Reduced skeletal muscle oxidative capacity and elevated ceramide but not diacylglycerol content in severe obesity

Obesity

Volumn 21, Issue 11, 2013, Pages 2362-2371

  Coen, P M ^a,b   Hames, K C ^b   Leachman, E M ^a   Delany, J P ^b   Ritov, V B ^b   Menshikova, E V ^b   Dube J J ^b   Stefanovic Racic, M ^b   Toledo, F G S ^b   Goodpaster, B H ^b  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL COENZYME A; CARBON DIOXIDE; CARDIOLIPIN; CERAMIDE; DIACYLGLYCEROL; DIACYLGLYCEROL ACYLTRANSFERASE 1; PERILIPIN; PERILIPIN 5; PNPLA2 PROTEIN; REGULATOR PROTEIN; SPHINGOLIPID; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; DGAT1 PROTEIN, HUMAN; DIACYLGLYCEROL ACYLTRANSFERASE; MUSCLE PROTEIN; OXPAT PROTEIN, HUMAN; PNPLA2 PROTEIN, HUMAN; SIGNAL PEPTIDE; TRIACYLGLYCEROL LIPASE;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; FATTY ACID OXIDATION; FEMALE; HUMAN; HUMAN TISSUE; INSULIN RESISTANCE; LIPID METABOLISM; MITOCHONDRION; MUSCLE BIOPSY; MUSCLE METABOLISM; MUSCLE OXIDATIVE CAPACITY; OBESITY; SKELETAL MUSCLE; WESTERN BLOTTING; BODY COMPOSITION; CASE CONTROL STUDY; GENETICS; METABOLISM; MIDDLE AGED; MORBID OBESITY; OXIDATION REDUCTION REACTION; PATHOLOGY;

ADULT; BODY COMPOSITION; CASE-CONTROL STUDIES; CERAMIDES; DIACYLGLYCEROL O-ACYLTRANSFERASE; DIGLYCERIDES; FEMALE; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIPASE; LIPID METABOLISM; MIDDLE AGED; MUSCLE PROTEINS; MUSCLE, SKELETAL; OBESITY, MORBID; OXIDATION-REDUCTION;

EID: 84887165238     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1002/oby.20381     Document Type: Article

References (40)

1. Hulver MW, Berggren JR, Cortright RN, et al. Skeletal muscle lipid metabolism with obesity. Am J Physiol Endocrinol Metab 2003; 284: E741-E747.
2. Berggren JR, Boyle KE, Chapman WH, et al. Skeletal muscle lipid oxidation and obesity: influence of weight loss and exercise. Am J Physiol Endocrinol Metab 2008; 294: E726-E732.
3. Hoeks J, Schrauwen P,. Muscle mitochondria and insulin resistance: a human perspective. Trends Endocrinol Metabol 2012; 23: 444-450.
4. Summers SA,. Ceramides in insulin resistance and lipotoxicity. Prog Lipid Res 2006; 45: 42-72.
5. Yu C, Chen Y, Cline GW, et al. Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle. J Biol Chem 2002; 277: 50230-50236.
6. Adams JM II, Pratipanawatr T, Berria R, et al. Ceramide content is increased in skeletal muscle from obese insulin-resistant humans. Diabetes 2004; 53: 25-31.
7. Skovbro M, Baranowski M, Skov-Jensen C, et al. Human skeletal muscle ceramide content is not a major factor in muscle insulin sensitivity. Diabetologia 2008; 51: 1253-1260.
8. Itani SI, Ruderman NB, Schmieder F, et al. Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha. Diabetes 2002; 51: 2005-2011.
9. Moro C, et al. Influence of gender, obesity, and muscle lipase activity on intramyocellular lipids in sedentary individuals. J Clin Endocrinol Metab 2009; 94: 3440-3447.
10. Anastasiou CA, et al. Diabetes mellitus is associated with increased intramyocellular triglyceride, but not diglyceride, content in obese humans. Metab Clin Exp 2009; 58: 1636-1642.
11. Coen PM, Dube JJ, Amati F, et al. Insulin resistance is associated with higher intramyocellular triglycerides in type I but not type II myocytes concomitant with higher ceramide content. Diabetes 2010; 59: 80-88.
12. Amati F, Dube JJ, Alvarez-Carnero E, et al. Skeletal muscle triglycerides, diacylglycerols, and ceramides in insulin resistance: another paradox in endurance-trained athletes? Diabetes 2011; 60: 2588-2597.
13. Vistisen B, Hellgren LI, Vadset T, et al. Effect of gender on lipid-induced insulin resistance in obese subjects. Eur J Endocrinol 2008; 158: 61-68.
14. Whaley MH, Brubaker PH, Otto RM, Armstrong LE,. American college of sports medicine: ACSM's guidelines for exercise testing and prescription, 7th edn. Lippincott Williams & Wilkins: Philadelphia, PA, 2006.
15. Evans WJ, Phinney SD, Young VR,. Suction applied to a muscle biopsy maximizes sample size. Med Sci Sports Exerc 1982; 14: 101-102.
16. Pruchnic R, Katsiaras A, He J, et al. Exercise training increases intramyocellular lipid and oxidative capacity in older adults. Am J Physiol Endocrinol Metab 2004; 287: E857-E862.
17. Bielawski J, Szulc ZM, Hannun YA, et al. Simultaneous quantitative analysis of bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry. Methods 2006; 39: 82-91.
18. Sun D, Cree MG, Wolfe RR,. Quantification of the concentration and 13C tracer enrichment of long-chain fatty acyl-coenzyme A in muscle by liquid chromatography/mass spectrometry. Anal Biochem 2006; 349: 87-95.
19. Cortright RN, Sandhoff KM, Basilio JL, et al. Skeletal muscle fat oxidation is increased in African-American and white women after 10 days of endurance exercise training. Obesity 2006; 14: 1201-1210.
20. Ritov VB, Menshikova EV, Kelley DE,. Analysis of cardiolipin in human muscle biopsy. J Chromatogr B Anal Technol Biomed Life Sci 2006; 831: 63-71.
21. Johannsen DL, Conley KE, Bajpeyi S, et al. Ectopic lipid accumulation and reduced glucose tolerance in elderly adults are accompanied by altered skeletal muscle mitochondrial activity. J Clin Endocrinol Metab 2012; 97: 242-250.
22. Kim JY, Hickner RC, Cortright RL, et al. Lipid oxidation is reduced in obese human skeletal muscle. Am J Physiol Endocrinol Metab 2000; 279: E1039-E1044.
23. Straczkowski M, Kowalska I, Baranowski M, et al. Increased skeletal muscle ceramide level in men at risk of developing type 2 diabetes. Diabetologia 2007; 50: 2366-2373.
24. Turinsky J, O'Sullivan DM, Bayly BP,. 1,2-Diacylglycerol and ceramide levels in insulin-resistant tissues of the rat in vivo. J Biol Chem 1990; 265: 16880-16885.
25. Jocken JW, Moro C, Goossens GH, et al. Skeletal muscle lipase content and activity in obesity and type 2 diabetes. J Clin Endocrinol Metab 2010; 95: 5449-5453.
26. De Vogel-van den Bosch J, Hoeks J, Timmers S, et al. The effects of long- or medium-chain fat diets on glucose tolerance and myocellular content of lipid intermediates in rats. Obesity 2011; 19: 792-799.
27. Erion DM, Shulman GI,. Diacylglycerol-mediated insulin resistance. Nat Med 2010; 16: 400-402.
28. Bergman BC, Hunerdosse DM, Kerege A, et al. Localisation and composition of skeletal muscle diacylglycerol predicts insulin resistance in humans. Diabetologia 2012; 55: 1140-1150.
29. Ellis BA, Poynten A, Lowy AJ, et al. Long-chain acyl-CoA esters as indicators of lipid metabolism and insulin sensitivity in rat and human muscle. Am J Physiol Endocrinol Metab 2000; 279: E554-E560.
30. Houmard JA, Tanner CJ, Yu C, et al. Effect of weight loss on insulin sensitivity and intramuscular long-chain fatty acyl-CoAs in morbidly obese subjects. Diabetes 2002; 51: 2959-2963.
31. Idell-Wenger JA, Grotyohann LW, Neely JR,. Coenzyme A and carnitine distribution in normal and ischemic hearts. J Biol Chem 1978; 253: 4310-4318.
32. Robishaw JD, Neely JR,. Coenzyme A metabolism. Am J Physiol 1985; 248: E1-E9.
33. Bosma M, Minnaard R, Sparks LM, et al. The lipid droplet coat protein perilipin 5 also localizes to muscle mitochondria. Histochem Cell Biol 2012; 137: 205-216.
34. Dalen KT, Dahl T, Holter E, et al. LSDP5 is a PAT protein specifically expressed in fatty acid oxidizing tissues. Biochim Biophys Acta 2007; 1771: 210-227.
35. Wolins NE, Quaynor BK, Skinner JR, et al. OXPAT/PAT-1 is a PPAR-induced lipid droplet protein that promotes fatty acid utilization. Diabetes 2006; 55: 3418-3428.
36. Koves TR, Ussher JR, Noland RC, et al. Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. Cell Metab 2008; 7: 45-56.
37. Turner N, Bruce CR, Beale SM, et al. Excess lipid availability increases mitochondrial fatty acid oxidative capacity in muscle: evidence against a role for reduced fatty acid oxidation in lipid-induced insulin resistance in rodents. Diabetes 2007; 56: 2085-2092.
38. Holloway GP, Thrush AB, Heigenhauser GJ, et al. Skeletal muscle mitochondrial FAT/CD36 content and palmitate oxidation are not decreased in obese women. Am J Physiol Endocrinol Metab 2007; 292: E1782-E1789.
39. Liu L, Shi X, Choi CS, et al. Paradoxical coupling of triglyceride synthesis and fatty acid oxidation in skeletal muscle overexpressing DGAT1. Diabetes 2009; 58: 2516-2524.
40. Badin PM, Louche K, Mairal A, et al. Altered skeletal muscle lipase expression and activity contribute to insulin resistance in humans. Diabetes 2011; 60: 1734-1742.