Activation of PPARδ up-regulates fatty acid oxidation and energy uncoupling genes of mitochondria and reduces palmitate-induced apoptosis in pancreatic β-cells

Biochemical and Biophysical Research Communications

Volumn 391, Issue 3, 2010, Pages 1567-1572

  Wan, Jun ^a   Jiang, Li ^a   Lü, Qingguo ^a   Ke, Linqiu ^a   Li, Xiaoyu ^b   Tong, Nanwei ^a  

^a SICHUAN UNIVERSITY   (China)

^b SICHUAN UNIVERSITY   (China)

Author keywords

Cell apoptosis; Fatty acid oxidation; Insulin secretion; Mitochondria; PPAR ; Uncoupling protein

Indexed keywords

[2 METHYL 4 [4 METHYL 2 (4 TRIFLUOROMETHYLPHENYL) 5 THIAZOLYLMETHYLTHIO]PHENOXY]ACETIC ACID; CARNITINE PALMITOYLTRANSFERASE I; FATTY ACID; INSULIN; LIPID; LONG CHAIN ACYL COENZYME A DEHYDROGENASE; MESSENGER RNA; PALMITIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PYRUVATE DEHYDROGENASE; PYRUVATE DEHYDROGENASE KINASE 4; UNCOUPLING PROTEIN 2; CARNITINE PALMITOYLTRANSFERASE; ION CHANNEL; MITOCHONDRIAL PROTEIN; MITOCHONDRIAL UNCOUPLING PROTEIN 2; PROTEIN KINASE; THIAZOLE DERIVATIVE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL FUNCTION; CELL SWELLING; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DIABETES MELLITUS; DRUG EFFECT; ENERGY; FATTY ACID OXIDATION; INSULIN RELEASE; LIPID OXIDATION; METABOLIC SYNDROME X; MITOCHONDRIAL GENE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION; ANIMAL; CELL LINE; DRUG POTENTIATION; GENE EXPRESSION REGULATION; GENETICS; HAMSTER; METABOLISM; MITOCHONDRION; OXIDATION REDUCTION REACTION; TRANSMISSION ELECTRON MICROSCOPY; ULTRASTRUCTURE;

ACYL-COA DEHYDROGENASE, LONG-CHAIN; ANIMALS; CARNITINE O-PALMITOYLTRANSFERASE; CELL LINE; CRICETINAE; FATTY ACIDS; GENE EXPRESSION REGULATION; GENES, MITOCHONDRIAL; INSULIN; INSULIN-SECRETING CELLS; ION CHANNELS; MICROSCOPY, ELECTRON, TRANSMISSION; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; OXIDATION-REDUCTION; PALMITIC ACID; PPAR DELTA; PROTEIN KINASES; THIAZOLES; UP-REGULATION;

EID: 73949116134     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.12.127     Document Type: Article

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