKCzeta-dependent mechanism. Mol. Cell Biol. 23, 7794-7808 (2003 (Pubitemid 37271476)
-
(2003)
Molecular and Cellular Biology
, vol.23
, Issue.21
, pp. 7794-7808
-
-
Powell, D.J.1
Hajduch, E.2
Kular, G.3
Hundal, H.S.4
-
62
-
-
34250344614
-
Ceramide recruits and activates protein kinase C ζ (PKCζ) within structured membrane microdomains
-
DOI 10.1074/jbc.M700082200
-
Fox TE, Houck KL, O'Neill SM et al. Ceramide recruits and activates protein kinase C zeta (PKC zeta) within structured membrane microdomains. J. Biol. Chem. 282, 12450-12457 (2007 (Pubitemid 47100622)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.17
, pp. 12450-12457
-
-
Fox, T.E.1
Houck, K.L.2
O'Neill, S.M.3
Nagarajan, M.4
Stover, T.C.5
Pomianowski, P.T.6
Unal, O.7
Yun, J.K.8
Naides, S.J.9
Kester, M.10
-
63
-
-
40449097575
-
Targeting of PKCζ and PKB to caveolin-enriched microdomains represents a crucial step underpinning the disruption in PKB-directed signalling by ceramide
-
DOI 10.1042/BJ20070936
-
Hajduch E, Turban S, Le Liepvre X et al. Targeting of PKCzeta and PKB to caveolin-enriched microdomains represents a crucial step underpinning the disruption in PKB-directed signalling by ceramide. Biochem. J. 410, 369-379 (2008 (Pubitemid 351346195)
-
(2008)
Biochemical Journal
, vol.410
, Issue.2
, pp. 369-379
-
-
Hajduch, E.1
Turban, S.2
Le Liepvre, X.3
Le Lay, S.4
Lipina, C.5
Dimopoulos, N.6
Dugail, I.7
Hundal, H.S.8
-
64
-
-
79955487247
-
Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice
-
Holland WL, Bikman BT, Wang LP et al. Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice. J. Clin. Invest. 121, 1858-1870 (2011
-
(2011)
J. Clin. Invest
, vol.121
, pp. 1858-1870
-
-
Holland, W.L.1
Bikman, B.T.2
Wang, L.P.3
-
65
-
-
84877294515
-
Plasma ceramides are elevated in female children and adolescents with Type 2 diabetes
-
Lopez X, Goldfine AB, Holland WL, Gordillo R, Scherer P. Plasma ceramides are elevated in female children and adolescents with Type 2 diabetes. J. Pediatr. Endocrinol. Metab. 26(9-10), 995-998 (2013
-
(2013)
J. Pediatr. Endocrinol. Metab
, vol.26
, Issue.9
, pp. 995-998
-
-
Lopez, X.1
Goldfine, A.B.2
Holland, W.L.3
Gordillo, R.4
Scherer, P.5
-
66
-
-
33847332202
-
Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance
-
Holland WL, Brozinick JT, Wang LP et al. Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance. Cell Metab. 5, 167-179 (2007
-
(2007)
Cell Metab
, vol.5
, pp. 167-179
-
-
Holland, W.L.1
Brozinick, J.T.2
Wang, L.P.3
-
67
-
-
77956022194
-
Inhibition of de novo ceramide synthesis reverses diet-induced insulin resistance and enhances whole-body oxygen consumption
-
Ussher JR, Koves TR, Cadete VJ et al. Inhibition of de novo ceramide synthesis reverses diet-induced insulin resistance and enhances whole-body oxygen consumption. Diabetes 59, 2453-2464 (2010
-
(2010)
Diabetes
, vol.59
, pp. 2453-2464
-
-
Ussher, J.R.1
Koves, T.R.2
Cadete, V.J.3
-
68
-
-
79953231189
-
Enzymatic activities of the human AGPAT isoform 3 and isoform 5: Localization of AGPAT5 to mitochondria
-
Prasad SS, Garg A, Agarwal A. Enzymatic activities of the human AGPAT isoform 3 and isoform 5: Localization of AGPAT5 to mitochondria. J. Lipid Res. 52, 451-462 (2010
-
(2010)
J. Lipid Res
, vol.52
, pp. 451-462
-
-
Prasad, S.S.1
Garg, A.2
Agarwal, A.3
-
69
-
-
0035172361
-
Intracellular localization of phospholipase D1 in mammalian cells
-
Freyberg Z, Sweeney D, Siddhanta A, Bourgoin S, Frohman M, Shields D. Intracellular localization of phospholipase D1 in mammalian cells. Mol. Biol. Cell 12, 943-955 (2001 (Pubitemid 33051990)
-
(2001)
Molecular Biology of the Cell
, vol.12
, Issue.4
, pp. 943-955
-
-
Freyberg, Z.1
Sweeney, D.2
Siddhanta, A.3
Bourgoin, S.4
Frohman, M.5
Shields, D.6
-
70
-
-
41949141028
-
Lipid messenger, diacylglycerol, and its regulator, diacylglycerol kinase, in cells, organs, and animals: History and perspective
-
DOI 10.1620/tjem.214.199
-
Goto K, Hozumi Y, Nakano T, Saino-Saito S, Martelli A. Lipid messenger, diacylglycerol, and its regulator, diacylglycerol kinase, in cells, organs, and animals: History and perspective. Tohoku J. Exp. Med. 214, 199-212 (2008 (Pubitemid 351513532)
-
(2008)
Tohoku Journal of Experimental Medicine
, vol.214
, Issue.3
, pp. 199-212
-
-
Goto, K.1
Hozumi, Y.2
Nakano, T.3
Saino-Saito, S.4
Martelli, A.M.5
-
71
-
-
58149094542
-
S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-(alpha) signaling through IKK2
-
Zhang J, Gao Z, Yin J, Quon MJ, Ye J. S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-(alpha) signaling through IKK2. J. Biol. Chem. 283, 35375-35382 (2008
-
(2008)
J. Biol. Chem
, vol.283
, pp. 35375-35382
-
-
Zhang, J.1
Gao, Z.2
Yin, J.3
Quon, M.J.4
Ye, J.5
-
72
-
-
84555178353
-
Detection of cytoplasmic and nuclear functions of mTOR by fractionation
-
Rosner M, Hengstschlager M. Detection of cytoplasmic and nuclear functions of mTOR by fractionation. Methods Mol. Biol. 821, 105-124 (2011)
-
(2011)
Methods Mol. Biol
, vol.821
, pp. 105-124
-
-
Rosner, M.1
Hengstschlager, M.2
|