Thioredoxin-interacting protein deficiency induces Akt/Bcl-xL signaling and pancreatic beta-cell mass and protects against diabetes

FASEB Journal

Volumn 22, Issue 10, 2008, Pages 3581-3594

  Chen, Junqin ^a   Hui, Simon T ^c   Couto, Francesca M ^a   Mungrue, Imran N ^d   Davis, Dawn B ^a,b   Attie, Alan D ^b   Lusis, Aldons J ^d   Davis, Roger A ^c   Shalev, Anath ^a,e  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

^c SAN DIEGO STATE UNIVERSITY   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e University of Wisconsin Health   (United States)

Author keywords

Apoptosis; bTKO; Insulin sensitivity; Islets; Obesity; TXNIP

Indexed keywords

CARRIER PROTEIN; GLUCOSE; INSULIN; STREPTOZOCIN; THIOREDOXIN; THIOREDOXIN INTERACTING PROTEIN; UNCLASSIFIED DRUG; PROTEIN BCL X; PROTEIN KINASE B; TXNIP PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE PREDISPOSITION; GLUCOSE BLOOD LEVEL; HYPOGLYCEMIA; MORPHOMETRICS; MOUSE; NICK END LABELING; NONHUMAN; OBESITY; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; ANIMAL; CELL COUNT; CHEMICALLY INDUCED DISORDER; EXPERIMENTAL DIABETES MELLITUS; GENETICS; INSULIN DEPENDENT DIABETES MELLITUS; METABOLISM; MOUSE MUTANT; NON INSULIN DEPENDENT DIABETES MELLITUS; PATHOLOGY; SIGNAL TRANSDUCTION;

MUS;

ANIMALS; APOPTOSIS; BCL-X PROTEIN; CARRIER PROTEINS; CELL COUNT; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 1; DIABETES MELLITUS, TYPE 2; HYPOGLYCEMIA; INSULIN-SECRETING CELLS; MICE; MICE, KNOCKOUT; OBESITY; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; THIOREDOXINS;

EID: 54049102845     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.08-111690     Document Type: Article

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