Glycerolipid signals alter mTOR complex 2 (mTORC2) to diminish insulin signaling

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 5, 2012, Pages 1667-1672

  Zhang, Chongben ^a   Wendel, Angela A ^a   Keogh, Matthew R ^a   Harris, Thurl E ^b   Chen, Jie ^c   Coleman, Rosalind A ^a  

^a IL   (United States)

^b UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^c UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Hepatic steatosis; Palmitate; Triacylglycerol

Indexed keywords

ACYLTRANSFERASE; DIACYLGLYCEROL; GLYCEROL 3 PHOSPHATE ACYLTRANSFERASE 1; GLYCEROLIPID; GLYCEROPHOSPHATE; INSULIN; LYSOPHOSPHATIDIC ACID; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; PHOSPHATIDIC ACID; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; GENE OVEREXPRESSION; GENE SILENCING; GLUCONEOGENESIS; INSULIN RESISTANCE; LIVER CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALS; GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE; INSULIN; LIPID METABOLISM; MICE; MICE, KNOCKOUT; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS;

MUS;

EID: 84863115883     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1110730109     Document Type: Article

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