Activation of PPARβ/δ protects pancreatic β cells from palmitate-induced apoptosis by upregulating the expression of GLP-1 receptor

Cellular Signalling

Volumn 26, Issue 2, 2014, Pages 268-278

  Yang, Yan ^a   Tong, Yuzhen ^a   Gong, Meng ^a   Lu, Yanrong ^a   Wang, Chengshi ^a   Zhou, Mingliang ^a   Yang, Qiu ^a   Mao, Tingrui ^a   Tong, Nanwei ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Apoptosis; GLP 1R; Palmitate; Pancreatic cells; PPAR

Indexed keywords

3 [(4 ANILINO 2 METHOXYPHENYL)SULFAMOYL] 2 THENOIC ACID METHYL ESTER; [2 METHYL 4 [4 METHYL 2 (4 TRIFLUOROMETHYLPHENYL) 5 THIAZOLYLMETHYLTHIO]PHENOXY]ACETIC ACID; CASPASE 3; CAVEOLIN 1; FATTY ACID; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; HOE 33342; INSULIN; PALMITIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN KINASE B; SMALL INTERFERING RNA; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL PROTECTION; CELL STIMULATION; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG MECHANISM; FLOW CYTOMETRY; GENETIC TRANSFECTION; IMMUNOBLOTTING; IMMUNOFLUORESCENCE TEST; INSULIN RELEASE; LIPOTOXICITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL FUNCTION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RAT; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

APOPTOSIS; ELISA; ENZYME-LINKED IMMUNOSORBENT ASSAY; EX; EXENDIN-4; FBS; FDA; FETAL BOVINE SERUM; FFA; FITC; FLUORESCEIN DIACETATE; FLUORESCEIN ISOTHIOCYANATE; FREE FATTY ACID; G PROTEIN COUPLED RECEPTOR; GLP-1R; GLUCAGON-LIKE PEPTIDE-1 RECEPTOR; GLUCOSE-FREE KREBS-RINGER BICARBONATE HEPES BUFFER; GLUCOSE-STIMULATED INSULIN SECRETION; GPCR; GSIS; GW; GW501516; HANKS' BALANCED SALT SOLUTION; HBSS; KRBH; PA; PALMITATE; PANCREATIC Β CELLS; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR Β/Δ; PI; PPARΒ/Δ; PROPIDIUM IODIDE; QPCR; QUANTITATIVE POLYMERASE CHAIN REACTION; SREBP-1C; STEROL REGULATORY ELEMENT BINDING PROTEIN-1C; T2D; TYPE 2 DIABETES;

ANIMALS; APOPTOSIS; CELLS, CULTURED; INSULIN; INSULIN-SECRETING CELLS; MALE; PALMITATES; PPAR DELTA; PPAR-BETA; RATS; RATS, WISTAR; RECEPTORS, GLUCAGON; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SULFONES; THIAZOLES; THIOPHENES; UP-REGULATION;

EID: 84889564748     PISSN: 08986568     EISSN: 18733913     Source Type: Journal    
DOI: 10.1016/j.cellsig.2013.11.019     Document Type: Article

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